How Infectious Was #Deflategate?

On Monday January 19, 2015 a story broke that the National Football League (NFL) had started an investigation into whether the New England Patriots deliberately deflated the footballs they used during their championship win over the Indianapolis Colts. Like an infectious disease, discussion regarding Deflategate grew rapidly on social media sites in the hours and days after the release of the story. However, after the Super Bowl was over, the scandal slowly began to dissipate and lost much of the attention it had originally had, as interest in the NFL wained at the completion of its season. We construct a simple epidemic model for the infectiousness of the Deflategate news story. We then use data from the social media site Twitter to estimate the parameters of this model using standard techniques from the study of inverse problems. We find that the infectiousness (as measured by the basic reproduction number) of Deflategate rivals that of any infectious disease that we are aware of, and is actually more infectious than recent news stories of greater importance - both in terms of the basic reproduction number and in terms of the average amount of time the average tweeter continued to tweet about the news story.Comment: 12 pages, 4 figure

Biomechanics of normal and anterior cruciate ligament deficient gait under braced and unbraced conditions.

The purposes of this study were to evaluate the running mechanics of normal and anterior cruciate ligament (ACL)-deficient individuals, and to investigate the running mechanics of normal and ACL-deficient individuals while wearing a derotation knee brace. Seven ACL-deficient males and seven uninjured males participated. Subjects were filmed during braced and unbraced straight-line running across a force platform. Selected kinematic and kinetic parameters were calculated to quantify the differences between normal and ACL-deficient individuals, and the effect of bracing the knee. It appears that ACL-deficiency may not alter the running mechanics of well-rehabilitated individuals during a low-risk, non-fatigued running task. Bracing the knee seemed to have no effect on the gait mechanics of normal or ACL-deficient individuals. Future studies may benefit from examining the muscle moments at the occurrence of specific events during the support period. (Abstract shortened by UMI.)Dept. of Kinesiology. Paper copy at Leddy Library: Theses & Major Papers - Basement, West Bldg. / Call Number: Thesis1992 .E337. Source: Masters Abstracts International, Volume: 31-04, page: 1775. Thesis (M.H.K.)--University of Windsor (Canada), 1992

The use of automated refractors in the military

The use of automated refractors in the militar

The effect of forced vergence on heart rate

The effect of forced vergence on heart rat

The impact of significant input of fine sediment on benthic fauna at tributary junctions: a case study of the Bermejo-Paraguay River confluence, Argentina

This study examines the morphological features, suspended sediment inputs and hydraulic conditions within a large river in association with ecological patterns before and after a tributary confluence. In order to examine these effects, the macroinvertebrate distributions from three reaches of the Paraguay and Bermejo Rivers (Paraguay-Argentina) are investigated. The Bermejo River is a tributary that supplies significant quantities of fine sediment to the Paraguay River, primarily in suspension. Two reaches were examined on the Paraguay River, upstream and downstream of the Bermejo River junction, with the third study reach located on the Bermejo River, upstream of the confluence with the Paraguay River. The results provide clear evidence that a significantly increased loading of fine sediment at a river confluence has effects on the distribution and potential movement of benthic invertebrates in the lotic environment by representing physical barriers at affected sites. These effects may be important at both local and regional scales, and such increases in suspended sediment (especially associated with anthropogenic change) may thus pose a major threat to ecosystem integrity that has been historically underestimated

Anomalous seafloor spreading of the Southeast Indian Ridge near the Amsterdam-St. Paul Plateau

The Amsterdam-St. Paul Plateau is bisected by the intermediate-rate spreading Southeast Indian Ridge, and numerous geophysical and tectonic anomalies arise from the interactions of the Amsterdam-St. Paul hotspot and the spreading center. The plate boundary geometry on the hotspot platform evolves rapidly (on timescales <1 Myr), off-axis volcanism is abundant, the seafloor does not deepen away from the axis, and transform faults do not have fracture zone extensions. Away from the hotspot platform the ridge-transform geometry is typical of mid-ocean ridges globally. In contrast, the Amsterdam-St. Paul Plateau spreading segments are shorter, they often overlap each other significantly, and the intervening discontinuities are smaller, more ephemeral, and more migratory. Abyssal hills are smaller and less uniform on the hotspot platform than on neighboring spreading segments. From gravity and isostasy analysis the average thickness of the platform crust is ~10 km, approximately 50% thicker than that of typical oceanic crust. Most of the isostatic compensation of the hotspot plateau occurs at the Moho or within the lower crust, and the effective elastic thickness of the plateau lithosphere is ~1.6 km, less than half that of adjacent spreading segments. Away from the platform some transform faults contain intratransform spreading centers; on the platform two transform faults have valleys which may be depocenters for abundant axial or off-axis volcanism and mass wasting. Although not well-constrained by magnetic coverage the Amsterdam-St. Paul hotspot appears to have been “captured” by the Southeast Indian Ridge, enhancing crustal production at the ridge since about 3.5 Ma. Prior to this time the hotspot formed a line of smaller, isolated volcanoes on older Australian plate. The underlying cause for the present-day crustal accretion anomalies is the effect of melt generation from separate sources of mantle upwelling (due to plate spreading and the hotspot) which has a consequent effect of weakening the lithosphere

