Resolved Depletion Zones and Spatial Differentiation of N2H+ and N2D+

We present a study on the spatial distribution of N2D+ and N2H+ in thirteen protostellar systems. Eight of thirteen objects observed with the IRAM 30m telescope show relative offsets between the peak N2D+ (J=2-1) and N2H+ (J=1-0) emission. We highlight the case of L1157 using interferometric observations from the Submillimeter Array and Plateau de Bure Interferometer of the N2D+ (J=3-2) and N2H+ (J=1-0) transitions respectively. Depletion of N2D+ in L1157 is clearly observed inside a radius of ~2000 AU (7") and the N2H+ emission is resolved into two peaks at radii of ~1000 AU (3.5"), inside the depletion region of N2D+. Chemical models predict a depletion zone in N2H+ and N2D+ due to destruction of H2D+ at T ~ 20 K and the evaporation of CO off dust grains at the same temperature. However, the abundance offsets of 1000 AU between the two species are not reproduced by chemical models, including a model that follows the infall of the protostellar envelope. The average abundance ratios of N2D+ to N2H+ have been shown to decrease as protostars evolve by Emprechtinger et al., but this is the first time depletion zones of N2D+ have been spatially resolved. We suggest that the difference in depletion zone radii for N2H+ and N2D+ is caused by either the CO evaporation temperature being above 20 K or an H2 ortho-to-para ratio gradient in the inner envelope.Comment: Accepted to ApJ. 44 pages 13 Figure

Climate change in Hong Kong : observations and projections

The Hong Kong Observatory has been making meteorological observations at its headquarters in Tsim Sha Tsui since 1884. Analysis of the extensive past records reveals that the temperature rise in Hong Kong during the past 125 years is in accord with the global rising trend. In last few decades anthropogenic influences, especially urbanization, have contributed significantly to the accelerated rising trend. A similar increasing trend is also observed for rainfall but the trend after 1947 is not statistically significant. Other observations such as increasing cloud amounts, decreasing total global solar radiation and rising sea level are all consistent with the global trend. Studies of past occurrences of extreme temperature and rainfall have recently been carried out. It is observed that cold episodes have become rarer while very hot days and heavy rain events are becoming more frequent. The corresponding return periods of heavy rain and very hot days are decreasing while those of very cold days are increasing. The Observatory also makes use of the data from the latest assessment report of the Intergovernmental Panel on Climate Change and employs statistical downscaling techniques to carry out projections of temperature and precipitation in the 21st century. In gist, the findings are that the rise in temperature will be slightly higher than the global mean in the 21st century. There will also be a significant decrease in the number of cold days and an increase in the number of very hot days and hot nights. The annual rainfall in Hong Kong is also expected to rise by the end of the 21st century, so is the year-to-year variability

Phase diagrams of the 2D t-t'-U Hubbard model from an extended mean field method

It is well-known from unrestricted Hartree-Fock computations that the 2D Hubbard model does not have homogeneous mean field states in significant regions of parameter space away from half filling. This is incompatible with standard mean field theory. We present a simple extension of the mean field method that avoids this problem. As in standard mean field theory, we restrict Hartree-Fock theory to simple translation invariant states describing antiferromagnetism (AF), ferromagnetism (F) and paramagnetism (P), but we use an improved method to implement the doping constraint allowing us to detect when a phase separated state is energetically preferred, e.g. AF and F coexisting at the same time. We find that such mixed phases occur in significant parts of the phase diagrams, making them much richer than the ones from standard mean field theory. Our results for the 2D t-t'-U Hubbard model demonstrate the importance of band structure effects.Comment: 6 pages, 5 figure

