Identities for Anderson generating functions for Drinfeld modules

Anderson generating functions are generating series for division values of points on Drinfeld modules, and they serve as important tools for capturing periods, quasi-periods, and logarithms. They have been fundamental in recent work on special values of positive characteristic L-series and in transcendence and algebraic independence problems. In the present paper we investigate techniques for expressing Anderson generating functions in terms of the defining polynomial of the Drinfeld module and determine new formulas for periods and quasi-periods.Comment: 18 page

Pattern and degree of left ventricular remodeling following a tailored surgical approach for hypertrophic obstructive cardiomyopathy.

Background The role of a tailored surgical approach for hypertrophic cardiomyopathy (HCM) on regional ventricular remodelling remains unknown. The aims of this study were to evaluate the pattern, extent and functional impact of regional ventricular remodelling after a tailored surgical approach. Methods From 2005 to 2008, 44 patients with obstructive HCM underwent tailored surgical intervention. Of those, 14 were ineligible for cardiac magnetic resonance (CMR) studies. From the remainder, 14 unselected patients (42±12 years) underwent pre- and post-operative CMR studies at a median 12 months post-operatively (range 4-37 months). Regional changes in left ventricular (LV) thickness as well as global LV function following surgery were assessed using CMR Tools (London, UK). Results Pre-operative mean echocardiographic septal thickness was 21±4 mm and mean LV outflow gradient was 69±32 mmHg. Following surgery, there was a significant degree of regional regression of LV thickness in all segments of the LV, ranging from 16% in the antero-lateral midventricular segment to 41% in the anterior basal segment. Wall thickening was significantly increased in basal segments but showed no significant change in the midventricular or apical segments. Globally, mean indexed LV mass decreased significantly after surgery (120±29g/m2 versus 154±36g/m2; p<0.001). There was a trend for increased indexed LV end-diastolic volume (70±13 mL versus 65±11 mL; p=0.16) with a normalization of LV ejection fraction (68±7% versus 75±9%; p<0.01). Conclusion Following a tailored surgical relief of outflow obstruction for HCM, there is a marked regional reverse LV remodelling. These changes could have a significant impact on overall ventricular dynamics and function

The effect of auditory stimulation on pain response of preterm infants

This study aimed to evaluate the effect of auditory stimulation on preterm infants' pain responses. A quasi-experimental design was utilized in this study. Thirty preterm infants were recruited for the study. They were one group used for three days as day one (routine care), day two (music intervention) and day three (recorded mother voice intervention) before, during and after blood sample procedure (heel prick) from Cairo University hospitals (El Monira and Kasar Aini). A tool containing two parts was used for data collection: 1) socio-demographic data for the preterm infants and the mothers, 2) Premature Infant Pain Profile (PIPP) tool for physiological responses (heart rate, oxygen saturation) behavioral state, brow bulge, eye squeeze, nasolabial furrow and respiratory rate was determined. Results of the study showed that during heel prick the majority of preterm infants (96.7%) who were exposed to recorded mother voice had highly statistical significant no or minimal pain followed by music groups (66.7%). On the other hand, nearly half of the cases (46.7%) had moderate pain and (30%) had severe pain among control group. There were significant differences between the three groups in the behavioral state, brow bulge, eye squeeze and nasolabial furrow (P≤0.001) and improved oxygen saturation (P≤0.05). After heel prick, the preterm infants (100%) who were exposed to recorded mother voice had highly statistically significant no or minimal pain in the items of behavioral state, eye squeeze and nasolabial furrow (P≤0.001), brow bulge was significantly lower (P≤0.05) when comparing by control or music group. In Conclusion, exposure to recorded mother voice during heel prick of preterm infants is better than exposure to music or no intervention and this was manifested by lower pain level, decrease heart rate, improved oxygen saturation and respiration. Key words: Auditory stimulation; recorded mother voice; music; pain response; physiological responses; behavioral stat

Two-divisibility of the coefficients of certain weakly holomorphic modular forms

We study a canonical basis for spaces of weakly holomorphic modular forms of weights 12, 16, 18, 20, 22, and 26 on the full modular group. We prove a relation between the Fourier coefficients of modular forms in this canonical basis and a generalized Ramanujan tau-function, and use this to prove that these Fourier coefficients are often highly divisible by 2.Comment: Corrected typos. To appear in the Ramanujan Journa

