Entre tú y yo: Compartiendo una experiencia de simulación de transferencia de innovación

How to cite: Acosta-Pérez, E. & Noboa-Ortega, P. (2005). Entre tú y yo: Compartiendo una experiencia de simulación de transferencia de innovación. Pedagogía, 38(1), 219-232.Cómo citar: Acosta-Pérez, E. & Noboa-Ortega, P. (2005). Entre tú y yo: Compartiendo una experiencia de simulación de transferencia de innovación. Pedagogía, 38(1), 219-232

Conocimiento y placer en la sexualidad femenina: ¿Y qué de la educación sexual?

How to cite: Acosta-Pérez, E., Serrano-García, I. & Hernández-Cartagena, M. R. (2002). Conocimiento y placer en la sexualidad femenina: ¿Y qué de la educación sexual? Pedagogía, 36(1), 158-184.Cómo citar: Acosta-Pérez, E., Serrano-García, I. & Hernández-Cartagena, M. R. (2002). Conocimiento y placer en la sexualidad femenina: ¿Y qué de la educación sexual? Pedagogía, 36(1), 158-184

A genome-wide association study of severe asthma exacerbations in Latino children and adolescents

Severe asthma exacerbations are a major cause of school absences and healthcare costs in children, particularly those in high-risk racial/ethnic groups. To identify susceptibility genes for severe asthma exacerbations in Latino children and adolescents, we conducted a meta-analysis of genome-wide association studies (GWAS) in 4010 Latino youth with asthma in four independent cohorts, including 1693 Puerto Ricans, 1019 Costa Ricans, 640 Mexicans, 256 Brazilians, and 402 members of other Latino subgroups. We then conducted methylation quantitative trait locus (mQTL), expression quantitative trait locus (eQTL), and expression quantitative trait methylation (eQTM) analyses to assess whether the top SNP in the meta-analysis is linked to DNA methylation and gene expression in nasal (airway) epithelium in separate cohorts of Puerto Rican and Dutch children and adolescents. In the meta-analysis of GWAS, a SNP in FLJ22447 (rs2253681) was significantly associated with 1.55 increased odds of severe asthma exacerbations (95% confidence interval=1.34 to 1.79, p=6.3×10-9). This SNP was significantly associated with DNA methylation of a CpG site (cg25024579) at the FLJ22447 locus, which was in turn associated with increased expression of KCNJ2-AS1 in nasal airway epithelium from Puerto Rican children and adolescents (β=0.10, p=2.18×10-7). Thus, SNP rs2253681 was significantly associated with both DNA methylation of a cis-CpG in FLJ22447 and severe asthma exacerbations in Latino youth. This may be partly explained by changes in airway epithelial expression of a gene recently implicated in atopic asthma in Puerto Rican children and adolescents (KCNJ2-AS1)

Gestión del conocimiento: perspectiva multidisciplinaria. Volumen 11

El libro “Gestión del Conocimiento. Perspectiva Multidisciplinaria”, Volumen 11, de la Colección Unión Global, es resultado de investigaciones. Los capítulos del libro, son resultados de investigaciones desarrolladas por sus autores. El libro cuenta con el apoyo de los grupos de investigación: Universidad Sur del Lago “Jesús María Semprúm” (UNESUR), Zulia – Venezuela; Universidad Politécnica Territorial de Falcón Alonso Gamero (UPTAG), Falcón – Venezuela; Universidad Politécnica Territorial de Mérida Kleber Ramírez (UPTM), Mérida – Venezuela; Universidad Guanajuato (UG) - Campus Celaya - Salvatierra - Cuerpo Académico de Biodesarrollo y Bioeconomía en las Organizaciones y Políticas Públicas (C.A.B.B.O.P.P), Guanajuato – México; Centro de Altos Estudios de Venezuela (CEALEVE), Zulia – Venezuela, Centro Integral de Formación Educativa Especializada del Sur (CIFE - SUR) - Zulia - Venezuela, Centro de Investigaciones Internacionales SAS (CIN), Antioquia - Colombia.y diferentes grupos de investigación del ámbito nacional e internacional que hoy se unen para estrechar vínculos investigativos, para que sus aportes científicos formen parte de los libros que se publiquen en formatos digital e impreso

