102 research outputs found
The neuroprotective effects of astaxanthin: therapeutic targets and clinical perspective
As the leading causes of human disability and mortality, neurological diseases affect
millions of people worldwide and are on the rise. Although the general roles of several signaling
pathways in the pathogenesis of neurodegenerative disorders have so far been identified, the exact
pathophysiology of neuronal disorders and their effective treatments have not yet been precisely
elucidated. This requires multi-target treatments, which should simultaneously attenuate neuronal
inflammation, oxidative stress, and apoptosis. In this regard, astaxanthin (AST) has gained growing
interest as a multi-target pharmacological agent against neurological disorders including Parkinsonâs
disease (PD), Alzheimerâs disease (AD), brain and spinal cord injuries, neuropathic pain (NP),
aging, depression, and autism. The present review highlights the neuroprotective effects of AST
mainly based on its anti-inflammatory, antioxidative, and anti-apoptotic properties that underlies its
pharmacological mechanisms of action to tackle neurodegeneration. The need to develop novel AST
delivery systems, including nanoformulations, targeted therapy, and beyond, is also consideredS
Prediction of Neurological Enzyme Targets for Known and New Compounds with a Model using Galvez's Topological Indices
The 18th International Electronic Conference on Synthetic Organic Chemistry session Computational ChemistryAlzheimer's Disease (AD), Parkinson, and other neurodegenerative diseases are a major health problem nowadays. In this sense, the discovery of new drugs for neurodiseases treatment is a goal of the major importance. Public databases, like ChEMBL, contain a large amount of data about multiplexing assays of inhibitors of a group of enzymes with special relevance in central nervous system. Mono Amino Oxidases (MAOs), Acetyl Cholinesterase (AChE), Glycogen Synthase Kinase-3 (GSK-3), AChE (AChE), and 5α-reductases (5αRs). This data conform an important information source for the application of multi-target computational models. However, almost all the computational models known focus in only one target. In this work, we developed mt-QSAR for inhibitors of 8 different enzymes promising in the treatment of different neurodiseases. In so doing, we combined by the first time the software DRAGON with Moving Average parameters with this objective. The best DRAGON model found predict with very high accuracy, specificity, and sensitivity >90% a very large data set >10000 cases in training and validation series. We also report experimental results about the assay of several 7
Hesperidin as a neuroprotective agent: a review of animal and clinical evidence
Neuroprotection is the preservation of function and networks of neural tissues
from damages caused by various agents, as well as neurodegenerative diseases such as
Parkinsonâs, Alzheimerâs, Huntingtonâs diseases, and multiple sclerosis. Hesperidin, a flavanone
glycoside, is a natural phenolic compound with a wide range of biological effects. Mounting
evidence has demonstrated that hesperidin possesses inhibitory effect against development of
neurodegenerative diseases. Our review discusses neuropharmacological mechanisms for preventive
and therapeutic effects of hesperidin in neurodegenerative diseases. In addition, the review
examines clinical evidence confirming its neuroprotective function. Various cellular and animal
models specific to neurodegenerative diseases have been conducted to evaluate the underlying
neuropharmacological mechanisms of hesperidin. Neuroprotective potential of this flavonoid is
mediated by improvement of neural growth factors and endogenous antioxidant defense functions,
diminishing neuro-inflammatory and apoptotic pathways. Despite the various preclinical studies on
the role of hesperidin in the neurodegenerative diseases, less is known about its definite effect on
humans. A limited number of clinical trials showed that hesperidin-enriched dietary supplements can
significantly improve cerebral blood flow, cognition, and memory performance. Further clinical trials
are also required for confirming neuroprotective efficacy of this natural flavonoid and evaluating its
safety profileS
Targeting Multiple Signal Transduction Pathways of SARS-CoV-2: Approaches to COVID-19 Therapeutic Candidates
