Incivility and Beyond at the Top Management Team Level

Although incivility has been gaining increasing attention in the literature as well as in the industry, academic studies have not examined the effects on top management team (TMT) members. TMT members are different from employees at other levels because they are officers of their organizations who are held to a much higher level of responsibility than those in lower echelons. They are crucial in setting the norms of an organization and have far-reaching influence. This article seeks to uncover the mechanisms that explain what happens when TMT members are targets of uncivil leadership behavior. Semistructured interviews were conducted with 15 TMT members. Findings suggest that TMT members tended to be analytical in their reactions, influencing their responses. This study contributes to the literature on incivility and leadership, filling the gap of addressing such behavior at the TMT level

A simple physical model for scaling in protein-protein interaction networks

It has recently been demonstrated that many biological networks exhibit a scale-free topology where the probability of observing a node with a certain number of edges (k) follows a power law: i.e. p(k) ~ k^-g. This observation has been reproduced by evolutionary models. Here we consider the network of protein-protein interactions and demonstrate that two published independent measurements of these interactions produce graphs that are only weakly correlated with one another despite their strikingly similar topology. We then propose a physical model based on the fundamental principle that (de)solvation is a major physical factor in protein-protein interactions. This model reproduces not only the scale-free nature of such graphs but also a number of higher-order correlations in these networks. A key support of the model is provided by the discovery of a significant correlation between number of interactions made by a protein and the fraction of hydrophobic residues on its surface. The model presented in this paper represents the first physical model for experimentally determined protein-protein interactions that comprehensively reproduces the topological features of interaction networks. These results have profound implications for understanding not only protein-protein interactions but also other types of scale-free networks.Comment: 50 pages, 17 figure

Magnetic Resonance Imaging Pilot Study of Intravenous Glyburide in Traumatic Brain Injury.

Pre-clinical studies of traumatic brain injury (TBI) show that glyburide reduces edema and hemorrhagic progression of contusions. We conducted a small Phase II, three-institution, randomized placebo-controlled trial of subjects with TBI to assess the safety and efficacy of intravenous (IV) glyburide. Twenty-eight subjects were randomized and underwent a 72-h infusion of IV glyburide or placebo, beginning within 10 h of trauma. Of the 28 subjects, 25 had Glasgow Coma Scale (GCS) scores of 6-10, and 14 had contusions. There were no differences in adverse events (AEs) or severe adverse events (ASEs) between groups. The magnetic resonance imaging (MRI) percent change at 72-168 h from screening/baseline was compared between the glyburide and placebo groups. Analysis of contusions (7 per group) showed that lesion volumes (hemorrhage plus edema) increased 1036% with placebo versus 136% with glyburide (p = 0.15), and that hemorrhage volumes increased 11.6% with placebo but decreased 29.6% with glyburide (p = 0.62). Three diffusion MRI measures of edema were quantified: mean diffusivity (MD), free water (FW), and tissue MD (MDt), corresponding to overall, extracellular, and intracellular water, respectively. The percent change with time for each measure was compared in lesions (n = 14) versus uninjured white matter (n = 24) in subjects receiving placebo (n = 20) or glyburide (n = 18). For placebo, the percent change in lesions for all three measures was significantly different compared with uninjured white matter (analysis of variance [ANOVA], p < 0.02), consistent with worsening of edema in untreated contusions. In contrast, for glyburide, the percent change in lesions for all three measures was not significantly different compared with uninjured white matter. Further study of IV glyburide in contusion TBI is warranted

Consequences of wall stiffness for a beta-soft potential

Modifications of the infinite square well E(5) and X(5) descriptions of transitional nuclear structure are considered. The eigenproblem for a potential with linear sloped walls is solved. The consequences of the introduction of sloped walls and of a quadratic transition operator are investigated.Comment: RevTeX 4, 8 pages, as published in Phys. Rev.

Telerobotics: A simulation facility for university research

An experimental telerobotics (TR) simulation suitable for studying human operator (H.O.) performance is described. Simple manipulator pick-and-place and tracking tasks allowed quantitative comparison of a number of calligraphic display viewing conditions. A number of control modes could be compared in this TR simulation, including displacement, rate and acceleratory control using position and force joysticks. A homeomorphic controller turned out to be no better than joysticks; the adaptive properties of the H.O. can apparently permit quite good control over a variety of controller configurations and control modes. Training by optimal control example seemed helpful in preliminary experiments. An introduced communication delay was found to produce decrease in performance. In considerable part, this difficulty could be compensated for by preview control information. That neurological control of normal human movement contains a data period of 0.2 second may relate to this robustness of H.O. control to delay. The Ames-Berkeley enhanced perspective display was utilized in conjunction with an experimental helmet mounted display system (HMD) that provided stereoscopic enhanced views

Can HERA See an eu−−>ece u --> e c Signal of a Virtual Leptoquark?

Virtual leptoquarks could be detected at HERA through some nonstandard effects. Here we explore the possibility that virtual leptoquarks could be discovered via $e u --> e c$ scattering, assuming integrated luminosity of 200 pb$^{-1}$ and charm identification efficiency of 1%. We study the implications of low energy data for the leptoquarks couplings and find that the most relevant bound for the HERA cross sections comes from inclusive $c --> e^+e^-~+~any$. This bound implies that the $e u --> e c$ cross sections for virtual leptoquarks are just too small for observation of the signal. With an improvement by a factor of ~2 on the luminosity or on charm identification it could be possible to see virtual leptoquarks with {\it maximum couplings} up to ~1.5 - 2 TeV. However, the prospects for discovering the virtual particles if their couplings are somewhat below present bounds are very dim. We point out that this cross section could be very large for leptoquarks lighter than HERA's kinematical limit, and if such a leptoquark is discovered we recommend searching for a possible $e u --> e c$ signal. Our results may also serve as an update on the maximum cross sections for leptoquark mediated $e u --> \mu c$ scattering.Comment: 15 Pages (LaTeX), including 4 postscript figures at the end of the file. Feynman diagrams available by reques

Thermodynamics of two lattice ice models in three dimensions

In a recent paper we introduced two Potts-like models in three dimensions, which share the following properties: (A) One of the ice rules is always fulfilled (in particular also at infinite temperature). (B) Both ice rules hold for groundstate configurations. This allowed for an efficient calculation of the residual entropy of ice I (ordinary ice) by means of multicanonical simulations. Here we present the thermodynamics of these models. Despite their similarities with Potts models, no sign of a disorder-order phase transition is found.Comment: 5 pages, 7 figure