237 research outputs found
Fairy tale traditions in amateur and professional young writersβ creativity
The turn of the 21st century has seen Russian writersβ increased interest in the genre of fairy
tale. This paper discusses young Russian writersβ approaches to fairy tale traditions in texts of
their own. The subjects of the study consisted of the Debut Prize winners and the so-called
amateur writers (fans of Tolkienβs and Rowlingβs books, and gamers) and their literary
works. The study is aimed at establishing main trends in usage of folklore traditions in the
first two decades of the 21st century; the paper is also concerned with examining similarities
and differences between two generations of modern Russian writers in the matter of their
approaches to classical heritage. To compare fairy tale texts, Vladimir Proppβs narrative
model has been applied. One of the central claims of the study is that young authors tend to
emulate literary samples by prominent contemporary Russian writers (mostly by Lyudmila
Petrushevskaya). Thus, an efficient way of creating a contemporary fairy tale by a young
author is to immerse its characters into the modern reality that is presented in a variety of its
manifestations β from everyday routine to philosophic ideas. The young writersβ texts display
such traditional features of literary folklorism as genuine fairy tale plots and motifs, their
structural and style models, characters, magical objects, and the artistic device of
estrangement
Π Π°Π·ΡΠ°Π±ΠΎΡΠΊΠ° ΡΡ Π΅ΠΌΡ ΠΌΠ°ΡΡΡΡΡΠΈΠ·Π°ΡΠΈΠΈ ΠΌΠ°Π³ΠΈΡΡΡΠ°Π»ΡΠ½ΠΎΠΉ ΡΠ΅ΡΠΈ ΠΏΠ΅ΡΠ΅Π΄Π°ΡΠΈ Π΄Π°Π½Π½ΡΡ Π΄Π»Ρ Π°Π²ΡΠΎΠΌΠ°ΡΠΈΠ·Π°ΡΠΈΠΈ ΡΠ°Π±ΠΎΡΡ ΠΡΠ°ΡΠ½ΠΎΡΡΡΠΊΠΎΠΉ ΠΆΠ΅Π»Π΅Π·Π½ΠΎΠΉ Π΄ΠΎΡΠΎΠ³ΠΈ Π½Π° ΠΏΡΠΈΠΌΠ΅ΡΠ΅ ΠΏΡΠΎΡΠΎΠΊΠΎΠ»Π° IS-IS
Π Π°Π΄ΠΈΠΊΠ°Π»ΡΠ½ΠΎ-ΡΠ΅ΠΏΠ½ΠΎΠ΅ ΠΎΠΊΠΈΡΠ»Π΅Π½ΠΈΠ΅ ΠΊΡΠΌΠΎΠ»Π° Π² ΠΏΡΠΈΡΡΡΡΡΠ²ΠΈΠΈ ΡΠ°Π·Π»ΠΈΡΠ½ΡΡ ΡΡΠΏΡΠ°ΠΌΠΎΠ»Π΅ΠΊΡΠ»ΡΡΠ½ΡΡ ΡΠΈΡΡΠ΅ΠΌ, ΡΠΎΠ΄Π΅ΡΠΆΠ°ΡΠΈΡ Π°Π½ΠΈΠΎΠ½-ΡΠ°Π΄ΠΈΠΊΠ°Π» ΠΊΠΈΡΠ»ΠΎΡΠΎΠ΄Π°
ΠΡΠΎΠ±Π»Π΅ΠΌΠ°ΡΠΈΠΊΠ°. Π£ Π±ΡΠ»ΡΡΠΎΡΡΡ ΠΏΡΠ±Π»ΡΠΊΠ°ΡΡΠΉ Π· ΠΏΡΠΎΠ±Π»Π΅ΠΌ, ΠΏΠΎΠ²βΡΠ·Π°Π½ΠΈΡ
Π· Π°ΠΊΡΠΈΠ²Π½ΠΈΠΌΠΈ ΡΠΎΡΠΌΠ°ΠΌΠΈ ΠΊΠΈΡΠ½Ρ, ΠΏΡΠ΄ΠΊΡΠ΅ΡΠ»ΡΡΡΡΡΡ ΡΡ
Π΄Π΅ΡΡΡΡΠΊΡΠΈΠ²Π½Π° Π΄ΡΡ Π½Π° ΠΌΠ΅ΠΌΠ±ΡΠ°Π½ΠΈ, Π½ΡΠΊΠ»Π΅ΡΠ½ΠΎΠ²Ρ ΠΊΠΈΡΠ»ΠΎΡΠΈ Ρ Π±ΡΠ»ΠΊΠΈ. ΠΠ»Π΅ ΠΏΠΎΠ·Π° ΡΠ²Π°Π³ΠΎΡ Π±Π°Π³Π°ΡΡΠΎΡ
Π΄ΠΎΡΠ»ΡΠ΄Π½ΠΈΠΊΡΠ² Π·Π°Π»ΠΈΡΠ°ΡΡΡΡΡ Π²Π΅Π»ΠΈΡΠ΅Π·Π½ΠΈΠΉ ΠΌΠ°ΡΠΈΠ² Π΄Π°Π½ΠΈΡ
, ΡΠΎ ΡΠ²ΡΠ΄ΡΠ°ΡΡ ΠΏΡΠΎ Π°Π±ΡΠΎΠ»ΡΡΠ½Ρ Π½Π΅ΠΎΠ±Ρ
ΡΠ΄Π½ΡΡΡΡ Π°ΠΊΡΠΈΠ²Π½ΠΈΡ
ΡΠΎΡΠΌ ΠΊΠΈΡΠ½Ρ Π΄Π»Ρ ΠΏΡΠΎΡΠ΅ΡΡΠ² ΠΆΠΈΡΡΡΠ΄ΡΡΠ»ΡΠ½ΠΎΡΡΡ. Π§ΠΈΡΠ»Π΅Π½Π½Ρ Π΅ΠΌΠΏΡΡΠΈΡΠ½Ρ Π΄Π°Π½Ρ Π²Ρ
ΠΎΠ΄ΡΡΡ Ρ ΡΡΠΏΠ΅ΡΠ΅ΡΠ½ΡΡΡΡ Π·Ρ ΡΡΠΎΡΠΌΠΎΠ²Π°Π½ΠΎΡ Π² ΠΊΠ»Π°ΡΠΈΡΠ½ΡΠΉ Π±ΡΠΎΡ
ΡΠΌΡΡ ΡΡ
Π΅ΠΌΠΎΡ, Π² ΡΠ°ΠΌΠΊΠ°Ρ
ΡΠΊΠΎΡ Π°ΠΊΡΠΈΠ²Π½Ρ ΡΠΎΡΠΌΠΈ ΠΊΠΈΡΠ½Ρ Π±Π°ΡΠ°ΡΡΡΡ Π»ΠΈΡΠ΅ ΡΠΊ Π½Π°Π΄Π°ΠΊΡΠΈΠ²Π½Ρ Ρ
ΡΠΌΡΡΠ½Ρ ΡΠ°ΡΡΠΈΠ½ΠΊΠΈ, ΡΠΊΡ ΠΌΠΎΠΆΡΡΡ ΠΏΠΎΡΡΡΡΠ²Π°ΡΠΈ ΡΡΡΡΠ½ΠΊΠΈΠΉ Ρ
ΡΠ΄ Π½ΠΎΡΠΌΠ°Π»ΡΠ½ΠΈΡ
Π±ΡΠΎΡ
ΡΠΌΡΡΠ½ΠΈΡ
ΠΏΡΠΎΡΠ΅ΡΡΠ². Π’ΠΎΠΌΡ Π°ΠΊΡΡΠ°Π»ΡΠ½ΠΈΠΌ Ρ Π²ΠΈΠ²ΡΠ΅Π½Π½Ρ ΡΠΎΠ»Ρ ΡΡΠΏΠ΅ΡΠΎΠΊΡΠΈΠ΄Π°Π½ΡΠΎΠ½Π° Π² ΠΏΡΠΎΡΠ΅ΡΠ°Ρ
ΡΠ°Π΄ΠΈΠΊΠ°Π»ΡΠ½ΠΎ-Π»Π°Π½ΡΡΠ³ΠΎΠ²ΠΎΠ³ΠΎ ΠΎΠΊΠΈΡΠ½Π΅Π½Π½Ρ, Π΄Π΅ ΠΉΠΎΠ³ΠΎ ΡΡΠ½ΠΊΡΡΡ ΡΠΊ ΠΌΠ΅Π΄ΡΠ°ΡΠΎΡΠ° ΠΏΡΠ°ΠΊΡΠΈΡΠ½ΠΎ Π½Π΅ Π΄ΠΎΡΠ»ΡΠ΄ΠΆΠ΅Π½Π°. ΠΠ΅ΡΠ° Π΄ΠΎΡΠ»ΡΠ΄ΠΆΠ΅Π½Π½Ρ. ΠΠΎΡΠ»ΡΠ΄ΠΆΠ΅Π½Π½Ρ ΠΏΡΠΎΡΠ΅ΡΡ ΡΠ½ΡΡΡΠΉΠΎΠ²Π°Π½ΠΎΠ³ΠΎ ΠΎΠΊΠΈΡΠ½Π΅Π½Π½Ρ ΠΊΡΠΌΠΎΠ»Ρ Π·Π° Π½Π°ΡΠ²Π½ΠΎΡΡΡ ΡΡΠ·Π½ΠΈΡ
ΡΡΠΏΡΠ°ΠΌΠΎΠ»Π΅ΠΊΡΠ»ΡΡΠ½ΠΈΡ
