Predicting success in graduate entry medical students undertaking a graduate entry medical program (GEM)

Background: Success in undergraduate medical courses in the UK can be predicted by school exit examination (A level) grades. There are no documented predictors of success in UK graduate entry medicine (GEM) courses. This study looks at the examination performance of GEM students to identify factors which may predict success; of particular interest was A level score. Methods: Data was collected for students graduating in 2004, 2005 and 2006, including demographic details (age and gender), details of previous academic achievement (A level total score and prior degree) and examination results at several points during the degree course. Results: Study group comprised 285 students. Statistical analyses identified no significant variables when looking at clinical examinations. Analysis of pass/fail data for written examinations showed no relationship with A level score. However, both percentage data for the final written examination and the analysis of the award of honours showed A level scores of AAB or higher were associated with better performance (p < 0.001). Discussion: A prime objective of introducing GEM programs was to diversify admissions to medical school. In trying to achieve this, medical schools have changed selection criteria. The findings in this study justify this by proving that A level score was not associated with success in either clinical examinations or passing written examinations. Despite this, very high achievements at A level do predict high achievement during medical school. Conclusions: This study shows that selecting graduate medical students with the basic requirement of an upper-second class honours degree is justifiable and does not disadvantage students who may not have achieved high scores in school leaver examinations

A Community Ice Sheet Model for Sea Level Prediction

Summary of a workshop that was held at Los Alamos National Laboratory, New Mexico, 18-20 August 2008, whose primary goal was to create a detailed plan for developing, testing, and implementing a Community Ice Sheet Model (CISM) to aid in predicting sea level rise

End-tidal and arterial carbon dioxide gradient in serious traumatic brain injury after prehospital emergency anaesthesia: a retrospective observational study.

OBJECTIVES: In the UK, 20% of patients with severe traumatic brain injury (TBI) receive prehospital emergency anaesthesia (PHEA). Current guidance recommends an end-tidal carbon dioxide (ETCO2) of 4.0-4.5 kPa (30.0-33.8 mm Hg) to achieve a low-normal arterial partial pressure of CO2 (PaCO2), and reduce secondary brain injury. This recommendation assumes a 0.5 kPa (3.8 mm Hg) ETCO2-PaCO2 gradient. However, the gradient in the acute phase of TBI is unknown. The primary aim was to report the ETCO2-PaCO2 gradient of TBI patients at hospital arrival. METHODS: A retrospective cohort study of adult patients with serious TBI, who received a PHEA by a prehospital critical care team in the East of England between 1 April 2015 and 31 December 2017. Linear regression was performed to test for correlation and reported as R-squared (R2). A Bland-Altman plot was used to test for paired ETCO2 and PaCO2 agreement and reported with 95% CI. ETCO2-PaCO2 gradient data were compared with a two-tailed, unpaired, t-test. RESULTS: 107 patients were eligible for inclusion. Sixty-seven patients did not receive a PaCO2 sample within 30 min of hospital arrival and were therefore excluded. Forty patients had complete data and were included in the final analysis; per protocol. The mean ETCO2-PaCO2 gradient was 1.7 (±1.0) kPa (12.8 mm Hg), with moderate correlation (R2=0.23, p=0.002). The Bland-Altman bias was 1.7 (95% CI 1.4 to 2.0) kPa with upper and lower limits of agreement of 3.6 (95% CI 3.0 to 4.1) kPa and -0.2 (95% CI -0.8 to 0.3) kPa, respectively. There was no evidence of a larger gradient in more severe TBI (p=0.29). There was no significant gradient correlation in patients with a coexisting serious thoracic injury (R2=0.13, p=0.10), and this cohort had a larger ETCO2-PaCO2 gradient, 2.0 (±1.1) kPa (15.1 mm Hg), p=0.01. Patients who underwent prehospital arterial blood sampling had an arrival PaCO2 of 4.7 (±0.2) kPa (35.1 mm Hg). CONCLUSION: There is only moderate correlation of ETCO2 and PaCO2 at hospital arrival in patients with serious TBI. The mean ETCO2-PaCO2 gradient was 1.7 (±1.0) kPa (12.8 mm Hg). Lower ETCO2 targets than previously recommended may be safe and appropriate, and there may be a role for prehospital PaCO2 measurement

Proceedings of the 42nd Annual Meeting, Southern Soybean Disease Workers (March 11-12, 2015, Pensacola Beach, Florida)

