Corpus callosum defect with dilated lateral ventricles and an occipital cyst in an Egyptian child with Diamond-Blackfan anemia

Diamond-Blackfan anemia (DBA), an inherited bone marrow failure syndrome characterized by anemia that usually presents before the first birthday or in early childhood, is associated with birth defects and an increased risk of cancer. Although anemia is the most prominent feature of DBA, the disease is also characterized by growth retardation and congenital malformations, in particular craniofacial, upper limb, heart, and urinary system defects that are present in approximately 30%-50% of patients. Herein, we present a patient with Diamond-Blackfan anemia associated craniofacial anomalies, pyramidal manifestations and corpus callosum defect and dilated lateral ventricles opening with each other and opening with a posterior occipital cyst, an association that to date has not been reported.Key Words: Diamond-Blackfan anemia, corpus callosum, dilated ventricles, occipital cyst

On modeling two immune effectors two strain antigen interaction

In this paper we consider the fractional order model with two immune effectors interacting with two strain antigen. The systems may explain the recurrence of some diseases e.g. tuberculosis (TB). The stability of equilibrium points are studied. Numerical solutions of this model are given. Using integer order system the system oscillates. Using fractional order system the system converges to a stable internal equilibrium. Ulam-Hyers stability of the system has been studied

Síntesis y evaluación de compuestos heterocíclicos derivados de ?-hidroxiácidos con interés industrial potencial.

The reaction of 2-hydroxyheptadecanoyl chloride (2) and anthranilic acid gave 2-(1-hydroxyheptadecyl)-4H-3,1-benzoxazin-4-one (3) which was used as starting material to synthesize some condensed and non-condensed heterocyclic compounds by a reaction with nitrogen nucleophiles (e.g., hydrazine hydrate, and formamide). The subsequent reaction of the synthetic products with different amounts of propylene oxide gave a novel group of nonionic compounds having a double function as antibacterial and surface active agents which may serve in the manufacturing of drugs, cosmetics, pesticides or as antibacterial and/or antifungal products. The surface active properties such as surface and interfacial tensions, cloud point, foaming height, wetting time, and emulsification power were determined. Antimicrobial and biodegradability were also screened.La reacción de cloruro de 2-hidroxiheptadecanoilo (2) con ácido antranílico produjo 2-(1-hidroxiheptadecil)-4H-3,1-benzoxazin-4-ona (3) que fue usada como material de partida en la síntesis de compuestos heterocíclicos condensados y no condensados por reacción con nucleófilos nitrogenados (hidracina y formamida). La reacción de los productos sintetizados con distintas cantidades de óxido de propileno dio un grupo nuevo de compuestos no iónicos con una función doble como antibacterianos y agentes tensioactivos que pueden servir en la manufactura de medicamentos, cosméticos, pesticidas, o como productos antibacterianos y/o antifúngicos. Se determinaron las propiedades tensioactivas así como la capacidad antimicrobiana y la biodegrabilidad de los compuestos sintetizados

Propiedades tensoactivas y actividad biológica de nuevos surfactantes no iónicos conteniendo pirimidinas y anillos nitrogenados relacionados

