Deployment Technology of a Heliogyro Solar Sail for Long Duration Propulsion

Interplanetary, multi-mission, station-keeping capabilities will require that a spacecraft employ a highly efficient propulsion-navigation system. The majority of space propulsion systems are fuel-based and require the vehicle to carry and consume fuel as part of the mission. Once the fuel is consumed, the mission is set, thereby limiting the potential capability. Alternatively, a method that derives its acceleration and direction from solar photon pressure using a solar sail would eliminate the requirement of onboard fuel to meet mission objectives. MacNeal theorized that the heliogyro-configured solar sail architecture would be lighter, less complex, cheaper, and less risky to deploy a large sail area versus a masted sail. As sail size increases, the masted sail requires longer booms resulting in increased mass, and chaotic uncontrollable deployment. With a heliogyro, the sail membrane is stowed as a roll of thin film forming a blade when deployed that can extend up to kilometers. Thus, a benefit of using a heliogyro-configured solar sail propulsion technology is the mission scalability as compared to masted versions, which are size constrained. Studies have shown that interplanetary travel is achievable by the heliogyro solar sail concept. Heliogyro solar sail concept also enables multi-mission missions such as sample returns, and supply transportation from Earth to Mars as well as station-keeping missions to provide enhanced warning of solar storm. This paper describes deployment technology being developed at NASA Langley Research Center to deploy and control the center-of-mass/center-of-pressure using a twin bladed heliogyro solar sail 6-unit (6U) CubeSat. The 6U comprises 2x2U blade deployers and 2U for payload. The 2U blade deployers can be mounted to 6U or larger scaled systems to serve as a non-chemical in-space propulsion system. A single solar sail blade length is estimated to be 2.4 km with a total area from two blades of 720 m2; total allowable weight of a 6U CubeSat is approximately 8 kg. This makes the theoretical characteristic acceleration of approximately 0.75 mm/s2 at I AU (astronomical unit), when compared to IKAROS (0.005 mm/s2) and NanoSail-D (0.02 mm/s2)

Germline genetic variation in ETV6 and risk of childhood acute lymphoblastic leukaemia: a systematic genetic study.

BackgroundHereditary predisposition is rarely suspected for childhood acute lymphoblastic leukaemia (ALL). Recent reports of germline ETV6 variations associated with substantial familial clustering of haematological malignancies indicated that this gene is a potentially important genetic determinant for ALL susceptibility. Our aims in this study were to comprehensively identify ALL predisposition variants in ETV6 and to determine the extent to which they contributed to the overall risk of childhood ALL.MethodsWhole-exome sequencing of an index family with several cases of ALL was done to identify causal variants for ALL predisposition. Targeted sequencing of ETV6 was done in children from the Children's Oncology Group and St Jude Children's Research Hospital front-line ALL trials. Patients were included in this study on the basis of their enrolment in these clinical trials and the availability of germline DNA. ETV6 variant genotypes were compared with non-ALL controls to define ALL-related germline risk variants. ETV6 variant function was characterised bioinformatically and correlated with clinical and demographic features in children with ALL.FindingsWe identified a novel non-sense ETV6 variant (p.Arg359X) with a high penetrance in an index family. Subsequent targeted sequencing of ETV6 in 4405 childhood ALL cases identified 31 exonic variants (four non-sense, 21 missense, one splice site, and five frameshift variants) that were potentially related to ALL risk in 35 cases (1%). 15 (48%) of 31 ALL-related ETV6 variants clustered in the erythroblast transformation specific domain and were predicted to be highly deleterious. Children with ALL-related ETV6 variants were significantly older at leukaemia diagnosis than those without (10·2 years [IQR 5·3-13·8] vs 4·7 years [3·0-8·7]; p=0·017). The hyperdiploid leukaemia karyotype was highly over-represented in ALL cases harbouring germline ETV6 risk variants compared with the wild-type group (nine [64%] of 14 cases vs 538 [27%] of 2007 cases; p=0·0050).InterpretationOur findings indicated germline ETV6 variations as the basis of a novel genetic syndrome associated with predisposition to childhood ALL. The development of recommendations for clinical interventions and surveillance for individuals harbouring ALL-related ETV6 variants are needed.FundingUS National Institutes of Health and American Lebanese Syrian Associated Charities