Neuroimaging in Functional Movement Disorders.

PURPOSE OF REVIEW: Functional movement disorders are common and disabling causes of abnormal movement control. Here, we review the current state of the evidence on the use of neuroimaging in Functional movement disorders, particularly its role in helping to unravel the pathophysiology of this enigmatic condition. RECENT FINDINGS: In recent years, there has been a shift in thinking about functional movement disorder, away from a focus on high-level psychological precipitants as in Freudian conversion theories, or even an implicit belief they are 'put-on' for secondary gain. New research has emphasised novel neurobiological models incorporating emotional processing, self-representation and agency. Neuroimaging has provided new insights into functional movement disorders, supporting emerging neurobiological theories implicating dysfunctional emotional processing, self-image and sense of agency. Recent studies have also found subtle structural brain changes in patients with functional disorders, arguing against a strict functional/structural dichotomy

Is the graduate attributes approach sufficient to develop work ready graduates?

Many universities have graduate attributes, sometimes referred to as generic skills, soft skills or work ready skills. This paper reports a study of the professional work experiences of recent Australian Information Technology (IT) graduates who identified that communication, time management, teamwork, working with people, working across cultures, project management and business skills were some of the major professional skills required for their work. A discussion of the study and its findings raises questions about the adequacy of the graduate attributes approach in the development of professional skills such as the ability of to work across cultures and on multiple projects which are major requirements of graduates in many IT (and other) workplaces. The study reveals the IT graduates’ perspectives on the challenges they faced at work, the typical professional skills requirements of their practice and how they acquired or developed them, the elements of their university study which had relevance to the required workplace professional skills and how well their studies prepared them to meet the professional needs of their practice

The Relevance of University Studies to Professional Skills Requirements of IT Workplaces: Australian IT Graduates’ Work Experiences

Are university studies relevant to the professional skills requirements of Information Technology professional practice? Recent Australian IT graduates’ viewpoints on the challenges they face at work, the typical professional skills requirements of their practice and how they acquired or developed them, the elements of their university study that are relevant to their work professional skills requirements and how well their studies prepared them to meet the professional needs of their practice are discussed. An analysis of what the professional work experiences of these graduates in professional practice tell us about their university studies is also presented. The research findings will provide IT (and other) faculties in universities and employers with evidence to support the preparation of graduates for professional practice through the development of appropriate curricula and transition-to-work support programmes when graduates commence employment

Resonances in coupled πk,ηK scattering from lattice QCD

Coupled-channel $\pi K$ and $\eta K$ scattering amplitudes are determined by studying the finite-volume energy spectra obtained from dynamical lattice QCD calculations. Using a large basis of interpolating operators, including both those resembling a $q\bar{q}$ construction and those resembling a pair of mesons with relative momentum, a reliable excited-state spectrum can be obtained. Working at ${m_\pi=391\,\mathrm{MeV}}$, we find a gradual increase in the $J^P=0^+$ $\pi K$ phase-shift which may be identified with a broad scalar resonance that couples strongly to $\pi K$ and weakly to $\eta K$. The low-energy behavior of this amplitude suggests a virtual bound-state that may be related to the $\kappa$ resonance. A bound state with $J^P=1^-$ is found very close to the $\pi K$ threshold energy, whose coupling to the $\pi K$ channel is compatible with that of the experimental $K^\star(892)$. Evidence is found for a narrow resonance in $J^P=2^+$. Isospin--3/2 $\pi K$ scattering is also studied and non-resonant phase-shifts spanning the whole elastic scattering region are obtained.We thank our colleagues within the Hadron Spectrum Collaboration. We also thank R. Briceno, M.R. Pennington, C.J.Shultz and A.P. Szczepaniak for fruitful discussions. Chroma [63] and QUDA [64, 65] were used to perform this work on clusters at Jefferson Laboratory under the USQCD Initiative and the LQCD ARRA project. Gauge configurations were generated using resources awarded from the U.S. Department of Energy INCITE program at Oak Ridge National Lab, the NSF Teragrid at the Texas Advanced Computer Center and the Pittsburgh Supercomputer Center, as well as at Jefferson Lab. RGE and JJD acknowledge support from U.S. Department of Energy contract DE-AC05-06OR23177, under which Jefferson Science Associates, LLC, manages and operates Jefferson Laboratory. JJD acknowledges support from the U.S. Department of Energy Early Career award contract DE-SC0006765. CET acknowledges partial support from the Science and Technology Facilities Council (U.K.) [grant number ST/L000385/1].This is the accepted manuscript. The final version is available at http://journals.aps.org/prd/abstract/10.1103/PhysRevD.91.054008

