Proportionate Risk-Based Approach to Groundwater Quality Sustainability in the Nigerian Niger Delta

The vulnerability of groundwater was assessed with the aim of evaluating how susceptible groundwater resources were to pollution from various unsafe acts in the study area. Therefore, fourteen (14) VES were taken using Schlumberger electrodes configuration and the field data was modelled using Res2DINV to obtain the final geolayer parameters. This was used to compute the longitudinal conductance (S) for the overburdens in the studied area; the values for the longitudinal conductance obtained were less than one (1) for the entire subsurface investigated. This suggested that groundwater resources in the studied area are vulnerable to pollution hazards. Because of   the large area of the groundwater resources exposed to pollution hazards from unsafe conditions, the study area was designated safeguards zone. The risk based approach towards protecting the designated area is the enforcement of good land use practices, controlling of high risk activities as well as drilling of monitoring wells especially within VES 10 - VES 14. Keywords: Unsafe act, Groundwater, Safeguard zone, Vulnerability, Unsafe conditions and Risk

Nitric oxide and proteoglycan biosynthesis by human articular chondrocytes in alginate culture

AbstractInterleukin-1α and β induced the production of large amounts of nitric oxide by normal, human articular chondrocytes in alginate culture; at the same time the biosynthesis of proteoglycan was strongly suppressed. In a dose-dependent manner, NG-monomethyl-l-arginine both inhibited nitric oxide formation and relieved the suppression of proteoglycan synthesis. However concentrations of NG-monomethyl-l-arginine which completely prevented nitric oxide production only partially restored proteoglycan biosynthesis, even at low doses of interleukin-1 where suppression of proteoglycan synthesis was modest. The organic donor of nitric oxide, S-nitrosyl-acetyl-d,l- penicillamine also inhibited proteoglycan biosynthesis, but not as extensively as interleukin-1. These data suggest that interleukin-1 suppresses synthesis of the cartilaginous matrix through more than one mechanism, at least one of which is dependent upon the production of nitric oxide

On the approach to the critical solution in leading order thin-film coating and rimming flow

The approach to the critical solution in leading order coating and rimming flow of a thin fluid film on a uniformly rotating horizontal cylinder is investigated. In particular, it is shown that the weight of the leading order 'full film' solution approaches its critical maximum value with logarithmically infinite slope as the volume flux approaches its critical value

Planar gunn diode characterisation and resonators elements to realise oscillator circuits

The paper describes the planar Gunn diode, which is well suited to providing milli-metric and tera hertz sources using microwave monolithic integrated circuit (MMIC) technologies. Different planar Gunn electrode geometries are described along with DC, RF and thermal characterisation. To realize the planar high frequency sources there is requirement for high frequency planar resonators, the paper will describe both the radial and new diamond shaped geometries

Trends in HIV testing and recording of HIV status in the UK primary care setting: a retrospective cohort study 1995-2005

Objectives: To provide nationally representative data on trends in HIV testing in primary care and to estimate the proportion of diagnosed HIV positive individuals known to general practitioners (GPs). Methods: We undertook a retrospective cohort study between 1995 and 2005 of all general practices contributing data to the UK General Practice Research Database (GPRD), and data on persons accessing HIV care (Survey of Prevalent HIV Infections Diagnosed). We identified all practice-registered patients where an HIV test or HIV positive status is recorded in their general practice records. HIV testing in primary care and prevalence of recorded HIV positive status in primary care were estimated. Results: Despite 11-fold increases in male testing and 19-fold increases in non-pregnant female testing between 1995 and 2005, HIV testing rates remained low in 2005 at 71.3 and 61.2 tests per 100 000 person years for males and females, respectively, peaking at 162.5 and 173.8 per 100 000 person years at 25–34 years of age. Inclusion of antenatal tests yielded a 129-fold increase in women over the 10-year period. In 2005, 50.7% of HIV positive individuals had their diagnosis recorded with a lower proportion in London (41.8%) than outside the capital (60.1%). Conclusion: HIV testing rates in primary care remain low. Normalisation of HIV testing and recording in primary care in antenatal testing has not been accompanied by a step change in wider HIV testing practice. Recording of HIV positive status by GPs remains low and GPs may be unaware of HIV-related morbidity or potential drug interactions