Evaluación de un programa de educación sobre crianza: Promoviendo la crianza positiva entre padres urbanos

This paper presents process and outcome evaluation data of a multi-component community-based parenting program for urban parents. A total of 1,118 participants in the Parenting Education Program completed pre and post surveys that measured parenting knowledge and behavioral intent. Paired-samples t-tests were employed to document change in scores. Descriptive and thematic analyses from surveys, phone interviews and a focus group were utilized to understand program satisfaction. Administrative data was gathered to document program implementation. The results indicate that changes in scores were significantly different (at least p< .05) between pre- and post-test for all waves of data collection for graduating parents in each age group class. Parents strongly agreed that they were satisfied with the program. How to cite: Sánchez-Cesáreo, M., Adams, M., Acosta-Pérez, E., & Bensinger, K. (2011). Evaluation of the Parenting Education Program: Promoting positive parenting among urban parents. Cuaderno de Investigación en la Educación, 26, 132-147. Retrieved from https://revistas.upr.edu/index.php/educacion/article/view/13321Este artículo presenta la evaluación del proceso y del Programa de Educación para Padres y Madres implementado en un contexto urbano. En este estudio participaron 1,118 personas, que completaron las pre y post pruebas, enfocadas en la adquisición de conocimiento sobre crianza positiva y las expectativas de comportamiento futuro. El análisis estadístico incluyó pruebas-T, análisis descriptivos y temáticos para medir la satisfacción de estos participantes. El análisis demostró que hay un cambio estadísticamente significativo (p< .05) en el conocimiento de estas personas sobre crianza positiva y en sus expectativas de comportamiento futuro. Dichos resultados fueron consistentes en todos los grupos de padres y madres. Los participantes, además, demostraron altos niveles de satisfacción con el program. Cómo citar: Sánchez-Cesáreo, M., Adams, M., Acosta-Pérez, E., & Bensinger, K. (2011). Evaluation of the Parenting Education Program: Promoting positive parenting among urban parents. Cuaderno de Investigación en la Educación, 26, 132-147. Recuperado de https://revistas.upr.edu/index.php/educacion/article/view/1332

Under-diagnosis of atopic dermatitis in Puerto Rican children

Background: Little is known about atopic dermatitis (AD) among children in Puerto Rico. Objective: To examine risk factors and identify approaches to better diagnose AD in Puerto Rican children. Methods: Case-control study of AD among 540 children aged 6–14 years in San Juan, Puerto Rico. AD was defined as: 1) physician-diagnosed AD, 2) RAST-AD: AD symptoms plus ≥1 positive IgE to allergens, and 3) STR-AD: AD-symptoms and skin test reactivity to ≥1 allergen. Logistic regression was used for the multivariable analysis. We also evaluated the diagnostic performance of various approaches by comparing their sensitivity, specificity, positive predicted value [PPV], negative predictive value [NPV], and area under curve [AUC]). Results: Of the 70 children with STR-AD, only 5 (7.1%) had PD-AD. In children without asthma, a positive IgE to Dermatophagoides (D.) pteronyssinus and signs of mold/mildew at home were significantly associated with 3.3 and 5 times increased odds of STR-AD, respectively. Among children with asthma, private/employer-based health insurance and a positive IgE to D. pteronyssinus were each significantly associated with approximately twofold increased odds of STR-AD. A combination of current eczema symptoms and a positive IgE to D. pteronyssinus yielded a sensitivity ≥70%, specificity and NPV ≥95%, PPV ≥88%, and an AUC ≥0.85 for STR-AD. Replacing a positive IgE to D. pteronyssinus with a positive IgE to ≥1 allergen slightly increased sensitivity without affecting other parameters. Conclusions: AD is markedly under-diagnosed by physicians in Puerto Rico. This could be improved by assessing eczema symptoms and measuring IgEs to common allergens. Keywords: Atopic dermatitis, Under-diagnosis, Puerto Rico, Childre

