Providing Diverse Trainees an Early and Transparent Introduction to Academic Appointment and Promotion Processes.

IntroductionThe growth in number of medical schools and increased numbers of faculty tracks have combined with evolving criteria for promotion to trigger a call for greater transparency of academic appointment and promotion processes. Most vulnerable to confusion about these changes are first-generation and diverse medical students and residents, the upstream pipeline of the academic medicine workforce. Diverse medical students have expressed diminished interest in academia because of perceived obstacles in appointment and promotion processes.MethodsThis workshop was designed to utilize didactics and career reflection exercises to help trainees learn: (1) how to define core terms related to academic appointment and promotion processes, (2) how to compare data elements for different CVs and portfolios, (3) common steps in submitting a promotion package, and (4) that they can immediately begin to document content for academic CVs, portfolios, and promotion packages.ResultsOne hundred forty-five diverse participants completed an evaluation at eight conferences across the U.S. More than 90% strongly agreed or agreed that the aforementioned objectives were met. Participants commented that the workshop was "illuminating," was "very informative," and "provided an inside look of how faculty are evaluated." Results showed an immediate impact on participants' self-reported confidence to negotiate appointment and promotion processes.DiscussionIncreases in self-rated confidence to negotiate appointment and promotion processes may help sustain trainees' interest in becoming future faculty. Further monitoring will be needed to determine if early exposure to these concepts improves probability of seeking, obtaining, and maintaining appointments

A Comparison of Markers of Iron Status between Vegetarian and Non-Vegetarian Female High School Cross Country Runners. Is Routine, Pre-Season Screening Warranted?

The purpose of the present study is to determine whether the circulating markers of iron status differ between vegetarian or non-vegetarian adolescent female high school cross-country runners. Fifteen non-vegetarian and six vegetarian female cross-country runners completed questionnaires used to obtain anthropometric data, health history, menstrual status, diet history and training history. Dietary intake was determined by self-report, using a food frequency questionnaire and a 3-day diet record. Blood samples were analyzed for serum iron, total iron binding capacity, serum ferritin, and transferrin saturation. No significant difference was found between vegetarians and non-vegetarians for serum iron or transferrin saturation. However, TIBC was significantly higher in vegetarians (p \u3c 0.05). Ferritin was lower in vegetarians, trending toward significance (p \u3c 0.10). Study results suggest the need for routine pre-season iron screenings as well as nutrition education, aimed at improving iron status for vegetarian and non-vegetarian adolescent female endurance athletes

SRG110 Stirling Generator Dynamic Simulator Vibration Test Results and Analysis Correlation

The U.S. Department of Energy (DOE), Lockheed Martin (LM), and NASA Glenn Research Center (GRC) have been developing the Stirling Radioisotope Generator (SRG110) for use as a power system for space science missions. The launch environment enveloping potential missions results in a random input spectrum that is significantly higher than historical radioisotope power system (RPS) launch levels and is a challenge for designers. Analysis presented in prior work predicted that tailoring the compliance at the generator-spacecraft interface reduced the dynamic response of the system thereby allowing higher launch load input levels and expanding the range of potential generator missions. To confirm analytical predictions, a dynamic simulator representing the generator structure, Stirling convertors and heat sources were designed and built for testing with and without a compliant interface. Finite element analysis was performed to guide the generator simulator and compliant interface design so that test modes and frequencies were representative of the SRG110 generator. This paper presents the dynamic simulator design, the test setup and methodology, test article modes and frequencies and dynamic responses, and post-test analysis results. With the compliant interface, component responses to an input environment exceeding the SRG110 qualification level spectrum were all within design allowables. Post-test analysis included finite element model tuning to match test frequencies and random response analysis using the test input spectrum. Analytical results were in good overall agreement with the test results and confirmed previous predictions that the SRG110 power system may be considered for a broad range of potential missions, including those with demanding launch environments

