Gamma-ray Bursts, Classified Physically

From Galactic binary sources, to extragalactic magnetized neutron stars, to long-duration GRBs without associated supernovae, the types of sources we now believe capable of producing bursts of gamma-rays continues to grow apace. With this emergent diversity comes the recognition that the traditional (and newly formulated) high-energy observables used for identifying sub-classes does not provide an adequate one-to-one mapping to progenitors. The popular classification of some > 100 sec duration GRBs as ``short bursts'' is not only an unpalatable retronym and syntactically oxymoronic but highlights the difficultly of using what was once a purely phenomenological classification to encode our understanding of the physics that gives rise to the events. Here we propose a physically based classification scheme designed to coexist with the phenomenological system already in place and argue for its utility and necessity.Comment: 6 pages, 3 figures. Slightly expanded version of solicited paper to be published in the Proceedings of ''Gamma Ray Bursts 2007,'' Santa Fe, New Mexico, November 5-9. Edited by E. E. Fenimore, M. Galassi, D. Palme

Rapidly expanding thenar eminence ganglion: a case report

Introduction This study documents the first reported case of a rapidly growing (volar) thenar eminence ganglion arising form the first carpometacarpal joint, masquerading as a sarcoma. The discussion informs the hand surgeon on the evidence regarding the unusual presenting features. Case presentation An 85 year old left hand dominant female presented with a six week history of rapidly growing lump on the thenar eminence. Clinical examination revealed a non-tender large lobulated mobile swelling measuring 5 × 4 cm and involving the whole thenar eminence. Conclusion Ganglia may present from the thenar eminence and are a source of diagnostic confusion

Perceived discrimination, mental health help-seeking attitudes, and suicide ideation, planning, and attempts among black young adults

Background: Developing an understanding of the negative impact of discrimination is critical when examining the suicidality of Black young adults in the US. Suicide rates among Black young adults have increased at alarming rates. One of the reasons for this increase is the disparities related to access to mental health services, which has long-term health consequences. This study addresses a significant gap in the literature by examining associations between experiences of everyday discrimination, attitudes towards mental health help-seeking attitudes, on the outcomes suicide ideation, planning to die by suicide, and suicide attempts. Methods: The data came from a national study of the experiences of Black young adults regarding mental, physical, and sexual health. Participants were recruited from across the Midwestern region of the United States through Qualtrics Panels, an online survey delivery service used to recruit study participants. The total sample for this study was N = 362, and the average age of the sample was 21 (SD: 1.96). We used a logistic regression analysis to examine the role of everyday discrimination, mental health support-seeking attitudes, and covariates on the outcomes: suicide ideation, planning to die by committing suicide, and suicide attempts. Results: Black young adults with positive mental health help-seeking attitudes were 34% less likely to attempt suicide (OR = 0.66; 95% CI: 0.46, 0.96) and 35% less likely to experience suicide ideation (OR = 0.65; 95% CI: 0.47, 0.89). However, those young adults who experienced discrimination daily were more likely to report having attempted suicide (OR = 1.70; 95% CI: 1.34, 2.15). Conclusions: Our findings offer valuable insights into the complex interplay between experiences of discrimination, attitudes toward seeking mental health support, and suicidal behaviors. However, our research also underscores how experiences of discrimination can significantly exacerbate feelings of isolation, hopelessness, and inadequacy, further contributing to suicidal behaviors in this population. By promoting positive mental health help-seeking behaviors, actively addressing discrimination, and applying an intersectional approach to suicide prevention efforts, we can take significant strides towards building a more supportive and inclusive society. This approach aims to empower individuals to seek help, reduce the risk of suicidal behaviors, and create a more welcoming environment for all members of our community.</p

Tests of a Digital Hadron Calorimeter

In the context of developing a hadron calorimeter with extremely fine granularity for the application of Particle Flow Algorithms to the measurement of jet energies at a future lepton collider, we report on extensive tests of a small scale prototype calorimeter. The calorimeter contained up to 10 layers of Resistive Plate Chambers (RPCs) with 2560 1 \times 1 cm2 readout pads, interleaved with steel absorber plates. The tests included both long-term Cosmic Ray data taking and measurements in particle beams, where the response to broadband muons and to pions and positrons with energies in the range of 1 - 16 GeV was established. Detailed measurements of the chambers efficiency as function of beam intensity have also been performed using 120 GeV protons at varying intensity. The data are compared to simulations based on GEANT4 and to analytical calculations of the rate limitations

IQN path ASBL report from the first European cfDNA consensus meeting:expert opinion on the minimal requirements for clinical ctDNA testing

Liquid biopsy testing is a new laboratory-based method that detects tumour mutations in circulating free DNA (cfDNA) derived from minimally invasive blood sampling techniques. Recognising the significance for clinical testing, in 2017, IQN Path provided external quality assessment for liquid biopsy testing. Representatives of those participating laboratories were invited to attend a workshop to discuss the findings and how to achieve quality implementation of cfDNA testing in the clinical setting, the discussion and outcomes of this consensus meeting are described below. Predictive molecular profiling using tumour tissue in order to select cancer patients eligible for targeted therapy is now routine in diagnostic pathology. If insufficient tumour tissue material is available, in some circumstances, recent European Medicines Agency (EMA) guidance recommends mutation testing with plasma cfDNA. Clinical applications of cfDNA include treatment selection based on clinically relevant mutations derived from pre-treatment samples and the detection of resistant mutations upon progression of the disease. In order to identify tumour-related mutations in amongst other nucleic acid material found in plasma samples, highly sensitive laboratory methods are needed. In the workshop, we discussed the variable approaches taken with regard to cfDNA extraction methods, the tests, and considered the impact of false-negative test results. We explored the lack of standardisation of complex testing procedures ranging from plasma collection, transport, processing and storage, cfDNA extraction, and mutation analysis, to interpretation and reporting of results. We will also address the current status of clinical validation and clinical utility, and its use in current diagnosis. This workshop revealed a need for guidelines on with standardised procedures for clinical cfDNA testing and reporting, and a requirement for cfDNA-based external quality assessment programs

AD Leonis: Radial Velocity Signal of Stellar Rotation or Spin–Orbit Resonance?

AD Leonis is a nearby magnetically active M dwarf. We find Doppler variability with a period of 2.23 days, as well as photometric signals: (1) a short-period signal, which is similar to the radial velocity signal, albeit with considerable variability; and (2) a long-term activity cycle of 4070 ± 120 days. We examine the short-term photometric signal in the available All-Sky Automated Survey and Microvariability and Oscillations of STars (MOST) photometry and find that the signal is not consistently present and varies considerably as a function of time. This signal undergoes a phase change of roughly 0.8 rad when considering the first and second halves of the MOST data set, which are separated in median time by 3.38 days. In contrast, the Doppler signal is stable in the combined High-Accuracy Radial velocity Planet Searcher and High Resolution Echelle Spectrometer radial velocities for over 4700 days and does not appear to vary in time in amplitude, phase, period, or as a function of extracted wavelength. We consider a variety of starspot scenarios and find it challenging to simultaneously explain the rapidly varying photometric signal and the stable radial velocity signal as being caused by starspots corotating on the stellar surface. This suggests that the origin of the Doppler periodicity might be the gravitational tug of a planet orbiting the star in spin–orbit resonance. For such a scenario and no spin–orbit misalignment, the measured v sin i indicates an inclination angle of 15°̣5 ± 2°̣5 and a planetary companion mass of 0.237 ± 0.047 M Jup