A Subset of Replication Proteins Enhances Origin Recognition and Lytic Replication by the Epstein-Barr Virus ZEBRA Protein

ZEBRA is a site-specific DNA binding protein that functions as a transcriptional activator and as an origin binding protein. Both activities require that ZEBRA recognizes DNA motifs that are scattered along the viral genome. The mechanism by which ZEBRA discriminates between the origin of lytic replication and promoters of EBV early genes is not well understood. We explored the hypothesis that activation of replication requires stronger association between ZEBRA and DNA than does transcription. A ZEBRA mutant, Z(S173A), at a phosphorylation site and three point mutants in the DNA recognition domain of ZEBRA, namely Z(Y180E), Z(R187K) and Z(K188A), were similarly deficient at activating lytic DNA replication and expression of late gene expression but were competent to activate transcription of viral early lytic genes. These mutants all exhibited reduced capacity to interact with DNA as assessed by EMSA, ChIP and an in vivo biotinylated DNA pull-down assay. Over-expression of three virally encoded replication proteins, namely the primase (BSLF1), the single-stranded DNA-binding protein (BALF2) and the DNA polymerase processivity factor (BMRF1), partially rescued the replication defect in these mutants and enhanced ZEBRA's interaction with oriLyt. The findings demonstrate a functional role of replication proteins in stabilizing the association of ZEBRA with viral DNA. Enhanced binding of ZEBRA to oriLyt is crucial for lytic viral DNA replication

In-Stent CTO Percutaneous Coronary Intervention: Individual Patient Data Pooled Analysis of 4 Multicenter Registries

OBJECTIVES: The authors sought to examine the outcomes of percutaneous coronary intervention (PCI) for in-stent restenosis (ISR) chronic total occlusions (CTOs). BACKGROUND: The outcomes of PCI for ISR CTOs have received limited study. METHODS: The authors examined the clinical and angiographic characteristics and procedural outcomes of 11,961 CTO PCIs performed in 11,728 patients at 107 centers in Europe, North America, Latin America, and Asia between 2012 and 2020, pooling patient-level data from 4 multicenter registries. In-hospital major adverse cardiovascular events (MACE) included death, myocardial infarction, stroke, and tamponade. Long-term MACE were defined as the composite of all-cause death, myocardial infarction, and target vessel revascularization. RESULTS: ISR represented 15% of the CTOs (n = 1,755). Patients with ISR CTOs had higher prevalence of diabetes (44% vs. 38%; p \u3c 0.0001) and prior coronary artery bypass graft surgery (27% vs. 24%; p = 0.03). Mean J-CTO (Multicenter CTO Registry in Japan) score was 2.32 ± 1.27 in the ISR group and 2.22 ± 1.27 in the de novo group (p = 0.01). Technical (85% vs. 85%; p = 0.75) and procedural (84% vs. 84%; p = 0.82) success was similar for ISR and de novo CTOs, as was the incidence of in-hospital MACE (1.7% vs. 2.2%; p = 0.25). Antegrade wiring was the most common successful strategy, in 70% of ISR and 60% of de novo CTOs, followed by retrograde crossing (16% vs. 23%) and antegrade dissection and re-entry (15% vs. 16%; p \u3c 0.0001). At 12 months, patients with ISR CTOs had a higher incidence of MACE (hazard ratio: 1.31; 95% confidence intervals: 1.01 to 1.70; p = 0.04). CONCLUSIONS: ISR CTOs represent 15% of all CTO PCIs and can be recanalized with similar success and in-hospital MACE as de novo CTOs

Period polynomials, derivatives of L-functions, and zeros of polynomials

Period polynomials have long been fruitful tools for the study of values of L-functions in the context of major outstanding conjectures. In this paper, we survey some facets of this study from the perspective of Eichler cohomology. We discuss ways to incorporate non-cuspidal modular forms and values of derivatives of L-functions into the same framework. We further review investigations of the location of zeros of the period polynomial as well as of its analogue for L-derivatives