The correlation between immunohistochemical expression of MMP-2 and the prognosis of epithelial ovarian cancer

Objectives: The Objectives: The goal of the study was to evaluate the correlation of matrix metalloproteinase-2 (MMP-2) expression with tumor spread, metastasis, survival and recurrence in early and advanced-stage Epithelial Ovarian Cancer (EOC). Material and methods: Medical records of patients, hospitalized at the Department of Obstetrics and Gynecology, İzmir Ataturk Training and Research Hospital between 2003 and 2008, were reviewed. Patient age, tumor size, localization, histologic type and tumor grade, stage, metastasis status, patient outcomes and follow-up data were obtained from the records of the obstetrics and gynecology clinic, as well as during face-to-face or telephone interviews. Results: The percentage of MMP-2 staining (expression) in the epithelial cells was not significantly associated with tumor stage and grade, histologic type, tumor diameter, recurrence and overall survival (p>0.05). A significant correlation was found between the percentage of MMP-2 staining (expression) and metastasis status (p0.05), but was with histologic type (p0,05). Stromal staining (expression) of MMP-2 was not significantly correlated with tumor stage and grade, histologic type, tumor diameter and outcomes (p>0.05), but was with recurrence and presence of metastasis (p0.05), total score (p>0.05) and staining intensity (p>0.05). The association of disease-free survival with the percentage of MMP-2 staining (p>0.05), total score (p>0.05), staining intensity (p>0.05) and stromal staining (p>0.05) was not statistically significant. The survival of patients with positive stromal staining was significantly shorter compared to cases with negative stromal staining (

Bazı Soya Hatlarının Kızıltepe Koşullarındaki Verim ve Verim Unsurlarının Belirlenmesi

Bu arastırma; Mardin Kızıltepe Çağıl Köyü ekolojik kosullarında, verim potansiyeli yüksek soya hatlarını belirlemek amacıyla, 2010 yılında Tesadüf Blokları Deneme desenine göre 3 tekerrürlü olarak yürütülmüstür. Arastırmada elde edilen verilere göre; en yüksek tohum verimi 275.80 kg/da ile 528 hattından elde edilirken, en düsük 121.36 kg/da ile Bataem-220 hattından elde edilmistir. En yüksek yağ oranı, % 23.01 ile Ata-135 hattından saptanırken, en düsük % 20.50 ile 705 hattından saptanmıstır. En yüksek protein oranı, % 44.99 ile Ataem-7 çesidinden saptanırken, en düsük % 32.44 ile 528 hattından saptanmıstır. Sonuç olarak; verim ve incelenen diğer özellikler bakımından 528, Bataem-204, Ataem-7 ve Ata-135 hatlarının Mardin Kızıltepe Çağıl Köyü ekolojik kosullarına daha uygun olduğu sonucuna varılmıstır. Anahtar Kelimeler: Soya, hat, verim, yağ ve protein oran

Ultrasonographic Measurement of Cartilage Thickness in Patients With Leprosy

Objectives: This study aims to evaluate femoral cartilage thickness in leprosy patients by using ultrasound

The correlation between immunohistochemical expression of MMP-2 and the prognosis of epithelial ovarian cancer

WOS: 000335208900006PubMed: 24745158Objectives: The Objectives: The goal of the study was to evaluate the correlation of matrix metalloproteinase-2 (MMP-2) expression with tumor spread, metastasis, survival and recurrence in early and advanced-stage Epithelial Ovarian Cancer (EOC). Material and methods: Medical records of patients, hospitalized at the Department of Obstetrics and Gynecology Izmir Ataturk Training and Research Hospital between 2003 and 2008, were reviewed. Patient age, tumor size, localization, histologic type and tumor grade, stage, metastasis status, patient outcomes and follow-up data were obtained from the records of the obstetrics and gynecology clinic, as well as during face-to-face or telephone interviews. Results: The percentage of MMP-2 staining (expression) in the epithelial cells was not significantly associated with tumor stage and grade, histologic type, tumor diameter; recurrence and overall survival (p>0.05). A significant correlation was found between the percentage of MMP-2 staining (expression) and metastasis status (p0.05), but was with histologic type (p0,05). Stromal staining (expression) of MMP-2 was not significantly correlated with tumor stage and grade, histologic type, tumor diameter and outcomes (p>0.05), but was with recurrence and presence of metastasis (p0.05), total score (p>0.05) and staining intensity (p>0.05). The association of disease-free survival with the percentage of MMP-2 staining (p>0.05), total score (p>0.05), staining intensity (p>0.05) and stromal staining (p>0.05) was not statistically significant. The survival of patients with positive stromal staining was significantly shorter compared to cases with negative stromal staining (p<0.05). Conclusions: Large-scale, comprehensive research is needed to verify whether MMP 2 may be used as a routine prognostic factor for EOC

Investigation of prognostic significance of CD109 expression in women with vulvar squamous cell carcinoma

WOS: 000319961400001PubMed: 23776335Objective: The goal of this study was to investigate the between cluster of differentiation 109 (CD109) expression and tumor diameter, invasion depth, tumor grade, presence of lymphnode metastasis, and overall survival in patients with vulvar squamous cell carcinoma, which is the most common type of vulvar cancer. Method: Twenty-six patients who underwent an operation for vulvar cancer between 1999 and 2009 in our clinic were included in this study. Immunohistochemical staining was performed on formalin-fixed and paraffin-embedded tissue. Result: Tumor diameter was not found to be significantly associated with CD109 expression, intensity of cytoplasmic staining, or combined score (P = 0.325, P = 0.169, P = 0.352, respectively). Invasion depth and combined score were also not significantly correlated with CD109 expression (P = 0.324 and P = 0.174 respectively). There was a negative correlation between invasion depth and the intensity of cytoplasmic staining (P = 0.042). There was no significant correlation between tumor stage and CD109 expression, the intensity of cytoplasmic staining, and the combined score (P = 0.574, P = 0.389, P = 0.605, respectively). A significant positive correlation was observed between tumor grade and CD109 expression, the intensity of cytoplasmic staining, and the combined score (P = 0.003, P = 0.018, P = 0.008, respectively). No significant difference was found between the percentages of CD109 expression in patients with positive (48%) and negative (11%) lymph nodes (P = 0.058). The percentage of CD109 expression did not significantly differ in relation to overall survival (P = 0.483). Conclusion: Comprehensive and more extensive studies are needed to examine the relationship between CD109 expression and vulvar malignant lesions