How Public Is the Internet? A Conversation on the Nature of Human Interactions On-line and the Implications for Research Methods

In the past decade, ???virtual??? research???empirical investigations conducted via the Internet???has increased dramatically across a variety of disparate disciplines. Areas such as cybersecurity and encryption, digital government and citizenship, consumer health informatics, and user behavior in online spaces have emerged to become signature iSchool research areas, often shared with particular disciplinary heritages (e.g., computer science, political science and communication, public health, and sociology???respectively, but not exclusively). In addition, the field of Information Science is dominated by research developing or using emerging technologies. These new technologies often occupy a gray area in which ethical issues either have not been sufficiently well-defined or push against existing definitions. Questions surrounding the ???public??? nature of the internet and Web 2.0-era information technologies have also emerged and have become increasingly urgent given the tightening of federal, state and University regulations as they relate to the protection of human subjects. At the convergence of multiple disciplinary and methodological perspectives, Information Science researchers are well-positioned to become more active participants in both scholarly and institutional conversations regarding the appropriate risks and benefits that participants in online research studies might be subject to. Critiques of IRB inconsistencies exist, what we need is a thoughtful and thorough community response to the innately complex nature of virtual research and a map which can guide us towards the future and the study of twenty-first century systems, selves and societies. Our goal for this wildcard event, is to generate a lively and rigorous debate which accomplishes the following three goals: 1) extends the dialogue within the Information Science field concerning the beneficence and respect for participants in online research; 2) enumerates a set of best practices for iSchool researchers in relation to conducting approved research on-line and; 3) moves us towards the process of drafting an iSchool set of ethical guidelines related to virtual research

Junior Faculty Engagement at iSchools: Personal Experience during the First Several Years

This roundtable discussion will explore how junior faculty at iSchools have been able to embed their research, teaching, and service activities within their schools, the larger institutions, and broader communities. The session will also focus on the ways in which junior faculty have received guidance in their roles--from the job search through the first several years in a tenure-track position. Roundtable leaders represent a variety of institutions and experiences--as faculty at the University of Illinois at Urbana-Champaign [WJM], the University of Maryland [SP], the University of North Carolina at Chapel Hill [PME], and the University of Texas at Austin [MW], and with doctoral-level preparation at the University of North Carolina at Chapel Hill [WJM, MW], the University of Toronto [SP], and the University of Washington [PME]. While the annual junior faculty mentoring event at the iConference specifically targets junior faculty as participants, this roundtable session offers a more inclusive environment for the discussion of this topic, specifically engaging doctoral students and senior faculty as well as their junior colleagues

Mechanical strength and thermophysical properties of PM212: A high temperature self-lubricating powder metallurgy composite

A powder metallurgy composite, PM212, composed of metal bonded chromium carbide and solid lubricants is shown to be self-lubricating to a maximum application temperature of 900 C. The high temperature compressive strength, tensile strength, thermal expansion and thermal conductivity data needed to design PM212 sliding contact bearings and seals are reported for sintered and isostatically pressed (HIPed) versions of PM212. Other properties presented are room temperature density, hardness, and elastic modulus. In general, both versions appear to have adequate strength to be considered as sliding contact bearing materials, but the HIPed version, which is fully dense, is much stronger than the sintered version which contains about 20 percent pore volume. The sintered material is less costly to make, but the HIPed version is better where high compressive strength is important

Use of swivel desks and aisle space to promote interaction in mid-sized college classrooms

Traditional designs for most mid-sized college classrooms discourage 1) face-to-face interaction among students, 2) instructor movement in the classroom, and 3) efficient transitions between different kinds of learning activities. An experimental classroom piloted during Spring Semester 2011 at the University of North Carolina at Chapel Hill uses clusters of stationary desks that swivel 360-degrees and aisle space to address these challenges. The findings from a study involving ten courses taught in the room suggest that there is a need for designs that not only promote quality interactions but also facilitate movement between small group work, class discussion, and lecture

What Is the Magnitude and Long-term Economic Cost of Care of the British Military Afghanistan Amputee Cohort?

Background Personal protection equipment, improved early medical care, and rapid extraction of the casualty have resulted in more injured service members who served in Afghanistan surviving after severe military trauma. Many of those who survive the initial trauma are faced with complex wounds such as multiple amputations. Although costs of care can be high, they have not been well quantified before. This is required to budget for the needs of the injured beyond their service in the armed forces. Question/purposes The purposes of this study were (1) to quantify and describe the extent and nature of traumatic amputations of British service personnel from Afghanistan; and (2) to calculate an estimate of the projected long-term cost of this cohort. Methods A four-stage methodology was used: (1) systematic literature search of previous studies of amputee care cost; (2) retrospective analysis of the UK Joint Theatre Trauma and prosthetic database; (3) Markov economic algorithm for healthcare cost and sensitivity analysis of results; and (4) statistical cost comparison between our cohort and the identified literature. Results From 2003 to 2014, 265 casualties sustained 416 amputations. The average number of limbs lost per casualty was 1.6. The most common type of amputation was a transfemoral amputation (153 patients); the next most common amputation type was unilateral transtibial (143 patients). Using a Markov model of healthcare economics, it is estimated that the total 40-year cost of the UK Afghanistan lower limb amputee cohort is £288 million (USD 444 million); this figure estimates cost of trauma care, rehabilitation, and prosthetic costs. A sensitivity analysis on our model demonstrated a potential ± 6.19% variation in costs. Conclusions The conflict in Afghanistan resulted in high numbers of complex injuries. Our findings suggest that a long-term facility to budget for veterans’ health care is necessary

Differential G-protein-coupled receptor phosphorylation provides evidence for a signaling bar code.

