Intensitätsbasierte Qualitätskontrolle und Skalierung von Genexpressionsdaten

Mithilfe von Sequenz-Datenbanken und Genom-Informationen können GeneChips die Expression zehntausender Transkripte parallel messen. Hier wird zunächst eine SPLUS-Bibliothek für GeneChip-Daten entwickelt. Dazu gehört ein Algorithmus zum Gruppieren, Benennen und Kombinieren von Experimenten in Abhängigkeit ihrer Merkmale. Um das Ausmaß der technischen Varianz im Aufarbeitungsprotokoll zu quantifizieren, werden Qualitätskriterien in eigenen und öffentlichen Datensätzen untersucht. Darüber hinaus wird ein Kriterium "Gesamtintensität entwickelt, welches bisherigen Qualitätskriterien in Teilaspekten überlegen ist. Über eine "Skalierung" werden Experimente vergleichbar gemacht. Sechs Bewertungsaspekte ermöglichen die objektive Beurteilung der Standardskalierung im Vergleich zu drei eigenen Entwicklungen. Es ergaben sich Hinweise auf eine Überlegenheit einer dieser Entwicklungen (sum.of.intens-Skalierung) zur Standardskalierung, welche in weiteren Experimenten überprüft werden sollte

Black Hole Lightning from the Peculiar Gamma-Ray Loud Active Galactic Nucleus IC 310

The nearby active galaxy IC 310, located in the outskirts of the Perseus cluster of galaxies is a bright and variable multi-wavelength emitter from the radio regime up to very high gamma-ray energies above 100 GeV. Originally, the nucleus of IC 310 has been classified as a radio galaxy. However, studies of the multi-wavelength emission showed several properties similarly to those found from blazars as well as radio galaxies. In late 2012, we have organized the first contemporaneous multi-wavelength campaign including radio, optical, X-ray and gamma-ray instruments. During this campaign an exceptionally bright flare of IC 310 was detected with the MAGIC telescopes in November 2012 reaching an averaged flux level in the night of up to one Crab above 1 TeV with a hard spectrum over two decades in energy. The intra-night light curve showed a series of strong outbursts with flux-doubling time scales as fast as a few minutes. The fast variability constrains the size of the gamma-ray emission regime to be smaller than 20% of the gravitational radius of its central black hole. This challenges the shock acceleration models, commonly used to explain gamma-ray radiation from active galaxies. Here, we will present more details on the MAGIC data and discuss several possible alternative emission models.Comment: 8 pages, 5 figures, Proceedings of the 34th International Cosmic Ray Conference, 30 July - 6 August, 2015, The Hague, The Netherland

The EVN view of the highly variable TeV active galaxy IC 310

Very-high-energy $\gamma$-ray observations of the active galaxy IC 310 with the MAGIC telescopes have revealed fast variability with doubling time scales of less than 4.8min. This implies that the emission region in IC 310 is smaller than 20% of the gravitational radius of the central supermassive black hole with a mass of $3\times 10^8 M_\odot$, which poses serious questions on the emission mechanism and classification of this enigmatic object. We report on the first quasi-simultaneous multi-frequency VLBI observations of IC 310 conducted with the EVN. We find a blazar-like one-sided core-jet structure on parsec scales, constraining the inclination angle to be less than $\sim 20^\circ$ but very small angles are excluded to limit the de-projected length of the large-scale radio jet.Comment: 4 pages, proceedings of the 12th European VLBI Network Symposium and Users Meeting - EVN 2014, 7-10 October 2014, Cagliari, Italy. Published online in PoS, ID.10

Insights into the particle acceleration of a peculiar gamma -ray radio galaxy IC 310

IC 310 has recently been identified as a gamma-ray emitter based on observations at GeV energies with Fermi-LAT and at very high energies (VHE, E > 100 GeV) with the MAGIC telescopes. Despite IC 310 having been classified as a radio galaxy with the jet observed at an angle > 10 degrees, it exhibits a mixture of multiwavelength properties of a radio galaxy and a blazar, possibly making it a transitional object. On the night of 12/13th of November 2012 the MAGIC telescopes observed a series of violent outbursts from the direction of IC 310 with flux-doubling time scales faster than 5 min and a peculiar spectrum spreading over 2 orders of magnitude. Such fast variability constrains the size of the emission region to be smaller than 20% of the gravitational radius of its central black hole, challenging the shock acceleration models, commonly used in explanation of gamma-ray radiation from active galaxies. Here we will show that this emission can be associated with pulsar-like particle acceleration by the electric field across a magnetospheric gap at the base of the jet.Comment: 2014 Fermi Symposium proceedings - eConf C14102.

