The history of professional education in Perm krai

Данная статья посвящена 75-летию Трудовых резервов. В статье ставятся задачи рассмотреть частично историю профессионального образования в России, показать важнейшую роль Трудовых резервов в развитии нашей страны, привести примеры из истории Пермского края (где проживает автор). Эта статья заинтересует людей тем или иным образом связанных с профессиональным образованием, например, педагогов, студентов и т.д.This article is dedicated to the 75th anniversary of the Labor reserves. The task of the article is to consider partially the history of professional education in Russia, to show the key role of Labour reserves in the development of our country, to give some examples from the history of the Perm region (where the author lives). This article will be interesting this way or another for people who connected with professional education, e.g. teachers, students, etc

Behavioral Impact of the Regulation of the Brain 2-Oxoglutarate Dehydrogenase Complex by Synthetic Phosphonate Analog of 2-Oxoglutarate: Implications into the Role of the Complex in Neurodegenerative Diseases

Decreased activity of the mitochondrial 2-oxoglutarate dehydrogenase complex (OGDHC) in brain accompanies neurodegenerative diseases. To reveal molecular mechanisms of this association, we treated rats with a specific inhibitor of OGDHC, succinyl phosphonate, or exposed them to hypoxic stress. In males treated with succinyl phosphonate and in pregnancy-sensitized females experiencing acute hypobaric hypoxia, we revealed upregulation of brain OGDHC (within 24 hours), with the activity increase presumably representing the compensatory response of brain to the OGDHC inhibition. This up-regulation of brain OGDHC was accompanied by an increase in exploratory activity and a decrease in anxiety of the experimental animals. Remarkably, the hypoxia-induced elevation of brain OGDHC and most of the associated behavioral changes were abrogated by succinyl phosphonate. The antagonistic action of hypoxia and succinyl phosphonate demonstrates potential therapeutic significance of the OGDHC regulation by the phosphonate analogs of 2-oxoglutarate

Epidemiology of septic infections caused by methicillin-resistant strains of Staphylococcus aureus

The purpose of the work is to reveal the patterns of methicillin-resistant strains of Staphylococcus aureus (MRSA) spread in medical institutions and to develop the approaches to the epidemiological surveillance and control in health care institutions, depending on the level of MRSA spread. Methods. The study of 193.869 samples of biological material has been carried out. We have used standard microbiological techniques, molecular-genetic and statistical methods. Results. Due to the epidemiological monitoring of the circulation of MRSA in Kemerovo region the heterogeneity of distribution of strains in certain territories (from 2.63% to 60.12%; χ2 = 40.97; p = 0.000) has been revealed. The incidence of infections caused by MRSA in patients of health care organizations has been 10.97 per 1000 patients. The differences of circulation intensity of MRSA in patients of hospitals of different profiles (from 219.4 to 131.8 per 1000 patients; c2 = 755, p = 0.0003) has been revealed. The belonging of the cultures to the clonal complex CC8/239 has been determined. The dependence of MRSA circulation on the frequency of disinfection processing of medical personnel hands has been established, the sensitivity of the cultures to disinfectant preparations and the preparations for local treatment of wounds has been investigated. Conclusions. 1. The circulation of MRSA in Kemerovo region in a population of people without pathological processes, in hospital patients and in closed institutions has been unequal. 2. The sources of MRSA in outpatient medical institutions are mostly patients with purulent infections of skin and soft tissues, infections of respiratory tract, ENT-organs and eyes. 3. The strains of MRSA, identified in surgical hospitals, have a significant pathogenic potential due to the genes embodying the synthesis of pathogenicity factors, that provide the immunosuppressive properties. 4. The dynamics of infections caused by MRSA remains stable; however, it is necessary to differentially develop the approaches to the surveillance of the given group of infections and correction of anti-epidemic measures depending on the prevalence of MRSA

Perspectives of using sodium alginate with different molecular weight in the complex cancer therapy

The article presents the results of screening research of influence of sodium alginate with different molecular weight on the development of transplantable tumor in mice and the effectiveness of cytostatic treatment. It was determined that sodium alginates with both high (М = 403 kDa) and low (M = 1-10 kDa and M = 1 kDa) molecular weight suppress growth of Ehrlich ascites carcinoma; using sodium alginate (M = 20-30 kDa) in the scheme of chemotherapy increases effectiveness of treatment. Alginates with low molecular weight arrest development of dissemination of Lewis lung carcinoma and sodium alginates (M = 403 kDa and M = 20-30 kDa) in combination with cyclophosphan increase its antimetastatic effect

The Outburst of the Blazar AO 0235+164 in 2006 December: Shock-in-Jet Interpretation

We present the results of polarimetric ($R$ band) and multicolor photometric ($BVRIJHK$) observations of the blazar AO 0235+16 during an outburst in 2006 December. The data reveal a short timescale of variability (several hours), which increases from optical to near-IR wavelengths; even shorter variations are detected in polarization. The flux density correlates with the degree of polarization, and at maximum degree of polarization the electric vector tends to align with the parsec-scale jet direction. We find that a variable component with a steady power-law spectral energy distribution and very high optical polarization (30-50%) is responsible for the variability. We interpret these properties of the blazar withina model of a transverse shock propagating down the jet. In this case a small change in the viewing angle of the jet, by $\lesssim 1^o$, and a decrease in the shocked plasma compression by a factor of $\sim$1.5 are sufficient to account for the variability.Comment: 22 pages, 8 figures, accepted for Ap

The priming of potato plants induced by brassinosteroids reduces oxidative stress and increases salt tolerance

This is the first study to show that brief pretreatment of potato plants with two brassinosteroids differing in structure causes in plants the ability to react to delayed salt stress by accumulation of compounds with antioxidant activity and by increased salt tolerance

