306 research outputs found

    Comparison of input devices in an ISEE direct timbre manipulation task

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    The representation and manipulation of sound within multimedia systems is an important and currently under-researched area. The paper gives an overview of the authors' work on the direct manipulation of audio information, and describes a solution based upon the navigation of four-dimensional scaled timbre spaces. Three hardware input devices were experimentally evaluated for use in a timbre space navigation task: the Apple Standard Mouse, Gravis Advanced Mousestick II joystick (absolute and relative) and the Nintendo Power Glove. Results show that the usability of these devices significantly affected the efficacy of the system, and that conventional low-cost, low-dimensional devices provided better performance than the low-cost, multidimensional dataglove

    Development of a transport model for East Kowloon, Hong Kong

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    After the relocation of the airport, much land-use change and redevelopment is expected in the East Kowloon District in the city of Hong Kong. Consequently, a comprehensive review of the land-use and transportation plans for the district was required. In the study, a sub-regional transport model for the district was developed. This model was used to forecast the vehicular, public transport and pedestrian demands arising from land-use and transportation system changes in and around the district. This paper describes the modelling approach and validation results. | After the relocation of the airport, much land-use change and redevelopment is expected in the East Kowloon District in the city of Hong Kong. Consequently, a comprehensive review of the land-use and transportation plans for the district was required. In the study, a sub-regional transport model for the district was developed. This model was used to forecast the vehicular, public transport and pedestrian demands arising from land-use and transportation system changes in and around the district. This paper describes the modelling approach and validation results.published_or_final_versio

    Studies of Sup35p : a yeast prion protein

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    [P S f] is a protein-based heritable phenotype of the yeast Saccharomyces cerevisiae that reflects the prion-like properties of the chromosome-encoded protein Sup35p. This protein is known to be an essential eukaryote polypeptide release factor, namely eRF3. In a /P S f] strain, the prion conformer of Sup35p exists predominantly as large oligomers, which results in the intracellular depletion of functional release factor (i.e. eRF3) and hence inefficient translation termination. Intriguingly, the prion conformer of Sup35p can be eliminated from [PSI+] strains by growth in the presence of the protein denaturant guanidine hydrochloride (GuHCl). Strains are ‘cured’ of [P S f] by millimolar concentrations of GuFICl, well below that normally required for protein denaturation. It was shown that the kinetics of GuHCl-induced curing fit a segregational model, whereby the heritable [P S f ] determinant is diluted from a culture following the total inhibition of prion replication. A hypothesis for the mechanism of curing is proposed namely that the guanidinium cation inhibits an arginine-modifying enzyme, whose action is required for the post-translational modification of Sup35p and ultimately [P S f] maintenance. The [P S f] determinant does not elicit a disease state in yeast, rather it was shown to confer a selective phenotypic advantage namely enhanced stress tolerance. Moreover, it was demonstrated that the efficiency of translation termination is regulated by environmental stress through a prion-mediated mechanism. This study has addressed the relationship between Sup35p, [PSP] and stress proteins of S.cerevisiae and revealed that prion proteins are not simply pathogenic misshapen proteins and that they may serve as a novel means to regulate many cellular processes in fungi

    Levinas, Durkheim, and the Everyday Ethics of Education

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    This article explores the influence of Émile Durkheim on the philosophy of Emmanuel Levinas in order both to open up the political significance of Levinas’s thought and to develop more expansive meanings of moral and political community within education. Education was a central preoccupation for both thinkers: Durkheim saw secular education as the site for promoting the values of organic solidarity, while Levinas was throughout his professional life engaged in debates on Jewish education and conceptualized ethical subjectivity as a condition of being taught. Durkheim has been accused of dissolving the moral into the social, and his view of education as a means of imparting a sense of civic republican values is sometimes seen as conservative, while Levinas’s argument for an ‘unfounded foundation’ for morality is sometimes seen as paralyzing the impetus for concrete political action. Against these interpretations, I argue that their approaches present provocative challenges for conceptualizing the nature of the social, offering theoretical resources to deepen understanding of education as the site of an everyday ethics and a prophetic politics opening onto more compelling ideals for education than those dominant within standard educational discourses
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