ΡΠΈΡΡΠ΅ΠΌ, ΡΠΎ ΠΌΡΡΡΡΡΡ Π°Π½ΡΠΎΠ½-ΡΠ°Π΄ΠΈΠΊΠ°Π» ΠΊΠΈΡΠ½Ρ. ΠΠ΅ΡΠΎΠ΄ΠΈΠΊΠ° ΡΠ΅Π°Π»ΡΠ·Π°ΡΡΡ. ΠΠΈΠΊΠΎΡΠΈΡΡΠ°Π½ΠΎ ΡΡΠ²Π½ΠΎΠ²Π°ΠΆΠ½Ρ ΡΠΎΠ·ΡΠΈΠ½ΠΈ ΡΡΠΏΡΠ°ΠΌΠΎΠ»Π΅ΠΊΡΠ»ΡΡΠ½ΠΈΡ
ΠΊΠΎΠΌΠΏΠ»Π΅ΠΊΡΡΠ² ΠΠ2*ΠΊΡΠ°ΡΠ½-Π΅ΡΡΡ, Π΄Π»Ρ ΡΠΊΠΈΡ
ΡΠ°Ρ Π΄ΠΎΡΡΠ³Π½Π΅Π½Π½Ρ ΡΡΠ²Π½ΠΎΠ²Π°Π³ΠΈ ΠΎΡΡΠ½ΡΠ²Π°Π²ΡΡ ΠΌΠ΅ΡΠΎΠ΄ΠΎΠΌ Π²ΠΈΠΌΡΡΡΠ²Π°Π½Π½Ρ Π΅Π»Π΅ΠΊΡΡΠΎΠΏΡΠΎΠ²ΡΠ΄Π½ΠΎΡΡΡ. ΠΠ° ΠΊΡΠ½Π΅ΡΠΈΠΊΠΎΡ ΠΎΠΊΠΈΡΠ½Π΅Π½Π½Ρ ΠΊΡΠΌΠΎΠ»Ρ Π·Π° Π½Π°ΡΠ²Π½ΠΎΡΡΡ Π°Π½ΡΠΎΠ½ΡΠ°Π΄ΠΈΠΊΠ°Π»Π° ΠΊΠΈΡΠ½Ρ ΡΠΏΠΎΡΡΠ΅ΡΡΠ³Π°Π»ΠΈ Π³Π°Π·ΠΎΠ²ΠΎΠ»ΡΠΌΠΎΠΌΠ΅ΡΡΠΈΡΠ½ΠΎ. ΠΠ»Ρ Π΄ΠΎΡΠ»ΡΠ΄ΠΆΠ΅Π½Π½Ρ Π²ΠΏΠ»ΠΈΠ²Ρ ΠΏΡΠΈΡΠΎΠ΄ΠΈ ΠΊΠ°ΡΡΠΎΠ½Π° Π½Π° ΠΏΡΠΎΡΠ΅Ρ ΠΎΠΊΠΈΡΠ½Π΅Π½Π½Ρ Π΄ΠΎΡΠ»ΡΠ΄Π½ΠΎΡ ΡΡΠΌΡΡΡ Π²ΠΈΠΊΠΎΡΠΈΡΡΠ°Π½ΠΎ ΡΡΠ·Π½Ρ ΠΊΡΠ°ΡΠ½-Π΅ΡΡΡΠΈ Π΄Π»Ρ ΡΡΠ²ΠΎΡΠ΅Π½Π½Ρ ΡΡΠΏΡΠ°ΠΌΠΎΠ»Π΅ΠΊΡΠ»ΡΡΠ½ΠΎΡ ΡΠΈΡΡΠ΅ΠΌΠΈ ΠΠ2*ΠΊΡΠ°ΡΠ½-Π΅ΡΡΡ Ρ ΡΠ΅ΡΠ΅Π΄ΠΎΠ²ΠΈΡΡ ΠΠΠ‘Π. Π Π΅Π·ΡΠ»ΡΡΠ°ΡΠΈ Π΄ΠΎΡΠ»ΡΠ΄ΠΆΠ΅Π½Π½Ρ. ΠΡΡΠ°Π½ΠΎΠ²Π»Π΅Π½ΠΎ, ΡΠΎ Π΅ΡΠ΅ΠΊΡΠΈΠ²Π½ΡΡΡΡ Π΄ΡΡ ΠΊΠΎΠΌΠΏΠ»Π΅ΠΊΡΡ ΠΠ2*ΠΊΡΠ°ΡΠ½-Π΅ΡΡΡ Π·Π°Π»Π΅ΠΆΠΈΡΡ Π²ΡΠ΄ ΠΏΡΠΈΡΠΎΠ΄ΠΈ ΠΊΡΠ°ΡΠ½Π΅ΡΡΡΡ, ΡΠΎ Π΄Π°Ρ Π·ΠΌΠΎΠ³Ρ Π²ΠΈΠ±ΡΠ°ΡΠΈ Π½Π°ΠΉΠ±ΡΠ»ΡΡ ΠΎΠΏΡΠΈΠΌΠ°Π»ΡΠ½Ρ ΡΠΈΡΡΠ΅ΠΌΡ Π΄Π»Ρ Π³ΠΎΡΡΠ²Π°Π½Π½Ρ ΡΠ½Π³ΡΠ±ΡΡΡΠΎΡ ΡΡΠΌΡΡΡ. ΠΠΈΡΠ½ΠΎΠ²ΠΊΠΈ. ΠΡΠΎΠ²Π΅Π΄Π΅Π½Ρ Π΄ΠΎΡΠ»ΡΠ΄ΠΆΠ΅Π½Π½Ρ Π΄Π°ΡΡΡ ΠΌΠΎΠΆΠ»ΠΈΠ²ΡΡΡΡ Π²ΠΈΠ±ΡΠ°ΡΠΈ ΠΎΠΏΡΠΈΠΌΠ°Π»ΡΠ½ΠΈΠΉ ΡΠ΅ΠΆΠΈΠΌ Ρ ΡΡΡΡΠΊΡΡΡΡ ΠΊΠΎΠΌΠΏΠ»Π΅ΠΊΡΡ β Π΄ΠΆΠ΅ΡΠ΅Π»Π° Π°Π½ΡΠΎΠ½-ΡΠ°Π΄ΠΈΠΊΠ°Π»Π° ΠΊΠΈΡΠ½Ρ Π·Π°Π»Π΅ΠΆΠ½ΠΎ Π²ΡΠ΄ ΡΡΠ»Π΅ΠΉ Π΅ΠΊΡΠΏΠ΅ΡΠΈΠΌΠ΅Π½ΡΡ. ΠΡΡΠΈΠΌΠ°Π½Ρ Π΄Π°Π½Π½Ρ ΠΌΠΎΠΆΡΡΡ ΠΌΠ°ΡΠΈ ΡΡΡΡΡΠ²Π΅ Π·Π½Π°ΡΠ΅Π½Π½Ρ ΠΏΡΠΈ Π²ΠΈΠ²ΡΠ΅Π½Π½Ρ ΡΠΎΠ»Ρ Π°ΠΊΡΠΈΠ²Π½ΠΈΡ
ΡΠΎΡΠΌ ΠΊΠΈΡΠ½Ρ Π² Π±ΡΠΎΡ
ΡΠΌΡΡΠ½ΠΈΡ
ΠΏΡΠΎΡΠ΅ΡΠ°Ρ
.Background. In most publications on the problems associated with reactive oxygen species, highlights their destructive effect on the membranes, nucleic acids and proteins. But many researchers overlooked the vast array of data showing the absolute necessity of reactive oxygen to vital processes. So many empirical data are in conflict with established in classical biochemistry scheme in which reactive oxygen species are seen only as hyperactive chemical particles that can disrupt normal harmonious progress of biochemical processes. In this regard, the study of superoxide anion role in the radical-chain oxidation processes is important, where its function as mediator remains virtually unexplored. Objective. The aim is to research the process of initiated cumene oxidation in the presence of different supramolecular systems containing anion radical oxygen. Methods. The paper used the equilibrium solutions of supramolecular complexes KO2*crown-ether, for which balance achieving time was estimated by measuring the electrical conductivity. The cumene oxidation kinetics in the presence of oxygen radical anion was monitored by gas volumetric method. To study the influence of the cation nature on the experimental mixture oxidation, we used various crown ethers to form supramolecular systems KO2*crown in DMSO. Results. It was stated that effectiveness of the complex action depends on the crown-ether nature, which allows choosing the most optimal system for the inhibiting mixture preparation. Conclusions. Our studies allow choosing the best mode and the complex structure - a source of oxygen anion radical, depending on the objectives and goals of the experiment. The received data can have significant value in studying the role of reactive oxygen species in biochemical processes.ΠΡΠΎΠ±Π»Π΅ΠΌΠ°ΡΠΈΠΊΠ°. Π Π±ΠΎΠ»ΡΡΠΈΠ½ΡΡΠ²Π΅ ΠΏΡΠ±Π»ΠΈΠΊΠ°ΡΠΈΠΉ ΠΏΠΎ ΠΏΡΠΎΠ±Π»Π΅ΠΌΠ°ΠΌ, ΡΠ²ΡΠ·Π°Π½Π½ΡΠΌ Ρ Π°ΠΊΡΠΈΠ²Π½ΡΠΌΠΈ ΡΠΎΡΠΌΠ°ΠΌΠΈ ΠΊΠΈΡΠ»ΠΎΡΠΎΠ΄Π°, ΠΏΠΎΠ΄ΡΠ΅ΡΠΊΠΈΠ²Π°Π΅ΡΡΡ ΠΈΡ
