Multiple conserved regulatory domains promote Fezf2 expression in the developing cerebral cortex.

BackgroundThe genetic programs required for development of the cerebral cortex are under intense investigation. However, non-coding DNA elements that control the expression of developmentally important genes remain poorly defined. Here we investigate the regulation of Fezf2, a transcription factor that is necessary for the generation of deep-layer cortical projection neurons.ResultsUsing a combination of chromatin immunoprecipitation followed by high throughput sequencing (ChIP-seq) we mapped the binding of four deep-layer-enriched transcription factors previously shown to be important for cortical development. Building upon this we characterized the activity of three regulatory regions around the Fezf2 locus at multiple stages throughout corticogenesis. We identified a promoter that was sufficient for expression in the cerebral cortex, and enhancers that drove reporter gene expression in distinct forebrain domains, including progenitor cells and cortical projection neurons.ConclusionsThese results provide insight into the regulatory logic controlling Fezf2 expression and further the understanding of how multiple non-coding regulatory domains can collaborate to control gene expression in vivo

Adhesive incisional drapes during cesarean delivery for preventing wound infection: A systematic review and meta-analysis of randomized controlled trials

OBJECTIVE: To compare the incidence of wound infection after cesarean delivery in procedures conducted using adhesive incisional drapes verses no adhesive incisional drapes. STUDY DESIGN: Searches were performed in electronic databases (MEDLINE, ClinicalTrials.gov, the Cochrane Central Register of Controlled Trials, Scopus, OVID, EMBASE, and the PROSPERO International Prospective Register of Systematic Reviews). We included randomized controlled trials comparing adhesive incisional drapes to no adhesive incisional drapes during cesarean delivery. The primary outcome of this meta-analysis was wound infection. Meta-analysis was performed using the random effects model of DerSimonian and Laird, to produce relative risk (RR) with 95% confidence interval (CI). RESULTS: 52 publications were identified through initial search of databases and two randomized controlled trials were eligible and included in the meta-analysis. Our meta-analysis examined a total of 1943 subjects and showed a statistically significant increase in wound infections in patients in the adhesive incisional drape group when compared to the control group (RR: 1.29, 95% CI: 1.02-1.65). CONCLUSION: Adhesive incisional drapes may increase the incidence of wound infections after cesarean delivery. Further studies are necessary to explore this relationship in the setting of current postoperative infection prophylaxis, including broad-spectrum antibiotic coverage, skin preparation and vaginal cleansing

"Too good to be true" : semi-naked bodies on social media

This chapter examines how body image deception is created and understood in social media. The au-thors focus specifically on the beach body, which is a narrower form of bodily representation online, but where deception is especially likely to occur. Focus group discussions with young adults revealed that editing and perfecting the beach body is commonplace and even normalized on social media. However, participants distinguished between celebrities and friends in expected use of manipulation and seemed to place a limit on the acceptable types of manipulation: body tan but not body shape, for example. The authors discuss the implications of these discussions and how applying deception theory in body image research can provide useful insights

Social Media Collaboration in Software Projects

Social media has had a big impact on the way that software projects are managed and the way that stakeholders interact with each other: indeed, the nature of soft-ware projects has evolved substantially in keeping with the evolution of technology. A direct consequence of the ubiquity of the internet is the increasing trend towards cooperation outside the boundaries of an office. The interactions involved in soft-ware projects have changed accordingly and can be broadly divided into two types (1) interactions among stakeholders who are in a single location, (for example people sharing the same office space) and (2) interactions among stakeholders who are in distributed locations (for example software projects which are partly implemented offshore). Social media has been and remains a significant facilitator to these kinds of interactions. This chapter looks at the implications of the use of social media in 21st Century software projects

A systematic review of interactive multimedia interventions to promote children's communication with health professionals: implications for communicating with overweight children

Background: Interactive multimedia is an emerging technology that is being used to facilitate interactions between patients and health professionals. The purpose of this review was to identify and evaluate the impact of multimedia interventions (MIs), delivered in the context of paediatric healthcare, in order to inform the development of a MI to promote the communication of dietetic messages with overweight preadolescent children. Of particular interest were the effects of these MIs on child engagement and participation in treatment, and the subsequent effect on health-related treatment outcomes. Methods: An extensive search of 12 bibliographic databases was conducted in April 2012. Studies were included if: one or more child-participant was 7 to 11 years-of-age; a MI was used to improve health-related behaviour; child-participants were diagnosed with a health condition and were receiving treatment for that condition at the time of the study. Data describing study characteristics and intervention effects on communication, satisfaction, knowledge acquisition, changes in self-efficacy, healthcare utilisation, and health outcomes were extracted and summarised using qualitative and quantitative methods. Results: A total of 14 controlled trials, published between 1997 and 2006 met the selection criteria. Several MIs had the capacity to facilitate engagement between the child and a clinician, but only one sought to utilise the MI to improve communication between the child and health professional. In spite of concerns over the quality of some studies and small study populations, MIs were found useful in educating children about their health, and they demonstrated potential to improve children’s health- related self-efficacy, which could make them more able partners in face-to-face communications with health professionals. Conclusions: The findings of this review suggest that MIs have the capacity to support preadolescent child-clinician communication, but further research in this field is needed. Particular attention should be given to designing appropriate MIs that are clinically relevant

Social media and healthcare : an overview

In our "e-society," social media are pervasive, rapidly evolving, and increasingly influencing the health care landscape. In fact, it is becoming more important that all health care providers understand the basic function of social media processes including what they are, who uses them, what they can be used for, and how they might affect one's practice. Social media are now integrated in many individuals' daily routines, and there is no question that social media are changing the way patients communicate with each other. For example, patients compare notes on support groups, new investigations, treatments, and even physicians and thus continue to take an active role in their health care [1]. With the continued growth of social media, physicians in practice and health care delivery organizations must understand this phenomenon and how it may be used in a positive way to connect with patients. It is beyond the scope of this article to explore in detail the types, uses, and impact of social media, but the authors will present a brief overview that covers the basics of how social media are being used in health care and beyond