A series of annelated pyrimidine derivatives has been synthesized via different heterocyclization reactions of suitably functionalized 6-(4-octadecyloxyphenyl)-4-oxo-2- thioxo-1,2,3,4-tetrahydropyrimidine-5-carbonitrile (4) with different electrophiles and nucleophiles. These heterocycles bear an active hydrogen atom (NH, OH or COOH) which could be propoxylated using propylene oxide with different moles, 5, 10 and 15, to produce nonionic surfactant having a long alkyl chain with molecular weight suitable for becoming an amphiphilic molecule with correct hydrophilic-lypophilic balance which enhances solubility, biodegradability and hence lowers the toxicity to human beings and becomes environmentally friendly. In addition, the antimicrobial activities of these compounds were screened and it was found that some of these compounds have similar or higher activity compared with commercial antibiotic drugs (sulphadiazine), which make them suitable for diverse applications like the manufacturing of drugs, pesticides, emulsifiers, cosmetics, etc.Una serie de derivados pirimidínicos y relacionados han sido preparados vía diferentes reacciones de formación de heterociclos entre 6-(4-octadeciloxifenil)-4-oxo-2-tioxo- 1,2,3,4-tetrahidropirimidina-5-carbonitrilo (4) y diferentes electrófilos y nucleófilos. Estos heterociclos tienen un átomo de hidrógeno activo (NH, OH, o COOH) que fue propoxilado con diferentes moles de óxido de propileno (5, 10, o 15) para producir surfactantes no iónicos con una cadena alquílica larga y peso molecular apropiado para convertirse en una molécula anfifílica con un balance hidrofílico-lipofílico correcto que aumenta la solubilidad y la biodedradabilidad, decrece la toxicidad a los seres humanos, y se convierte en respetuoso con el medio ambiente. Además, las actividades antimicrobianas de estos compuestos fueron determinadas y se encontró que algunos de estos compuestos tuvieron una actividad similar o más alta que antibióticos comerciales (sulfadiazina), lo que los hace apropiados para aplicaciones diversas como la manufactura de medicamentos, pesticidas, emulsificantes, cosméticos, etc

Síntesis y propiedades antibacterianas y tensoactivas de derivados 1,2,4-triazólicos

The use of sodium 1-(4-amino-5-mercapto-4H-[1,2,4] triazol-3-yl) and heptadecane-1-sulfonate (2) as new precursors to synthesize some important biologically active heterocycles has been found to be effective. The reaction of 2 with carbon disulphide in pyridine and acid chlorides yielded the 1,2,4-triazole derivatives 3, 4a and 4b.The condensation of 2 with appropriate aldehydes gave 5a-c which were cyclized by treating with thioglycollic acid to yield 6a-c. The reactions of 2 with phthalic anhydride and 4-methylbenzene-sulfonylchloride gave 7 and 8. In addition, the reaction of 2 with chloroacetaldehyde, phenacyl bromide, urea and chloroacetyl chloride yielded 9, 10, 11 and 12. At the same time, refluxing 2 with phenyl isothiocyanate gave 13 and 14. All these products have antimicrobial activity and they can be used as surface active agents.Es interesante el uso del 1-(4-amino-5-mercapto-4H- [1,2,4]triazol-3-il)heptadecano-1-sulfonato sódico (2) como un nuevo precursor en la síntesis de compuestos heterocíclicos biológicamente importantes. La reacción de 2 con disulfuro de carbono en piridina y cloruros de acilo rindió derivados 1,2,4-triazólicos. Condensación de 2 con aldehídos apropiados produjo 5a-c que ciclaron por tratamiento con ácido tioglicólico para dar lugar a 6a-c. Reacciones de 2 con anhídrido ftálico y cloruro de 4-metilbenzenosulfonilo produjeron 7 y 8. Además, la reacción de 2 con cloroacetaldehído, bromuro de fenacilo, urea, cloruro de tiacetilo produjo 9, 10, 11, y 12. Por otra parte, el reflujo de 2 con isocianato de fenilo dio 13 y 14. Todos los productos tuvieron actividad antimicrobiana y propiedades tensoactivas

n-Butyl 2-(2,4-dichloro­anilino)-4,4-dimethyl-6-oxocyclo­hex-1-enecarbo­dithio­ate

The cyclo­hexene ring in the title compound, C19H23Cl2NOS2, adopts an envelope conformation, with the C atom bearing the two methyl groups representing the flap. This atom deviates by 0.630 (2) Å from the plane passing through the other five atoms of the ring (r.m.s. deviation = 0.020 Å). The mol­ecular conformation is stabilized by an intra­molecular N—H⋯S hydrogen bond