The blazar-like radio structure of the TeV source IC310

Context. The radio galaxy IC310 in the Perseus cluster has recently been detected in the gamma-ray regime at GeV and TeV energies. The TeV emission shows time variability and an extraordinarily hard spectrum, even harder than the spectrum of the similar nearby gamma-ray emitting radio galaxy M87. Aims. High-resolution studies of the radio morphology help to constrain the geometry of the jet on sub-pc scales and to find out where the high-energy emission might come from. Methods. We analyzed May 2011 VLBA data of IC310 at a wavelength of 3.6 cm, revealing the parsec-scale radio structure of this source. We compared our findings with more information available from contemporary single-dish flux density measurements with the 100-m Effelsberg radio telescope. Results. We have detected a one-sided core-jet structure with blazar-like, beamed radio emission oriented along the same position angle as the kiloparsec scale radio structure observed in the past by connected interferometers. Doppler-boosting favoritism is consistent with an angle of theta < 38 degrees between the jet axis and the line-of-sight, i.e., very likely within the boundary dividing low-luminosity radio galaxies and BL Lac objects in unified schemes. Conclusions. The stability of the jet orientation from parsec to kiloparsec scales in IC310 argues against its classification as a headtail radio galaxy; i.e., there is no indication of an interaction with the intracluster medium that would determine the direction of the tail. IC310 seems to represent a low-luminosity FRI radio galaxy at a borderline angle to reveal its BL Lac-type central engine.Comment: 5 pages, 3 figures (1 color); A&A, accepte

FACT - Threshold prediction for higher duty cycle and improved scheduling

The First G-APD Cherenkov telescope (FACT) is the first telescope using silicon photon detectors (G-APD aka. SiPM). The use of Silicon devices promise a higher photon detection efficiency, more robustness and higher precision than photo-multiplier tubes. Being operated during different light-conditions, the threshold settings of a Cherenkov telescope have to be adapted to feature the lowest possible threshold but also an efficient suppression of triggers from night-sky background photons. Usually this threshold is set either by experience or a mini-ratescan. Since the measured current through the sensors is directly correlated with the noise level, the current can be used to set the best threshold at any time. Due to the correlation between the physical threshold and the final energy threshold, the current can also be used as a measure for the energy threshold of any observation. This presentation introduces a method which uses the properties of the moon and the source position to predict the currents and the corresponding energy threshold for every upcoming observation allowing to adapt the observation schedule accordingly

FACT - Long-term stability and observations during strong Moon light

The First G-APD Cherenkov Telescope (FACT) is the first Cherenkov telescope equipped with a camera made of silicon photon detectors (G-APD aka. SiPM). Since October 2011, it is regularly taking data on the Canary Island of La Palma. G-APDs are ideal detectors for Cherenkov telescopes as they are robust and stable. Furthermore, the insensitivity of G-APDs towards strong ambient light allows to conduct observations during bright Moon and twilight. This gain in observation time is essential for the long-term monitoring of bright TeV blazars. During the commissioning phase, hundreds of hours of data (including data from the the Crab Nebula) were taken in order to understand the performance and sensitivity of the instrument. The data cover a wide range of observation conditions including different weather conditions, different zenith angles and different light conditions (ranging from dark night to direct full Moon). We use a new parmetrisation of the Moon light background to enhance our scheduling and to monitor the atmosphere. With the data from 1.5 years, the long-term stability and the performance of the camera during Moon light is studied and compared to that achieved with photomultiplier tubes so far.Comment: 3 pages, 3 figures, FACT Contribution to the 33rd International Cosmic Ray Conference (ICRC), Rio de Janeir

FACT - Long-term Monitoring of Bright TeV-Blazars

Since October 2011, the First G-APD Cherenkov Telescope (FACT) is operated successfully on the Canary Island of La Palma. Apart from the proof of principle for the use of G-APDs in Cherenkov telescopes, the major goal of the project is the dedicated long-term monitoring of a small sample of bright TeV blazars. The unique properties of G-APDs permit stable observations also during strong moon light. Thus a superior sampling density is provided on time scales at which the blazar variability amplitudes are expected to be largest, as exemplified by the spectacular variations of Mrk 501 observed in June 2012. While still in commissioning, FACT monitored bright blazars like Mrk 421 and Mrk 501 during the past 1.5 years so far. Preliminary results including the Mrk 501 flare from June 2012 will be presented.Comment: 4 pages, 4 figures, presented at the 33rd ICRC (2013