Cause of Death and Predictors of All-Cause Mortality in Anticoagulated Patients With Nonvalvular Atrial Fibrillation : Data From ROCKET AF

M. Kaste on työryhmän ROCKET AF Steering Comm jäsen.Background-Atrial fibrillation is associated with higher mortality. Identification of causes of death and contemporary risk factors for all-cause mortality may guide interventions. Methods and Results-In the Rivaroxaban Once Daily Oral Direct Factor Xa Inhibition Compared with Vitamin K Antagonism for Prevention of Stroke and Embolism Trial in Atrial Fibrillation (ROCKET AF) study, patients with nonvalvular atrial fibrillation were randomized to rivaroxaban or dose-adjusted warfarin. Cox proportional hazards regression with backward elimination identified factors at randomization that were independently associated with all-cause mortality in the 14 171 participants in the intention-to-treat population. The median age was 73 years, and the mean CHADS(2) score was 3.5. Over 1.9 years of median follow-up, 1214 (8.6%) patients died. Kaplan-Meier mortality rates were 4.2% at 1 year and 8.9% at 2 years. The majority of classified deaths (1081) were cardiovascular (72%), whereas only 6% were nonhemorrhagic stroke or systemic embolism. No significant difference in all-cause mortality was observed between the rivaroxaban and warfarin arms (P=0.15). Heart failure (hazard ratio 1.51, 95% CI 1.33-1.70, P= 75 years (hazard ratio 1.69, 95% CI 1.51-1.90, P Conclusions-In a large population of patients anticoagulated for nonvalvular atrial fibrillation, approximate to 7 in 10 deaths were cardiovascular, whereasPeer reviewe

Interim report on American University of Beirut excavations at Tell Fadous-Kfarabida

International audienceDetailed preliminary report on the last fieldwork seasons at Tell Fadous-Kfarabida (Lebanese coast), with study of architectural features, ceramic materials and material culture by occupational phases between Late Chalcolithic and Bronze Age

Interim report on American University of Beirut excavations at Tell Fadous-Kfarabida

International audienceDetailed preliminary report on the last fieldwork seasons at Tell Fadous-Kfarabida (Lebanese coast), with study of architectural features, ceramic materials and material culture by occupational phases between Late Chalcolithic and Bronze Age

Interim report on American University of Beirut excavations at Tell Fadous-Kfarabida

International audienceDetailed preliminary report on the last fieldwork seasons at Tell Fadous-Kfarabida (Lebanese coast), with study of architectural features, ceramic materials and material culture by occupational phases between Late Chalcolithic and Bronze Age