A Note on Fluxes and Superpotentials in M-theory Compactifications on Manifolds of G_2 Holonomy

We consider the breaking of N=1 supersymmetry by non-zero G-flux when M-theory is compactified on a smooth manifold X of G_2 holonomy. Gukov has proposed a superpotential W to describe this breaking in the low-energy effective theory. We check this proposal by comparing the bosonic potential implied by W with the corresponding potential deduced from the eleven-dimensional supergravity action. One interesting aspect of this check is that, though W depends explicitly only on G-flux supported on X, W also describes the breaking of supersymmetry by G-flux transverse to X.Comment: 15 pages, harvmac, v2: reference adde

Superconducting Films for Absorber-Coupled MKID Detectors for Sub-Millimeter and Far-Infrared Astronomy

We describe measurements of the properties, at dc, gigahertz, and terahertz frequencies, of thin (10 nm) aluminum films with 10 ohm/{rm square}$ normal state sheet resistance. Such films can be applied to construct microwave kinetic inductance detector arrays for submillimeter and far-infrared astronomical applications in which incident power excites quasiparticles directly in a superconducting resonator that is configured to present a matched-impedance to the high frequency radiation being detected. For films 10 nm thick, we report normal state sheet resistance, resistance-temperature curves for the superconducting transition, quality factor and kinetic inductance fraction for microwave resonators made from patterned films, and terahertz measurements of sheet impedance measured with a Fourier Transform Spectrometer. We compare properties with similar resonators made from niobium 600 nm thick

A Quasioptical Vector Interferometer for Polarization Control

We present a mathematical description of a Quasioptical Vector Interferometer (QVI), a device that maps an input polarization state to an output polarization state by introducing a phase delay between two linear orthogonal components of the input polarization. The advantages of such a device over a spinning wave-plate modulator for measuring astronomical polarization in the far-infrared through millimeter are: 1. The use of small, linear motions eliminates the need for cryogenic rotational bearings, 2. The phase flexibility allows measurement of Stokes V as well as Q and U, and 3. The QVI allows for both multi-wavelength and broadband modulation. We suggest two implementations of this device as an astronomical polarization modulator. The first involves two such modulators placed in series. By adjusting the two phase delays, it is possible to use such a modulator to measure Stokes Q, U, and V for passbands that are not too large. Conversely, a single QVI may be used to measure Q and V independent of frequency. In this implementation, Stokes U must be measured by rotating the instrument. We conclude this paper by presenting initial laboratory results

Influence of UVB radiation on the lethal and sublethal toxicity of dispersed crude oil to planktonic copepod nauplii

AbstractToxic effects of petroleum to marine zooplankton have been generally investigated using dissolved petroleum hydrocarbons and in the absence of sunlight. In this study, we determined the influence of natural ultraviolet B (UVB) radiation on the lethal and sublethal toxicity of dispersed crude oil to naupliar stages of the planktonic copepods Acartia tonsa, Temora turbinata and Pseudodiaptomus pelagicus. Low concentrations of dispersed crude oil (1 μL L−1) caused a significant reduction in survival, growth and swimming activity of copepod nauplii after 48 h of exposure. UVB radiation increased toxicity of dispersed crude oil by 1.3–3.8 times, depending on the experiment and measured variables. Ingestion of crude oil droplets may increase photoenhanced toxicity of crude oil to copepod nauplii by enhancing photosensitization. Photoenhanced sublethal toxicity was significantly higher when T. turbinata nauplii were exposed to dispersant-treated oil than crude oil alone, suggesting that chemical dispersion of crude oil may promote photoenhanced toxicity to marine zooplankton. Our results demonstrate that acute exposure to concentrations of dispersed crude oil and dispersant (Corexit 9500) commonly found in the sea after oil spills are highly toxic to copepod nauplii and that natural levels of UVB radiation substantially increase the toxicity of crude oil to these planktonic organisms. Overall, this study emphasizes the importance of considering sunlight in petroleum toxicological studies and models to better estimate the impact of crude oil spills on marine zooplankton

A human embryonic kidney 293T cell line mutated at the Golgi -mannosidase II locus