SRG110 Stirling Generator Dynamic Simulator Vibration Test Results and Analysis Correlation

The U.S. Department of Energy (DOE), Lockheed Martin (LM), and NASA Glenn Research Center (GRC) have been developing the Stirling Radioisotope Generator (SRG110) for use as a power system for space science missions. The launch environment enveloping potential missions results in a random input spectrum that is significantly higher than historical RPS launch levels and is a challenge for designers. Analysis presented in prior work predicted that tailoring the compliance at the generator-spacecraft interface reduced the dynamic response of the system thereby allowing higher launch load input levels and expanding the range of potential generator missions. To confirm analytical predictions, a dynamic simulator representing the generator structure, Stirling convertors and heat sources was designed and built for testing with and without a compliant interface. Finite element analysis was performed to guide the generator simulator and compliant interface design so that test modes and frequencies were representative of the SRG110 generator. This paper presents the dynamic simulator design, the test setup and methodology, test article modes and frequencies and dynamic responses, and post-test analysis results. With the compliant interface, component responses to an input environment exceeding the SRG110 qualification level spectrum were all within design allowables. Post-test analysis included finite element model tuning to match test frequencies and random response analysis using the test input spectrum. Analytical results were in good overall agreement with the test results and confirmed previous predictions that the SRG110 power system may be considered for a broad range of potential missions, including those with demanding launch environments

Complementary and Alternative Medicine Use in Musculoskeletal Disorders: Does Medical Skepticism Matter?

Medical skepticism is the reservation about the ability of conventional medical care to significantly improve health. Individuals with musculoskeletal disorders seeing specialists usually experience higher levels of disability; therefore it is expected they might be more skeptical of current treatment and thus more likely to try Complementary and Alternative Medicine (CAM). The goal of this study was to define these relationships. These data were drawn from a cross-sectional survey from two cohorts: those seeing specialists (n=1,344) and non-specialists (n=724). Site-level fixed effects logistic regression models were used to test associations between medical skepticism and 10 CAM use categories. Some form of CAM was used by 88% of the sample. Increased skepticism was associated with one CAM category for the non-specialist group and six categories for the specialist group. Increased medical skepticism is associated with CAM use, but medical skepticism is more often associated with CAM use for those seeing specialists

The Grizzly, April 19, 1984

New Facilities Will Result in Improved English, Modern Language Departments • UC Backs Hart at Bloomsburg Convention • Stress Management Topic of Lecture • Collector\u27s Plates Displayed at Ursinus • Beverly Oehlert Makes a Difference • The Elvis Brothers: Movin\u27 Up • Team Effort Produces Wins for Softball • Ursinus Professor Reviews Books • Men\u27s Lacrosse Evens Record at 3-3 • Men\u27s Track Off to Quick Start • Netmen Victorious • Grizzlies Drop Game to Widener • UC Women Spark Olympic Field Hockey Team to the Gold • Women\u27s Tennis Wins Three; Record Is 4-3 • Grizzly Bears Fell Into a Tailspin • Ursinus Golf Team Begins Spring Seasonhttps://digitalcommons.ursinus.edu/grizzlynews/1117/thumbnail.jp

