32 research outputs found

    Supersymmetry and other beyond the Standard Model physics: Prospects for determining mass, spin and CP properties

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    The prospects of measuring masses, spin and CP properties within Supersymmetry and other beyond the Standard Model extensions at the LHC are reviewed. Emphasis is put on models with missing transverse energy due to undetected particles, as in Supersymmetry or Universal Extra Dimensions.Comment: 5 pages, 6 pdf figues, contributed to the Proceedings of XXXVIII International Symposium on Multiparticle Dynamics ISMD 200

    Molecular and functional profiling identifies therapeutically targetable vulnerabilities in plasmablastic lymphoma

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    Plasmablastic lymphoma (PBL) represents a rare and aggressive lymphoma subtype frequently associated with immunosuppression. Clinically, patients with PBL are characterized by poor outcome. The current understanding of the molecular pathogenesis is limited. A hallmark of PBL represents its plasmacytic differentiation with loss of B-cell markers and, in 60% of cases, its association with Epstein-Barr virus (EBV). Roughly 50% of PBLs harbor a MYC translocation. Here, we provide a comprehensive integrated genomic analysis using whole exome sequencing (WES) and genome-wide copy number determination in a large cohort of 96 primary PBL samples. We identify alterations activating the RAS-RAF, JAK-STAT, and NOTCH pathways as well as frequent high-level amplifications in MCL1 and IRF4. The functional impact of these alterations is assessed using an unbiased shRNA screen in a PBL model. These analyses identify the IRF4 and JAK-STAT pathways as promising molecular targets to improve outcome of PBL patients

    Measurement of the charge asymmetry in top-quark pair production in the lepton-plus-jets final state in pp collision data at s=8TeV\sqrt{s}=8\,\mathrm TeV{} with the ATLAS detector

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    ATLAS Run 1 searches for direct pair production of third-generation squarks at the Large Hadron Collider

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    Supersymmetry and other beyond the Standard Model physics: Prospects for determining mass, spin and CP properties

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    The prospects of measuring masses, spin and CP properties within Supersymmetry and other beyond the Standard Model extensions at the LHC are reviewed. Emphasis is put on models with missing transverse energy due to undetected particles, as in Supersymmetry or Universal Extra Dimensions
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