Charophyta, Chlorophyta y Cryptophyta del embalse Riogrande II (Antioquia), Colombia

In monthly samples collected from August 2011 to August 2012 in the Riogrande II reservoir (Grande River drainage, Antioquia, Colombia). 29 genera, 48 species and one taxonomic variety belonging to Charophyta, Chlorophyta and Cryptophyta were identified. 18 species and one variety are new reports to the algal flora of Colombia. Chlorophyta was the Division with the largest number of genera and Staurastrum (Charophyta) the most diverse genus and also the largest contributer to biomass. Differences from the characteristics described in the literature and those observed in the specimens studied, made some taxonomic identification rather difficult, pointing out the need for careful and meticulous morphological studies before reaching taxonomical identifications.En muestras recolectadas mensualmente, entre agosto de 2011 y agosto de 2012, en el embalse Riogrande II(cuenca del río Grande, Antioquia, Colombia), se identificaron en total 29 géneros, 48 especies y una variedadtaxonómica, pertenecientes a Charophyta, Chlorophyta y Cryptophyta. De las 48 especies, 18 especies y unavariedad, son nuevos reportes para la ficoflórula colombiana. La división con mayor número de géneros fueChlorophyta, sin embargo, Staurastrum (Charophyta) fue el género más diverso y de mayor contribución a labiomasa. Las diferencias entre las características descritas en la literatura y las observadas en los ejemplares,dificultaron la determinación taxonómica, lo cual plantea la necesidad de realizar estudios morfológicosdetallados

Charophyta, Chlorophyta y Cryptophyta del embalse Riogrande II (Antioquia), Colombia

En muestras recolectadas mensualmente, entre agosto de 2011 y agosto de 2012, en el embalse Riogrande II (cuenca del río Grande, Antioquia, Colombia), se identificaron en total 29 géneros, 48 especies y una variedad taxonómica, pertenecientes a Charophyta, Chlorophyta y Cryptophyta. De las 48 especies, 18 especies y una variedad, son nuevos reportes para la ficoflórula colombiana. La división con mayor número de géneros fue Chlorophyta, sin embargo, Staurastrum (Charophyta) fue el género más diverso y de mayor contribución a la biomasa. Las diferencias entre las características descritas en la literatura y las observadas en los ejemplares, dificultaron la determinación taxonómica, lo cual plantea la necesidad de realizar estudios morfológicos detallados

Clinical features and outcomes of 134 Brazilians with acute promyelocytic leukemia who received ATRA and anthracyclines

We report an increased incidence of high relapse risk features in 157 APL Brazilian patients. Out of 134 patients treated with ATRA and anthracyclines, only 91 (67.9%) achieved remission because 43 (32%) died during induction. the death rate during consolidation was 10.5%. Bleeding complications were the most frequent cause of failure (21.6%).Med Sch Riberao Preto, Dept Internal Med, Ribeirao Preto, BrazilHosp Amaral Carvalho, Bone Marrow Transplantat Unit, Jau, BrazilUniv Fed Minas Gerais, Hematol Serv, Belo Horizonte, MG, BrazilSanta Casa São Paulo, Hematol Serv, São Paulo, BrazilFundacao Pio XII Barretos, Barretos, BrazilClin Hematol Riberao Preto, Ribeirao Preto, BrazilUniversidade Federal de São Paulo, Dept Hematol & Hemotherapy, São Paulo, BrazilUniv Estadual Campinas, Hemoctr, Campinas, BrazilSt Jude Childrens Hosp, Internal Outreach Program, Memphis, TN USAUniversidade Federal de São Paulo, Dept Hematol & Hemotherapy, São Paulo, BrazilWeb of Scienc

Cross-cultural adaptation of the City Birth Trauma Scale for the Brazilian context

Background: Posttraumatic stress disorder consists of a set of symptoms that occurs in response to one or more traumatic events and can occur in postpartum, from traumatic situations related to the birth or to the baby’s health in the first days of life. It is important tracking the presence of birth trauma, but there is not available instruments in the Brazilian context for this purpose. Objectives: To present the cross-cultural adaptation of City Birth Trauma Scale (BiTS) into Brazilian portuguese. Methods: Cross-cultural adaptation involved independent translations, synthesis,back-translation, and submission to the original author’s appreciation. After the scale was subjected to face validity, followed by a pilot study with postpartum mothers. Results: All steps were performed for the cross-cultural adaptation. Regarding face validity, items evaluated concerning different types of equivalence, presented satisfactory agreement values (≥4.20). Most of the expert’s suggestions were followed, being the main ones related to adjustments in prepositions, pronouns and verbal subjects. Pilot study showed that the mothers had been able to understand and respond to the instrument without adjustments. Discussion: BiTS’s Brazilian version proved to be cross-culturally adapted, ensuring the possibility of intercultural data comparison from the semantic, idiomatic, cultural, and conceptual perspectives. New studies are being conducted to attest its psychometric adequac

The clinical use of circulating tumor cells (CTCs) enumeration for staging of metastatic breast cancer (MBC): International expert consensus paper

BACKGROUND: The heterogeneity of metastatic breast cancer (MBC) necessitates novel biomarkers allowing stratification of patients for treatment selection and drug development. We propose to use the prognostic utility of circulating tumor cells (CTCs) for stratification of patients with stage IV disease. METHODS: In a retrospective, pooled analysis of individual patient data from 18 cohorts, including 2436 MBC patients, a CTC threshold of 5 cells per 7.5\u2009ml was used for stratification based on molecular subtypes, disease location, and prior treatments. Patients with 65 5 CTCs were classified as Stage IVaggressive, those with < 5 CTCs as Stage IVindolent. Survival was analyzed using Kaplan-Meier curves and the log rank test. RESULTS: For all patients, Stage IVindolent patients had longer median overall survival than those with Stage IVaggressive (36.3 months vs. 16.0 months, P\u2009<\u20090.0001) and similarly for de novo MBC patients (41.4 months Stage IVindolent vs. 18.7 months Stage IVaggressive, p\u2009<\u20090.0001). Moreover, patients with Stage IVindolent disease had significantly longer overall survival across all disease subtypes compared to the aggressive cohort: hormone receptor-positive (44 months vs. 17.3 months, P\u2009<\u20090.0001), HER2-positive (36.7 months vs. 20.4 months, P\u2009<\u20090.0001), and triple negative (23.8 months vs. 9.0 months, P\u2009<\u20090.0001). Similar results were obtained regardless of prior treatment or disease location. CONCLUSIONS: We confirm the identification of two subgroups of MBC, Stage IVindolent and Stage IVaggressive, independent of clinical and molecular variables. Thus, CTC count should be considered an important tool for staging of advanced disease and for disease stratification in prospective clinical trials