The Grizzly, May 4, 1984

Sir Thomson to Speak at Commencement • Changes to Take Place in Student Life Office • Yatsko Wins Fellowship • UC Hosts USWLA Championship • Professor with the Quiet Manner: George Storey Retires From English • UC Students Attend Model UN • Chamber Groups to Perform • Work Snarls Traffic on Bridge • A Legend Retires as Pancoast Leaves • Union Pub a Hit • Solution for a Printing Crisis • Letters to the Editor: Suggestions for Social Life • Standeven Wins Chemistry Award • \u2784 Ruby Orders Being Taken Now • Play Simon Sez With Bobby Gold • 3 Seniors Land Top Accounting Jobs • Post Graduation Plans for Class of 1984 • Tursi Goes to Scotland • UC Discovers Charm of Trivial Pursuit • Language Honor Society Forms Local Chapter • Richter Announces Death of Dr. Rice • Students Debate Deployment of Missiles • Ursinus, A Well Kept Secret • Forum Relieves Tension • Shiatsu Cures Stress • UC Poet Writes About Amish • Final Exam Schedule Posted • Men\u27s Lacrosse Reaches Turning Point • Men\u27s Tennis Beats Wilkes, Loses to Mules • Greek Week Reveals Student Spirit • Gasser Named New Basketball Coach • Men\u27s Track Wins 2, Drop 1 for 7-3 Record • UC Fencers Place in Tournament • Softball at 14-3 • UC Field Hockey to Visit Europe • Jamison Breaks Recordhttps://digitalcommons.ursinus.edu/grizzlynews/1118/thumbnail.jp

Multiomics modeling of the immunome, transcriptome, microbiome, proteome and metabolome adaptations during human pregnancy.

MotivationMultiple biological clocks govern a healthy pregnancy. These biological mechanisms produce immunologic, metabolomic, proteomic, genomic and microbiomic adaptations during the course of pregnancy. Modeling the chronology of these adaptations during full-term pregnancy provides the frameworks for future studies examining deviations implicated in pregnancy-related pathologies including preterm birth and preeclampsia.ResultsWe performed a multiomics analysis of 51 samples from 17 pregnant women, delivering at term. The datasets included measurements from the immunome, transcriptome, microbiome, proteome and metabolome of samples obtained simultaneously from the same patients. Multivariate predictive modeling using the Elastic Net (EN) algorithm was used to measure the ability of each dataset to predict gestational age. Using stacked generalization, these datasets were combined into a single model. This model not only significantly increased predictive power by combining all datasets, but also revealed novel interactions between different biological modalities. Future work includes expansion of the cohort to preterm-enriched populations and in vivo analysis of immune-modulating interventions based on the mechanisms identified.Availability and implementationDatasets and scripts for reproduction of results are available through: https://nalab.stanford.edu/multiomics-pregnancy/.Supplementary informationSupplementary data are available at Bioinformatics online

The osteoarthritis prevention study (TOPS) - A randomized controlled trial of diet and exercise to prevent Knee Osteoarthritis:Design and rationale

Background: Osteoarthritis (OA), the leading cause of disability among adults, has no cure and is associated with significant comorbidities. The premise of this randomized clinical trial is that, in a population at risk, a 48-month program of dietary weight loss and exercise will result in less incident structural knee OA compared to control. Methods/design: The Osteoarthritis Prevention Study (TOPS) is a Phase III, assessor-blinded, 48-month, parallel 2 arm, multicenter randomized clinical trial designed to reduce the incidence of structural knee OA. The study objective is to assess the effects of a dietary weight loss, exercise, and weight-loss maintenance program in preventing the development of structural knee OA in females at risk for the disease. TOPS will recruit 1230 ambulatory, community dwelling females with obesity (Body Mass Index (BMI) ​≥ ​30 ​kg/m2) and aged ≥50 years with no radiographic (Kellgren-Lawrence grade ≤1) and no magnetic resonance imaging (MRI) evidence of OA in the eligible knee, with no or infrequent knee pain. Incident structural knee OA (defined as tibiofemoral and/or patellofemoral OA on MRI) assessed at 48-months from intervention initiation using the MRI Osteoarthritis Knee Score (MOAKS) is the primary outcome. Secondary outcomes include knee pain, 6-min walk distance, health-related quality of life, knee joint loading during gait, inflammatory biomarkers, and self-efficacy. Cost effectiveness and budgetary impact analyses will determine the value and affordability of this intervention. Discussion: This study will assess the efficacy and cost effectiveness of a dietary weight loss, exercise, and weight-loss maintenance program designed to reduce incident knee OA.Trial registration: ClinicalTrials.gov Identifier: NCT05946044.</p