1,217 research outputs found
Gate-controlled Guiding of Electrons in Graphene
Ballistic semiconductor structures have allowed the realization of
optics-like phenomena in electronics, including magnetic focusing and lensing.
An extension that appears unique to graphene is to use both n and p carrier
types to create electronic analogs of optical devices having both positive and
negative indices of refraction. Here, we use gate-controlled density with both
p and n carrier types to demonstrate the analog of the fiber-optic guiding in
graphene. Two basic effects are investigated: (1) bipolar p-n junction guiding,
based on the principle of angle-selective transmission though the graphene p-n
interface, and (2) unipolar fiber-optic guiding, using total internal
reflection controlled by carrier density. Modulation of guiding efficiency
through gating is demonstrated and compared to numerical simulations, which
indicates that interface roughness limits guiding performance, with
few-nanometer effective roughness extracted. The development of p-n and
fiber-optic guiding in graphene may lead to electrically reconfigurable wiring
in high-mobility devices.Comment: supplementary materal at
http://marcuslab.harvard.edu/papers/OG_SI.pd
Spectral Line-by-Line Pulse Shaping of an On-Chip Microresonator Frequency Comb
We report, for the first time to the best of our knowledge, spectral phase
characterization and line-by-line pulse shaping of an optical frequency comb
generated by nonlinear wave mixing in a microring resonator. Through
programmable pulse shaping the comb is compressed into a train of
near-transform-limited pulses of \approx 300 fs duration (intensity full width
half maximum) at 595 GHz repetition rate. An additional, simple example of
optical arbitrary waveform generation is presented. The ability to characterize
and then stably compress the frequency comb provides new data on the stability
of the spectral phase and suggests that random relative frequency shifts due to
uncorrelated variations of frequency dependent phase are at or below the 100
microHertz level.Comment: 18 pages, 4 figure
Comparative chromosome painting discloses homologous Segments in distantly related mammals
Comparative chromosome painting, termed ZOO-FISH, using DNA libraries from flow
sorted human chromosomes 1,16,17 and X, and mouse chromosome 11 discloses the
presence of syntenic groups in distantly related mammalian Orders ranging from
primates (Homo sapiens), rodents (Mus musculus), even-toed ungulates (Muntiacus
muntjak vaginalis and Muntiacus reevesi) and whales (Balaenoptera physalus). These
mammalian Orders have evolved separately for 55-80 million years (Myr). We conclude
that ZOO-FISH can be used to generate comparative chromosome maps of a large
number of mammalian species
Translational selection on SHH genes
Codon usage bias has been observed in various organisms. In this study, the correlation between SHH genes expression in some tissues and codon usage features was analyzed by bioinformatics. We found that translational selection may act on compositional features of this set of genes
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Projected WIMP sensitivity of the LUX-ZEPLIN dark matter experiment
LUX-ZEPLIN (LZ) is a next-generation dark matter direct detection experiment that will operate 4850 feet underground at the Sanford Underground Research Facility (SURF) in Lead, South Dakota, USA. Using a two-phase xenon detector with an active mass of 7 tonnes, LZ will search primarily for low-energy interactions with weakly interacting massive particles (WIMPs), which are hypothesized to make up the dark matter in our galactic halo. In this paper, the projected WIMP sensitivity of LZ is presented based on the latest background estimates and simulations of the detector. For a 1000 live day run using a 5.6-tonne fiducial mass, LZ is projected to exclude at 90% confidence level spin-independent WIMP-nucleon cross sections above 1.4×10-48 cm2 for a 40 GeV/c2 mass WIMP. Additionally, a 5σ discovery potential is projected, reaching cross sections below the exclusion limits of recent experiments. For spin-dependent WIMP-neutron(-proton) scattering, a sensitivity of 2.3×10-43 cm2 (7.1×10-42 cm2) for a 40 GeV/c2 mass WIMP is expected. With underground installation well underway, LZ is on track for commissioning at SURF in 2020
Simulations of events for the LUX-ZEPLIN (LZ) dark matter experiment
The LUX-ZEPLIN dark matter search aims to achieve a sensitivity to the WIMP-nucleon spin-independent cross-section down to (1–2)×10−12 pb at a WIMP mass of 40 GeV/c2. This paper describes the simulations framework that, along with radioactivity measurements, was used to support this projection, and also to provide mock data for validating reconstruction and analysis software. Of particular note are the event generators, which allow us to model the background radiation, and the detector response physics used in the production of raw signals, which can be converted into digitized waveforms similar to data from the operational detector. Inclusion of the detector response allows us to process simulated data using the same analysis routines as developed to process the experimental data
