Ventilatory functions response to breathing training versus aerobic training in asthmatic children

Background: There is worldwide public interest in physical therapies for asthma. Objective: To compare the effects of a program of breathing training and aerobic training on ventilatory functions in children with bronchial asthma. Methods: Forty asthmatic children from both genders (22 boys and 18 girls) were recruited to participate with age range 6-13 years. The children were divided into two groups of equal number, group A received a program of breathing training and group B received a program of aerobic training on cycle ergometer three times per week for three months. Ventilatory functions were measured before beginning and after finishing the training. Results: The results showed high statistical significant differences in the FVC, FEV1, PEF, FEF25-75% and MVV within each group while on comparing the two groups, the ventilatory functions were comparable. Conclusion: Breathing training and aerobic training can be used as a safe complement to medical treatment in asthma.Keywords: Asthmatic children; ventilatory functions, breathing training; aerobic trainingEgypt J Pediatr Allergy Immunol 2012;10(1):33-3

Sclerodactyly and Diabetic Complications among Egyptian Adolescent Type 1 Diabetic Patient

BACKGROUND: One of the common complications of diabetic patients is sclerodactyly which is considered as a part of limited joint mobility. AIM: To assess sclerodactyly in adolescent type 1 diabetics and to detect its relation to other diabetic complications. METHODS: Sixty-three diabetics and 60 controls were studied. Clinical, laboratory assessment, ultrasonography of the skin, carotid artery intima-media thickness (cIMT) & renal colour duplex were done for all participants. RESULTS: Sclerodactyly was positive in 12 (19%) of diabetics. Patients with sclerodactyly had a significantly thickened skin compared to patients without sclerodactyly and controls, P = 0.0001. Male diabetics had significantly thickened skin (p = 0.0001). Diabetic patients with sclerodactyly had significant higher systolic blood pressure (p = 0.03), cholesterol (p = 0.05) and triglyceride (p = 0.004) and lower HDL-c (p = 0.04). Skin thickness had a significant positive correlation with age of diabetic patients (p = 0.02), waist/height ratio (p = 0.04), glycosylated hemoglobin (p = 0.03), albumin/creatinine ratio (p = 0.03), and cIMT (p = 0.03). CONCLUSION: Ultrasound easily diagnoses sclerodactyly. Diabetic patients had a high prevalence of sclerodactyly with increased macrovascular and microvascular complications. Sclerodactyly may be a marker for diabetic vascular complications. Frequent follow up of diabetic patients for early detection of sclerodactyly in uncontrolled diabetic patients is recommended. It could be an alarming sign for microalbuminuria, hypertension, hyperlipidaemia and atherosclerosis

Effect of Foundation Deformations on the Damage of a Masonry Villa (Case History)

Cracks in the masonry walls of a one storey villa due to foundation deformations are investigated in this paper. In spite of the fact that the soil formation in the site was found to be almost uniform, hogging deformation profile took place in the strip foundation due to unequal loading. Analysis of the walls together with their supporting soil, as one integrated system, showed that very small foundation deformation can produce tensile stresses in the wall higher than its tensile strength. Repair of the cracks was proposed and carried out successfully

Death associated protein kinase-1 gene methylation pattern in some leukemic patients attending Zagazig University hospitals: is it a clue?

Background: Leukemia is a type of cancer arising from white blood cells (WBCs) and resulting from malignant transformation of different types of white blood cell precursors. The objective was to study the DAPK-1 gene methylation pattern in leukemic patients and to through some light on its possible role as a risk factor for leukemia.Methods: Forty-one patients diagnosed as leukemic patients and 41 age-matched healthy unrelated volunteers taken as a control group. The analysis of aberrant promoter DAPK1 gene methylation was done by specific polymerase chain reaction.Results: The results of the present study showed that there was a significant association of methylated DAPK-1 promoter area among leukemic group than in control group Chi-square (X2) was 21.98, or value patients was 10.46 and there was a significant association when compared with the control group (p <0.001). And there was no significant association when compared according to gender Chi-square (X2) was 0.43 and (p=0.51). Our results revealed in the AML group DAPK-1 promoter area were methylated with percentage of 73.9%. or value for AML patients was 13.76 and there was a significant association when compared with the control group (p <0.001), in the ALL group 4 patients had methylated DAPK-1 promoter area with percentage of 57.1% or value for all patients was 6.47 and there was a significant association when compared with the control group (p=0.03) and in the CLL group 7 patients had methylated DAPK-1 promoter area with percentage of 63.6%. OR value for CCL patients was 8.5 and there was a significant association when compared with the control group (p=0.004). On the contrary, we didn’t observe any significant associations between DAPK-1 promoter area methylation and the type of leukemia (p = 0.65).Conclusions: These results suggested that DAPK1 promoter methylation might play a significant role in the pathogenesis of different types of leukemia. And the DAPK1 promoter methylation has a predictive value in the prediction of leukemia occurrence.