ИММУНОГЕНЕТИЧЕСКИЕ ОСОБЕННОСТИ КОРОВ КРАСНО-ПЁСТРОЙ ПОРОДЫ В ЗАВИСИМОСТИ ОТ ИХ ЛИНЕЙНОЙ ПРИНАДЛЕЖНОСТИ

The paper explores the urgency of increasing efficiency of breeding Red-and-White dairy cattle that take the main part of the population in the Krasnoyarsk region (69.7%), the immunogenetic characteristics of animals that belong to Montwick Chiftein and Pabst Hoverner (n=52) lines. The research on the blood groups of cows were conducted in the laboratory of immunogenetic analysis of Krasnoyarskagroplem. The authors revealed the differences in the incidence of specific antigens in the cows of two lines. The article found out that antigens A’2, B2, E’3, O3, and T2 (P>0.95-0.99) were found to be more frequent in Montwick Chiftein line cows, and antigen P2 (P>0.95) wasfound in Pabst Governer line cows. It was also revealed that the most rare antigens in the Montwick Chifthein line are antigens A’, A’1, O2, O4, Y1, R1, X1, M and E’2, and antigens B’’, O4, U and U’’in the Pabst Governer line. Interestingly, the authors identified the antigens that were not present in the animals of both lines and in each line separately. The average index of antigen incidence in the cows of each line showed a relatively low value. Due to this the authors made a conclusion about a high degree of heterozygosity of the studied individuals. The index of genetic similarity among the animals of two lines demonstrates a high value of 0.863. The polymorphism of the antigens in the EAF-V locus was studied and a significant incidence predominance in cows of the F allele over the V allele was found out. The impact of genotype according to the EAF-V locus on dairy productivity and live weight of the cows was determined: in the Montwick Chifthein line, cows with the FF genotype (5986,60172,41 kg) had a higher yield, in the Pabst Governer line - with the FV genotype (5914,20208,19 kg). Animals of both lines that had genotype V/V had higher live weight parmeters than animals with genotypes F/V and F/F. The comparative analysis of the obtained results was carried out with the results of other Russian authors who conducted similar studies.В связи с актуальностью повышения эффективности селекции молочного скота красно-пестрой породы, занимающего основную долю популяции в Красноярском крае (69,7%), изучены иммуногенетические особенности животных, принадлежащих к линиям Монтвик Чифтейн и Пабст Говернер (n=52). Исследования по определению групп крови коров проведены в лаборатории иммуногенетической экспертизы Краснояркагроплема. Выявлены отличия по частоте встречаемости отдельных антигенов у коров двух линий. Установлено, что у коров линии Монтвик Чифтейн значительно чаще встречались антигены Aʹ 2, В2 , Bʹ, E′3 , O3 , Pʹ 2 , T2 иUʹ (P>0,95–0,99), а у коров линии Пабст Говернер – антигены Eʹ 2 , G2 , P2 , T1 и X1 (P>0,95). Также выявлено, что в линии Монтвик Чифтейн наиболее редко встречаются антигены A′1 , O2 , O4 , Y1 , R1 и X1 , а в линии Пабст Говернер – антигены O4 , Pʹ 2 Q, U и U′. Помимо этого определены антигены, отсутствующие у животных каждой линии. Средний индекс встречаемости антигенов у коров каждой линии показал относительно низкое значение, из чего был сделан вывод о высокой степени гетерозиготности исследуемых особей. Индекс генетического сходства между животными двух линий показал высокое значение – 0,937. Изучен полиморфизм антигенов в локусе EAF-V и установлено значительное преобладание частоты встречаемости у коров аллеля F над аллелем V. Определено влияние генотипа по локусу EAF-V на молочную продуктивность и показатели живой массы коров: в линии Монтвик Чифтейн более высокий удой имели коровы с генотипом FF (5986,60±172,41 кг), разница с коровами генотипа FV составила 556,6 кг (P>0,95). Проведен сравнительный анализ полученных результатов с результатами других российских авторов, которые проводили аналогичные исследования

Another look at the BL Lacertae flux and spectral variability

The GLAST-AGILE Support Program (GASP) of the Whole Earth Blazar Telescope (WEBT) monitored BL Lacertae in 2008-2009 at radio, near-IR, and optical frequencies. During this period, high-energy observations were performed by XMM-Newton, Swift, and Fermi. We analyse these data with particular attention to the calibration of Swift UV data, and apply a helical jet model to interpret the source broad-band variability. The GASP-WEBT observations show an optical flare in 2008 February-March, and oscillations of several tenths of mag on a few-day time scale afterwards. The radio flux is only mildly variable. The UV data from both XMM-Newton and Swift seem to confirm a UV excess that is likely caused by thermal emission from the accretion disc. The X-ray data from XMM-Newton indicate a strongly concave spectrum, as well as moderate flux variability on an hour time scale. The Swift X-ray data reveal fast (interday) flux changes, not correlated with those observed at lower energies. We compare the spectral energy distribution (SED) corresponding to the 2008 low-brightness state, which was characterised by a synchrotron dominance, to the 1997 outburst state, where the inverse-Compton emission was prevailing. A fit with an inhomogeneous helical jet model suggests that two synchrotron components are at work with their self inverse-Compton emission. Most likely, they represent the radiation from two distinct emitting regions in the jet. We show that the difference between the source SEDs in 2008 and 1997 can be explained in terms of pure geometrical variations. The outburst state occurred when the jet-emitting regions were better aligned with the line of sight, producing an increase of the Doppler beaming factor. Our analysis demonstrates that the jet geometry can play an extremely important role in the BL Lacertae flux and spectral variability.Comment: 12 pages, 10 figures, accepted for publication in A&