Contents Schedule Southern United States Soybean Disease Loss Estimates for 2014. TW Allen, JP Damicone, NS Dufault, TR Faske, DE Hershman, CA Hollier, T Isakeit, RC Kemerait, NM Kleczewski, SR Koenning, HL Mehl, JD Mueller, C Overstreet, P Price, EJ Sikora, and H Young Graduate student competition (Trey Price, moderator) Effect of Secondary Nutrient Applications on Suppression of Charcoal Rot in Soybean. T Wilkerson, M Tomasu-Peterson, BR Golden, S Lu, AB Johnson, and TW Allen Molecular Characterization of the G143A Mutation Leading to QoI Fungicide Resistance among Fungal Pathogens Causing Cercospora Leaf Blight and Purple Seed Stain of Soybean. S Albu, P Price, V Doyle, and RW Schneider The Effects of Starter Fertilizer on Soybean Infected with Fusarium virguliforme or Rhizoctonia solani. J Miller, C Vick, A Vick, and J Bond Root-knot Nematodes (Meloidogyne spp.) Associated with Soybean in Arkansas. C Khanal, RT Robbins, C Overstreet, and EC McGawley Tillage, Fungicide, and Cultivar Effects on Frogeye Leaf Spot Severity and Yield in Soybean. J Jordan, A Mengistu, HM Kelly, N Bellaloui, PR Arelli, KN Reddy, and AJ Wrather Frogeye Leaf Spot Response to Solo and Combination Fungicides. AM Cochran, HM Kelly, K Lamour, and C Bradley A New Perspective on Cercospora Leaf Blight Symptoms on Soybean. EC Silva, TG Garcia, AV Lygin, AK Chanda, CL Robertson, BM Ward, and RW Schneider Using a Hill Plot Technique for Evaluating Soybean Varieties for Resistance to Sudden Death Syndrome. J Padgett, A Vick, C Vick, C Schmidt, and J Bond Evaluating the Resistance of Some Soybean Varieties/Cultivars on Reniform Isolates from Louisiana. MT Kularathna, C Overstreet, EC McGawley, and DM Xavier Investigating Fungicide Sensitivities Beyond the QoIs in Cercospora sojina from Mississippi. JR Standish, M Tomaso-Peterson, TW Allen, S Sabanadzovic, and N Aboughanem-Sabanadzovic Using Fluopyram as a Seed Treatment to Reduce Sudden Death Syndrome in Resistant and Susceptible Soybean Varieties. D Esker, C Vick, A Vick, and J Bond Glyphosate Affects Cercospora Leaf Blight and Brown Spot of Soybean. TG Garcia, EC Silva, BM Ward, CL Robertson, R Levy, and RW Schneider Efficacy of Seed Treatments for Management of Fusarium virguliforme and Heterodera glycines. N Frederking, A Fakhoury, J Bond Minor Element Application as a Management Strategy for Soybean Rust and Cercospora Leaf Blight. BM Ward, CL Robertson, EC Silva, TG Garcia, and RW Schneider Management of Frogeye Leaf Spot and Determining the Impact of Fungicide Phytotoxicity in Mississippi Soybean. WJ Mansour, JT Irby, BR Golden, TH Wilkerson, and TW Allen Contributed papers (Heather Kelly, moderator) Soybean Disease Management Issues in Louisiana During 2014. P Price, MA Purvis, and HN Pruitt Soybean Vein Necrosis Virus in Mississippi N. Aboughanem-Sabanadzovic, S. Sabanadzovic. TW Allen, WF Moore, and RC Stephenson Monitoring for Soybean Vein Necrosis Virus in Alabama (2014). E Sikora, K Conner, and L Zhang Challenges and Opportunities in the Use of Molecular Tools to Detect Strobilurin/QoI Fungicide Resistance: The Case of Frogeye Leaf Spot. H Kelly and B Vega An Update of Research on Phomopsis Seed Decay in Soybean. S Li, J Rupe, P Chen, G Shannon, and G Sciumbato Assessment of Several Commercially Available Triazole and Premix Fungicides for Management of Frogeye Leaf Spot in Arkansas. TR Faske and M Emerson ILeVO® Seed Treatment for Control of SDS and Nematodes in Soybeans. C Graham Use of Random Point Assignments to Determine the Impact of Sudden Death Syndrome and Other Soilborne Diseases. T Spurlock and W Kirkpatrick Effect of Planting Date, Planting Density, Seed Treatment, and Seed Quality on Soybean Stand and Yield in Arkansas. JC Rupe, AJ Steger, RT Holland, CS Rothrock, EE Gbur, Jr, WJ Ross, and MP Popp Proceedings of the Southern Soybean Disease Workers are published annually by the Southern Soybean Disease Workers. Text, references, figures, and tables are reproduced as they were submitted by authors. The opinions expressed by the participants at this conference are their own and do not necessarily represent those of the Southern Soybean Workers. Mention of a trademark or proprietary products in this publication does not constitute a guaran-tee, warranty, or endorsement of that product by the Southern Soybean Disease Workers

Internal convection in thermoelectric generator models

Coupling between heat and electrical currents is at the heart of thermoelectric processes. From a thermal viewpoint this may be seen as an additional thermal flux linked to the appearance of electrical current in a given thermoelectric system. Since this additional flux is associated to the global displacement of charge carriers in the system, it can be qualified as convective in opposition to the conductive part associated with both phonons transport and heat transport by electrons under open circuit condition, as, e.g., in the Wiedemann-Franz relation. In this article we demonstrate that considering the convective part of the thermal flux allows both new insight into the thermoelectric energy conversion and the derivation of the maximum power condition for generators with realistic thermal coupling.Comment: 8 pages, 3 figure

