Systemological Bases of Management Consulting

The problem of management consulting for sustainable development organization support is discussed. The problem is formally described by means of systemological terms. The mathematical problem solving is considered. Practical use of the obtained results is outlined

Cloud ArcGIS Online as an innovative tool for developing geoinformation competence with future geography teachers

The article dwells upon the scientifically relevant problem of using cloud-based GIS-technologies when training future geography teachers (based on ArcGIS Online application). The authors outline the basic principles for implementing ArcGIS Online in the educational process (interdisciplinary integration, the sequence of individualization in training, communicability, distance education and regional studies), and provide an example of an interactive map created with the help of the specified cloud GIS, since this kind of map is the most popular a form of research by geography students. In the article it is noted that integration of ArcGIS Online into the educational process allows the teacher to follow a clear pedagogical strategy, taking into account possible variants of its use (demonstration, direct mastering of GIS in a computer class and independent work in an individual mode). Considering cloud GIS as a new stage in the development of geoinformational education, the authors emphasize their key benefits (round-the-clock access, work with GIS package in the cloud, the ability to use other maps as well as the creation of their own maps and webapplications) and disadvantages (monetization of services, underestimation of the GIS role in the curriculum of the higher school, the lack of Ukrainian content, etc.)

Innovative practice in the training of future doctors

Modernization of medical education has key directions. The first direction is the system of continuing medical education. Continuing medical education ensures the improvement of professional knowledge and skills throughout the course of professional activity. The principles of continuing medical education are: individuality, continuity, community with professional medical and pharmaceutical organizations, the widespread use of distance technologies, simulation and e-learning. The second direction is the introduction of a system of accreditation of specialists, which makes it possible to determine the readiness of specialists in the field of medicine to carry out professional activities. The practical part of training specialists in the field of medicine is a mandatory component of the educational standard and educational process. The formation of research skills prepares a medical student for the independent implementation of research activities in the relevant field of professional activity. The results of the study are presented, which reflect the level of formation of research skills in students of the specialty “Medical biochemistry”. According to the results of the study, groups of students with different levels of research skills were identified

The New Science Intensive Standard of Master Preparation in Sphere of Competitive Intelligence on the Basis of Systemological Knowledge-Oriented Technologies

Methodological, theoretical and technological bases of the new branch standard of Ukraine higher education which regulates preparation process of masters - professionals in the information area and information analysts are considered. The new systemological knowledge-oriented technologies developed in KNURE which considerably surpass foreign analogues are put as the basis of training

Optimization of the company strategic management system in the context of economic instability

The article makes and confirms the following hypothesis: a difficult current macro-economic situation in Russia requires to change the work of enterprises management in terms of forming strategies related to developing the activity of legal entities they control as a whole, and forecasting results of the activity on various levels of the enterprise in particular within improving the efficiency of the organization activity under conditions of instable external environment. In order to confirm the made hypothesis, the article considers elements of the company management under conditions of instability within forming the level approach. It defines the methodological basis of selecting methods and approaches by commercial organizations to form their forecasts and strategic of developing under conditions of turbulence. It analyses the activity of the specific legal entity established in the form of the limited liability company (LLC). On its basis conclusions about the state of its strategic potential are made. The article offers measures on optimizing the system of strategic management of the analyzed enterprise, and estimates consequences of its implementation.peer-reviewe

Solvent-free synthesis of cyclic carbonates from CO2 and epoxides catalyzed by reusable alumina-supported zinc dichloride

There is an ongoing interest to advance in the production of cyclic carbonates from carbon dioxide and epoxides under sustainable conditions. The ZnCl2/Al2O3-TBAI system has evinced to be a cheap, simple, readily accessible and reusable catalyst for the reaction of carbon dioxide with aromatic, aliphatic, cyclic and fluorinated epoxides with a low metal loading under solvent-free and mild conditions. This system has been also shown to be adequate for the reaction of epoxides with carbon disulfide to form the sulfur-containing cyclic carbonate analogs.This study was generously supported by the Russian Science Foundation [project no. 14-23-00186 P], the M. V. Lomonosov Moscow State University Program of Development, the Spanish Ministerio de Ciencia, Innovación y Universidades [MICIU; grant no. CTQ2017-88171-P] and the Generalitat Valenciana [GV; grant no. AICO/2017/007]