G-protein-coupled receptors are hyper-phosphorylated in a process that controls receptor coupling to downstream signaling pathways. The pattern of receptor phosphorylation has been proposed to generate a "bar code" that can be varied in a tissue-specific manner to direct physiologically relevant receptor signaling. If such a mechanism existed, receptors would be expected to be phosphorylated in a cell/tissue-specific manner. Using tryptic phosphopeptide maps, mass spectrometry, and phospho-specific antibodies, it was determined here that the prototypical G(q/11)-coupled M(3)-muscarinic receptor was indeed differentially phosphorylated in various cell and tissue types supporting a role for differential receptor phosphorylation in directing tissue-specific signaling. Furthermore, the phosphorylation profile of the M(3)-muscarinic receptor was also dependent on the stimulus. Full and partial agonists to the M(3)-muscarinic receptor were observed to direct phosphorylation preferentially to specific sites. This hitherto unappreciated property of ligands raises the possibility that one mechanism underlying ligand bias/functional selectivity, a process where ligands direct receptors to preferred signaling pathways, may be centered on the capacity of ligands to promote receptor phosphorylation at specific sites

What are the effects that two author-fee subsidy programs have on researchers’ work practices and publishing behaviors?

Emerging alternatives or complements to ‘traditional’ publication practices include publishing in open access journals; self-archiving manuscripts; submitting pre- and post-prints to institutional- and disciplinary-repositories; and complying with funding agency mandates for sharing results from federally-funded research. Each of these alternatives bears an associated set of economic, temporal, technological, and procedural challenges for authors. This in-progress pilot study elicits perspectives of UNC authors—particularly regarding the ways in which these individuals utilize support services provided by campus administration, University Libraries, and agencies that fund their research

Trial protocol OPPTIMUM : does progesterone prophylaxis for the prevention of preterm labour improve outcome?

Background Preterm birth is a global problem, with a prevalence of 8 to 12% depending on location. Several large trials and systematic reviews have shown progestogens to be effective in preventing or delaying preterm birth in selected high risk women with a singleton pregnancy (including those with a short cervix or previous preterm birth). Although an improvement in short term neonatal outcomes has been shown in some trials these have not consistently been confirmed in meta-analyses. Additionally data on longer term outcomes is limited to a single trial where no difference in outcomes was demonstrated at four years of age of the child, despite those in the “progesterone” group having a lower incidence of preterm birth. Methods/Design The OPPTIMUM study is a double blind randomized placebo controlled trial to determine whether progesterone prophylaxis to prevent preterm birth has long term neonatal or infant benefit. Specifically it will study whether, in women with singleton pregnancy and at high risk of preterm labour, prophylactic vaginal natural progesterone, 200 mg daily from 22 – 34 weeks gestation, compared to placebo, improves obstetric outcome by lengthening pregnancy thus reducing the incidence of preterm delivery (before 34 weeks), improves neonatal outcome by reducing a composite of death and major morbidity, and leads to improved childhood cognitive and neurosensory outcomes at two years of age. Recruitment began in 2009 and is scheduled to close in Spring 2013. As of May 2012, over 800 women had been randomized in 60 sites. Discussion OPPTIMUM will provide further evidence on the effectiveness of vaginal progesterone for prevention of preterm birth and improvement of neonatal outcomes in selected groups of women with singleton pregnancy at high risk of preterm birth. Additionally it will determine whether any reduction in the incidence of preterm birth is accompanied by improved childhood outcome

Seasonal calibration of the end-cretaceous Chicxulub impact event

The end-Cretaceous Chicxulub impact triggered Earth’s last mass-extinction, extinguishing ~ 75% of species diversity and facilitating a global ecological shift to mammal-dominated biomes. Temporal details of the impact event on a fine scale (hour-to-day), important to understanding the early trajectory of mass-extinction, have largely eluded previous studies. This study employs histological and histo-isotopic analyses of fossil fish that were coeval with a unique impact-triggered mass-death assemblage from the Cretaceous-Paleogene (KPg) boundary in North Dakota (USA). Patterns of growth history, including periodicity of ẟ18O and ẟ13C and growth band morphology, plus corroborating data from fish ontogeny and seasonal insect behavior, reveal that the impact occurred during boreal Spring/Summer, shortly after the spawning season for fish and most continental taxa. The severity and taxonomic symmetry of response to global natural hazards are influenced by the season during which they occur, suggesting that post-impact perturbations could have exerted a selective force that was exacerbated by seasonal timing. Data from this study can also provide vital hindsight into patterns of extant biotic response to global-scale hazards that are relevant to both current and future biomes

Guidelines to improve airport preparedness against chemical and biological terrorism.

Guidelines to Improve Airport Preparedness Against Chemical and Biological Terrorism is a 100-page document that makes concrete recommendations on improving security and assessing vulnerable areas and helps its readers understand the nature of chemical and biological attacks. The report has been turned over to Airports Council International (ACI) and the American Association of Airport Executives (AAAE), two organizations that together represent the interests of thousands of airport personnel and facilities in the U.S. and around the world