Molecular Cloud Formation Behind Shock Waves

We examine the formation of molecular gas behind shocks in atomic gas using a chemical/dynamical model, particular emphasis is given to constraints the chemistry places on the dynamical evolution. The most important result of this study is to stress the importance of shielding the molecular gas from the destructive effects of UV radiation. For shock ram pressures comparable to or exceeding typical local ISM pressures, self-shielding controls the formation time of H2 but CO formation requires shielding of the interstellar radiation field by dust grains. We find that the molecular hydrogen fractional abundance can become significant well before CO forms. The timescale for (CO) molecular cloud formation is not set by H2 formation, but rather by the timescale for accumulating a sufficient column density or extinction, A_V > 0.7. The local ratio of atomic to molecular gas (4:1), coupled with short estimates for cloud lifetimes (3-5 Myr), suggests that the timescales for accumulating molecular clouds from atomic material typically must be no longer than about 12-20 Myr. Based on the shielding requirement, this implies that the typical product of pre-shock density and velocity must be n*v > 20 cm^-3 km s^-1. Based on these results we find that flow-driven formation of molecular clouds in the local interstellar medium can occur sufficiently rapidly to account for observations. We also provide detailed predictions of atomic and molecular emission and absorption that track molecular cloud formation, with a view toward helping to verify cloud formation by shock waves. Finally, we provide an analytic solution for time-dependent H2 formation which may be of use in numerical hydrodynamic calculations.Comment: 43 pages, 13 figures, accepted by ApJ main journa

Identification and Characterization of RcMADS1, an AGL24 Ortholog from the Holoparasitic Plant Rafflesia cantleyi Solms-Laubach (Rafflesiaceae)

10.1371/journal.pone.0067243PLoS ONE86-POLN

Expression signatures of TP53 mutations in serous ovarian cancers

<p>Abstract</p> <p>Background</p> <p>Mutations in the <it>TP53 </it>gene are extremely common and occur very early in the progression of serous ovarian cancers. Gene expression patterns that relate to mutational status may provide insight into the etiology and biology of the disease.</p> <p>Methods</p> <p>The <it>TP53 </it>coding region was sequenced in 89 frozen serous ovarian cancers, 40 early stage (I/II) and 49 advanced stage (III/IV). Affymetrix U133A expression data was used to define gene expression patterns by mutation, type of mutation, and cancer stage.</p> <p>Results</p> <p>Missense or chain terminating (null) mutations in <it>TP53 </it>were found in 59/89 (66%) ovarian cancers. Early stage cancers had a significantly higher rate of null mutations than late stage disease (38% vs. 8%, p < 0.03). In advanced stage cases, mutations were more prevalent in short term survivors than long term survivors (81% vs. 30%, p = 0.0004). Gene expression patterns had a robust ability to predict <it>TP53 </it>status within training data. By using early versus late stage disease for out of sample predictions, the signature derived from early stage cancers could accurately (86%) predict mutation status of late stage cancers.</p> <p>Conclusions</p> <p>This represents the first attempt to define a genomic signature of <it>TP53 </it>mutation in ovarian cancer. Patterns of gene expression characteristic of <it>TP53 </it>mutation could be discerned and included several genes that are known p53 targets or have been described in the context of expression signatures of <it>TP53 </it>mutation in breast cancer.</p

Touché: Data-Driven Interactive Sword Fighting in Virtual Reality

VR games offer new freedom for players to interact naturally using motion. This makes it harder to design games that react to player motions convincingly. We present a framework for VR sword fighting experiences against a virtual character that simplifies the necessary technical work to achieve a convincing simulation. The framework facilitates VR design by abstracting from difficult details on the lower “physical” level of interaction, using data-driven models to automate both the identification of user actions and the synthesis of character animations. Designers are able to specify the character's behaviour on a higher “semantic” level using parameterised building blocks, which allow for control over the experience while minimising manual development work. We conducted a technical evaluation, a questionnaire study and an interactive user study. Our results suggest that the framework produces more realistic and engaging interactions than simple hand-crafted interaction logic, while supporting a controllable and understandable behaviour design

Role of P-Glycoprotein and the Intestine in the Excretion of DPC 333 [(2R)-2-{(3R)-3-Amino-3-[4-(2-methylquinolin- 4-ylmethoxy)phenyl]-2-oxopyrrolidin-1-yl}-N-hydroxy- 4-methylpentanamide] in Rodents

ABSTRACT: The role of the intestine in the elimination of (2R)-2-{(3R)-3-amino-3-[4-(2-methylquinolin-4-ylmethoxy)phenyl]-2-oxopyrrolidin-1-yl}