Associations between the standardized uptake value of F-18-FDG PET/CT and demographic, clinical, pathological, radiological factors in lung cancer

Objectives: F-18-fluoro-2-deoxyglucose (FDG) positron emission tomography (PET)/computed tomography (CT) is extensively used to diagnose and stage of lung cancer. The aim of the current study was to investigate the correlation of demographic, clinical, pathological and radiological factors with primer tumor FDG Uptake in patients with lung cancer. Materials and methods: This cross-sectional, clinical study was performed on a total of 57 lung cancer patients newly diagnosed that underwent FDG PET/CT. In addition to descriptive variables, histopathological diagnosis, tumor site and size, hemoglobin level, red cell distribution width, neutrophil to lymphocyte ratio were noted for each patient. The correlation of these variables to SUVmax values in FDG PET/CT was investigated. Results: A total of 57 patients (4 women, 53 men) with an average age of 60.8 +/- 9.4 (range: 33-89) participated in the study. Histopathological diagnoses were consistent with squamous cell carcinoma (28, 49.1%), adenocarcinoma (15, 26.3%) and small cell cancer (14, 24.6%). The SUVmax of primary tumor was positively correlated with tumor size (P<0.001). The tumor SUVmax of squamous cell carcinoma (SqCC) (17.49 +/- 8.37) was higher than that of adenocarcinoma (AC) (12.80 +/- 4.77) and small cell carcinoma (SCC) (12.40 +/- 5.80) (P=0.038). Conclusion: SUVmax value was significantly higher for squamous cell carcinoma and it SUVmax values in PET scans was found to be positively correlated with tumor size. This study suggests that, tumor size and histologic subtype had influences upon FDG uptake in lung cancer

Obstructive sleep apnea related to rapid-eye-movement or non-rapid-eye-movement sleep: comparison of demographic, anthropometric, and polysomnographic features

Objective : To determine whether there are significant differences between rapid-eye-movement (REM)-related obstructive sleep apnea (OSA) and non-REM (NREM)-related OSA, in terms of the demographic, anthropometric, and polysomnographic characteristics of the subjects. Methods : This was a retrospective study of 110 patients (75 males) with either REM-related OSA (n = 58) or NREM-related OSA (n = 52). To define REM-related and NREM-related OSA, we used a previously established criterion, based on the apnea-hypopnea index (AHI): AHI-REM/AHI-NREM ratio > 2 and ≤ 2, respectively. Results : The mean age of the patients with REM-related OSA was 49.5 ± 11.9 years, whereas that of the patients with NREM-related OSA was 49.2 ± 12.6 years. The overall mean AHI (all sleep stages combined) was significantly higher in the NREM-related OSA group than in the REM-related OSA group (38.6 ± 28.2 vs. 14.8 ± 9.2; p < 0.05). The mean AHI in the supine position (s-AHI) was also significantly higher in the NREM-related OSA group than in the REM-related OSA group (49.0 ± 34.3 vs. 18.8 ± 14.9; p < 0.0001). In the NREM-related OSA group, the s-AHI was higher among the men. In both groups, oxygen desaturation was more severe among the women. We found that REM-related OSA was more common among the patients with mild-to-moderate OSA, whereas NREM-related OSA was more common among those with severe OSA. Conclusions : We found that the severity of NREM-related OSA was associated mainly with s-AHI. Our findings suggest that the s-AHI has a more significant effect on the severity of OSA than does the AHI-REM. When interpreting OSA severity and choosing among treatment modalities, physicians should take into consideration the sleep stage and the sleep posture

Erectile dysfunction is a marker for obstructive sleep apnea

Purpose: To investigate the prevalence of erectile dysfunction (ED) in patients with obstructive sleep apnea (OSA) with and without any other comorbidities

Primitive Neuroectodermal Tumor/Ewing Sarcoma Presenting with Pulmonary Nodular Lesions

Primitive neuroectodermal tumors (PNETs) and Ewing sarcoma (EWS) belong to the same family of malignant, small, round cell neoplasms of soft tissue or bone origin. EWS-PNETs that arise in the lung parenchyma involvement are extremely rare in adults. A case of a 32-year-old male presenting with chest pain and diffuse pulmonary nodules on chest X-ray and diagnosed with Ewing sarcoma-PNETs will be presented here

Ruptured Pulmonary Hydatid Cysts in The Course of Enteric Fever; An Unreported Case

A thirty-two-years-old female admitted to the emergency department of a peripheral hospital with complaints of fever, cough, nausea, vomiting, heartburn, and abdominal pain. An empiric treatment has been given to the patient. Three days later, the patient has been referred to the department of internal medicine through increased complaints and was diagnosed with reflux and enteric fever by esophagography and serology. After an evaluation requested from our clinic due to ground-glass-opacities and a cavitary-lesion observed on the radiography, a ruptured cystic-echinococcosis was considered. The diagnosis was confirmed by IHA-test and cystic-membranes detected on computed tomography (CT). The patient refused the surgical treatment and was followed up for three months with oral albendazole. On the CT, taken in the second month, there was not any pathology other than the old ruptured cyst. As a result, this case will be the first case of pulmonary hydatid cyst reported being ruptured in the course of enteric fever

Original Article A silent pre-stroke damage: obstructive sleep apnea syndrome

Abstract: Objectives: We investigated the prevalence of silent cerebro-vascular lesions and atrophy in patients with obstructive sleep apnea syndrome (OSAS) and the correlation between OSAS severity and prevalence of silent cerebrovascular lesions in Turkish patients. Methods: Study subjects were 56.35 OSAS, polysomnography (PSG)-confirmed patients who visited the sleep disorders clinic in our university hospital. None had a history of cerebrovascular disease (CVD). The control group consisted of normal subjects who had no history of snorring, apnea, excessive daytime sleepiness and had under 10 score of epworth sleepiness score. We performed a cross-sectional study on OSAS severity and the prevalence of silent cerebrovascular lesions and atrophy detected by brain MRI analysis. Results: The control group included 21 subjects, the moderate OSAS (AHI 15 to &lt; 30/h) group included 7 patients with a mean AHI of 22.0 ± 5.3/h while the severe OSAS (AHI ≥ 30/h) group included 28 patients with a mean AHI of 60.0 ± 27.4/h. A larger percentage of patients with severe OSAS had a higher BMI than those with moderate OSAS and control subjects (P &lt; 0.05). Silent ischemic gliotic lesions was identified in 10 (38.2%) control subjects, 27 (61.8%) with moderate and severe OSAS. Among control subjects and the moderate, and severe OSA groups, 10 (38.2%), 6 (85.7%) and 21 (77.7%) respectively, had periventricular hyperintensity (PVH); most PVH was mild to moderate. Conclusion: Results indicate that patients with moderate to severe (AHI ≥ 15/h) OSAS have a higher prevalence of silent cerebrovascular lesion than those with no OSAS

Erectile dysfunction is a marker for obstructive sleep apnea

Purpose: To investigate the prevalence of erectile dysfunction (ED) in patients with obstructive sleep apnea (OSA) with and without any other comorbidities

The Role of Pneumococcal Pneumonia among CommunityAcquired Pneumonia in Adult Turkish Population: TurkCAP Study

OBJECTIVE: To evaluate the rate of pneumococcal pneumonia (PP) among patients with community-acquired pneumonia (CAP) in Turkey and to investigate and compare features of PP and non-PP CAP patients