Synthesis of N1-phenethyl substituted indole derivatives as new melatoninergic agonists and antagonists

The potency of new indolic N1-phenethyI substituted melatoninergic ligands with and without methyl groups in the α and β position of the alkanamidoethyl side chain was examined using the pigment aggregation response in a clonal line of Xenopus laevis melanophores. The non 5-OMe substituted compounds, 8a-e, are all weak antagonists while introduction of the 5-OMe group, 9a-e, increases both agonist and antagonist activity except for 9c (R=C 3H7), which is only an agonist and 9e (R=C-C 4H7), which is only an antagonist. Introduction of an α-methyl group into the 5-OMe derivatives, 14a-e, reduces the agonist potency while introduction of a β-methyl group has only a small effect on either the agonist or antagonist potency. Double β-methyl substitution of the 5-OMe derivatives, 20a-e, generally increases the agonist potential (20c, R=C3H7 is the most potent agonist of the compounds described) and decreases the antagonist potency, except for 20a (R=CH 3), which is the most potent antagonist of this series of compounds. © 2002 Pharmaceutical Society of Japan

Serial magnetic resonance imaging of metal-on-metal total hip replacements. Follow-up of a cohort of 28 mm Ultima TPS THRs

Metal artefact reduction (MAR) MRI is now widely considered to be the standard for imaging metal-on-metal (MoM) hip implants. The Medicines and Healthcare Products Regulatory Agency (MHRA) has recommended cross-sectional imaging for all patients with symptomatic MoM bearings. This paper describes the natural history of MoM disease in a 28 mm MoM total hip replacement (THR) using MAR MRI. Inclusion criteria were patients with MoM THRs who had not been revised and had at least two serial MAR MRI scans. All examinations were reported by an experienced observer and classified as A (normal), B (infection) or C1-C3 (mild, moderate, severe MoM-related abnormalities). Between 2002 and 2011 a total of 239 MRIs were performed on 80 patients (two to four scans per THR); 63 initial MRIs (61%) were normal. On subsequent MRIs, six initially normal scans (9.5%) showed progression to a disease state; 15 (15%) of 103 THRs with sequential scans demonstrated worsening disease on subsequent imaging. Most patients with a MoM THR who do not undergo early revision have normal MRI scans. Late progression (from normal to abnormal, or from mild to more severe MoM disease) is not common and takes place over several years

Knowledge on thyroid cancer, attitude and practice on thyroid gland self-examination among women residents of selected barangays in Amadeo, Cavite.

This study used correlational research design utilizing stratified random sampling technique. There are 411 respondents aged 20 years old and above from the two (2) selected barangays from rural and urban part of Amadeo, Cavite. Self-made questionnaire was used to measure the knowledge on thyroid cancer, attitude on and practice of thyroid gland self-examination. The data gathered was statistically treated using ANOVA, Chi-square, frequency, percentage and Spearman Rho coefficient, Based on the .results, 1) most of the respondents are 36 to 55 years old, had no family history of thyroid, reached secondary level and belonged to the poverty level with monthly income of Php10,000 and below; 2) the knowledge of the women respondents when they are grouped according to risk factors, signs and symptoms and their overall knowledge is fair; 3) the attitude of the respondents on thyroid gland self-examination specifically in perceived seriousness, perceived susceptibility, perceived barriers, perceived benefit and confidence were positive except for health motivation which was neutral; 4) most of the respondents do not practice thyroid gland self-examination; 5) the knowledge on thyroid cancer of the respondents was the same regardless of their age, educational attainment and monthly family income; 6) the attitude of the respondents towards thyroid gland self-examination is the same regardless of age, educational attainment and monthly family income; 7) the practice of thyroid gland self-examination when the respondents are grouped according to age and monthly family income is the same; 8) there is a significant relationship between knowledge on thyroid cancer and attitude on thyroid self-examination of the respondents; 9) there is a significant relationship between the knowledge on thyroid cancer and practice of thyroid gland self-examination; 10) the respondents’ attitude on thyroid cancer is associated with their practice of thyroid gland self-examination