ARQ-197, a small-molecule inhibitor of c-Met, reduces tumour burden and prevents myeloma-induced bone disease in vivo

The receptor tyrosine kinase c-Met, its ligand HGF, and components of the downstream signalling pathway, have all been implicated in the pathogenesis of myeloma, both as modulators of plasma cell proliferation and as agents driving osteoclast differentiation and osteoblast inhibition thus, all these contribute substantially to the bone destruction typically caused by myeloma. Patients with elevated levels of HGF have a poor prognosis, therefore, targeting these entities in such patients may be of substantial benefit. We hypothesized that ARQ-197 (Tivantinib), a small molecule c-Met inhibitor, would reduce myeloma cell growth and prevent myeloma-associated bone disease in a murine model. In vitro we assessed the effects of ARQ-197 on myeloma cell proliferation, cytotoxicity and c-Met protein expression in human myeloma cell lines. In vivo we injected NOD/SCID-γ mice with PBS (non-tumour bearing) or JJN3 cells and treated them with either ARQ-197 or vehicle. In vitro exposure of JJN3, U266 or NCI-H929 cells to ARQ-197 resulted in a significant inhibition of cell proliferation and an induction of cell death by necrosis, probably caused by significantly reduced levels of phosphorylated c-Met. In vivo ARQ-197 treatment of JJN3 tumour-bearing mice resulted in a significant reduction in tumour burden, tumour cell proliferation, bone lesion number, trabecular bone loss and prevented significant decreases in the bone formation rate on the cortico-endosteal bone surface compared to the vehicle group. However, no significant differences on bone parameters were observed in non-tumour mice treated with ARQ-197 compared to vehicle, implying that in tumour-bearing mice the effects of ARQ-197 on bone cells was indirect. In summary, these res ults suggest that ARQ-197 could be a promising therapeutic in myeloma patients, leading to both a reduction in tumour burden and an inhibition of myeloma-induced bone disease

Social Network and Sentiment Analysis of the #Nutrition Discourse on Twitter

Social media platforms allow people to share information, connect, and build networks at an unprecedented scale with positive and negative consequences. Social network analysis (SNA) applies mathematical network and graph theory to visualise information transfer as relational networks of connected nodes. Measuring node connectivity (centrality) permits the identification of ‘influencers’. SNA has been applied to analyse the spread of misinformation on Twitter (1), but to date, no research has examined nutrition networks. Therefore, this study examined the #Nutrition conversations on Twitter utilising SNA and linguistic analyses. English language tweets including ‘#Nutrition’ on 1–21 March 2023 were collected using the SNA tool, NodeXL Pro (Network Overview for Discovery and Exploration in Excel) (2). SNA is a multistep process that calculates graph metrics and develops a network graph to measure the relationships between users. SNA also identifies semantically related words, hashtags, and word pairs and identifies the sentiment of words used, as measured against the Opinion Lexicon (2). The #Nutrition network included 17,129 vertices (users) with 26,809 unique edges (connections); edges with duplicates were merged. The network density was low, suggesting that most users communicate heavily with a small number of users. The average geodesic distance between any two users was 5.26, revealing a dispersed online discussion. SNA identified the top 10 influencers in this network, measured by high betweenness centrality (23,375,543–5,207,998). Influential users were from a mix of accounts including personal, online blogs, and government organisations. High betweenness centrality identified the users with the greatest influence, acting as bridges between network groups and therefore amplifying #Nutrition messages. Sentiment analysis found the discourse was more positive (0.047, 22,218 words) than negative (0.015, 6795 words). Semantic analysis calculated the total words, 468,191, and identified the most frequently used words in the tweets: #nutrition, #health, food, more, nutrition, health, #diet, #healthylifestlye, #fitness, and #food. Social network analysis shows the discourse on Twitter relating to #Nutrition is dispersed without clear polarising views. Semantic analysis showed that ‘health’ was the main topic discussed in relation to nutrition in this network and was most frequently associated with #Nutrition. The narrative was positively framed, as identified through sentiment analysis

