A kiloparsec-scale nuclear stellar disk in the milky way as a possible explanation of the high velocity peaks in the galactic bulge

The Apache Point Observatory Galactic Evolution Experiment has measured the stellar velocities of red giant stars in the inner Milky Way. We confirm that the line of sight velocity distributions (LOSVDs) in the mid-plane exhibit a second peak at high velocities, whereas those at | b| =2^\circ do not. We use a high resolution simulation of a barred galaxy, which crucially includes gas and star formation, to guide our interpretation of the LOSVDs. We show that the data are fully consistent with the presence of a thin, rapidly rotating, nuclear disk extending to ∼1 kpc. This nuclear disk is orientated perpendicular to the bar and is likely to be composed of stars on x2 orbits. The gas in the simulation is able to fall onto such orbits, leading to stars populating an orthogonal disk

J-integral analysis: An EDXD and DIC comparative study for a fatigue crack

Synchrotron Energy Dispersive X-ray Diffraction (EDXD) and Digital Image Correlation (DIC) have been applied to map simultaneously the 2D elastic strain and displacement fields of a propagating fatigue crack in the HAZ of a welded Cr2Ni4MoV bainitic steel. The position of the crack tip was tracked via a phase congruency analysis of the displacement field, and also by detection of its cyclic plastic zone. Both types of full field data provided independent inputs to finite element/J-integral analyses that directly quantified the elastic cyclic stress intensity factor range applied to the crack. No knowledge was required of the specimen geometry, crack length or applied loads. The agreement between the two analyses in this controlled study shows that strain mapping by synchrotron EDXD can provide a reliable method to study the crack fields in more complex problems, such as interactions between crack closure, residual stresses and applied loading

Predicted Stellar Kinematics of a Kiloparsec-Scale Nuclear Disc (or Ring) in the Milky Way

In Debattista et al. (2015), we proposed that a kiloparsec-scale nuclear disc is responsi- ble for the high-velocity secondary peak in the stellar line-of-sight velocity distributions (LOSVDs) seen at positive longitudes in the bulge by the Apache Point Observatory Galactic Evolution Experiment (APOGEE). Here, we make further qualitative but distinctive predictions of the kinematic properties of a nuclear disc, including for the LOSVDs at negative longitudes (which APOGEE-2 will observe) and examine the proper motions throughout the disc. Since a nuclear ring is also able to produce similar high-velocity LOSVD peaks, we present predictions for the proper motion signatures which distinguish between a nuclear disc and a nuclear ring. We also demonstrate that the stars in a nuclear disc, which would be on x2 orbits perpendicular to the bar, can remain on these orbits for a long time and can therefore be old. We show that such (old) nuclear discs of comparable size exist in external galaxies

J-integral analysis: an EDXD and DIC comparative study for a fatigue crack

Synchrotron Energy Dispersive X-ray Diffraction (EDXD) and Digital Image Correlation (DIC) have been applied to map simultaneously the 2D elastic strain and displacement fields of a propagating fatigue crack in the HAZ of a welded Cr2Ni4MoV bainitic steel. The position of the crack tip was tracked via a phase congruency analysis of the displacement field, and also by detection of its cyclic plastic zone. Both types of full field data provided independent inputs to finite element/J-integral analyses that directly quantified the elastic cyclic stress intensity factor range applied to the crack. No knowledge was required of the specimen geometry, crack length or applied loads. The agreement between the two analyses in this controlled study shows that strain mapping by synchrotron EDXD can provide a reliable method to study the crack fields in more complex problems, such as interactions between crack closure, residual stresses and applied loading

The tilting rate of the Milky Way's disc

We present tilting rates for galaxies comparable to the Milky Way (MW) in a Λ cold dark matter cosmological hydrodynamical simulation, and compare these with the predicted tilting rate detection limit of the Gaia satellite 0.28° Gyr−1. We first identify galaxies with mass comparable to the MW (9 × 1011 ≤ M200 ≤ 1.2 × 1012 M⊙) and consider the tilting rates between z = 0.3 and 0. This sample yields a tilting rate of 7.6° ± 4.5° Gyr−1. We constrain our sample further to exclude any galaxies that have high stellar accretion during the same time. We still find significant tilting, with an average rate of 6.3° Gyr−1. Both subsamples tilt with rates significantly above Gaia's predicted detection limit. We show that our sample of galaxies covers a wide range of environments, including some similar to the MW's. We find galaxies in denser regions tilt with higher rates then galaxies in less dense regions. We also find correlations between the angular misalignment of the hot gas corona and the tilting rate. Gaia is likely to be able to directly measure tilting in the MW. Such a detection will provide an important constraint on the environment of the MW, including the rate of gas cooling on to the disc, the shape and orientation of its dark matter halo, and the mass of the Large Magellanic Cloud. Conversely, failure to detect tilting may suggest the MW is in a very quiet configuration

On a simple quartic family of Thue equations over imaginary quadratic number fields

Let $t$ be any imaginary quadratic integer with $|t|\geq 100$. We prove that the inequality $$|F_t(X,Y)| = | X^4 - t X^3 Y - 6 X^2 Y^2 + t X Y^3 + Y^4 | \leq 1$$ has only trivial solutions $(x,y)$ in integers of the same imaginary quadratic number field as $t$. Moreover, we prove results on the inequalities $|F_t(X,Y)| \leq C|t|$ and $|F_t(X,Y)| \leq |t|^{2 -\varepsilon}$. These results follow from an approximation result that is based on the hypergeometric method. The proofs in this paper require a fair amount of computations, for which the code (in Sage) is provided.Comment: 27 page