B1 resonance in coupled πω, πφ scattering from lattice QCD

We present the first lattice QCD calculation of coupled $\pi\omega$ and $\pi\phi$ scattering, incorporating coupled $S$ and $D$-wave $\pi\omega$ in $J^P=1^+$. Finite-volume spectra in three volumes are determined via a variational analysis of matrices of two-point correlation functions, computed using large bases of operators resembling single-meson, two-meson and three-meson structures, with the light-quark mass corresponding to a pion mass of $m_\pi \approx 391$ MeV. Utilizing the relationship between the discrete spectrum of finite-volume energies and infinite-volume scattering amplitudes, we find a narrow axial-vector resonance ($J^{PC}=1^{+-}$), the analogue of the $b_1$ meson, with mass $m_{R}\approx1380$ MeV and width $\Gamma_{R}\approx 91$ MeV. The resonance is found to couple dominantly to $S$-wave $\pi\omega$, with a much-suppressed coupling to $D$-wave $\pi\omega$, and a negligible coupling to $\pi\phi$ consistent with the `OZI rule'. No resonant behavior is observed in $\pi\phi$, indicating the absence of a putative low-mass $Z_s$ analogue of the $Z_c$ claimed in $\pi J/\psi$. In order to minimally present the contents of a unitary three-channel scattering matrix, we introduce an $n$-channel generalization of the traditional two-channel Stapp parameterization

Decays of an exotic 1-+ hybrid meson resonance in QCD

We present the first determination of the hadronic decays of the lightest exotic $J^{PC}=1^{-+}$ resonance in lattice QCD. Working with SU(3) flavor symmetry, where the up, down and strange quark masses approximately match the physical strange-quark mass giving $m_\pi \sim 700$ MeV, we compute finite-volume spectra on six lattice volumes which constrain a scattering system featuring eight coupled channels. Analytically continuing the scattering amplitudes into the complex energy plane, we find a pole singularity corresponding to a narrow resonance which shows relatively weak coupling to the open pseudoscalar--pseudoscalar, vector--pseudoscalar and vector--vector decay channels, but large couplings to at least one kinematically-closed axial-vector--pseudoscalar channel. Attempting a simple extrapolation of the couplings to physical light-quark mass suggests a broad $\pi_1$ resonance decaying dominantly through the $b_1 \pi$ mode with much smaller decays into $f_1 \pi$, $\rho \pi$, $\eta' \pi$ and $\eta \pi$. A large total width is potentially in agreement with the experimental $\pi_1(1564)$ candidate state, observed in $\eta \pi$, $\eta' \pi$, which we suggest may be heavily suppressed decay channels

Scenario dependence of linear site-effect factors for short-period response spectral ordinates

Ground‐motion models for response spectral ordinates commonly partition site‐response effects into linear and nonlinear components. The nonlinear components depend upon the earthquake scenario being considered implicitly through the use of the expected level of excitation at some reference horizon. The linear components are always assumed to be independent of the earthquake scenario. This article presents empirical and numerical evidence as well as a theoretical explanation for why the linear component of site response depends upon the magnitude and distance of the earthquake scenario. Although the impact is most pronounced for small‐magnitude scenarios, the finding has significant implications for a number of applications of more general interest including the development of site‐response terms within ground‐motion models, the estimation of ground‐motion variability components ϕS2SϕS2S and ϕSSϕSS , the construction of partially nonergodic models for site‐specific hazard assessments, and the validity of the convolution approach for computing surface hazard curves from those at a reference horizon, among others. All of these implications are discussed in the present article

Isolation of polymorphic microsatellites in the stemless thistle (Cirsium acaule) and their utility in other Cirsium species

The genus Cirsium includes species with both widespread and restricted geographical distributions, several of which are serious weeds. Nine polymorphic microsatellite loci were isolated from the stemless thistle Cirsium acaule. Eight were polymorphic in C. acaule, six in C. arvense and seven in C. heterophyllum. One locus monomorphic in C. acaule showed polymorphism in C. heterophyllum. The mean number of alleles per locus was 4.1 in C. acaule, 6.2 in C. arvense and 2.9 in C. heterophyllum. These nine loci were also amplified in C. eriophorum and C. vulgare, suggesting that these markers may be of use throughout the genus

The importance of nanoscale confinement to electrocatalytic performance

Electrocatalytic nanoparticles that mimic the three-dimensional geometric architecture of enzymes where the reaction occurs down a substrate channel isolated from bulk solution, referred to herein as nanozymes, were used to explore the impact of nano-confinement on electrocatalytic reactions. Surfactant covered Pt-Ni nanozyme nanoparticles, with Ni etched from the nanoparticles, possess a nanoscale channel in which the active sites for electrocatalysis of oxygen reduction are located. Different particle compositions and etching parameters allowed synthesis of nanoparticles with different average substrate channel diameters that have varying amounts of nano-confinement. The results showed that in the kinetically limited regime at low overpotentials, the smaller the substrate channels the higher the specific activity of the electrocatalyst. This is attributed to higher concentrations of protons, relative to bulk solution, required to balance the potential inside the nano-confined channel. However, at higher overpotentials where limitation by mass transport of oxygen becomes important, the nanozymes with larger substrate channels showed higher electrocatalytic activity. A reaction-diffusion model revealed that the higher electrocatalytic activity at low overpotentials with smaller substrate channels can be explained by the higher concentration of protons. The model suggests that the dominant mode of mass transport to achieve these high concentrations is by migration, exemplifying how nano-confinement can be used to enhance reaction rates. Experimental and theoretical data show that under mass transport limiting potentials, the nano-confinement has no effect and the reaction only occurs at the entrance of the substrate channel at the nanoparticle surface