Π΄Π΅ΡΡΡΡΠΊΡΠΈΠ²Π½ΠΎΠ΅ Π΄Π΅ΠΉΡΡΠ²ΠΈΠ΅ Π½Π° ΠΌΠ΅ΠΌΠ±ΡΠ°Π½Ρ, Π½ΡΠΊΠ»Π΅ΠΈΠ½ΠΎΠ²ΡΠ΅ ΠΊΠΈΡΠ»ΠΎΡΡ ΠΈ Π±Π΅Π»ΠΊΠΈ. ΠΠΎ Π±Π΅Π· Π²Π½ΠΈΠΌΠ°Π½ΠΈΡ ΠΌΠ½ΠΎΠ³ΠΈΡ
ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°ΡΠ΅Π»Π΅ΠΉ ΠΎΡΡΠ°Π΅ΡΡΡ ΠΎΠ³ΡΠΎΠΌΠ½ΡΠΉ ΠΌΠ°ΡΡΠΈΠ² Π΄Π°Π½Π½ΡΡ
, ΡΠ²ΠΈΠ΄Π΅ΡΠ΅Π»ΡΡΡΠ²ΡΡΡΠΈΡ
ΠΎΠ± Π°Π±ΡΠΎΠ»ΡΡΠ½ΠΎΠΉ Π½Π΅ΠΎΠ±Ρ
ΠΎΠ΄ΠΈΠΌΠΎΡΡΠΈ Π°ΠΊΡΠΈΠ²Π½ΡΡ
ΡΠΎΡΠΌ ΠΊΠΈΡΠ»ΠΎΡΠΎΠ΄Π° Π΄Π»Ρ ΠΏΡΠΎΡΠ΅ΡΡΠΎΠ² ΠΆΠΈΠ·Π½Π΅Π΄Π΅ΡΡΠ΅Π»ΡΠ½ΠΎΡΡΠΈ. ΠΠ½ΠΎΠ³ΠΎΡΠΈΡΠ»Π΅Π½Π½ΡΠ΅ ΡΠΌΠΏΠΈΡΠΈΡΠ΅ΡΠΊΠΈΠ΅ Π΄Π°Π½Π½ΡΠ΅ Π²Ρ
ΠΎΠ΄ΡΡ Π² ΠΏΡΠΎΡΠΈΠ²ΠΎΡΠ΅ΡΠΈΠ΅ ΡΠΎ ΡΠ»ΠΎΠΆΠΈΠ²ΡΠ΅ΠΉΡΡ Π² ΠΊΠ»Π°ΡΡΠΈΡΠ΅ΡΠΊΠΎΠΉ Π±ΠΈΠΎΡ
ΠΈΠΌΠΈΠΈ ΡΡ
Π΅ΠΌΠΎΠΉ, Π² ΡΠ°ΠΌΠΊΠ°Ρ
ΠΊΠΎΡΠΎΡΠΎΠΉ Π°ΠΊΡΠΈΠ²Π½ΡΠ΅ ΡΠΎΡΠΌΡ ΠΊΠΈΡΠ»ΠΎΡΠΎΠ΄Π° Π²ΠΈΠ΄ΡΡΡΡ ΡΠΎΠ»ΡΠΊΠΎ ΠΊΠ°ΠΊ ΡΠ²Π΅ΡΡ
Π°ΠΊΡΠΈΠ²Π½ΡΠ΅ Ρ
ΠΈΠΌΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΡΠ°ΡΡΠΈΡΡ, ΠΊΠΎΡΠΎΡΡΠ΅ ΠΌΠΎΠ³ΡΡ Π½Π°ΡΡΡΠ°ΡΡ ΡΡΡΠΎΠΉΠ½ΡΠΉ Ρ
ΠΎΠ΄ Π½ΠΎΡΠΌΠ°Π»ΡΠ½ΡΡ
Π±ΠΈΠΎΡ
ΠΈΠΌΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΏΡΠΎΡΠ΅ΡΡΠΎΠ². Π ΡΠ²ΡΠ·ΠΈ Ρ ΡΡΠΈΠΌ Π°ΠΊΡΡΠ°Π»ΡΠ½ΠΎΠ΅ Π·Π½Π°ΡΠ΅Π½ΠΈΠ΅ ΠΏΡΠΈΠΎΠ±ΡΠ΅ΡΠ°Π΅Ρ ΠΈΠ·ΡΡΠ΅Π½ΠΈΠ΅ ΡΠΎΠ»ΠΈ ΡΡΠΏΠ΅ΡΠΎΠΊΡΠΈΠ΄-Π°Π½ΠΈΠΎΠ½Π° Π² ΠΏΡΠΎΡΠ΅ΡΡΠ°Ρ
ΡΠ°Π΄ΠΈΠΊΠ°Π»ΡΠ½ΠΎ-ΡΠ΅ΠΏΠ½ΠΎΠ³ΠΎ ΠΎΠΊΠΈΡΠ»Π΅Π½ΠΈΡ, Π³Π΄Π΅ Π΅Π³ΠΎ ΡΡΠ½ΠΊΡΠΈΡ ΠΊΠ°ΠΊ ΠΌΠ΅Π΄ΠΈΠ°ΡΠΎΡΠ° ΠΎΡΡΠ°Π΅ΡΡΡ ΠΏΡΠ°ΠΊΡΠΈΡΠ΅ΡΠΊΠΈ Π½Π΅ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½Π½ΠΎΠΉ. Π¦Π΅Π»Ρ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ. ΠΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠ΅ ΠΏΡΠΎΡΠ΅ΡΡΠ° ΠΈΠ½ΠΈΡΠΈΠΈΡΠΎΠ²Π°Π½Π½ΠΎΠ³ΠΎ ΠΎΠΊΠΈΡΠ»Π΅Π½ΠΈΡ ΠΊΡΠΌΠΎΠ»Π° Π² ΠΏΡΠΈΡΡΡΡΡΠ²ΠΈΠΈ ΡΠ°Π·Π»ΠΈΡΠ½ΡΡ
ΡΡΠΏΡΠ°ΠΌΠΎΠ»Π΅ΠΊΡΠ»ΡΡΠ½ΡΡ
ΡΠΈΡΡΠ΅ΠΌ, ΡΠΎΠ΄Π΅ΡΠΆΠ°ΡΠΈΡ
Π°Π½ΠΈΠΎΠ½-ΡΠ°Π΄ΠΈΠΊΠ°Π» ΠΊΠΈΡΠ»ΠΎΡΠΎΠ΄Π°. ΠΠ΅ΡΠΎΠ΄ΠΈΠΊΠ° ΡΠ΅Π°Π»ΠΈΠ·Π°ΡΠΈΠΈ. ΠΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½Ρ ΡΠ°Π²Π½ΠΎΠ²Π΅ΡΠ½ΡΠ΅ ΡΠ°ΡΡΠ²ΠΎΡΡ ΡΡΠΏΡΠ°ΠΌΠΎΠ»Π΅ΠΊΡΠ»ΡΡΠ½ΡΡ
ΠΊΠΎΠΌΠΏΠ»Π΅ΠΊΡΠΎΠ² ΠΠ2*ΠΊΡΠ°ΡΠ½-ΡΡΠΈΡ, Π΄Π»Ρ ΠΊΠΎΡΠΎΡΡΡ
Π²ΡΠ΅ΠΌΡ Π΄ΠΎΡΡΠΈΠΆΠ΅Π½ΠΈΡ ΡΠ°Π²Π½ΠΎΠ²Π΅ΡΠΈΡ ΠΎΡΠ΅Π½ΠΈΠ²Π°Π»ΠΎΡΡ ΠΌΠ΅ΡΠΎΠ΄ΠΎΠΌ ΠΈΠ·ΠΌΠ΅ΡΠ΅Π½ΠΈΡ ΡΠ»Π΅ΠΊΡΡΠΎΠΏΡΠΎΠ²ΠΎΠ΄Π½ΠΎΡΡΠΈ. ΠΠ° ΠΊΠΈΠ½Π΅ΡΠΈΠΊΠΎΠΉ ΠΎΠΊΠΈΡΠ»Π΅Π½ΠΈΡ ΠΊΡΠΌΠΎΠ»Π° Π² ΠΏΡΠΈΡΡΡΡΡΠ²ΠΈΠΈ Π°Π½ΠΈΠΎΠ½-ΡΠ°Π΄ΠΈΠΊΠ°Π»Π° ΠΊΠΈΡΠ»ΠΎΡΠΎΠ΄Π° ΡΠ»Π΅Π΄ΠΈΠ»ΠΈ Π³Π°Π·ΠΎΠ²ΠΎΠ»ΡΠΌΠΎΠΌΠ΅ΡΡΠΈΡΠ΅ΡΠΊΠΈ. ΠΠ»Ρ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ Π²Π»ΠΈΡΠ½ΠΈΡ ΠΏΡΠΈΡΠΎΠ΄Ρ ΠΊΠ°ΡΠΈΠΎΠ½Π° Π½Π° ΠΏΡΠΎΡΠ΅ΡΡ ΠΎΠΊΠΈΡΠ»Π΅Π½ΠΈΡ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°ΡΠ΅Π»ΡΡΠΊΠΎΠΉ ΡΠΌΠ΅ΡΠΈ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½Ρ ΡΠ°Π·Π»ΠΈΡΠ½ΡΠ΅ ΠΊΡΠ°ΡΠ½-ΡΡΠΈΡΡ Π΄Π»Ρ ΠΎΠ±ΡΠ°Π·ΠΎΠ²Π°Π½ΠΈΡ ΡΡΠΏΡΠ°ΠΌΠΎΠ»Π΅ΠΊΡΠ»ΡΡΠ½ΠΎΠΉ ΡΠΈΡΡΠ΅ΠΌΡ ΠΠ2*ΠΊΡΠ°ΡΠ½-ΡΡΠΈΡ Π² ΡΡΠ΅Π΄Π΅ ΠΠΠ‘Π. Π Π΅Π·ΡΠ»ΡΡΠ°ΡΡ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ. Π£ΡΡΠ°Π½ΠΎΠ²Π»Π΅Π½ΠΎ, ΡΡΠΎ ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ Π΄Π΅ΠΉΡΡΠ²ΠΈΡ ΠΊΠΎΠΌΠΏΠ»Π΅ΠΊΡΠ° Π·Π°Π²ΠΈΡΠΈΡ ΠΎΡ ΠΏΡΠΈΡΠΎΠ΄Ρ ΠΊΡΠ°ΡΠ½-ΡΡΠΈΡΠ°, ΡΡΠΎ ΠΏΠΎΠ·Π²ΠΎΠ»ΡΠ΅Ρ Π²ΡΠ±ΡΠ°ΡΡ Π½Π°ΠΈΠ±ΠΎΠ»Π΅Π΅ ΠΎΠΏΡΠΈΠΌΠ°Π»ΡΠ½ΡΡ ΡΠΈΡΡΠ΅ΠΌΡ Π΄Π»Ρ ΠΏΡΠΈΠ³ΠΎΡΠΎΠ²Π»Π΅Π½ΠΈΡ ΠΈΠ½Π³ΠΈΠ±ΠΈΡΡΡΡΠ΅ΠΉ ΡΠΌΠ΅ΡΠΈ. ΠΡΠ²ΠΎΠ΄Ρ. ΠΡΠΎΠ²Π΅Π΄Π΅Π½Π½ΡΠ΅ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ ΠΏΠΎΠ·Π²ΠΎΠ»ΡΡΡ Π²ΡΠ±ΡΠ°ΡΡ ΠΎΠΏΡΠΈΠΌΠ°Π»ΡΠ½ΡΠΉ ΡΠ΅ΠΆΠΈΠΌ ΠΈ ΡΡΡΡΠΊΡΡΡΡ ΠΊΠΎΠΌΠΏΠ»Π΅ΠΊΡΠ° β ΠΈΡΡΠΎΡΠ½ΠΈΠΊΠΈ Π°Π½ΠΈΠΎΠ½-ΡΠ°Π΄ΠΈΠΊΠ°Π»Π° ΠΊΠΈΡΠ»ΠΎΡΠΎΠ΄Π° Π² Π·Π°Π²ΠΈΡΠΈΠΌΠΎΡΡΠΈ ΠΎΡ Π·Π°Π΄Π°ΡΠΈ ΠΈ ΡΠ΅Π»Π΅ΠΉ ΡΠΊΡΠΏΠ΅ΡΠΈΠΌΠ΅Π½ΡΠ°. ΠΠΎΠ»ΡΡΠ΅Π½Π½ΡΠ΅ Π΄Π°Π½Π½ΡΠ΅ ΠΌΠΎΠ³ΡΡ ΠΈΠΌΠ΅ΡΡ ΡΡΡΠ΅ΡΡΠ²Π΅Π½Π½ΠΎΠ΅ Π·Π½Π°ΡΠ΅Π½ΠΈΠ΅ ΠΏΡΠΈ ΠΈΠ·ΡΡΠ΅Π½ΠΈΠΈ ΡΠΎΠ»ΠΈ Π°ΠΊΡΠΈΠ²Π½ΡΡ