Proposal of a Selection Protocol for Replication of Studies in Sports and Exercise Science

To improve the rigor of science, experimental evidence for scientific claims ideally needs to be replicated repeatedly with comparable analyses and new data to increase the collective confidence in the veracity of those claims. Large replication projects in psychology and cancer biology have evaluated the replicability of their fields but no collaborative effort has been undertaken in sports and exercise science. We propose to undertake such an effort here. As this is the first large replication project in this field, there is no agreed-upon protocol for selecting studies to replicate. Criticism of previous selection protocols include claims they were non-randomised and non-representative. Any selection protocol in sports and exercise science must be representative to provide an accurate estimate of replicability of the field. Our aim is to produce a protocol for selecting studies to replicate for inclusion in a large replication project in sports and exercise science

An SH2 Domain-dependent, Phosphotyrosine-independent Interaction between Vav1 and the Mer Receptor Tyrosine Kinase: A MECHANISM FOR LOCALIZING GUANINE NUCLEOTIDE-EXCHANGE FACTOR ACTION

Mer belongs to the Mer/Axl/Tyro3 receptor tyrosine kinase family, which regulates immune homeostasis in part by triggering monocyte ingestion of apoptotic cells. Mutations in Mer can also cause retinitis pigmentosa, again due to defective phagocytosis of apoptotic material. Although, some functional aspects of Mer have been deciphered, how receptor activation lead to the physiological consequences is not understood. By using yeast two-hybrid assays, we identified the carboxyl-terminal region of the guanine nucleotide-exchange factor (GEF) Vav1 as a Mer-binding partner. Unlike similar (related) receptors, Mer interacted with Vav1 constitutively and independently of phosphotyrosine, yet the site of binding localized to the Vav1 SH2 domain. Mer activation resulted in tyrosine phosphorylation of Vav1 and release from Mer, whereas Vav1 was neither phosphorylated nor released from kinase-dead Mer. Mutation of the Vav1 SH2 domain phosphotyrosine coordinating Arg-696 did not alter Mer/Vav1 constitutive binding or Vav1 tyrosine phosphorylation but did retard Vav1 release from autophosphorylated Mer. Ligand-dependent activation of Mer in human monocytes led to Vav1 release and stimulated GDP replacement by GTP on RhoA family members. This unusual constitutive, SH2 domain-dependent, but phosphotyrosine-independent, interaction and its regulated local release and subsequent activation of Rac1, Cdc42, and RhoA may explain how Mer coordinates precise cytoskeletal changes governing the ingestion of apoptotic material by macrophages and pigmented retinal epithelial cells

The formation of stellar nuclear discs in bar-induced gas inflows

The role of gas in the mass assembly at the nuclei of galaxies is still subject to some uncertainty. Stellar nuclear discs bridge the gap between the large-scale galaxy and the central massive objects that reside there. Using a high-resolution simulation of a galaxy forming out of gas cooling and settling into a disc, we study the formation and properties of nuclear discs. Gas, driven to the centre by a bar, settles into a rotating star-forming nuclear disc (ND). This ND is thinner, younger, kinematically cooler and more metal rich than the surrounding bar. The ND is elliptical and orthogonal to the bar. The complex kinematics in the region of the ND are a result of the superposition of older stars streaming along the bar and younger stars circulating within the ND. The signature of the ND is therefore subtle in the kinematics. Instead the ND stands out clearly in metallicity and age maps. We compare the model to the density and kinematics of real galaxies with NDs finding qualitative similarities. Our results suggest that gas dissipation is very important for forming nuclear structure

Does self-monitoring reduce blood pressure? Meta-analysis with meta-regression of randomized controlled trials

Introduction. Self-monitoring of blood pressure (BP) is an increasingly common part of hypertension management. The objectives of this systematic review were to evaluate the systolic and diastolic BP reduction, and achievement of target BP, associated with self-monitoring. Methods. MEDLINE, Embase, Cochrane database of systematic reviews, database of abstracts of clinical effectiveness, the health technology assessment database, the NHS economic evaluation database, and the TRIP database were searched for studies where the intervention included self-monitoring of BP and the outcome was change in office/ambulatory BP or proportion with controlled BP. Two reviewers independently extracted data. Meta-analysis using a random effects model was combined with meta-regression to investigate heterogeneity in effect sizes. Results. A total of 25 eligible randomized controlled trials (RCTs) (27 comparisons) were identified. Office systolic BP (20 RCTs, 21 comparisons, 5,898 patients) and diastolic BP (23 RCTs, 25 comparisons, 6,038 patients) were significantly reduced in those who self-monitored compared to usual care (weighted mean difference (WMD) systolic −3.82 mmHg (95% confidence interval −5.61 to −2.03), diastolic −1.45 mmHg (−1.95 to −0.94)). Self-monitoring increased the chance of meeting office BP targets (12 RCTs, 13 comparisons, 2,260 patients, relative risk = 1.09 (1.02 to 1.16)). There was significant heterogeneity between studies for all three comparisons, which could be partially accounted for by the use of additional co-interventions. Conclusion. Self-monitoring reduces blood pressure by a small but significant amount. Meta-regression could only account for part of the observed heterogeneity