69 research outputs found

    Feeding Disorders In Childhood Autism

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    Influence of helicity on scaling regimes in the extended Kraichnan model

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    We have investigated the advection of a passive scalar quantity by incompressible helical turbulent flow in the frame of extended Kraichnan model. Turbulent fluctuations of velocity field are assumed to have the Gaussian statistics with zero mean and defined noise with finite time-correlation. Actual calculations have been done up to two-loop approximation in the frame of field-theoretic renormalization group approach. It turned out that space parity violation (helicity) of turbulent environment does not affect anomalous scaling which is peculiar attribute of corresponding model without helicity. However, stability of asymptotic regimes, where anomalous scaling takes place, strongly depends on the amount of helicity. Moreover, helicity gives rise to the turbulent diffusivity, which has been calculated in one-loop approximation.Comment: 16 pages, talk given by M. Hnatich at "Renormalization Group 2005", Helsinki, Finland 30 August - 3 September 2005. To apear in J. Phys. A: Math. Ge

    Hysteresis phenomenon in turbulent convection

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    Coherent large-scale circulations of turbulent thermal convection in air have been studied experimentally in a rectangular box heated from below and cooled from above using Particle Image Velocimetry. The hysteresis phenomenon in turbulent convection was found by varying the temperature difference between the bottom and the top walls of the chamber (the Rayleigh number was changed within the range of 10710810^7 - 10^8). The hysteresis loop comprises the one-cell and two-cells flow patterns while the aspect ratio is kept constant (A=22.23A=2 - 2.23). We found that the change of the sign of the degree of the anisotropy of turbulence was accompanied by the change of the flow pattern. The developed theory of coherent structures in turbulent convection (Elperin et al. 2002; 2005) is in agreement with the experimental observations. The observed coherent structures are superimposed on a small-scale turbulent convection. The redistribution of the turbulent heat flux plays a crucial role in the formation of coherent large-scale circulations in turbulent convection.Comment: 10 pages, 9 figures, REVTEX4, Experiments in Fluids, 2006, in pres

    Effect of large-scale coherent structures on turbulent convection

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    We study an effect of large-scale coherent structures on global properties of turbulent convection in laboratory experiments in air flow in a rectangular chamber with aspect ratios A2A \approx 2 and A4A\approx 4 (with the Rayleigh numbers varying in the range from 5×1065 \times 10^6 to 10810^8). The large-scale coherent structures comprise the one-cell and two-cell flow patterns. We found that a main contribution to the turbulence kinetic energy production in turbulent convection with large-scale coherent structures is due to the non-uniform large-scale motions. Turbulence in large Rayleigh number convection with coherent structures is produced by shear, rather than by buoyancy. We determined the scalings of global parameters (e.g., the production and dissipation of turbulent kinetic energy, the turbulent velocity and integral turbulent scale, the large-scale shear, etc.) of turbulent convection versus the temperature difference between the bottom and the top walls of the chamber. These scalings are in an agreement with our theoretical predictions. We demonstrated that the degree of inhomogeneity of the turbulent convection with large-scale coherent structures is small.Comment: 10 pages, 12 figures, REVTEX

    Formation of Large-Scale Semi-Organized Structures in Turbulent Convection

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    A new mean-field theory of turbulent convection is developed. This theory predicts the convective wind instability in a shear-free turbulent convection which causes formation of large-scale semi-organized fluid motions in the form of cells or rolls. Spatial characteristics of these motions, such as the minimum size of the growing perturbations and the size of perturbations with the maximum growth rate, are determined. This study predicts also the existence of the convective shear instability in a sheared turbulent convection which results in generation of convective shear waves with a nonzero hydrodynamic helicity. Increase of shear promotes excitation of the convective shear instability. Applications of the obtained results to the atmospheric turbulent convection and the laboratory experiments on turbulent convection are discussed. This theory can be applied also for the describing a mesogranular turbulent convection in astrophysics.Comment: 16 pages, 10 figures, REVTEX4, PHYSICAL REVIEW E, v. 67, in press (2003

    Sialylation of MUC4β N-glycans by ST6GAL1 orchestrates human airway epithelial cell differentiation associated with type-2 inflammation

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    Although type-2-induced (T2-induced) epithelial dysfunction is likely to profoundly alter epithelial differentiation and repair in asthma, the mechanisms for these effects are poorly understood. A role for specific mucins, heavily N-glycosylated epithelial glycoproteins, in orchestrating epithelial cell fate in response to T2 stimuli has not previously been investigated. Levels of a sialylated MUC4 beta isoform were found to be increased in airway specimens from asthmatic patients in association with T2 inflammation. We hypothesized that IL-13 would increase sialylation of MUC4 beta, thereby altering its function and that the beta-galactoside alpha-2,6-sialyltransferase 1 (ST6GAL1) would regulate the sialylation. Using human biologic specimens and cultured primary human airway epithelial cells (HAECs), we demonstrated that IL-13 increases ST6GAL1-mediated sialylation of MUC4 beta and that both were increased in asthma, particularly in sputum supernatant and/or fresh isolated HAECs with elevated T2 biomarkers. ST6GAL1-induced sialylation of MUC4 beta altered its lectin binding and secretion. Both ST6GAL1 and MUC4 beta inhibited epithelial cell proliferation while promoting goblet cell differentiation. These in vivo and in vitro data provide strong evidence for a critical role for ST6GAL1-induced sialylation of MUC4 beta in epithelial dysfunction associated with T2-high asthma, thereby identifying specific sialylation pathways as potential targets in asthma.NIH [R01 HL069174]; National Heart, Lung, and Blood Institute [R01 HL064937, R01 HL069116, P01 HL103453, R01 HL69167, U01 HL109086, U10 HL109152, R21 AI122071]; National Institute of Allergy and Infectious Diseases [P01 AI106684]; Nikon A1 [NIH 1S10OD019973-01]This item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at [email protected]

    Subjectivity 2.0 : digital technologies, participatory media and communicative capitalism

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    Drawing on observations and focus group material from pervasive drama project, The Memory Dealer, this article explores both the dynamics and the limitations of existing models of digital subjectivity. It interrogates, in particular, constructions of the digital subject within critical internet studies, focusing on the work of Jodi Dean. This model of subjectivity argues that participatory digital media are a conduit through which the subject is ‘captured’ and shaped to suit the needs of capital. It is suggested here, however, that framing subjective engagements with technology as inevitably being relations of capture, is dangerous in foreclosing scope for resistance and inter-subjective political action. The article ultimately argues that there is a need to reconceptualise the digital subject away from models of capture and towards a more situated, material analysis of the affordances enabled by subjective entanglements with technology

    Challenges of tracking topical discussion networks online

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    Attempts to map online networks, representing relationships between people and sites, have covered sites including Facebook, Twitter, and blogs. However, the predominant approach of static network visualization, treating months of data as a single case rather than depicting changes over time or between topics, remains a flawed process. As different events and themes provoke varying interactions and conversations, it is proposed that case-by-case analysis would aid studies of online social networks by further examining the dynamics of links and information flows. This study uses hyperlink analysis of a population of French political blogs to compare connections between sites from January to August 2009. Themes discussed in this period were identified for subsequent analysis of topic-oriented networks. By comparing static blogrolls with topical citations within posts, this research addresses challenges and methods in mapping online networks, providing new information on temporal aspects of linking behaviors and information flows within these systems
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