Copeptin as a Biomarker of Atherosclerosis in Type 1 Diabetic Patients

AIM: To evaluate copeptin as an early marker of atherosclerosis in adolescent type 1 diabetics. METHODS: Sixty-two type 1 diabetic patients and 50 healthy volunteers were enrolled in the study. Serum copeptin, glycosylated haemoglobin (HbA1c), lipid profile, oxidised low-density lipoprotein (OxLDL), urinary albumin/creatinine ratio, carotid intimal medial thickness (cIMT), aortic intimal medial thickness (aIMT) and resistivity index were assessed for all participant in the study. RESULTS: HbA1, albumin/creatinine ratio, lipid profile, OxlDL, copeptin, cIMT and aIMT were significantly higher in diabetic patients. Copeptin was higher in patients with positive cIMT and aIMT. Copeptin correlated with cIMT and aIMT. Stepwise multiple regression analysis found that copeptin correlated with aIMT. ROC curve showed that copeptin had 100 % specificity with aIMT and cIMT and 95.2 and 60,7 sensitivity with aIMT and cIMT respectively. CONCLUSION: Copeptin can be used as a marker for early detection of atherosclerosis of type 1 diabetic patients

French women and Nazi concentration camps: A study of the testimonies of French female survivors

This thesis is a study of the experiences of French women deported to Nazi concentration camps during World War Two, conducted with reference to an extensive corpus of published and archival autobiographical testimonies written by French female camp survivors. The testimonies of French male survivors and non-French writers are also utilised to a lesser degree as supplementary and comparative sources. The thesis aims to contribute to concentration camp scholarship by configuring a hitherto unrealised comprehensive portrait of the French female body of writing, elucidating how French women depict their camp experience, their responses to the unique challenges of testimonial writing and the gender specificity of this literature. Focusing on those aspects which are most significant within the testimonies of French women, the study demonstrates how social and biological gender specificity shape and particularize the narratives of these women. It also encompasses the pivotal theme of inmate relations, revealing the simultaneous externalization and redefinition of the notion of prisoner privilege which occurs in these writers' portrayal of hierarchical prisoner interaction, as well as the marked emphasis which French female survivors place upon the concepts of solidarity, mutual aid and collective structures. The purely textual level is also examined, detailing both the variety of responses to the issues of testimonial writing manifested by these writers and the cross-narrative authorial conception of the testimony as ultimately problematic. These areas of inquiry combine to yield a portrait of a highly complex testimonial genre, characterized by often unresolved tensions which are reflective of the complex and consistently nuanced nature of the wider camp experience

Osteopontin for Early Detection of Microvascular and Macrovascular Type 1 Diabetic Complication

AIM: To evaluate the relationship between osteopontin and diabetes complication in type 1 diabetic patient. PATIENTS AND METHODS: Seventy types 1 diabetic and 60 healthy volunteers were studied. Full history, examination, laboratory tests of glycosylated haemoglobin (HbA1c), serum lipids {cholesterol, triglyceride (Tg), high-density lipoprotein-cholesterol (HDL-c), low-density lipoprotein – cholesterol (LDL-c)}, oxidised low-density lipoprotein (OxLDL), Osteopontin and urinary microalbuminuria (albumin/creatinine ratio) were done. Image study in the form of a carotid intimal medial thickness (cIMT) and aortic intimal medial thickness (aIMT), renal doppler for resistivity index was also done for all participant included in the study. RESULTS: Urinary albumin/creatinine ratio, lipid profile, osteopontin, cIMT and aIMT were higher in people with diabetes. Osteopontin was higher in people with diabetes with positive microalbuminuria and cIMT. Systolic blood pressure, microalbuminuria and cIMT had a positive correlation with osteopontin in people with diabetes. Stepwise multiple regression analysis showed that osteopontin had a significant correlation with cIMT. Receiver operating characteristic (ROC) curve showed that the cut off value of Osteopontin for detection of cIMT was &gt; 60 with a specificity of 100% and sensitivity 80.5%, while that of albumin/creatinine ratio was &gt; 64 with a specificity of 66.7 and sensitivity of 92.3. CONCLUSION: Osteopontin is higher in type 1 diabetics and is useful for early detection of diabetic microvascular and macrovascular complication

Irisin in Adolescent Type 1 Diabetic Patients and its Relation to Diabetes Control and Atherosclerosis

AIM: The objective of this was to determine the role of irisin in adolescent type 1 diabetes (T1D) patients. METHODS: This study was conducted on 65 patients with T1D and 50 healthy individuals as control group. Serum irisin, glycosylated hemoglobin (HbA1c), lipid profile, oxidized low-density lipoprotein (OxLDL), urinary albumin/creatinine ratio; carotid intimal medial thickness (cIMT), and aortic intimal medial thickness (aIMT) were evaluated for all participant. RESULTS: HbA1c, lipid profile, albumin/creatinine ratio, OxLDL, irisin, aIMT and cIMT were significantly higher in diabetic patients. Irisin had a positive correlation with age of diabetic patients, onset of diabetes, mid arm circumference, waist/height ratio, body mass index, HbA1c, and cIMT. CONCLUSION: Irisin is a marker for detection of diabetes control and early detection of subclinical atherosclerosis. Irisin had a relation with obesity

Estimating and Mapping Chlorophyll a Concentration as a Function of Environmental Changes of Manzala Lagoon, Egypt Using Landsat 7 ETM+ Images

Abstract: This study is aiming at developing a robust methodology for estimating Chlorophyll-a (Chl a) concentration in one of the largest costal lagoon of Egypt, Lake Manzala, using Landsat 7 ETM+ data. The method based on band ratioing and regression modelling established from in-situ measurements and the optical satellite images. The Landsat data was geometrically and radiometrically corrected, which subsequently converted into irradiance at sensor. Single band ratioing, particularly the visible bands 1, 2 and 3, were used to establish a logarithmic regression model. Ratio of ETM+ band 1 and ETM+ band 3 shown the most significant ratio in estimating chlorophyll-a with a maximum correlation coefficient of R = 0.75. This ratio is then used to estimate the spatial 2 distribution of Chl a along the lake. The methodology and environmental factors are detailed in the paper