Due to the complicated pathogenic pathways of coronavirus disease 2019 (COVID-19), related medicinal therapies have remained a clinical challenge. COVID-19 highlights the urgent need to develop mechanistic pathogenic pathways and effective agents for preventing/treating future epidemics. As a result, the destructive pathways of COVID-19 are in the line with clinical symptoms induced by severe acute coronary syndrome (SARS), including lung failure and pneumonia. Accordingly, revealing the exact signaling pathways, including inflammation, oxidative stress, apoptosis, and autophagy, as well as relative representative mediators such as tumor necrosis factor-α (TNF-α), nuclear factor erythroid 2-related factor 2 (Nrf2), Bax/caspases, and Beclin/LC3, respectively, will pave the road for combating COVID-19. Prevailing host factors and multiple steps of SARS-CoV-2 attachment/entry, replication, and assembly/release would be hopeful strategies against COVID-19. This is a comprehensive review of the destructive signaling pathways and hostâpathogen interaction of SARS-CoV-2, as well as related therapeutic targets and treatment strategies, including potential natural products-based candidatesJ.E. gratefully acknowledges funding from CONICYT (PAI/ACADEMIA N°79160109)S
Antiangiogenic effects of coumarins against cancer: from chemistry to medicine
Angiogenesis, the process of formation and recruitment of new blood vessels from
pre-existing vessels, plays an important role in the development of cancer. Therefore, the use of
antiangiogenic agents is one of the most critical strategies for the treatment of cancer. In addition,
the complexity of cancer pathogenicity raises the need for multi-targeting agents. Coumarins are
multi-targeting natural agents belonging to the class of benzopyrones. Coumarins have several
biological and pharmacological effects, including antimicrobial, antioxidant, anti-inflammation,
anticoagulant, anxiolytic, analgesic, and anticancer properties. Several reports have shown
that the anticancer effect of coumarins and their derivatives are mediated through targeting
angiogenesis by modulating the functions of vascular endothelial growth factor as well as
vascular endothelial growth factor receptor 2, which are involved in cancer pathogenesis. In the
present review, we focus on the antiangiogenic effects of coumarins and related structure-activity
relationships with particular emphasis on cancerS
Ageratum conyzoides L. and Its Secondary Metabolites in the Management of Different Fungal Pathogens
Ageratum conyzoides L. (FamilyâAsteraceae) is an annual aromatic invasive herb, mainly distributed over the tropical and subtropical regions of the world. It owns a reputed history of indigenous remedial uses, including as a wound dressing, an antimicrobial, and mouthwash as well as in treatment of dysentery, diarrhea, skin diseases, etc. In this review, the core idea is to present the antifungal potential of the selected medicinal plant and its secondary metabolites against different fungal pathogens. Additionally, toxicological studies (safety profile) conducted on the amazing plant A. conyzoides L. are discussed for the possible clinical development of this medicinal herb. Articles available from 2000 to 2020 were reviewed in detail to exhibit recent appraisals of the antifungal properties of A. conyzoides. Efforts were aimed at delivering evidences for the medicinal application of A. conyzoides by using globally recognized scientific search engines and databases so that an efficient approach for filling the lacunae in the research and development of antifungal drugs can be adopted. After analyzing the literature, it can be reported that the selected medicinal plant effectively suppressed the growth of numerous fungal species, such as Aspergillus, Alternaria, Candida, Fusarium, Phytophthora, and Pythium, owing to the presence of various secondary metabolites, particularly chromenes, terpenoids, flavonoids and coumarins. The possible mechanism of action of different secondary metabolites of the plant against fungal pathogens is also discussed briefly. However, it was found that only a few studies have been performed to demonstrate the plantâs dosage and safety profile in humans. Considered all together, A. conyzoides extract and its constituents may act as a promising biosource for the development of effective antifungal formulations for clinical use. However, in order to establish safety and efficacy, additional scientific research is required to explore chronic toxicological effects of ageratum, to determine the probability of interactions when used with different herbs, and to identify safe dosage. The particulars presented here not only bridge this gap but also furnish future research strategies for the investigators in microbiology, ethno-pharmacology, and drug discoveryS
Natural Products for Neurodegeneration: Regulating Neurotrophic Signals