Disruption of Golgi -mannosidase II activity can result in type II congenital dyserythropoietic anemia and can induce lupus-like autoimmunity in mice. Here, we isolate a mutant human embryonic kidney (HEK) 293T cell line, called Lec36, that displays sensitivity to ricin that lies between the parental HEK 293T cells, whose secreted and membrane-expressed proteins are dominated by complex-type glycosylation, and 293S Lec1 cells, which only produce oligomannose-type N-linked glycans. The stem cell marker, 19A, was transiently expressed in the HEK 293T Lec36 cells, and in parental HEK 293T cells with and without the potent Golgi -mannosidase II inhibitor, swainsonine. Negative-ion nano-electrospray ionization mass spectra of the 19A N-linked glycans from HEK 293T Lec36 and swainsonine-treated HEK 293T cells were qualitatively indistinguishable and, as shown by collision-induced dissociation spectra, dominated by hybrid-type glycosylation. Nucleotide sequencing revealed mutations in each allele of MAN2A1, the gene encoding Golgi -mannosidase II: a point mutation in one allele mapping to the active site and an in-frame deletion of twelve-nucleotides in the other. Expression of wild-type but not the mutant MAN2A1 alleles in Lec36 cells restored processing of the 19A reporter glycoprotein to complex-type glycosylation. The Lec36 cell line will be useful for expressing therapeutic glycoproteins with hybrid-type glycans and provides a sensitive host for detecting mutations in human MAN2A1 causing type II congenital dyserythropoietic anemia

Effect of Light Fermions on the Confinement Transition in QCD-like Theories

Dependence of the confinement transition parameters on the fermion content provides information on the mechanism of confinement. Recent progress in lattice gauge theories has allowed to study it for light flavor number $N_f\sim O(10)$ and found this transition to shift toward significantly stronger coupling. We propose an explanation for that: light fermions can occupy the chromo-magnetic monopoles, via zero modes, making them "distinguishable" and unsuitable for Bose-Einstein Condensation. Such dilution of unoccuplied monopoles is compensated by stronger coupling that makes them lighter and more numerous. We also suggest that flavor-carrying quark-monopole objects account for the density beyond quark Fermi sphere seen in cold dense phase of $N_c=2$ lattice QCD.Comment: 4 pages, 1 figure; few references added; close to the final published versio

Nano-dimensionality effect on electrochemical aptamer-based sensor performance for MUC1 liquid biopsy

ABSTRACT: The modularity of electrochemical aptamer-based (E-AB) sensors has made them useful candidates for real-time and specific determination of molecular targets (irrespective of their chemical reactivity). In this work, we have emphasized the role of the electrode surface's morphological dimensions on the E-AB sensor's performance for the detection of breast cancer biomarker MUC1 in the human serum sample. To accomplish this, bottom-up approaches were utilized for the synthesis of one- and three-dimensional gold substrates (with 0.072 cm² and 0.079 cm² ECSAs, respectively) that were later used in the construction of E-AB sensors, and the results were compared to a planar gold electrode (two-dimensional with an ECSA of 0.02 cm²). The selection of a regular gold electrode as the two-dimensional substrate was essential to make the study relevant and comparable with the widely used type of electrode that is commonly used in the fabrication of E-AB sensors. Our data show that the E-AB sensor based on the three-dimensional gold substrate with a limit of detection (LOD) of 6.8 nM did not significantly improve the regular electrode (two-dimensional) with a LOD of 7.8 nM, whereas the one-dimensional gold substrate proved to be the most electrochemically sensitive surface with a LOD of 3.5 nM. This enhancement is likely due to the attributes of the surface organization. Therefore, our findings suggest that a large surface area alone does not necessarily guarantee a better sensitivity unless causing a fruitful contribution to the aptamers' surface organization

Cryogenic Applications of Commercial Electronic Components

We have developed a range of techniques useful for constructing analog and digital circuits for operation in a liquid Helium environment (4.2K), using commercially available low power components. The challenges encountered in designing cryogenic electronics include finding components that can function usefully in the cold and possess low enough power dissipation so as not to heat the systems they are designed to measure. From design, test, and integration perspectives it is useful for components to operate similarly at room and cryogenic temperatures; however this is not a necessity. Some of the circuits presented here have been used successfully in the MUSTANG and in the GISMO camera to build a complete digital to analog multiplexer (which will be referred to as the Cryogenic Address Driver board). Many of the circuit elements described are of a more general nature rather than specific to the Cryogenic Address Driver board, and were studied as a part of a more comprehensive approach to addressing a larger set of cryogenic electronic needs