Bifilm defects and porosity in Al cast alloys

Liquid Al and Mg-base alloys are so reactive that it is reasonable to assume that the surface layer is always oxidised. If liquid aluminium entered a mould cavity with a velocity greater than a critical value, the surface skin of the liquid metal would fold over onto itself and be submerged into the bulk liquid with a volume of air entrapped within it, creating what is called a bifilm defect. This defect not only acts as a crack but also it is recognized to initiate hydrogen porosity in the solidified casting, which has been found to have detrimental effects on the tensile and fatigue properties of the castings produced. Previous research suggested that during solidification the hydrogen, in excess of the solubility limit, comes out of solution and diffuses into the bifilm gap, expanding it into a pore. Also, placing liquid metal in a vacuum may cause its entrained bifilms to expand, enhancing their buoyancy and therefore their floatation to the surface of the melt. In this work, a casting from an A356 Al alloy was allowed to solidify under vacuum. The solidified casting was sectioned into two halves, and the internal surfaces of the pores were investigated using an SEM to determine their relationship with double oxide film defects

Characterization of Microplastics in the Atmosphere

For the purposes of this research, microplastics (MPs) can be defined as small fragments of plastic or synthetic polymer material that are less than 5mm in size. The goal of this study is to investigate MPs in the atmosphere. Previous research has primarily focused on MPs in marine and coastal environments; however, we are directing our attention to the atmospheric presence of MPs. This is due to the uncertainties associated with the impacts of MPs on human health upon inhalation. By the means of active and passive sampling, we aim to determine the atmospheric transport of MPs operating from the Embry-Riddle Aeronautical University at the Daytona Beach Campus. Active sampling entails using the Tisch High Volume Air Sampler, which will be collected daily. On the other hand, passive sampling utilizes a setup devised to hold the filter to collect MPs, this will be collected weekly. From this point, the MPs will be isolated and analyzed under a ZEISS Axioscope 7 compound microscope to determine the size of the microplastic particles. Fourier transform infrared (FTIR) spectroscopy will be utilized to investigate chemical properties of MPs. Utilizing these methods, we will obtain a thorough understanding of the composition and origin of these atmospheric particles. To further assess the effect of weather conditions on the transportation of MPs in the atmosphere, this work will be conducted seasonally. This study has implications for the effects of MPs on human health via inhalation, as well as their effects on water bodies and soil upon deposition

2-Hydroxy­ethyl 2-(2,4-dichloro­anilino)-4,4-dimethyl-6-oxocyclo­hex-1-ene­carbo­dithio­ate

The six-membered cyclo­hexene ring in the title compound, C17H19Cl2NOS2, adopts an envelope conformation, with the C atom bearing the two methyl groups representing the flap. This atom deviates by 0.716 (3) Å from the plane passing through the other five atoms of the ring (r.m.s. deviation = 0.072 Å). The mol­ecular conformation is stabilized by an intra­molecular N—H⋯S hydrogen bond. The hydr­oxy group engages in inter­molecular O—H⋯O hydrogen bonding with adjacent acceptor atoms to generate a zigzag chain running along the c axis

Resistance of Alkali Activated Water-Cooled Slag Geopolymer to Sulphate Attack

Ground granulated blast furnace slag is a finely ground, rapidly chilled aluminosilicate melt material that is separated from molten iron in the blast furnace as a by-product. Rapid cooling results in an amorphous or a glassy phase known as GGBFS or water cooled slag (WCS). Alkaline activation of latent hydraulic WCS by sodium hydroxide and/or sodium silicate in different ratios was studied. Curing was performed under 100 % relative humidity and at a temperature of 38°C. The results showed that mixing of both sodium hydroxide and sodium silicate in ratio of 3:3 wt.,% is the optimum one giving better mechanical as well as microstructural characteristics as compared with cement mortar that has various cement content (cement : sand were 1:3 and 1:2). Durability of the water cooled slag in 5 % MgSO4 as revealed by better microstructure and high resistivity-clarifying that activation by 3:3 sodium hydroxide and sodium silicate, respectively is better than using 2 and 6 % of sodium hydroxide