ΡΠΎΡΠΌ ΠΊΠΈΡΠ»ΠΎΡΠΎΠ΄Π° Π² Π±ΠΈΠΎΡ
ΠΈΠΌΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΏΡΠΎΡΠ΅ΡΡΠ°Ρ
SAFETY ASSESSMENT OF FOOD-STUFF RAW MATERIAL AND FOOD PRODUCTS IN BURYAT REPUBLIC
The aim of study was a hygienic assessment on sanitary and chemical, microbiological indicators of food and the food staples, realized in the territory of the Buryat Republic during 2008-2012. Preparation for processing of primary data and the subsequent statistical analysis made with Excel and the integrated package STATISTICA 6.0. Calculation of percent of tests of hygienic standards not conforming to requirements (%) on areas and as a whole on the republic is carried out. The specified sizes are determined as for separate years, and on the average for the period. To average values 95% confidential intervals (CI) are calculated. As significant deviations from the average levels the sizes which are going out of CI were considered. The performed result of assessment of the laboratory studies may testify that the stable high percent of the samples which don't accord to the normative in the sanitary-chemical indices is available at present. Using the cluster analyses allowed to reveal that according to the sanitary-chemical indices 52,4 % of all the regions in which the portion of the non-standard samples was found to be in the range of 95% confidence interval (CI) [6,5-9,0] % of the average level have formed the more numerous (1st) cluster. The second cluster consisted of the Zaigrayevskiy and Bichurskiy regions in which the statistically significant increase in the prevalence of the non-standard samples was revealed. In 5 regions and the capital of Republic (Ulan-Ude) in the third cluster the most significant percent of the samples which don't accord to the hygienic claims (CI [15,0-29,0] %) is continuously registered. The fourth cluster consisted of three regions situated in the northern part of Buryat Republic in which the non-standard samples are extremely rare revealed (CI [0,5-2,2] %). The samples portion which don't accord to the hygienic normative in the microbiological indices was found to increase by 1,4-fold compared to the 2009-2011 years and amounted 3,8 % in 2012 year. The analysis based on the territorial factor has shown that the high levels of the non-standard samples of the food products in the microbiological indices were found to be in the regions of the first cluster: Eravninskiy, Mukhorshibirskiy, Kabanskiy and Ulan-Ude (CI [5,1-7,8] %), the last revealed level is the regions of the third cluster: Zakamenskiy, Bichurskiy, Barguzinskiy, Kurumkanskiy, Okinskiy, Bauntovskiy (CI [0,10-0,24] %). The control of microbiological safety allowed to reveal the most significant, in epidemic relation, food products: milk, meat, fish products, the products of children's food as well as the poultry products
Frequency of hyperglycemia and polymorphism of TNF and TP53 genes in patients with acute pancreatitis, chronic pancreatitis, pancreatic cancer
