The Scalar Curvature Problem on the Four Dimensional Half Sphere

In this paper, we consider the problem of prescribing the scalar curvature under minimal boundary conditions on the standard four dimensional half sphere. We provide an Euler-Hopf type criterion for a given function to be a scalar curvature to a metric conformal to the standard one. Our proof involves the study of critical points at infinity of the associated variational problem.Comment: 19 page

Les Mélanomes Malins Nasosinusiens

Le mélanome malin nasosinusien est une tumeur rare prenant naissance au niveau des mélanocytes de la muqueuse respiratoire. Les auteurs rapportent deux observations de mélanomes malins nasosinusiens suivis et traités au service d\'ORL et de CCF de l\'hôpital Habib Thameur entre 1999 et 2005. Il s\'agit d\'un homme et d\'une femme âgés respectivement de 62 et 68 ans. La symptomatologie clinique est dominée par l\'obstruction nasale et l\'épistaxis. Le diagnostic est histologique après biopsie de la tumeur. Le traitement chirurgical est suivi d\'une radiothérapie externe dans les deux cas. L\'évolution est marquée par une récidive tumorale dans un cas. Primary mucosal melanoma of the nasal cavity and paranasal sinuses is an uncommun clinical entity occurring on the level of the melanocytes respiratory mucous membrane. The authors report two observations of malignant melanoma of sinonasal mucosa treated between 1999 and 2005. It acts of an old man and a woman respectively 62 and 68 years old, both presented with nasal obstruction and epistaxis. The diagnosis was histological after biopsy of the tumour. The surgical treatment was followed of an external radiotherapy in both cases. The evolution was marked by a local recurrence in one case. Journal Tunisien d\'ORL et de chirurgie cervico-faciale Vol. 16 2006: pp. 50-5

Le carcinome indifférencié des glandes salivaires

Le carcinome indifferencie primitif des glandes salivaires est rare. Son association avec le virus Epstein Barr, initialement decrite chez les esquimaux, est retrouvee dans la majorite des cas publies. Nous rapportons un nouveau cas tunisien survenu chez un homme age de 64 ans, revele par une tumefaction de la glande parotide gauche. Microscopiquement se discutait le caractere primitif ou secondaire de la tumeur, etaye par les examens complementaires. Le patient etait traite par une parotidectomie suivie d’un curage ganglionnaire et d’une radiotherapie. L’evolution etait favorable apres un an de recul.  Mots clès : Glande salivaire- Carcinome indifferencie- Virus Epstein Bar

Prognostic impact of lipid profile in adult Egyptian acute leukemia patients

Introduction: Acute leukemia is a malignant disorder which results from clonal proliferation of lymphoid and myeloid blast cells. Several studies have reported changes in lipid metabolism at the time of diagnosis of leukemia. Although investigators have reported decreased total cholesterol, decreased high-density lipoprotein, and elevated triglyceride (TG) in leukemic patients, there is a lack of agreement about these changes among different types of leukemia and between children and adult patients, in addition to different data about their impacts on prognosis. In this study, lipid profile has been examined at the time of diagnosis of acute leukemia in order to correlate it with response to therapy. Material and methods: This is a prospective study carried out at the Oncology Center at Mansoura University, Egypt between 2018 and 2019. Fifty patients newly diagnosed with de novo acute leukemia were included. Thirty-four patients were diagnosed with acute myeloid leukemia (AML) (68%), while 16 patients were diagnosed with acute lymphoblastic leukemia (ALL) (32%). Lipid profile and body mass index (BMI) data was obtained. Results: Overweight/obese patients showed a more statistically significant association with female patients than with male patients (p = 0.009). By comparing the lipid profile between overweight/obese patients and other patients, there was no statistically significant association. 76.7% of AML patients were overweight or obese (p = 0.015), and 81.3% of ALL patients showed hypertriglyceridemia (p = 0.014). There was no statistically significant association between lipid profile and complete response (CR) rate; however, there was a marginally significant association between non-CR rate and overweight and obese patients (p = 0.051). In addition, there was no impact of BMI or lipid profile on overall survival among acute leukemia patients. Conclusions: Female, and acute myeloid leukemia, patients were more commonly associated with overweight and obesity, and high TG level was found to be associated with acute lymphoid leukemia. Changes in lipid profile showed no impact on complete response rate or on overall survival in acute leukemia patients

Spectroimmunohistochemistry: A Novel Form of MALDI Mass Spectrometry Imaging Coupled to Immunohistochemistry for Tracking Antibodies.

Peer reviewe

Prevalence and risk factors of hepatitis B and C viruses among haemodialysis patients in Gaza strip, Palestine

<p>Abstract</p> <p>Background</p> <p>The prevalence of hepatitis B virus (HBV) and hepatitis C virus (HCV) and its associated risk factors among haemodialysis (HD) patients in Gaza strip was investigated using serological and molecular techniques.</p> <p>Results</p> <p>The overall prevalence of HBV among the four HD centers was 8.1%. The main risk factors were HD center (p = 0.05), history of blood transfusion (p < 0.01), and treatment abroad (p = 0.01). The overall prevalence of HCV among the four HD centers was 22%. The main risk factors were HD center (p < 0.01), time duration on HD (p < 0.01), history of blood transfusion (p < 0.01), treatment abroad (p < 0.01), and history of blood transfusion abroad (p < 0.01). Serum aminotransferases levels decreased in HD patients compared with normal population but still there was a direct association between the activity of liver enzymes and both HBV (p < 0.01) and HCV (p < 0.01) infection.</p> <p>Conclusion</p> <p>The much higher prevalence of Hepatitis viruses among HD patients compared to the normal population of Gaza strip indicates a causative relation between HD and hepatitis viruses transmission. Therefore extremely careful observation of preventive infection control measures is essential to limit Hepatitis viruses' transmission in HD centers.</p

CP-31398, a putative p53-stabilizing molecule tested in mammalian cells and in yeast for its effects on p53 transcriptional activity

BACKGROUND: CP-31398 is a small molecule that has been reported to stabilize the DNA-binding core domain of the human tumor suppressor protein p53 in vitro. The compound was also reported to function as a potential anti-cancer drug by rescuing the DNA-binding activity and, consequently, the transcription activation function of mutant p53 protein in mammalian tissue culture cells and in mice. RESULTS: We performed a series of gene expression experiments to test the activity of CP-31398 in yeast and in human cell cultures. With these cell-based assays, we were unable to detect any specific stimulation of mutant p53 activity by this compound. Concentrations of CP-31398 that were reported to be active in the published work were highly toxic to the human H1299 lung carcinoma and Saos-2 cell lines in our experiments. CONCLUSION: In our experiments, the small molecule CP-31398 was unable to reactivate mutant p53 protein. The results of our in vivo experiments are in agreement with the recently published biochemical analysis of CP-31398 showing that this molecule does not bind p53 as previously claimed, but intercalates into DNA