Whole genome sequencing for the diagnosis of neurological repeat expansion disorders in the UK: a retrospective diagnostic accuracy and prospective clinical validation study

BACKGROUND: Repeat expansion disorders affect about 1 in 3000 individuals and are clinically heterogeneous diseases caused by expansions of short tandem DNA repeats. Genetic testing is often locus-specific, resulting in underdiagnosis of people who have atypical clinical presentations, especially in paediatric patients without a previous positive family history. Whole genome sequencing is increasingly used as a first-line test for other rare genetic disorders, and we aimed to assess its performance in the diagnosis of patients with neurological repeat expansion disorders. METHODS: We retrospectively assessed the diagnostic accuracy of whole genome sequencing to detect the most common repeat expansion loci associated with neurological outcomes (AR, ATN1, ATXN1, ATXN2, ATXN3, ATXN7, C9orf72, CACNA1A, DMPK, FMR1, FXN, HTT, and TBP) using samples obtained within the National Health Service in England from patients who were suspected of having neurological disorders; previous PCR test results were used as the reference standard. The clinical accuracy of whole genome sequencing to detect repeat expansions was prospectively examined in previously genetically tested and undiagnosed patients recruited in 2013-17 to the 100 000 Genomes Project in the UK, who were suspected of having a genetic neurological disorder (familial or early-onset forms of ataxia, neuropathy, spastic paraplegia, dementia, motor neuron disease, parkinsonian movement disorders, intellectual disability, or neuromuscular disorders). If a repeat expansion call was made using whole genome sequencing, PCR was used to confirm the result. FINDINGS: The diagnostic accuracy of whole genome sequencing to detect repeat expansions was evaluated against 793 PCR tests previously performed within the NHS from 404 patients. Whole genome sequencing correctly classified 215 of 221 expanded alleles and 1316 of 1321 non-expanded alleles, showing 97·3% sensitivity (95% CI 94·2-99·0) and 99·6% specificity (99·1-99·9) across the 13 disease-associated loci when compared with PCR test results. In samples from 11 631 patients in the 100 000 Genomes Project, whole genome sequencing identified 81 repeat expansions, which were also tested by PCR: 68 were confirmed as repeat expansions in the full pathogenic range, 11 were non-pathogenic intermediate expansions or premutations, and two were non-expanded repeats (16% false discovery rate). INTERPRETATION: In our study, whole genome sequencing for the detection of repeat expansions showed high sensitivity and specificity, and it led to identification of neurological repeat expansion disorders in previously undiagnosed patients. These findings support implementation of whole genome sequencing in clinical laboratories for diagnosis of patients who have a neurological presentation consistent with a repeat expansion disorder. FUNDING: Medical Research Council, Department of Health and Social Care, National Health Service England, National Institute for Health Research, and Illumina

Gravitational Waves From Known Pulsars: Results From The Initial Detector Era

We present the results of searches for gravitational waves from a large selection of pulsars using data from the most recent science runs (S6, VSR2 and VSR4) of the initial generation of interferometric gravitational wave detectors LIGO (Laser Interferometric Gravitational-wave Observatory) and Virgo. We do not see evidence for gravitational wave emission from any of the targeted sources but produce upper limits on the emission amplitude. We highlight the results from seven young pulsars with large spin-down luminosities. We reach within a factor of five of the canonical spin-down limit for all seven of these, whilst for the Crab and Vela pulsars we further surpass their spin-down limits. We present new or updated limits for 172 other pulsars (including both young and millisecond pulsars). Now that the detectors are undergoing major upgrades, and, for completeness, we bring together all of the most up-to-date results from all pulsars searched for during the operations of the first-generation LIGO, Virgo and GEO600 detectors. This gives a total of 195 pulsars including the most recent results described in this paper.United States National Science FoundationScience and Technology Facilities Council of the United KingdomMax-Planck-SocietyState of Niedersachsen/GermanyAustralian Research CouncilInternational Science Linkages program of the Commonwealth of AustraliaCouncil of Scientific and Industrial Research of IndiaIstituto Nazionale di Fisica Nucleare of ItalySpanish Ministerio de Economia y CompetitividadConselleria d'Economia Hisenda i Innovacio of the Govern de les Illes BalearsNetherlands Organisation for Scientific ResearchPolish Ministry of Science and Higher EducationFOCUS Programme of Foundation for Polish ScienceRoyal SocietyScottish Funding CouncilScottish Universities Physics AllianceNational Aeronautics and Space AdministrationOTKA of HungaryLyon Institute of Origins (LIO)National Research Foundation of KoreaIndustry CanadaProvince of Ontario through the Ministry of Economic Development and InnovationNational Science and Engineering Research Council CanadaCarnegie TrustLeverhulme TrustDavid and Lucile Packard FoundationResearch CorporationAlfred P. Sloan FoundationAstronom