Monoclonal Antibodies

Monoclonal antibodies are established in clinical practice for the treatment of cancer, and autoimmune and infectious diseases. The first generation of antibodies has been dominated by classical IgG antibodies, however, in the last decade, the field has advanced, and, nowadays, a large proportion of antibodies in development have been engineered. This Special Issue on "Monoclonal Antibodies" includes original manuscripts and reviews covering various aspects related to the discovery, analytical characterization, manufacturing and development of therapeutic and engineered antibodies

The Ursinus Weekly, January 7, 1952

Students asked to submit roster choices • Twelve outstanding seniors elected as members of college Who\u27s Who • Schedule presented for Ruby pictures • Y news • Alpha Psi Omega greets new members • Music Club concert to be given Thursday • Trip canceled • Sigma Nu, Beta Sig entertain children • I. R. C. hears Rudloff; Ann Knauer to speak • Visual aid lecture listed for future teachers • Forum speaker lists topic for Wednesday night • Navy recruiter plans interviews for seniors • Editorials: There\u27s still time; New Year topic is war • Engagements • Idea for Student Union at Ursinus gets impetus • Delaware favored in court race • PMC downs Bears in league opener • Schedule announced for badminton season • Grapplers open campaign with win over Mules • Pharmacy hands Bears third loss, 70-53https://digitalcommons.ursinus.edu/weekly/1531/thumbnail.jp

The Ursinus Weekly, October 10, 1949

Spirit revives as Bears, Fords deadlock 14-14 in first home game: Pep takes spotlight in rival skirmishes • Stassen to appear at annual program for Founders\u27 Day • Isaacs to consider communism in Asia Wednesday evening • Tumblers add novelty to day • Men\u27s council acts on damage problem • Thespians discard group play system • Radio experts build new, improved set for college station • Y commissions plan for initial meetings • Traffic man helps maids in distress • Sophs plan dance, hayride; Name H. Lintner treasurer • Pre-med group to meet tonight • Lantern seeks new writers to augment present staff • Booster committee reorganizes; Reed accepts eight new members • Editorial: Customs • Moores enjoy college life a la Swiss • Alumni-society notes • Letters to the editor • Vice-president participates in \u2749 education congress • Athletic organization sells socks • Professor receives appointment • Briefs: French Club; Pre-legal society; Chess Club; Future Teachers of America • Harberger wields baton • Coeds make ready for hockey opener • Wieneke installs T.; Pleased with spirit • Ursinus to meet Dickinson in third gridiron clash • Bears tie Fords 14-14 in first home game • Player of the week • Dorm teams start with full program • Booters to launch season on Saturday • Frosh lads rejuvenate customs pandemonium • Rally and dance win merit of enthusiastic students • Women\u27s government names committee representativeshttps://digitalcommons.ursinus.edu/weekly/3128/thumbnail.jp

LACK OF DISTINCTIVE SURFACE ANTIGEN ON CELLS TRANSFORMED BY MURINE SARCOMA VIRUS

Some murine sarcoma virus (MSV)-transformed mouse 3T3 cells contain the MSV genome in the absence of infectious helper murine leukemia virus (MuLV) and MSV production. These cells, designated S+L- (sarcoma positive, leukemia negative), were analyzed for the presence of a possible MSV-determined membrane antigen by the mixed hemadsorption test and in vitro lymphocyte cytotoxicity assay. Two different serological approaches were used: (a) isoantibody-free sera were obtained by immunizing with MSV of syngeneic origin or by allowing primary, autologous MSV sarcomas to regress, or (b) alloantisera obtained by immunizing C57BL mice with S+L- cells were absorbed with the corresponding nontransformed 3T3 cells until all activity against 3T3 had been removed. While MuLV-superinfected S+L- cells and a culture line of an MSV sarcoma known to produce both MSV and MLV were highly reactive, normal 3T3 and S+L- cells were negative. Similarly, lymph node cells from MSV immune mice or rats did not kill S+L- cells, although they were cytotoxic against target cells known to carry MuLV-associated antigens. Thus, the present study gives no positive evidence for the existence of any MSV-induced new surface antigen in the transformed target cell, known to carry the viral genome

Fractional Klein-Kramers equation for superdiffusive transport: normal versus anomalous time evolution in a differential L{\'e}vy walk model

We introduce a fractional Klein-Kramers equation which describes sub-ballistic superdiffusion in phase space in the presence of a space-dependent external force field. This equation defines the differential L{\'e}vy walk model whose solution is shown to be non-negative. In the velocity coordinate, the probability density relaxes in Mittag-Leffler fashion towards the Maxwell distribution whereas in the space coordinate, no stationary solution exists and the temporal evolution of moments exhibits a competition between Brownian and anomalous contributions.Comment: 4 pages, REVTe

