Serum protein and enzyme levels in rats following administration of antioxidant vitamins during caffeinated and non-caffeinated paracetamol induced hepatotoxicity

The effects of caffeinated and non-caffeinated paracetamol administration, with or without vitamins A and E supplementation on the protein and enzyme levels in Wistar albino rats were investigated using cafeinated paracetamol and paracetamol as caffeinated and non-caffeinated paracetamol respectively, and water soluble acetic acid derivatives of vitamins A and E. Serum AST, ALT and ALP levels (u/l) significantly increased (

Phytochemical Screening Of Activity Directed Extracts A Of Vernonia Amygdalina Leaves

Fractionation of the crude ethanolic extract of vernonia amygdalina using organic solvents of increasing polarities yielded activity directed fractions of benzene, chloroform, ethyl acetate, butanol, methanol and residue E. Phytochemical screening of the fractions show that there were significant differences (p≤0.05) qualitatively in the levels of tannins, flavonoids, cardiac glycosides, terpenoids, saponins and alkaloids in the various fractions. While the benzene extract had very low levels of tannins, saponins and alkaloids, the ethyl acetate fraction had low levels of tannins and terpenoids as well as very low levels of flavonoids, cardiac glycosides, and alkaloids. The butanol fraction had a high level of tannins, low level of flavonoids and saponins while the methanol fraction had high levels of tannins and flavonoids as well as low levels of cardiac glycosides, saponins and alkaloids with a very low level of terpenoids. The water soluble residue E had very high levels of tannins, a high level of saponins, low levels of alkaloids and very low levels of flavonoids, cardiac glycosides and terpenoids. Phytochemical content of the various fractions increased with increasing polarities of the organic solvent used. The relatively high Phytochemical content of the butanol, methanol and residue E fractions may be exploited for medicinal purposes

EFFECT OF ETHANOLIC ROOT AND TWIG EXTRACTS OF VERNONIA AMYGDALINA (ETIDOT) ON LIVER FUNCTION PARAMETERS OF STREPTOZOTOCIN INDUCED HYPERGLYCAEMIC AND NORMAL WISTAR RATS

The effects of various concentrations of ethanolic extracts of Vernonia amygdalina (VA) stem and root on some biochemical indices of liver function in streptozotocin-induced diabetic and non-diabetic rats treated with 200mg/kg b.w and 400mg/kg b.w was determined. LD50 value of 1000 mg/kg was established. The oral administration of the extracts lasted for 28 days. The rats were divided into five parallel groups of non-diabetic and diabetic rats, with six rats in each group. Group 1 received Dimethy sulfoxide(DMSO) and served as the negative control. Group 2 received 200mg/kg b.w Vernonia amygdalina (stem), group 3 received 400mg/kg b.w Vernonia amygdalina (stem). Group 4 received 200mg/kg b.w Vernonia amygdalina (root). Group 5 was given 400mg/kg b.w Vernonia amygdalina (root). Both stem and root extracts (200 and 400) mg/kg b.w significantly improved body weight and reduced whole blood glucose levels to normal but not up to hypoglycaemic level in diabetic treated rats. Total protein and albumin in serum were increased in diabetic rats treated with stem (200 and 400) mg/kg b.w respectively. The findings suggest that V. amygdalina ethanolic stem and root extracts is hepatoprotective in diabetic rats and may be of nutritional/ clinical relevance amongst African populations for treatment of different ailments

Prolactin lowering effect of aligator pepper (aframomum milligueta)

No Abstrac

Comparative chemical composition of leaves of some antidiabetic medicinal plants: Azadirachta indica, Vernonia amygdalina and Gongronema latifolium

No Abstrac