Neurodegenerative disorders (NDs) are heterogeneous groups of ailments typically characterized by progressive damage of the nervous system. Several drugs are used to treat NDs but they have only symptomatic benefits with various side effects. Numerous researches have been performed to prove the advantages of phytochemicals for the treatment of NDs. Furthermore, phytochemicals such as polyphenols might play a pivotal role in rescue from neurodegeneration due to their various effects as anti-inflammatory, antioxidative, and antiamyloidogenic agents by controlling apoptotic factors, neurotrophic factors (NTFs), free radical scavenging system, and mitochondrial stress. On the other hand, neurotrophins (NTs) including nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), NT4/5, and NT3 might have a crucial neuroprotective role, and their diminution triggers the development of the NDs. Polyphenols can interfere directly with intracellular signaling molecules to alter brain activity. Several natural products also improve the biosynthesis of endogenous genes encoding antiapoptotic Bcl-2 as well as NTFs such as glial cell and brain-derived NTFs. Various epidemiological studies have demonstrated that the initiation of these genes could play an essential role in the neuroprotective function of dietary compounds. Hence, targeting NTs might represent a promising approach for the management of NDs. In this review, we focus on the natural product-mediated neurotrophic signal-modulating cascades, which are involved in the neuroprotective effectsThis work was funded by the Deanship of Scientific Research at Princess Nourah bint Abdulrahman University through the Fast-track Research Funding ProgramS
The International Natural Product Sciences Taskforce (INPST) and the power of Twitter networking exemplified through #INPST hashtag analysis
Background: The development of digital technologies and the evolution of open innovation approaches have enabled the creation of diverse virtual organizations and enterprises coordinating their activities primarily online. The open innovation platform titled "International Natural Product Sciences Taskforce" (INPST) was established in 2018, to bring together in collaborative environment individuals and organizations interested in natural product scientific research, and to empower their interactions by using digital communication tools. Methods: In this work, we present a general overview of INPST activities and showcase the specific use of Twitter as a powerful networking tool that was used to host a one-week "2021 INPST Twitter Networking Event" (spanning from 31st May 2021 to 6th June 2021) based on the application of the Twitter hashtag #INPST. Results and Conclusion: The use of this hashtag during the networking event period was analyzed with Symplur Signals (https://www.symplur.com/), revealing a total of 6,036 tweets, shared by 686 users, which generated a total of 65,004,773 impressions (views of the respective tweets). This networking event's achieved high visibility and participation rate showcases a convincing example of how this social media platform can be used as a highly effective tool to host virtual Twitter-based international biomedical research events
Applied Biological and Physicochemical Activity of Isoquinoline Alkaloids: Oxoisoaporphine and Boldine
The aim of this study was to determine the electronic influence of substituent groups and annelated rings such as oxazole-oxazinone on the physicochemical and photoprotection, antioxidant capacity, toxicity and singlet oxygen photosensitization biological properties of isoquinoline alkaloid frameworks. Thus, oxoisoaporphine derivatives 1â5 and 3-azaoxoisoaporphine (6), some of them with phenolic structures, did not present any antioxidant capacity, possibly either by formation of keto-enol tautomerism species or the formation of unstable free radicals. Due to the singlet oxygen quantum yields (FD) near to unity, and greater photostability than phenalenone, oxoisoaporphines 4â6 may be considered as photosensitizers for singlet oxygen production and can be used as new universal study tools. The biological application as antibacterial agents is an important and possible tool in the study of compounds with low cytotoxicity and high reactivity in antineoplastic chemotherapy. On the other hand, when boldine and its annelated derivatives B1â4 are irradiated, a photoprotector effect is observed (SPF = 2.35), even after 30 minutes of irradiation. They also act as photoprotectors in cell fibroblast cultures. No hemolysis was detected for boldine hydrochloride and its salts without irradiation. In solutions irradiated before incubation (at concentrations over 200 ppm) photoproducts were toxic to the nauplii of Artemia salinaE. S.-S. gratefully acknowledges the financial support of the âIsidro Parga Pondalâ Program, Xunta de GaliciaS
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