51,172 research outputs found
Mechanism for the failure of the Edwards hypothesis in the SK spin glass
The dynamics of the SK model at T=0 starting from random spin configurations
is considered. The metastable states reached by such dynamics are atypical of
such states as a whole, in that the probability density of site energies,
, is small at . Since virtually all metastable states
have a much larger , this behavior demonstrates a qualitative failure of
the Edwards hypothesis. We look for its origins by modelling the changes in the
site energies during the dynamics as a Markov process. We show how the small
arises from features of the Markov process that have a clear physical
basis in the spin-glass, and hence explain the failure of the Edwards
hypothesis.Comment: 5 pages, new title, modified text, additional reference
Spiral vortices traveling between two rotating defects in the Taylor-Couette system
Numerical calculations of vortex flows in Taylor-Couette systems with counter
rotating cylinders are presented. The full, time dependent Navier-Stokes
equations are solved with a combination of a finite difference and a Galerkin
method. Annular gaps of radius ratio and of several heights are
simulated. They are closed by nonrotating lids that produce localized Ekman
vortices in their vicinity and that prevent axial phase propagation of spiral
vortices. Existence and spatio temporal properties of rotating defects, of
modulated Ekman vortices, and of the spiral vortex structures in the bulk are
elucidated in quantitative detail.Comment: 9 pages, 9 figure
The impact of Chinese import penetration on the South African manufacturing sector
This article uses a Chenery-type decomposition and econometric estimation to evaluate the impact of Chinese trade on production and employment in South African manufacturing from 1992 to 2010. The results suggest that increased import penetration from China caused South African manufacturing output to be 5 per cent lower in 2010 than it otherwise would have been. The estimated reduction of total employment in manufacturing as a result of trade with China is larger – in 2010 about 8 per cent – because the declines in output were concentrated on labour-intensive industries and because the increase in imports raised labour productivity within industries
Establishing a support service for educational technology within a university
This paper covers some of the issues associated with the support of learning technology within an institution. It describes the activities of a working support service, and highlights approaches to some of the academic, technological, political and management issues that have helped it perform effectively over a four‐year period
Cost and cost effectiveness of Herpes simplex virus-type 2 (hsv-2) suppressive therapy in HIV-1 and HSV-2 infected women in Johannesburg, South Africa
The role of HER1-HER4 and EGFRvIII in hormone-refractory prostate cancer
<b>Purpose</b>: The role of the type I receptor tyrosine kinase (HER) family in progression of prostate cancer is controversial. Breast cancer studies show that these receptors should be investigated as a family. The current study investigates expression of HER1-HER4 and EGFRvIII in matched hormone-sensitive and hormone-refractory prostate tumors.
<b>Experimental Design</b>: Immunohistochemical analysis was used to investigate protein expression of HER1-HER4, EGFRvIII, and phosphorylated Akt (pAkt) in matched hormone-sensitive and hormone-refractory prostate tumors.
<b>Results</b>: Surprisingly, high HER2 membrane expression in hormone-sensitive tumors was associated with an increased time to biochemical relapse (<i>P</i> = 0.0003), and this translated into longer overall survival (<i>P</i> = 0.0021). Consistent with other studies, HER4 membrane expression in hormone-sensitive tumors was associated with longer time to biochemical relapse (<i>P</i> = 0.042), and EGFRvIII membrane expression was associated with shorter time to biochemical relapse (<i>P</i> = 0.015). An increase in pAkt expression was associated with reduced survival (<i>P</i> = 0.0098). Multivariate analysis showed that HER2 was an independent positive predictive marker of time to relapse in hormone-sensitive prostate tumors (<i>P</i> = 0.014). In contrast, high HER2 expression in hormone-refractory tumors was associated with decreased time to death from biochemical relapse (<i>P</i> = 0.039), and EGFRvIII nuclear expression was associated with decreased time to death from biochemical relapse and decreased overall survival (<i>P</i> = 0.02 and <i>P</i> = 0.005).
<b>Conclusion</b>: These results suggest that the HER family may have multiple roles in prostate cancer, and that expression of the proteins alone is insufficient to predict the biological response that they may elicit
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Healthy shopper? Blood pressure testing in a shopping centre Pop-Up in England
Background: Improving detection of elevated blood pressure (BP) remains a public health need. We present results from a Pop-Up health check stationed in shopping centres in England. We hypothesise the rate of case detection is related to measurable ‘unhealthiness’ of the shopping centres.
Methods: A Pop-Up health check was sited in four and three shopping centres sampled from the top ten unhealthiest and top 15 healthiest shopping regions respectively, following a report ranking towns/cities based on their unhealthy and healthy retail outlets. On one day in each shopping centre, people were approached and consented to BP testing. Outcome measure was people flagged with BP ≥ 140/90 mmHg (cases).
Results: We detected 45 (22.6%) and 20 (13.1%) cases from testing 199 and 152 adults in the unhealthy and healthy locations respectively (relative risk 1.72; 95% confidence interval: 1.06 to 2.78). A measure of unhealthy retail outlets (e.g. fast-food outlets) within each shopping centre was associated with detection rate (R2 = 0.61; p = 0.04).
Conclusion: An association exists between cases of suspect hypertension found in a health check Pop-Up and measured ‘unhealthiness’ of the shopping centre site. Results hint at strategies for public testing of BP, potentially in the context of reducing health inequalities
Scattered Lyman-alpha Radiation Around Sources Before Cosmological Reionization
The spectra of the first galaxies and quasars in the Universe should be
strongly absorbed shortward of their rest-frame Lyman-alpha wavelength by
neutral hydrogen (HI) in the intervening intergalactic medium. However, the
Lyman-alpha line photons emitted by these sources are not eliminated but rather
scatter until they redshift out of resonance and escape due to the Hubble
expansion of the surrounding intergalactic HI. We calculate the resulting
brightness distribution and the spectral shape of the diffuse Lyman-alpha line
emission around high redshift sources, before the intergalactic medium was
reionized. Typically, the Lyman-alpha photons emitted by a source at z=10
scatter over a characteristic angular radius of order 15 arcseconds around the
source and compose a line which is broadened and redshifted by about a thousand
km/s relative to the source. The scattered photons are highly polarized.
Detection of the diffuse Lyman-alpha halos around high redshift sources would
provide a unique tool for probing the neutral intergalactic medium before the
epoch of reionization. On sufficiently large scales where the Hubble flow is
smooth and the gas is neutral, the Lyman-alpha brightness distribution can be
used to determine the cosmological mass densities of baryons and matter.Comment: 21 pages, 5 Postscript figures, accepted by ApJ; figures 1--3
corrected; new section added on the detectability of Lyman alpha halos;
conclusions update
Effect of dislocations on charge carrier mobility-lifetime product in synthetic single crystal diamond
The authors report correlations between variations in charge transport of electrons and holes in synthetic single crystal diamond and the presence of nitrogen impurities and dislocations. The spatial distribution of these defects was imaged using their characteristic luminescence emission and compared with maps of carrier drift length measured by ion beam induced charge imaging. The images indicate a reduction of electron and hole mobility-lifetime product due to nitrogen impurities and dislocations. Very good charge transport is achieved in selected regions where the dislocation density is minimal
Glassy dynamics in granular compaction
Two models are presented to study the influence of slow dynamics on granular
compaction. It is found in both cases that high values of packing fraction are
achieved only by the slow relaxation of cooperative structures. Ongoing work to
study the full implications of these results is discussed.Comment: 12 pages, 9 figures; accepted in J. Phys: Condensed Matter,
proceedings of the Trieste workshop on 'Unifying concepts in glass physics
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