FDG-PET/CT for differentiating between aseptic and septic delayed union in the lower extremity

Background: 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography (PET)/computed tomography (CT) has proven to have a high diagnostic accuracy for the detection of bone infections. In patients with delayed union it may be clinically important to differentiate between aseptic and septic delayed union. The aim of this study was to evaluate the efficacy and to assess the optimal diagnostic accuracy of FDG-PET/CT in differentiating between aseptic and septic delayed union in the lower extremity. Methods: This is a retrospective study of consecutive patients who underwent FDG-PET/CT scanning for suspicion of septic delayed union of the lower extremity. Diagnosis of aseptic delayed union or septic delayed union was made based on surgical deep cultures following PET/CT scanning and information on clinical follow-up. FDG-uptake values were measured at the fractured site by use of the maximum standardized uptake value (SUVmax). Sensitivity, specificity and diagnostic accuracy of FDG-PET/CT were calculated at various SUVmax cut-off points. Results: A total of 30 patients were included; 13 patients with aseptic delayed unions and 17 patients with septic delayed unions. Mean SUVmax in aseptic delayed union patients was 3.23 (SD ± 1.21). Mean SUVmax in septic delayed union patients was 4.77 (SD ± 1.87). A cut-off SUVmax set at 4.0 showed sensitivity, specificity and diagnostic accuracy of FDG-PET/CT were 65, 77 and 70% to differentiate between aseptic and septic delayed union, respectively. Conclusion: Using a semi-quantitative measure (SUVmax) for interpretation of FDG-PET/CT imaging seems to be a promising tool for the discrimination between aseptic and septic delayed union

Modeling the magnetic field in the galactic disk using new rotation measure observations from the Very Large Array

We have determined 194 Faraday rotation measures (RMs) of polarized extragalactic radio sources using new, multi-channel polarization observations at frequencies around 1.4 GHz from the Very Large Array (VLA) in the Galactic plane at 17◦ ≤ l ≤ 63◦ and 205◦ ≤ l ≤ 253◦. This catalog fills in gaps in the RM coverage of the Galactic plane between the Canadian Galactic Plane Survey and Southern Galactic Plane Survey. Using this catalog we have tested the validity of recently-proposed axisymmetric and bisymmetric models of the largescale (or regular) Galactic magnetic field, and found that of the existing models we tested, an axisymmetric spiral model with reversals occurring in rings (as opposed to along spiral arms) best matched our observations. Building on this, we have performed our own modeling, using RMs from both extragalactic sources and pulsars. By developing independent models for the magnetic field in the outer and inner Galaxy, we conclude that in the inner Galaxy, the magnetic field closely follows the spiral arms, while in the outer Galaxy, the field is consistent with being purely azimuthal. Furthermore, the models contain no reversals in the outer Galaxy, and together seem to suggest the existence of a single reversed region that spirals out from the Galactic cente

The Grime Scene: Social media, music, creation and consumption

In this paper we start to explore and unpack the work of Grime music producers and performers with a focus on their attitudes, working practices and use of social media. We explore the origins of grime and describe a complex set of interactions between people and technology in order to facilitate the production and dissemination of audio content in an evolving digital climate. We explore how individuals in this space curate and collect content, with a view to reuse in the future. We also explore how grime is evolving and ways in which technology might be able to facilitate many of these processes more effectively. Finally, we explore technological issues that pertain to music production and dissemination in its current state and implications for design for future applications and contexts

Identifying diachronic topic-based research communities by clustering shared research trajectories

Communities of academic authors are usually identified by means of standard community detection algorithms, which exploit ‘static’ relations, such as co-authorship or citation networks. In contrast with these approaches, here we focus on diachronic topic-based communities –i.e., communities of people who appear to work on semantically related topics at the same time. These communities are interesting because their analysis allows us to make sense of the dynamics of the research world –e.g., migration of researchers from one topic to another, new communities being spawn by older ones, communities splitting, merging, ceasing to exist, etc. To this purpose, we are interested in developing clustering methods that are able to handle correctly the dynamic aspects of topic-based community formation, prioritizing the relationship between researchers who appear to follow the same research trajectories. We thus present a novel approach called Temporal Semantic Topic-Based Clustering (TST), which exploits a novel metric for clustering researchers according to their research trajectories, defined as distributions of semantic topics over time. The approach has been evaluated through an empirical study involving 25 experts from the Semantic Web and Human-Computer Interaction areas. The evaluation shows that TST exhibits a performance comparable to the one achieved by human experts

What we do and do not know about the s-process

AGB stars are the source for the main component of the $s$-process. Here we discuss both the properties which are reasonably well known and those which still suffer from substantial uncertainties. In the former case, we are fairly sure that the $s$-process contribution from AGB stars comes from masses between about 1 and 3 \msun, and the dominant neutron source is the $^{13}$C$(\alpha$,n)$^{16}$O reaction. In the latter category remains the formation mechanism for the $^{13}$C-pocket. Attempts at including rotation seem to inhibit neutron capture reactions. Explaining the observations seems to require a spread in the size of the $^{13}$C-pocket so some stochastic process, such as rotation, must be involved.Comment: To be published in Nuclear Physics A; Invited Review for "Nuclei in the Cosmos VIII", Vancouver, July 200

A hybrid semantic approach to building dynamic maps of research communities

In the last ten years, ontology-based recommender systems have been shown to be effective tools for predicting user preferences and suggesting items. There are however some issues associated with the ontologies adopted by these approaches, such as: 1) their crafting is not a cheap process, being time consuming and calling for specialist expertise; 2) they may not represent accurately the viewpoint of the targeted user community; 3) they tend to provide rather static models, which fail to keep track of evolving user perspectives. To address these issues, we propose Klink UM, an approach for extracting emergent semantics from user feedbacks, with the aim of tailoring the ontology to the users and improving the recommendations accuracy. Klink UM uses statistical and machine learning techniques for finding hierarchical and similarity relationships between keywords associated with rated items and can be used for: 1) building a conceptual taxonomy from scratch, 2) enriching and correcting an existing ontology, 3) providing a numerical estimate of the intensity of semantic relationships according to the users. The evaluation shows that Klink UM performs well with respect to handcrafted ontologies and can significantly increase the accuracy of suggestions in content-based recommender systems

Magnetic Fields in the Milky Way

This chapter presents a review of observational studies to determine the magnetic field in the Milky Way, both in the disk and in the halo, focused on recent developments and on magnetic fields in the diffuse interstellar medium. I discuss some terminology which is confusingly or inconsistently used and try to summarize current status of our knowledge on magnetic field configurations and strengths in the Milky Way. Although many open questions still exist, more and more conclusions can be drawn on the large-scale and small-scale components of the Galactic magnetic field. The chapter is concluded with a brief outlook to observational projects in the near future.Comment: 22 pages, 5 figures, to appear in "Magnetic Fields in Diffuse Media", eds. E.M. de Gouveia Dal Pino and A. Lazaria