Development and manufacture of printable next-generation gel polymer ionic liquid electrolyte for Zn/MnO\u3csub\u3e2\u3c/sub\u3e batteries

While much energy storage research focuses on the performance of individual components, such as the electrolyte or a single electrode, few investigate the electrochemical system as a whole. This research reports on the design, composition, and performance of a Zn/MnO2 battery as affected by the manufacturing method and next-generation gel polymer electrolyte composed of the ionic liquid [BMIM][Otf], ZnOtf salt, and PVDF-HFP polymer binder. Materials and manufacturing tests are discussed with a focus on water concentration, surface features as produced by printing processes, and the effect of including a gel polymer phase. Cells produced for this research generated open circuit voltages from 1.0 to 1.3 V. A dry [BMIM][Otf] electrolyte was found to have 87.3 ppm of H2O, while an electrolyte produced in ambient conditions contained 12400 ppm of H2O. Cells produced in a dry, Ar environment had an average discharge capacity of 0.0137 mAh/cm2, while one produced in an ambient environment exhibited a discharge capacity at 0.05 mAh/cm2. Surface features varied significantly by printing method, where a doctor blade produced the most consistent features. The preliminary results herein suggest that water, surface roughness, and the gel polymer play important roles in affecting the performance of printed energy storage

Nerve growth factor improves the muscle regeneration capacity of muscle stem cells in dystrophic muscle.

Researchers have attempted to use gene- and cell-based therapies to restore dystrophin and alleviate the muscle weakness that results from Duchenne muscular dystrophy (DMD). Our research group has isolated populations of muscle-derived stem cells (MDSCs) from the postnatal skeletal muscle of mice. In comparison with satellite cells, MDSCs display an improved transplantation capacity in dystrophic mdx muscle that we attribute to their ability to undergo long-term proliferation, self-renewal, and multipotent differentiation, including differentiation toward endothelial and neuronal lineages. Here we tested whether the use of nerve growth factor (NGF) improves the transplantation efficiency of MDSCs. We used two methods of in vitro NGF stimulation: retroviral transduction of MDSCs with a CL-NGF vector and direct stimulation of MDSCs with NGF protein. Neither method of NGF treatment changed the marker profile or proliferation behavior of the MDSCs, but direct stimulation with NGF protein significantly reduced the in vitro differentiation ability of the cells. NGF stimulation also significantly enhanced the engraftment efficiency of MDSCs transplanted within the dystrophic muscle of mdx mice, resulting in the regeneration of numerous dystrophin-positive muscle fibers. These findings highlight the importance of NGF as a modulatory molecule, the study of which will broaden our understanding of its biologic role in the regeneration and repair of skeletal muscle by musclederived cells

First order phase transition with a logarithmic singularity in a model with absorbing states

Recently, Lipowski [cond-mat/0002378] investigated a stochastic lattice model which exhibits a discontinuous transition from an active phase into infinitely many absorbing states. Since the transition is accompanied by an apparent power-law singularity, it was conjectured that the model may combine features of first- and second-order phase transitions. In the present work it is shown that this singularity emerges as an artifact of the definition of the model in terms of products. Instead of a power law, we find a logarithmic singularity at the transition. Moreover, we generalize the model in such a way that the second-order phase transition becomes accessible. As expected, this transition belongs to the universality class of directed percolation.Comment: revtex, 4 pages, 5 eps figure