OPN/CD44v6 overexpression in laryngeal dysplasia and correlation with clinical outcome

Laryngeal dysplasia is a common clinical concern. Despite major advancements, a significant number of patients with this condition progress to invasive squamous cell carcinoma. Osteopontin (OPN) is a secreted glycoprotein, whose expression is markedly elevated in several types of cancers. We explored OPN as a candidate biomarker for laryngeal dysplasia. To this aim, we examined OPN expression in 82 cases of dysplasia and in hyperplastic and normal tissue samples. OPN expression was elevated in all severe dysplasia samples, but not hyperplastic samples, with respect to matched normal mucosa. OPN expression levels correlated positively with degree of dysplasia (P=0.0094) and negatively with disease-free survival (P<0.0001). OPN expression was paralleled by cell surface reactivity for CD44v6, an OPN functional receptor. CD44v6 expression correlated negatively with disease-free survival, as well (P=0.0007). Taken as a whole, our finding identify OPN and CD44v6 as predictive markers of recurrence or aggressiveness in laryngeal intraepithelial neoplasia, and overall, point out an important signalling complex in the evolution of laryngeal dysplasia

Varieties of Non-ordinary Experiences in Brazil—a Critical Review of the Contribution of Studies of ‘Religious Experience’ to the Study of Religion

According to the latest national census, 64.6% of Brazilians identified themselves as Roman Catholic. However, the census has little or nothing to do with actual practice or belief. Professing to be a Christian (within any confessional specification) is still part of being Brazilian. But the self-identification does not take into account that religiosity is expressed in very diverse ways nor does it prevent people from believing and practising one of the many Brazilian traditions though identifying themselves as Christian in the census. This perception represents the framework of the following discussion of non-ordinary experiences in Brazil, whether they are perceived as religious, spiritual or ‘just’ extraordinary. This article presents an overview of studies about non-ordinary experiences in Brazil. The aim is to show the importance of these experiences for the understanding of the religious landscape of Brazil

Esperança de vida ao nascer: impacto das variações na mortalidade por idade e causas de morte no Município de Campinas, São Paulo, Brasil Life expectancy at birth: impact of variation in mortality by age group and cause of death in Campinas, São Paulo State, Brazil

O objetivo do estudo foi examinar o impacto das mudanças na mortalidade por idades e causas de morte sobre o aumento da esperança de vida ao nascer no Município de Campinas, São Paulo, Brasil, entre 1991, 2000 e 2005. Foram construídas tábuas de vida. O método de Pollard foi aplicado para estimar as contribuições das idades e causas de morte na variação da longevidade. O grupo etário de 0-1 ano foi o que mais contribuiu com o aumento da vida média masculina (31,1%) e feminina (22,9%) em 1991/2000. Entre 2000 e 2005, as idades de 15-44 anos responderam por 79% do ganho masculino. A maior contribuição entre 1991 e 2000 foi gerada pelas doenças cardiovasculares (66,1% entre os homens e 43,5% entre as mulheres). As causas externas subtraíram 1,1 ano entre os homens. Entre 2000 e 2005, com a queda da mortalidade por estas causas, a esperança de vida masculina aumentou em 2,3 anos. As neoplasias provocaram redução de 0,11 ano para homens e 0,15 ano para mulheres. Estes resultados podem auxiliar na orientação de políticas públicas de saúde para redução da mortalidade e aumento da esperança de vida ao nascer.<br>This study investigated the impact of variation in mortality by age group and cause of death on gains in life expectancy at birth in the city of Campinas, São Paulo State, Brazil, in 1991, 2000, and 2005. Life tables were constructed. Pollard's method was used to estimate the contributions by age group and cause of death on gains in life expectancy. In 1991-2000, the age group that most contributed was 0-1 year (31.1% for males and 22.9% for females). In 2000-2005, 79% of the gain for males was the result of mortality improvements in the 15-44-year bracket. Cardiovascular diseases made the largest contribution in 1991-2000 (66.1% for males and 43.5% for females). A loss in longevity was seen in men (1.1 year) resulting from increased mortality from external causes. In 2000-2005, the substantial gain (2.3 year) in male life expectancy was due to a reduction in mortality from external causes. Neoplasms had a negative effect on the gain (0.11 year for males and 0.15 for females). These findings should help support public health policies to reduce mortality risks and increase life expectancy