20 research outputs found

    Area-wide appraisal of drug resistance in trypanosomes infecting cattle in East and Southern Africa

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    The extent and significance of trypanocidal drug resistance was investigated in priority areas of three East and Southern African Countries under a project. The project was built on the results of two previous projects. Existing methods currently available for the demonstration of drug-resistance, namely therapeutic tests in domestic livestock and rodents, and tests on trypanosome isolates in vitro, have particular drawbacks. In this project, these were supplemented with a novel approach, the use of ELISAs able to quantify the concentrations of trypanocidal drugs circulating in treated cattle

    Fluctuation scaling and covariance matrix of constituents’ flows on a bipartite graph

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    We investigate an association between a power-law relationship of constituents’ flows (mean versus standard deviation) and their covariance matrix on a directed bipartite network. We propose a Poisson mixture model and a method to infer states of the constituents’ flows on such a bipartite network from empirical observation without a priori knowledge on the network structure. By using a proposed parameter estimation method with high frequency financial data we found that the scaling exponent and simultaneous cross-correlation matrix have a positive correspondence relationship. Consequently we conclude that the scaling exponent tends to be 1/2 in the case of desynchronous (specific dynamics is dominant), and to be 1 in the case of synchronous (common dynamics is dominant)
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