Evaluation of the IHS tribal management grant program.

There were three principle objectives of this study: 1) determine if the Tribal Management Grant Program (TMGP) is meeting its goals and objectives as stated in The Indian Self-Determination and Education Assistance Act and by the Indian Health Service (IHS) as stated in the TMGP guidelines; 2) identify problems and obstacles faced by the program; and 3) identify possible solutions to program problems. The report defines and prioritizes eligible projects to be funded under the TMGP. Collected data consisted of in-depth interviews with potential tribal management grantees, and IHS staff in IHS Headquarters and Area Offices representatives. It found that the TMGP is meeting its objective of improving the management capacity of tribes to enter into 638 health contracts. The report lists specific findings and provides recommendations including: 1) enhance the grant and contract information system; 2) modify the TMGP funding priority system; 3) improve communication/coordination among IHS Headquarters, Area Offices and TM Grantees; 4) automate the TM grantee tracking system; and 5) assist tribes in obtaining local sources of training and technical assistance. The report also includes specific interview results and an index

A constructive algorithm for the Cartan decomposition of SU(2^N)

We present an explicit numerical method to obtain the Cartan-Khaneja-Glaser decomposition of a general element G of SU(2^N) in terms of its `Cartan' and `non-Cartan' components. This effectively factors G in terms of group elements that belong in SU(2^n) with n<N, a procedure that can be iterated down to n=2. We show that every step reduces to solving the zeros of a matrix polynomial, obtained by truncation of the Baker-Campbell-Hausdorff formula, numerically. All computational tasks involved are straightforward and the overall truncation errors are well under control.Comment: 15 pages, no figures, matlab file at http://cam.qubit.org/users/jiannis

Surface plasmon resonance study of the actin-myosin sarcomeric complex and tubulin dimers

Biosensors based on the principle of surface plasmon resonance (SPR) detection were used to measure biomolecular interactions in sarcomeres and changes of the dielectric constant of tubulin samples with varying concentration. At SPR, photons of laser light efficiently excite surface plasmons propagating along a metal (gold) film. This resonance manifests itself as a sharp minimum in the reflection of the incident laser light and occurs at a characteristic angle. The dependence of the SPR angle on the dielectric permittivity of the sample medium adjacent to the gold film allows the monitoring of molecular interactions at the surface. We present results of measurements of cross-bridge attachment/detachment within intact mouse heart muscle sarcomeres and measurements on bovine tubulin molecules pertinent to cytoskeletal signal transduction models.Comment: Submitted to Journal of Modern Optics *Corresponding author: Andreas Mershin ([email protected]

J-integral analysis: An EDXD and DIC comparative study for a fatigue crack

Synchrotron Energy Dispersive X-ray Diffraction (EDXD) and Digital Image Correlation (DIC) have been applied to map simultaneously the 2D elastic strain and displacement fields of a propagating fatigue crack in the HAZ of a welded Cr2Ni4MoV bainitic steel. The position of the crack tip was tracked via a phase congruency analysis of the displacement field, and also by detection of its cyclic plastic zone. Both types of full field data provided independent inputs to finite element/J-integral analyses that directly quantified the elastic cyclic stress intensity factor range applied to the crack. No knowledge was required of the specimen geometry, crack length or applied loads. The agreement between the two analyses in this controlled study shows that strain mapping by synchrotron EDXD can provide a reliable method to study the crack fields in more complex problems, such as interactions between crack closure, residual stresses and applied loading

Predicted Stellar Kinematics of a Kiloparsec-Scale Nuclear Disc (or Ring) in the Milky Way

In Debattista et al. (2015), we proposed that a kiloparsec-scale nuclear disc is responsi- ble for the high-velocity secondary peak in the stellar line-of-sight velocity distributions (LOSVDs) seen at positive longitudes in the bulge by the Apache Point Observatory Galactic Evolution Experiment (APOGEE). Here, we make further qualitative but distinctive predictions of the kinematic properties of a nuclear disc, including for the LOSVDs at negative longitudes (which APOGEE-2 will observe) and examine the proper motions throughout the disc. Since a nuclear ring is also able to produce similar high-velocity LOSVD peaks, we present predictions for the proper motion signatures which distinguish between a nuclear disc and a nuclear ring. We also demonstrate that the stars in a nuclear disc, which would be on x2 orbits perpendicular to the bar, can remain on these orbits for a long time and can therefore be old. We show that such (old) nuclear discs of comparable size exist in external galaxies

J-integral analysis: an EDXD and DIC comparative study for a fatigue crack

Synchrotron Energy Dispersive X-ray Diffraction (EDXD) and Digital Image Correlation (DIC) have been applied to map simultaneously the 2D elastic strain and displacement fields of a propagating fatigue crack in the HAZ of a welded Cr2Ni4MoV bainitic steel. The position of the crack tip was tracked via a phase congruency analysis of the displacement field, and also by detection of its cyclic plastic zone. Both types of full field data provided independent inputs to finite element/J-integral analyses that directly quantified the elastic cyclic stress intensity factor range applied to the crack. No knowledge was required of the specimen geometry, crack length or applied loads. The agreement between the two analyses in this controlled study shows that strain mapping by synchrotron EDXD can provide a reliable method to study the crack fields in more complex problems, such as interactions between crack closure, residual stresses and applied loading

A fusion peptide in the spike protein of MERS coronavirus

Coronaviruses represent current and emerging threats for many species, including humans. Middle East respiratory syndrome-related coronavirus (MERS-CoV) is responsible for sporadic infections in mostly Middle Eastern countries, with occasional transfer elsewhere. A key step in the MERS-CoV replication cycle is the fusion of the virus and host cell membranes mediated by the virus spike protein, S. The location of the fusion peptide within the MERS S protein has not been precisely mapped. We used isolated peptides and giant unilamellar vesicles (GUV) to demonstrate membrane binding for a peptide located near the N-terminus of the S2 domain. Key residues required for activity were mapped by amino acid replacement and their relevance in vitro tested by their introduction into recombinant MERS S protein expressed in mammalian cells. Mutations preventing membrane binding in vitro also abolished S-mediated syncytium formation consistent with the identified peptide acting as the fusion peptide for the S protein of MERS-CoV

Care Transitions in Childhood Cancer Survivorship: Providers' Perspectives

Purpose: Most adolescent and young adult (AYA)-aged childhood cancer survivors develop physical and/or psychosocial sequelae; however, many do not receive long-term follow-up (LTF) critical for screening, prevention, and treatment of late effects. To develop a health services research agenda to optimize care models, we conducted qualitative research with LTF providers examining existing models, and successes and challenges in maintaining survivors' connections to care across their transition to adulthood

Resources and users in the tagging process: approaches and case studies

In this contribution we propose a comparison between two distinct approaches to the annotation of digital resources. The former, top-down, is rooted in the cathedral model and is based on an authoritative, centralized definition of the adopted mark-up language; the latter, bottom-up, refers to the bazaar model and is based on the contributions of a community of users. These two approaches are analyzed taking into account both their descriptive potential and the constraints they impose on the reasoning process of recommender systems, with special reference to user profiling. Three case studies are described, with reference to research projects that apply these approaches in the contexts of e-learning and knowledge management