BACKGROUND: Β«The vicious circleΒ» of associations of diabetes mellitus (DM) with pancreatic pathology, when pancreatic diseases can initiate DM, and type 2 DM β cause functional and organic pancreatic pathology, determines the search for possible associations. Some studies have established a relationship between TNF or TP53 polymorphisms with DM or with pancreatic diseases.AIMS: to determine and compare fasting plasma glucose and the frequency of hyperglycemia in patients with acute pancreatitis (APp), chronic pancreatitis (CPp), pancreatic cancer (PCp) depending on gender, etiology or stage of the disease, polymorphism -308G/A TNF gene in all patients, and polymorphism 72Arg/Pro gene TP53 in PCp..MATERIALS AND METHODS: At the observational multicenter clinical cross-sectional uncontrolled case-study 44 APp, 97 CPp and 45 PCp were examined; the groups were comparable by sex/age. Informed consent form for participate in the study was obtained from all patients. The main outcome of the study: frequency of hyperglycemia in APp, CPp, PCp, considering the polymorphism TNF and TP53 genes.Β RESULTS: The lowest age-standardized fasting plasma glucose (FPG) was found in CPp (6,2Β±0,2 mmol/l) than in APp (6,7Β±0,2 mmol/l, p=0,041). In PCp (6,6Β±0,2 mmol/l), the average levels of FPG did not differ substantially when compared with APp (p=0,749) or CPp (p=0,092). In APp, the norm of GP was detected less frequently (31,8%) than in CPp (54,6%, Ο2 =6,3, p=0,012), and the frequency of the norm of GP in PCp (48,9%) did not differ with that in APp or CPp. The frequency of FPGβ₯6,1<7,0 mmol/l did not differ in APp (20,5%), CPp (9,3%) or PCp (17,8%). The frequency of FGPβ₯7.0 mmol/l did not differ in APp CPp and PCp: 47,7, 36,1, 33,3%. Logistic regression analysis revealed a tendency for an increased chance of having stage 3β4 PC with FPGβ₯7,0 mmol/l (Exp (B)=3,205 95%CI 0,866β11,855, p=0,081) in PCp, but not in patients with pancreatic necrosis or βdefiniteΒ» Π‘P.The frequencies of G/G (71,4, 74,7, 76,2%), G/A (26,2, 24,1, 23,8%) of TNF genotypes did not differ in APp, CPp or PCp, p>0,05. In PCp genotypes Arg/Arg, Arg/Pro, Pro/Pro polymorphism gene 72Arg/Pro TP53 in 2,4, 35,7, 61,9% of cases. No associations of GPβ₯7,0 mmol/l with TNF polymorphism in APp, CPp, PCp and with TP53 polymorphism in PCp were obtained.CONCLUSIONS: The frequency of FGPβ₯7,0 mmol/l did not differ for various pancreatic disease and was not associated with the risk of pancreatic necrosis and βdefinedβ CP. The -308G/A polymorphism TNF gene did not differ in APp, CPp or PCp and was not associated with impaired carbohydrate metabolism. The 72Arg/Pro polymorphism TP53 gene in PCp was not associated with impaired carbohydrate metabolism
ΠΠ±ΠΎΡΠ½ΠΎΠ²Π°Π½ΠΈΠ΅ ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ ΡΠΈΡΡΠ΅ΠΌΡ Π²Π·Π°ΠΈΠΌΠΎΠΎΡΠ½ΠΎΡΠ΅Π½ΠΈΠΉ Ρ ΠΊΠ»ΠΈΠ΅Π½ΡΠ°ΠΌΠΈ
