The role of spin-orbit coupling in topologically protected interface states in Dirac materials

We highlight the fact that two-dimensional materials with Dirac-like low energy band structures and spin-orbit coupling will produce linearly dispersing topologically protected Jackiw-Rebbi modes at interfaces where the Dirac mass changes sign. These modes may support persistent spin or valley currents parallel to the interface, and the exact arrangement of such topologically protected currents depends crucially on the details of the spin-orbit coupling in the material. As examples, we discuss buckled two-dimensional hexagonal lattices such as silicene or germanene, and transition metal dichalcogenides such as MoS$_2$.Comment: 8 pages, 2 figure

Pharmacokinetic and pharmacodynamic modelling after subcutaneous, intravenous and buccal administration of a high-concentration formulation of buprenorphine in conscious cats

The aim of this study was to describe the joint pharmacokinetic-pharmacodynamic model and evaluate thermal antinociception of a high-concentration formulation of buprenorphine (Simbadol™) in cats

Normalizing the Temperature Function of Clusters of Galaxies

We re-examine the constraints which can be robustly obtained from the observed temperature function of X-ray cluster of galaxies. The cluster mass function has been thoroughly studied in simulations and analytically, but a direct simulation of the temperature function is presented here for the first time. Adaptive hydrodynamic simulations using the cosmological Moving Mesh Hydro code of Pen (1997a) are used to calibrate the temperature function for different popular cosmologies. Applying the new normalizations to the present-day cluster abundances, we find $\sigma_8=0.53\pm 0.05 \Omega_0^{-0.45}$ for a hyperbolic universe, and $\sigma_8=0.53\pm 0.05 \Omega_0^{-0.53}$ for a spatially flat universe with a cosmological constant. The simulations followed the gravitational shock heating of the gas and dark matter, and used a crude model for potential energy injection by supernova heating. The error bars are dominated by uncertainties in the heating/cooling models. We present fitting formulae for the mass-temperature conversions and cluster abundances based on these simulations.Comment: 20 pages incl 5 figures, final version for ApJ, corrected open universe \gamma relation, results unchange

Group-cluster merging and the formation of starburst galaxies

A significant fraction of clusters of galaxies are observed to have substructure, which implies that merging between clusters and subclusters is a rather common physical process of cluster formation. It still remains unclear how cluster merging affects the evolution of cluster member galaxies. We report the results of numerical simulations, which show the dynamical evolution of a gas-rich late-type spiral in a merger between a small group of galaxies and a cluster. The simulations demonstrate that time-dependent tidal gravitational field of the merging excites non-axisymmetric structure of the galaxy, subsequently drives efficient transfer of gas to the central region, and finally triggers a secondary starburst. This result provides not only a new mechanism of starbursts but also a close physical relationship between the emergence of starburst galaxies and the formation of substructure in clusters. We accordingly interpret post-starburst galaxies located near substructure of the Coma cluster as one observational example indicating the global tidal effects of group-cluster merging. Our numerical results furthermore suggest a causal link between the observed excess of blue galaxies in distant clusters and cluster virialization process through hierarchical merging of subclusters.Comment: 5 pages 3 color figures, ApJL in pres

The Beta Problem: A Study of Abell 262

We present an investigation of the dynamical state of the cluster A262. Existing optical line of sight velocities for select cluster galaxies have been augmented by new data obtained with the Automated Multi-Object Spectrograph at Lick Observatory. We find evidence for a virialized early-type population distinct from a late-type population infalling from the Pisces-Perseus supercluster ridge. We also report on a tertiary population of low luminosity galaxies whose velocity dispersion distinguishes them from both the early and late-type galaxies. We supplement our investigation with an analysis of archival X-ray data. A temperature is determined using ASCA GIS data and a gas profile is derived from ROSAT HRI data. The increased statistics of our sample results in a picture of A262 with significant differences from earlier work. A previously proposed solution to the "beta-problem" in A262 in which the gas temperature is significantly higher than the galaxy temperature is shown to result from using too low a velocity dispersion for the early-type galaxies. Our data present a consistent picture of A262 in which there is no "beta-problem", and the gas and galaxy temperature are roughly comparable. There is no longer any requirement for extensive galaxy-gas feedback to drastically overheat the gas with respect to the galaxies. We also demonstrate that entropy-floor models can explain the recent discovery that the beta values determined by cluster gas and the cluster core radii are correlated.Comment: 31 pages, 14 figures, AAS LaTeX v5.0, Encapsulated Postscript figures, to be published in The Astrophysical Journa