The Ursinus Weekly, February 20, 1950

Yearbook to stage Horror, inc. night in week campaign • Fraternities welcome 67 as rushing season ends • Organization join to send assistance for schools abroad • Y chats to discuss U.S. foreign policy; Religion week near • Seniors head cast for Dream waltz , Straus\u27 music show • WAA femmes plan night of minstrelsy, comedy and music • Dean\u27s men capture bitter 110-97 victory over busy b-listers • Thespians to enter Junior miss trials for May production • Dr. White narrates Color Day history; reviews progress of Ursinus women • Women to sponsor Senator Wood here • Miller takes leave for speaking tour • March 14 to close \u2750 pageant contest • Varsity Club men initiate new attendance regulation • Boswell, Chandler to take sides in debate on economic situation • Economics to see twenty-year slump, thanks to Roberts • Tony adds ltalian zest to Ursinus dining fare • Forum speaker urges return to verse, reconciliation of all people with poets • Derrites formulate unique mental law as result of finals • \u2751ers\u27 harmony to vie with college foursomes • Bruins yield 65-49 to league leaders; Forsyth gets honor • Belles down Albright for first win 38-31 • Second loss comes to badminton team • Courtmen divide tilts over busy week-end • Bruin grapplers continue long undefeated record • Jayvees drop two after Delaware win • Garnet gets 38-19 victory over Ursinus tank team • Lassies lose 37-26; rally gives margin to Immaculata gals • Meistersingers group sings in Lebanon and Springfield • March of Dimes receives poor campus total of $27https://digitalcommons.ursinus.edu/weekly/1584/thumbnail.jp

The Ursinus Weekly, October 29, 1951

Sororities bid upperclassmen during week • Lachman named vice-president • Henning Prentis delivers Founders Day Address • Curtain Club reveals leads for Fall play • Y group hears talk; Four at conference • Pianist to perform in Bomberger Hall on November 8 • Frosh give show; Custom period ends • Junior bazaar slated • Ruby takes photos; Tentative dates set • Movie list made up • Editorials: Alumni spirit; And in this corner; Sororities, fraternities do nothing for Ursinus • Donahue, \u2751 alumnus, reports on life among Arabs in French Morocco • Letters to the editor • Jones to read Saki at English meeting • Practice teachers look for professional savoir faire • Optimistic graduates explore world • Garnet hands Ursinus soccer team third defeat by downing locals 10-1 • Ursinus hopes for upset in game with F&M eleven • Temptation of Norma Gorinowski • Soccer team downs alumni • Curtis Hall remains leader in football • Undefeated Owlettes down Ursinus; Locals down Chestnut Hill eleven • Fynan\u27s conversion gives 13-12 win over Wagner • Jr. Bearettes win to stay unbeaten • Ryan to speak at magic showhttps://digitalcommons.ursinus.edu/weekly/1525/thumbnail.jp

The Ursinus Weekly, February 19, 1951

MSGA accepts modifications to Soph rules • Curtain Club to present one-act play, Feb. 27 • Dr. Krishnayya gives Indian position, clarifies Nehru\u27s policies on Red China • Complications feature plot of Speak easy • Ursinus graduate to address Pre-Legal society Tuesday • Thespians to produce Arsenic and Old Lace • All-Ursinus cast to appear March 17 on Stars in Your Eyes television show • Frosberg and Brownback named co-editors of Alumni Journal • Chi Alpha plans seminary visit, discusses ministerial course • Juniors pick Fuhrman • Campus displays colors for annual ceremony • Dean\u27s Office lists enrollment at 771; 19 enter this term • Lorelei lures males, wrecks egos with curious corsages • French Club sponsors mid-week Mardi Gras • Larry Livingston, chemist, to present lecture on Progress in Better Living • Editorial: Brotherhood, modern style; Lenten thoughts • English office, place of cheerful disorder, is the ultimate authority for all knowledge • Soft music provides impetus for study in relaxed atmosphere of record room • Turnabout: Professors divulge trade secrets, disclose examples of Ursinus student boners • If you tought you saw a puddie-cat in Pfahler, you did • Bears toppled from loop lead by Haverford five • Girls vying for Badminton berths • Swarthmore hands Ursinus Mermaids first defeat, 42-15 • Blue Hens triumph over Bears 23-11; Helfferich victor • Shreiner-Baird squad leads in intramural competition • Garnet cops 63-49 win over staggering Grizzlies • Brodbeck fives top intramural circuit • Should America\u27s women be drafted? • Chesterfield announces names of photography contest winners • IRC hears views of State Department as Miller reports off-record session • Spanish Club studies music • Board member to show film depicting Amish life April 26https://digitalcommons.ursinus.edu/weekly/1559/thumbnail.jp

Measurement of scintillation efficiency for nuclear recoils in liquid argon

The scintillation light yield of liquid argon from nuclear recoils relative to electronic recoils has been measured as a function of recoil energy from 10 keVr up to 250 keVr at zero electric field. The scintillation efficiency, defined as the ratio of the nuclear recoil scintillation response to the electronic recoil response, is 0.25±0.01+0.01 (correlated) above 20 keVr. © 2012 American Physical Society