[For the English abstract and full text of the article please see the attached PDF-File (English version follows Russian version)].ABSTRACT The article describes an approach of the method to study effectiveness of modern system of relationships with customers based on information technologies. In addition direct economic effects, indirect effects and effects of reducing risks in the performance of transport and logistics services are considered. Creating such a system in the holding Russian Railways is intended to increase the competitiveness of rail transport, to attract new customers, to increase revenue and reduce unproductive losses, which arise due to unsatisfactory performance referring to fulfillment of contractual obligations in the field of carriage of goods. Keywords: railway, CRM, holding company, service quality, transportation market, customer focus, logistics, efficiency, system of customer relationship, information technologies. REFERENCES 1.Tereshina, N.P.Economic regulation and comΒpetitiveness of transportation [Ekonomicheskoe reguΒlirovanie i konkurentosposobnostβ perevozok].Moscow, Railway Ministry, 1994, 132 p. 2.Khusainov, F.I.Railways and the market: a collection of articles [Zheleznye dorogi i rynok: sbornik statej].Moscow, Nauka publ., 2015, 582 p. 3.Sokolov , Yu.I.The economics of quality of transport service of cargo owners: monograph [Ekonomika kachestva transportnogo obsluzhivanija gruzovladelβcev: monografija].Moscow, TMC for education on railway transport, 2011, 184 p. 4.Lavrov, I.M.Economic evaluation of the quality of transport services of cargo owners in terms of multiplicΒity of participants in transportation process [EkonomichesΒkaja ocenka kachestva transportnogo obsluzhivanija gruzovladelβcev v uslovijah mnozhestvennosti uchastnikov perevozochnogo processa].Ph.D.(Economics) thesis.Moscow, 2015, 167 p. 5.Macheret, D.A.Methodological problems of studies on railway transport [Metodologicheskie problemy issledovanij na zheleznodorozhnom transporte].Ekonomika zheleznyh dorog, 2015, Iss.3, pp.12-26. 6.Subjects and methods to assess the quality of transport services in terms of competition in the freight transportation market [Subβekty i metody ocenki kachestva transportnogo obsluzhivanija v uslovijah konkurencii na rynke gruzovyh perevozok].Vektor transporta, 2014, Vol.2, pp.44-52. 7.Sokolov, Yu.I.Service quality should be assessed by the clients themselves.World of Transport and Transportation, Vol.13, 2015, Iss.4, pp.100-109. 8.Baginova, V.V., Fedorov, L.S., Lievin, S.B.Logistics business: harmony of costs and outcome.World of Transport and Transportation, Vol.12, Iss.5, pp.112- 115.Π’Π΅ΠΊΡΡ Π°Π½Π½ΠΎΡΠ°ΡΠΈΠΈ Π½Π° Π°Π½Π³Π». ΡΠ·ΡΠΊΠ΅ ΠΈ ΠΏΠΎΠ»Π½ΡΠΉ ΡΠ΅ΠΊΡΡ ΡΡΠ°ΡΡΠΈ Π½Π° Π°Π½Π³Π». ΡΠ·ΡΠΊΠ΅ Π½Π°Ρ
ΠΎΠ΄ΠΈΡΡΡ Π² ΠΏΡΠΈΠ»Π°Π³Π°Π΅ΠΌΠΎΠΌ ΡΠ°ΠΉΠ»Π΅ ΠΠΠ€ (Π°Π½Π³Π». Π²Π΅ΡΡΠΈΡ ΡΠ»Π΅Π΄ΡΠ΅Ρ ΠΏΠΎΡΠ»Π΅ ΡΡΡΡΠΊΠΎΠΉ Π²Π΅ΡΡΠΈΠΈ).Π ΡΡΠ°ΡΡΠ΅ Π΄Π΅ΠΌΠΎΠ½ΡΡΡΠΈΡΡΡΡΡΡ ΠΏΠΎΠ΄Ρ
ΠΎΠ΄Ρ ΠΊ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ ΡΠΎΠ²ΡΠ΅ΠΌΠ΅Π½Π½ΠΎΠΉ ΡΠΈΡΡΠ΅ΠΌΡ Π²Π·Π°ΠΈΠΌΠΎΠΎΡΠ½ΠΎΡΠ΅Π½ΠΈΠΉ Ρ ΠΊΠ»ΠΈΠ΅Π½ΡΠ°ΠΌΠΈ Π½Π° ΠΎΡΠ½ΠΎΠ²Π΅ ΠΈΠ½ΡΠΎΡΠΌΠ°ΡΠΈΠΎΠ½Π½ΡΡ
ΡΠ΅Ρ
Π½ΠΎΠ»ΠΎΠ³ΠΈΠΉ. Π ΡΠΎΠΌ ΡΠΈΡΠ»Π΅ ΡΠ°ΡΡΠΌΠ°ΡΡΠΈΠ²Π°ΡΡΡΡ ΠΏΡΡΠΌΡΠ΅ ΠΈ ΠΊΠΎΡΠ²Π΅Π½Π½ΡΠ΅ ΡΠΊΠΎΠ½ΠΎΠΌΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΡΡΡΠ΅ΠΊΡΡ ΠΈ ΡΡΡΠ΅ΠΊΡΡ ΡΠ½ΠΈΠΆΠ΅Π½ΠΈΡ ΡΠΈΡΠΊΠΎΠ² ΠΏΡΠΈ Π²ΡΠΏΠΎΠ»Π½Π΅Π½ΠΈΠΈ ΡΡΠ°Π½ΡΠΏΠΎΡΡΠ½ΠΎ- Π»ΠΎΠ³ΠΈΡΡΠΈΡΠ΅ΡΠΊΠΈΡ
ΡΡΠ»ΡΠ³. Π‘ΠΎΠ·Π΄Π°Π½ΠΈΠ΅ ΡΠ°ΠΊΠΎΠΉ ΡΠΈΡΡΠ΅ΠΌΡ Π² Ρ
ΠΎΠ»Π΄ΠΈΠ½Π³Π΅ Β«Π ΠΠΒ» ΠΏΡΠ΅ΡΠ»Π΅Π΄ΡΠ΅Ρ ΡΠ΅Π»ΠΈ ΠΏΠΎΠ²ΡΡΠΈΡΡ ΠΊΠΎΠ½ΠΊΡΡΠ΅Π½ΡΠΎΡΠΏΠΎΡΠΎΠ±Π½ΠΎΡΡΡ ΠΆΠ΅Π»Π΅Π·Π½ΠΎΠ΄ΠΎΡΠΎΠΆΠ½ΠΎΠ³ΠΎ ΡΡΠ°Π½ΡΠΏΠΎΡΡΠ°, ΠΏΡΠΈΠ²Π»Π΅ΡΡ Π½ΠΎΠ²ΡΡ