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Projected sensitivity of the LUX-ZEPLIN experiment to the 0νββ decay of Xe 136
The LUX-ZEPLIN (LZ) experiment will enable a neutrinoless double β decay search in parallel to the main science goal of discovering dark matter particle interactions. We report the expected LZ sensitivity to Xe136 neutrinoless double β decay, taking advantage of the significant (>600 kg) Xe136 mass contained within the active volume of LZ without isotopic enrichment. After 1000 live-days, the median exclusion sensitivity to the half-life of Xe136 is projected to be 1.06×1026 years (90% confidence level), similar to existing constraints. We also report the expected sensitivity of a possible subsequent dedicated exposure using 90% enrichment with Xe136 at 1.06×1027 years
Determining the neurotransmitter concentration profile at active synapses
Establishing the temporal and concentration profiles of neurotransmitters during synaptic release is an essential step towards understanding the basic properties of inter-neuronal communication in the central nervous system. A variety of ingenious attempts has been made to gain insights into this process, but the general inaccessibility of central synapses, intrinsic limitations of the techniques used, and natural variety of different synaptic environments have hindered a comprehensive description of this fundamental phenomenon. Here, we describe a number of experimental and theoretical findings that has been instrumental for advancing our knowledge of various features of neurotransmitter release, as well as newly developed tools that could overcome some limits of traditional pharmacological approaches and bring new impetus to the description of the complex mechanisms of synaptic transmission
Corporate constructed and dissent enabling public spheres: differentiating dissensual from consensual corporate social responsibility
I here distinguish dissensual from consensual corporate social responsibility (CSR) on the grounds that the former is more concerned to organize (or portray) corporate-civil society disagreement than it is corporate-civil society agreement. In doing so, I first conceive of consensual CSR, and identify a positive and negative view thereof. Second, I conceive of dissensual CSR, and suggest that it can be actualized through the construction of dissent enabling, rather than consent-oriented, public spheres. Following this, I describe four actor-centred institutional theories-i.e. a sociological, ethical, transformative and economic perspective, respectively-and suggest that an economic perspective is generally well suited to explaining CSR activities at the organizational level. Accordingly, I then use the economic perspective to analyse a dissent enabling public sphere that Shell has constructed, and within which Greenpeace participated. In particular, I explain Shell's employment of dissensual CSR in terms of their core business interests; and identify some potential implications thereof for Shell, Greenpeace, and society more generally. In concluding, I highlight a number of ways in which the present paper can inform future research on business and society interactions
Mice lacking the Cβ subunit of PKA are resistant to angiotensin II-induced cardiac hypertrophy and dysfunction
<p>Abstract</p> <p>Background</p> <p>PKA is a ubiquitous, multi-subunit cellular kinase that regulates a number of different physiological responses in response to cAMP, including metabolism, cell division, and cardiac function. Numerous studies have implicated altered PKA signaling in cardiac dysfunction. Recently, it has been shown that mice lacking the catalytic β subunit of PKA (PKA Cβ) are protected from age-related problems such as weight gain and enlarged livers, and we hypothesized that these mice might also be resistant to cardiomyopathy.</p> <p>Findings</p> <p>Angiotensin II (ang II) induced hypertension in both PKA Cβ null mice and their WT littermates. However, PKA Cβ null mice were resistant to a number of ang II-induced, cardiopathological effects observed in the WT mice, including hypertrophy, decreased diastolic performance, and enlarged left atria.</p> <p>Conclusion</p> <p>The Cβ subunit of PKA plays an important role in angiotensin-induced cardiac dysfunction. The Cβ null mouse highlights the potential of the PKA Cβ subunit as a pharmaceutical target for hypertrophic cardiac disease.</p
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