Volcano Popocatepetl, Mexico: ULF geomagnetic anomalies observed at Tlamacas station during March?July, 2005

International audienceIn this paper the first results of ULF (Ultra Low Frequency) geomagnetic anomalies observed at Tlamacas station (Long. 261.37, Lat. 19.07) located at 4 km near the volcano Popocatepetl (active volcano, Long. 261.37, Lat. 19.02) for the period March?July, 2005 and their analysis are presented. The geomagnetic data were collected with a 3-axial fluxgate magnetometer designed at UCLA (University of California, Los Angeles, 1 Hz sampling rate frequency, GPS). Our analysis reveals some anomalies which are suspected to be generated by local volcanic origin: the EM background in the vicinity of the volcano is significantly noisier than in other reference stations; the sporadic strong noise-like geomagnetic activity observed in the H-component; locally generated geomagnetic pulsations (without preferred polarization) are detected only at Tlamacas station

Geomagnetic anomalies observed at volcano Popocatepetl, Mexico

International audienceResults of the ULF geomagnetic monitoring of the volcano Popocatepetl (Mexico) and their analysis are summarized and presented for the period 2003?2006. Our analysis reveals some anomalies which are considered to be of local volcanic origin: the EM background in the vicinity of the volcano was found to be significantly noisier than at other reference stations; sporadic strong noise-like geomagnetic activity was observed in the H-component; some geomagnetic pulsations were observed only at the Tlamacas station (located at 4 km near the volcano). The results are discussed in terms of a physical mechanism involving the presence of a second magmatic chamber within the volcano and, finally, further perspective directions to study volcanic geodynamical processes besides the traditional ones are given

Clinical consequences of BRCA2 hypomorphism

Altres ajuts: Asociación Española contra el Cáncer (LABAE16020PORTT)Altres ajuts: Asociación Española contra el Cáncer (ERAPERMED2019-215)The tumor suppressor FANCD1/BRCA2 is crucial for DNA homologous recombination repair (HRR). BRCA2 biallelic pathogenic variants result in a severe form of Fanconi anemia (FA) syndrome, whereas monoallelic pathogenic variants cause mainly hereditary breast and ovarian cancer predisposition. For decades, the co-occurrence in trans with a clearly pathogenic variant led to assume that the other allele was benign. However, here we show a patient with biallelic BRCA2 (c.1813dup and c.7796 A > G) diagnosed at age 33 with FA after a hypertoxic reaction to chemotherapy during breast cancer treatment. After DNA damage, patient cells displayed intermediate chromosome fragility, reduced survival, cell cycle defects, and significantly decreased RAD51 foci formation. With a newly developed cell-based flow cytometric assay, we measured single BRCA2 allele contributions to HRR, and found that expression of the missense allele in a BRCA2 KO cellular background partially recovered HRR activity. Our data suggest that a hypomorphic BRCA2 allele retaining 37-54% of normal HRR function can prevent FA clinical phenotype, but not the early onset of breast cancer and severe hypersensitivity to chemotherapy

Volviéndonos mejores: necesidad de acción inmediata ante el reto de la obesidad. Una postura de profesionales de la salud.

La creciente epidemia de obesidad ha sido uno de los retos más importantes de salud pública en México durante los últimos años. Con apoyo de la Federación Mundial de Obesidad, en 2021 formamos un grupo de profesionales para identificar y resumir las acciones prioritarias en las que puede enfocarse nuestro país para hacer frente a esta epidemia. Al proceso de desarrollo y discusión de este grupo se sumaron más de 1 000 profesionales de la salud para retomar recomendaciones de documentos y guías de alto nivel previamente publicados. En conmemoración del Día Mundial de la Obesidad, en este 2022 se presenta esta postura como insumo para el desarrollo de acciones en el ámbito profesional y de los diferentes sectores, en la que se incluyen 10 recomendaciones de acción, desde la perspectiva poblacional hasta la atención individualizada, y se enfatiza en la importancia de la participación social, de las intervenciones integrales con visión centrada en la persona y de la sostenibilidad planetaria, además de mejorar la educación y las campañas de difusión, propiciar un ambiente promotor de entornos activos y blindar de conflictos de interés los esfuerzos de prevención y control. La postura hace un llamado para abordar la obesidad de manera seria, con base en la evidencia científica, oportuna e integral, con enfoque de curso de vida, de forma ética y sensible, y sin perpetuar las barreras del estigma de peso en la sociedad

Solar Irradiation Evaluation through GIS Analysis Based on Grid Resolution and a Mathematical Model: A Case Study in Northeast Mexico

The estimation of the solar resource on certain surfaces of the planet is a key factor in deciding where to establish solar energy collection systems. This research uses a mathematical model based on easy-access geographic and meteorological information to calculate total solar radiation at ground surface. This information is used to create a GIS analysis of the State of Nuevo León in Mexico and identify solar energy opportunities in the territory. The analyzed area was divided into a grid and the coordinates of each corner are used to feed the mathematical model. The obtained results were validated with statistical analyses and satellite-based estimations from the National Aeronautics and Space Administration (NASA). The applied approach and the results may be replicated to estimate solar radiation in other regions of the planet without requiring readings from on-site meteorological stations and therefore reducing the cost of decision-making regarding where to place the solar energy collection equipment