Probing ultracold Fermi gases with light-induced gauge potentials

We theoretically investigate the response of a two component Fermi gas to vector potentials which couple separately to the two spin components. Such vector potentials may be implemented in ultracold atomic gases using optically dressed states. Our study indicates that light-induced gauge potentials may be used to probe the properies of the interacting ultracold Fermi gas, providing. amongst other things, ways to measure the superfluid density and the strength of pairing.Comment: 8 pages, 3 figure

Revertant fibres and dystrophin traces in Duchenne muscular dystrophy: Implication for clinical trials

Duchenne muscular dystrophy (DMD) is characterised by the absence of dystrophin in muscle biopsies, although residual dystrophin can be present, either as dystrophin-positive (revertant) fibres or traces. As restoration of dystrophin expression is the end point of clinical trials, such residual dystrophin is a key factor in recruitment of patients and may also confound the analysis of dystrophin restoration in treated patients, if, as previously observed in the mdx mouse, revertant fibres increase with age. In 62% of the diagnostic biopsies reports of 65 DMD patients studied, traces or revertants were recorded with no correlation between traces or revertants, the patients' performance, or corticosteroids response. In nine of these patients, there was no increase in traces or revertants in biopsies taken a mean of 8.23 years (5.8-10.4 years) after the original diagnostic biopsy. This information should help in the design and execution of clinical trials focused on dystrophin restoration strategies. (C) 2010 Elsevier B.V. All rights reserved

Reexamination of the galaxy formation-regulated gas evolution model in groups and clusters

As an alternative explanation of the entropy excess and the steepening of the X-ray luminosity-temperature relation in groups and clusters, the galaxy formation-regulated gas evolution (GG) model proposed recently by Bryan makes an attempt to incorporate the formation of galaxies into the evolution of gas without additional heating by nongravitational processes. This seems to provide a unified scheme for our understanding of the structures and evolution of both galaxies and gas in groups and clusters. In this paper, we present an extensive comparison of the X-ray properties of groups and clusters predicted by the GG model and those revealed by current X-ray observations, using various large data sources in the literature and also taking the observational selection effects into account. These include an independent check of the fundamental working hypothesis of the GG model, i.e., galaxy formation was less efficient in rich clusters than in groups, a new test of the radial gas distributions revealed by both the gas mass fraction and the X-ray surface brightness profiles, and an reexamination of the X-ray luminosity-temperature and entropy-temperature relations. In particular, it shows that the overall X-ray surface brightness profiles predicted by the GG model are very similar in shape, insensitive to the X-ray temperature, and the shallower X-ray surface brightness profiles seen at low-temperature systems may arise from the current observational selection effect. This can be used as the simplest approach to distinguishing between the GG model and the preheating scenario. The latter yields an intrinsically shallower gas distribution in groups than in rich clusters.Comment: 30 pages, 10 figures, accepted for publication in Ap

Wigner-Poisson statistics of topological transitions in a Josephson junction

The phase-dependent bound states (Andreev levels) of a Josephson junction can cross at the Fermi level, if the superconducting ground state switches between even and odd fermion parity. The level crossing is topologically protected, in the absence of time-reversal and spin-rotation symmetry, irrespective of whether the superconductor itself is topologically trivial or not. We develop a statistical theory of these topological transitions in an N-mode quantum-dot Josephson junction, by associating the Andreev level crossings with the real eigenvalues of a random non-Hermitian matrix. The number of topological transitions in a 2pi phase interval scales as sqrt(N) and their spacing distribution is a hybrid of the Wigner and Poisson distributions of random-matrix theory.Comment: 12 pages, 15 figures; v2 to appear in PRL, with appendix in the supplementary materia