ΠΊΠ»ΠΈΠ΅Π½ΡΠΎΠ², ΡΠ²Π΅Π»ΠΈΡΠΈΡΡ Π΄ΠΎΡ
ΠΎΠ΄Ρ ΠΈ ΡΠΎΠΊΡΠ°ΡΠΈΡΡ Π½Π΅ΠΏΡΠΎΠΈΠ·Π²ΠΎΠ΄ΠΈΡΠ΅Π»ΡΠ½ΡΠ΅ ΠΏΠΎΡΠ΅ΡΠΈ, ΠΊΠΎΡΠΎΡΡΠ΅ Π²ΠΎΠ·Π½ΠΈΠΊΠ°ΡΡ Π²ΡΠ»Π΅Π΄ΡΡΠ²ΠΈΠ΅ Π½Π΅ΡΠ΄ΠΎΠ²Π»Π΅ΡΠ²ΠΎΡΠΈΡΠ΅Π»ΡΠ½ΠΎΠ³ΠΎ Π²ΡΠΏΠΎΠ»Π½Π΅Π½ΠΈΡ Π²Π·ΡΡΡΡ
Π½Π° ΡΠ΅Π±Ρ ΠΎΠ±ΡΠ·Π°ΡΠ΅Π»ΡΡΡΠ² ΠΏΠΎ ΠΏΠ΅ΡΠ΅Π²ΠΎΠ·ΠΊΠ΅ Π³ΡΡΠ·ΠΎΠ²
Familial adenomatosis of the colon: current state of the problem
The urgency of the problem of familial adenomatosis of the colon (FAC) is caused both by the severity of the disease with the inevitable development of cancer without timely treatment, and the involvement of the patient's blood relatives in this problem. Due to the rare incidence of this disease, many issues require discussion. Aim. To determine the possibility of timely treatment of FAC patients maintaining a satisfactory quality of life. Materials and methods. The data on 5 FAC patients and 12 their blood relatives were studied. Clinical, endoscopic and genetic characteristics of the disease and treatment were analyzed. Results. demonstrated that family history, genetic and endoscopic examinations allow diagnosis of FAC. Colectomy with rectal resection and the creation of a small intestine reservoir with reservoir-rectal anastomosis provide a sufficient quality of life for patients. Examination of the patient's blood relatives reveals new patients requiring additional examination and treatment. Conclusion. The problem of FAC is multidisciplinary and involves therapists, gastroenterologists, pediatricians, geneticists, endoscopists, radiologists, surgeons and oncologists. Only a timely diagnosis can help the patient to undergo radical treatment before the development of colon cancer
Extracellular vesicles derived from Acholeplasma laidlawii PG8
Extracellular vesicle production is believed to be a ubiquitous process in bacteria, but the data on such a process in Mollicutes are absent. We report the isolation of ultramicroforms - extracellular vesicles from supernatants of Acholeplasma laidlawii PG8 (ubiquitous mycoplasma; the main contaminant of cell culture). Considering sizes, morphology, and ultrastructural organization, the ultramicroforms of A. laidlawii PG8 are similar to membrane vesicles of Gram-positive and Gram-negative bacteria. We demonstrate that A. laidlawii PG8 vesicles contain genetic material and proteins, and are mutagenic to lymphocytes of human peripheral blood. We show that Mycoplasma gallisepticum S6, the other mycoplasma, also produce similar structures, which suggests that shedding of the vesicles might be the common phenomenon in Mollicutes. We found that the action of stress conditions results in the intensive formation of ultramicroforms in mycoplasmas. The role of vesicular formation in mycoplasmas remains to be studied. Β©2011 with author. Published by TheScientificWorld
Metabolic Risk Factors and Their Impact on Quality of Life in Patients with Pancreatic Cancer, Acute or Exacerbated Chronic Pancreatitis