On Forecasting Conflict in Sudan: 2009-2012

The paper considers univariate and multivariate models to forecast monthly conflict events in the Sudan over the out-of-sample period 2009 – 2012. The models used to generate these forecasts were based on a specification from a machine learning algorithm fit to 2000 – 2008 monthly data. The idea here is that for policy purposes we need models that can forecast conflict events before they occur. The model that includes previous month’s wheat price performs better than a similar model which does not include past wheat prices (the univariate model). Both models did not perform well in forecasting conflict in a neighborhood of the 2012 “Heglig Crisis”. Such a result is generic, as “outlier or unusual events” are hard for models and policy experts to forecast

Enhancing the African bioethics initiative

BACKGROUND: Medical ethics has existed since the time of Hippocrates. However, formal training in bioethics did not become established until a few decades ago. Bioethics has gained a strong foothold in health sciences in the developed world, especially in Europe and North America. The situation is quite different in many developing countries. In most African countries, bioethics – as established and practiced today in the west- is either non-existent or is rudimentary. DISCUSSION: Though bioethics has come of age in the developed and some developing countries, it is still largely "foreign" to most African countries. In some parts of Africa, some bioethics conferences have been held in the past decade to create research ethics awareness and ensure conformity to international guidelines for research with human participants. This idea has arisen in recognition of the genuine need to develop capacity for reviewing the ethics of research in Africa. It is also a condition required by external sponsors of collaborative research in Africa. The awareness and interest that these conferences have aroused need to be further strengthened and extended beyond research ethics to clinical practice. By and large, bioethics education in schools that train doctors and other health care providers is the hook that anchors both research ethics and clinical ethics. SUMMARY: This communication reviews the current situation of bioethics in Africa as it applies to research ethics workshops and proposes that in spite of the present efforts to integrate ethics into biomedical research in Africa, much still needs to be done to accomplish this. A more comprehensive approach to bioethics with an all-inclusive benefit is to incorporate formal ethics education into health training institutions in Africa

Global Cicada Sound Collection I: Recordings from South Africa and Malawi by BW Price and MH Villet and harvesting of BioAcoustica data by GBIF

Sound collections for singing insects provide important repositories that underpin existing research (eg Price et al. 2007 at http://bio. acousti. ca/node/11801; Price et al. 2010) and make bioacoustic collections available for future work, including insect communication (Ordish 1992), systematics (eg David et al. 2003), and automated identification (Bennett et al. 2015). The BioAcoustica platform (Baker et al. 2015) is both a repository and analysis platform for bioacoustic collections: allowing collections to be available in perpetuity, and also facilitating complex analyses using the BioVeL cloud infrastructure (Vicario et al. 2011). The Global Cicada Sound Collection is a project to make recordings of the world's cicadas (Hemiptera: Cicadidae) available using open licences to maximise their potential for study and reuse. This first component of the Global Cicada Sound Collection comprises recordings made between 2006 and 2008 of Cicadidae in South Africa and Malawi

Understanding the dynamics of Toll-like Receptor 5 response to flagellin and its regulation by estradiol

© 2017 The Author(s). Toll-like receptors (TLRs) are major players of the innate immune system. Once activated, they trigger a signalling cascade that leads to NF-ΰ B translocation from the cytoplasm to the nucleus. Single cell analysis shows that NF-ΰ B signalling dynamics are a critical determinant of transcriptional regulation. Moreover, the outcome of innate immune response is also affected by the cross-talk between TLRs and estrogen signalling. Here, we characterized the dynamics of TLR5 signalling, responsible for the recognition of flagellated bacteria, and those changes induced by estradiol in its signalling at the single cell level. TLR5 activation in MCF7 cells induced a single and sustained NF-k B translocation into the nucleus that resulted in high NF-k B transcription activity. The overall magnitude of NF-k B transcription activity was not influenced by the duration of the stimulus. No significant changes are observed in the dynamics of NF-k B translocation to the nucleus when MCF7 cells are incubated with estradiol. However, estradiol significantly decreased NF-k B transcriptional activity while increasing TLR5-mediated AP-1 transcription. The effect of estradiol on transcriptional activity was dependent on the estrogen receptor activated. This fine tuning seems to occur mainly in the nucleus at the transcription level rather than affecting the translocation of the NF-k B transcription factor

Clinical Psychologists’ Firearm Risk Management Perceptions and Practices

The purpose of this study was to investigate the current perceptions and practices of discussing firearm risk management with patients diagnosed with selected mental health problems. A three-wave survey was mailed to a national random sample of clinical psychologists and 339 responded (62%). The majority (78.5%) believed firearm safety issues were greater among those with mental health problems. However, the majority of clinical psychologists did not have a routine system for identifying patients with access to firearms (78.2%). Additionally, the majority (78.8%) reported they did not routinely chart or keep a record of whether patients owned or had access to firearms. About one-half (51.6%) of the clinical psychologists reported they would initiate firearm safety counseling if the patients were assessed as at risk for self-harm or harm to others. Almost half (46%) of clinical psychologists reported not receiving any information on firearm safety issues. Thus, the findings of this study suggest that a more formal role regarding anticipatory guidance on firearms is needed in the professional training of clinical psychologists