Environmental Stressors Suffered by Women with Gynecological Cancers in the Aftermath of Hurricanes Irma and María in Puerto Rico

Background: Hurricanes are the immediate ways that people experience climate impacts in the Caribbean. These events affect socio-ecological systems and lead to major disruptions in the healthcare system, having effects on health outcomes. In September 2017, Puerto Rico (PR) and the United States Virgin Islands (USVI) experienced one of the most catastrophic hurricane seasons in recent history (Hurricane Irma was a Category 5 and Hurricane María was a Category 4 when they hit PR). Objective: This study examines environmental stressors experienced by women with gynecologic (GYN) cancers from PR and USVI who received oncologic cancer care in PR, in the aftermath of the hurricanes. Methods: A descriptive qualitative study design was used to obtain rich information for understanding the context, barriers, knowledge, perspectives, risks, vulnerabilities, and attitudes associated to these hurricanes. We performed focus groups among GYN cancer patients (n = 24) and key-informant interviews (n = 21) among health-care providers and administrators. Interviews were conducted from December 2018–April 2019. Results: Environmental health stressors such as lack of water, heat and uncomfortable temperatures, air pollution (air quality), noise pollution, mosquitos, and rats ranked in the top concerns among cancer patients and key-informants. Conclusions: These findings are relevant to cancer patients, decision-makers, and health providers facing extreme events and disasters in the Caribbean. Identifying environmental secondary stressors and the most relevant cascading effects is useful for decision-makers so that they may address and mitigate the effects of hurricanes on public health and cancer care

Transcriptomics of atopy and atopic asthma in white blood cells from children and adolescents

International audienceEarly allergic sensitisation (atopy) is the first step in the development of allergic diseases such as atopic asthma later in life. Genes and pathways associated with atopy and atopic asthma in children and adolescents have not been well characterised.A transcriptome-wide association study (TWAS) of atopy and atopic asthma in white blood cells (WBCs) or whole blood was conducted in a cohort of 460 Puerto Ricans aged 9-20 years (EVA-PR study) and in a cohort of 250 Swedish adolescents (BAMSE study). Pathway enrichment and network analyses were conducted to further assess top findings, and classification models of atopy and atopic asthma were built using expression levels for the top differentially expressed genes (DEGs).In a meta-analysis of the study cohorts, both previously implicated genes (e.g. IL5RA and IL1RL1) and genes not previously reported in TWASs (novel) were significantly associated with atopy and/or atopic asthma. Top novel genes for atopy included SIGLEC8 (p=8.07×10-13), SLC29A1 (p=7.07×10-12) and SMPD3 (p=1.48×10-11). Expression quantitative trait locus analyses identified multiple asthma-relevant genotype-expression pairs, such as rs2255888/ALOX15 Pathway enrichment analysis uncovered 16 significantly enriched pathways at adjusted p<0.01, including those relevant to T-helper cell type 1 (Th1) and Th2 immune responses. Classification models built using the top DEGs and a few demographic/parental history variables accurately differentiated subjects with atopic asthma from nonatopic control subjects (area under the curve 0.84).We have identified genes and pathways for atopy and atopic asthma in children and adolescents, using transcriptome-wide data from WBCs and whole blood samples

Top twenty genes with most significant local associations.

<p>For each gene, the most significant SNP was reported. Beta is the increase (+) or decrease (-) unit of transcript per unit increase of reference allele (A1). Reported p-value is adjusted by FDR. R² is the proportion of expression variability explained by the reported SNP.</p><p>Top twenty genes with most significant local associations.</p