Πim: to evaluate metabolic risk factors and their impact on quality of life in patients with pancreatic cancer (PC) and in patients with acute or exacerbated chronic pancreatitis.Materials and methods. Forty-five patients with PC (group 1) and 141 patients with acute pancreatitis or exacerbated chronic pancreatitis (group 2) in an observational multicenter clinical cross-sectional uncontrolled study were examined. Clinical, laboratory and instrumental examination of patients and assessment of risk factors (lipid profile, blood plasma glucose, obesity, arterial hypertension) were carried out in accordance with clinical recommendations. Patients completed the SF-36 questionnaire once to assess quality of life at hospital admission before treatment.Results. In group 1, indicators of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C) in blood serum (3.7 Β± 0.2; 2.2 Β± 0.2 and 0.8 Β± 0.1 mmol/L) were lower than in group 2 (5.1 Β± 0.1; 3.1 Β± 0.1 and 1.2 Β± 0.1 mmol/L; p < 0.05). Arterial hypertension was more common in group 1 (55.6 %) than in group 2 (34.8 %; p = 0.013). The presence of arterial hypertension increases the chance of having PC by 2.7 times (p < 0.05). Body mass index parameters, including obesity, as well as parameters of triglycerides, and fasting plasma glucose, did not differ between the groups. Logistic regression analysis revealed a direct relationship with PC HDL hypocholesterolemia (Exp B = 4.976; p < 0.001) and arterial hypertension (Exp B = 2.742; p = 0.027) and an inverse relationship β with hypercholesterolemia (Exp B = 0.204; p = 0.002). The chance of having PC was not associated with age, fasting plasma glucose Β³ 7.0 mmol/L, obesity. Quality of life indicators were higher in group 1 than in group 2 on four SF-36 scales: bodily pain (68.1 Β± 5.1 and 36.8 Β± 2.0; p < 0.001), general health (51.1 Β± 2.5 and 38.0 Β± 1.7 points; p < 0.001), social functioning (74.7 Β± 3.0 and 64.5 Β± 2.2 points; p = 0.007), role emotional functioning (28.2 Β± 5.2 and 12.5 Β± 3.1 points; p = 0.007) and in the general domain βphysical component of healthβ (40.2 Β± 1.0 and 33.6 Β± 0.8 points; p < 0.001). In group 1 with HDL hypocholesterolemia compared with its absence, the indicators of role emotional functioning (22.2 Β± 5.1 and 51.9 Β± 13.7 points; p = 0.020) were lower, with arterial hypertension compared with its absence β role physical functioning (5.0 Β± 4.0 and 25.5 Β± 7.5 points; p = 0.036) and role emotional functioning (16.0 Β± 5.1 and 43.3 Β± 8.8 points; p = 0.007) were lower.Conclusions. In patients with PC arterial hypertension was more common and the levels of total cholesterol, LDL-C and HDL-C were lower than in patients with acute or exacerbated chronic pancreatitis. The chance of having PC is directly associated with HDL hypocholesterolemia, with arterial hypertension, inversely β with hypercholesterolemia, and is not associated with age, fasting plasma glucose Β³ 7 mmol/L, or obesity. In patients with PC, quality of life indicators were higher on four SF-36 scales and on the general domain βphysical component of healthβ than in the group with acute or exacerbated chronic pancreatitis. In patients with PC metabolic factors significantly worsened self-assessment of quality of life in terms of role functioning; in patients with acute or exacerbated chronic pancreatitis there was no such association
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