Prenatal exposures and exposomics of asthma

This review examines the causal investigation of preclinical development of childhood asthma using exposomic tools. We examine the current state of knowledge regarding early-life exposure to non-biogenic indoor air pollution and the developmental modulation of the immune system. We examine how metabolomics technologies could aid not only in the biomarker identification of a particular asthma phenotype, but also the mechanisms underlying the immunopathologic process. Within such a framework, we propose alternate components of exposomic investigation of asthma in which, the exposome represents a reiterative investigative process of targeted biomarker identification, validation through computational systems biology and physical sampling of environmental medi

Analytical lenses on barriers in the governance of climate change adaptation

Barriers to adaptation have become an important concept in scientific and political discussions in the governance of climate change adaptation. Over the past years, these discussions have been dominated by one analytical lens in examining barriers and proposing ways to overcome them: the problem solving lens. In this paper, we aim to demonstrate theoretically and empirically that the choice of analytical lens influences how barriers to adaptation are constructed and the intervention strategies proposed. Drawing from recent governance literature, we explore the rationale of three dominant philosophies in the study of governance: the optimist, the realist, and the pessimist philosophy. Next, we demonstrate how these philosophies are operationalized and guide scientific inquiry on barriers to adaptation through four empirically rooted analytical lenses: i) governance as problem solving, ii) governance as competing values and interests, iii) governance as institutional interaction, and iv) governance as dealing with structural constraints. We investigate the Dutch government’s Spatial Adaptation to Climate Change programme through each of the four lenses. We discuss how each analytical lens frames barriers in a specific way, identifies different causes of barriers, leads to competing interpretations of key events, and presents other types of interventions to overcome barriers. We conclude that it is necessary to increase analytical variety in order to critically engage in theoretical debates about barriers and to empower policy practitioners in their search for successful intervention strategies to implement adaptation measure

Ecosystem services from smallholder forestry and agroforestry in the tropics

Smallholder forestry and agroforestry systems in the tropics provide essential products and services for millions of producers, their surrounding communities, national and international consumers, and global society. The diversity of products provided by these systems meet the needs of smallholder producers for fuelwood, food, animal fodder, and other household and farm needs; they provide additional income to supplement major commodity crops; and they offer flexibility in production and income to buffer against falling commodity prices, crop failure, or other sources of financial or economic difficulty. The sustainability of these systems is increasingly dependent upon sources of income beyond the sale of conventional products, such as price premiums from sustainability certification and agro- and ecotourism. Payments for ecosystem services (PES) programs have been developed at multiple levels to provide incentives for smallholders to conserve and enhance tree cover and management practices to provide ecosystem services such as watershed protection and carbon sequestration. Ecotourism provides an enterprise-based strategy to engage producers in conservation and enhancement of these services. This review evaluates the ability of smallholder systems to support the provision of ecosystem services (ES) and the capacity of smallholders to participate in support programs and take advantage of other emerging opportunities to support smallholder enterprises