Effects of Modified Magnetite Nanoparticles on Bacterial Cells and Enzyme Reactions

Current paper presents biological effects of magnetite nanoparticles (MNPs). Relations of MNP’ characteristics (zeta-potential and hydrodynamic diameters) with effects on bacteria and their enzymatic reactions were the main focus. Photobacterium phosphoreum and bacterial enzymatic reactions were chosen as bioassays. Three types of MNPs were under study: bare Fe3O4, Fe3O4 modified with 3-aminopropyltriethoxysilane (Fe3O4/APTES), and humic acids (Fe3O4/HA). Effects of the MNPs were studied at a low concentration range (< 2 mg/L) and attributed to availability and oxidative activity of Fe3+, high negative surface charge, and low hydrodynamic diameter of Fe3O4/HA, as well as higher Fe3+ content in suspensions of Fe3O4/HA. Low-concentration suspensions of bare Fe3O4 provided inhibitory effects in both bacterial and enzymatic bioassays, whereas the MNPs with modified surface (Fe3O4/APTES and Fe3O4/HA) did not affect the enzymatic activity. Under oxidative stress (i.e., in the solutions of model oxidizer, 1,4-benzoquinone), MNPs did not reveal antioxidant activity, moreover, Fe3O4/HA demonstrated additional inhibitory activity. The study contributes to the deeper understanding of a role of humic substances and silica in biogeochemical cycling of iron. Bioluminescence assays, cellular and enzymatic, can serve as convenient tools to evaluate bioavailability of Fe3+ in natural dispersions of iron-containing nanoparticles, e.g., magnetite, ferrihydrite, etc

Angiotensin II and transforming growth factor β affect cardiovascular and renal disease in patients with type 2 diabetes mellitus: benefits of dpp-4 inhibitors treatment

BACKGROUND: Diabetes mellitus type 2 (T2DM) is associated with impaired glucose metabolism and peripheral insulin resistance, which is accompanied by an high risk of cardiovascular disease (CVD) and nephropathy. Metabolic syndrome and T2DM are accompanied by renin-angiotensin system (RAS) activation, which is also associated with increased risk of CVD and kidney damage. Obesity lead to a wide range of pathophysiological changes, that stimulate cardiac fibrosis, and various fibrosis processes initiation, including activation of transforming growth factor &beta; (TGF-&beta;). AIMS: To determine activity of angiotensin II (Ang II) and TGF-&beta; in patients with obesity and T2DM and their association with heart and kidney damage. MATERIALS AND METHODS: Ang II and TGF-&beta; were identified in the peripheral blood of 66 obese patients aged 48-65 years. The first group included 21 patients with coronary heart disease (CHD) and T2DM; The second group included 22 patients with T2DM and excluded CHD; The third group &ndash; 20 patients with normal glucose metabolism and excluded CHD. RESULTS: The values of TGF-&beta; in the 1st group (patients with CHD) were statistically lower than in the group of metabolically healthy obesity (p=0.021). Patients who received DPP-4 inhibitors had a lower Ang II level compared to patients with other hypoglycemic therapy (p=0.005). TGF-&beta; positively correlated with glomerular filtration rate (eGFR) in all patients (r=-0.414, p=0.006). TGF-&beta; negatively correlated with the degree of internal carotid artery stenosis in patients of the 2nd group (r=-0.42, p=0.09) and LDL-cholesterol in all patients (r=-0.426, p=0.038). CONCLUSIONS: TGF-&beta; negatively correlated with the factors that contribute to CVD progression. TGF-&beta; correlated with pathological angiogenesis and changes in normal cardiac geometry in obesity, T2DM and CHD. DPP-4 inhibitors can improve the cardiovascular prognosis in this group of patients by affecting Ang II level. Low levels of TGF-&beta; were associated with higher cardiovascular risk and were commonly found in patients with more severe nephropathy