Desain Modul Ajar Berbasis Kearifan Lokal untuk Memperkuat Karakter Pelajar Pancasila

Mengintegrasikan kearifan lokal dalam pembelajaran Bahasa Indonesia dapat meningkatkan rasa cinta dan bangga terhadap budaya sendiri serta membantu siswa memahami nilai-nilai yang terkandung di dalamnya. Penelitian ini bertujuan untuk menganalisis kebutuhan siswa dan guru terhadap bahan ajar pada materi menanggapi dan menganalisis bacaan. Metode penelitian yang digunakan adalah survey pada siswa dan guru Bahasa Indonesia kelas VII di SMP Muhammadiyah Rappang. Data dikumpulkan melalui angket dan wawancara. Hasil penelitian menunjukkan bahwa siswa dan guru setuju untuk mengintegrasikan kearifan lokal untuk memahami materi pembelajaran. Kearifan lokal yang dibutuhkan adalah konsep Sipakatau, Sipakalebbi, dan Sipakainge. Jenis bahan ajar yang disukai adalah cetak dan elektronik. Oleh karena itu, disarankan untuk mendesain dan mengembangkan bahan ajar berbasis kearifan lokal untuk penguatan karakter berbasis profil pelajar Pancasila. Dengan demikian, integrasi kearifan lokal dalam bahan ajar materi menanggapi dan menganalisis bacaan merupakan suatu kebutuhan yang penting untuk memperkaya pengalaman belajar siswa serta membangun karakter yang sesuai dengan nilai-nilai budaya dan Pancasila.Integrating local wisdom into Indonesian language learning can enhance students' love and pride in their own culture while helping them understand the values embedded within it. This research employed a qualitative descriptive method aimed at analyzing the needs of students and teachers for teaching materials based on local wisdom in the subject responding to and analyzing texts. Research data were collected through surveys using questionnaires and interviews with seventh-grade students and Indonesian language teachers at SMP Muhammadiyah Rappang. The results showed that both students and teachers agreed on the integration of local wisdom to improve understanding of the learning material. The local wisdom concepts identified as essential are Sipakatau, Sipakalebbi, and Sipakainge. The preferred types of teaching materials include both print and electronic formats. Therefore, it is recommended to design and develop teaching materials based on local wisdom to support character development aligned with the Pancasila Student Profile framework. In conclusion, integrating local wisdom into teaching materials for responding to and analyzing texts is a crucial need to enrich students' learning experiences and foster character development rooted in cultural values and Pancasila principles.

ANALISIS PENGARUH KUALITAS LAYANAN APLIKASI MOBILE BANKING DAN PRODUK BANK TERHADAP KEPUASAN NASABAH UNITED OVERSEAS BANK INDONESIA DI BATAM

Bank services in physical or non-physical service clould be another strategy to win the attention of customer. The satisfaction from the customers is very highly important to establish since the industry is very competitive. UOB Bank is one of the private banks in Batam city that provide mobile banking application which called TMRW and it has several bank products like housing credit, credit cards, deposit and other financial product as well. Research here is conducted to explore the effect of the mobile application of the UOB called TMRW along with the product tha effect satisfaction of the customer. The researcher took random sample in this case with the regresseion method for the hypthesis test. The result of the researh showed the profile of the responden averagely has minimum 2 bank product on their possesion and 100% using the TMRW application. The Regression showed that partially the qualitity of the mobile application TMRW has effects to the customers satisfaction, the variabel of the Quality of bank product has effects for the customers satifaction. Simultaneously quality of the mobile app TMRW and Quality of the bank product has effects for the customers satisfactio

Incontro e scontro di culture: i confinati antifascisti a Eboli e ad Aliano

The political confinement was one of the instrument of persecution of the Fascist regime. This paper aims to analyze how this form of limitation of freedom, based on expulsion and isolation, political but also cultural, economic and social, has helped to overcome the concept of border. The political confinement made new relationships between the Antifascists deported and the local population. The famous novel by Carlo Levi "Christ Stopped at Eboli" describes how the men and women sent to Aliano, the town where Carlo Levi was actually imprisoned, transformed punitive experience in an encounter between different cultures, thanks to the contact with the South of Italy. What happened to Eboli, the country of Salerno mentioned in the title? Are there differences between the case of Eboli, Aliano and the South of Italy?Through the analysis of the 250 letters sent by seventy Antifascist confinemented to Eboli and Aliano, we can identify some of the main policy results, economic, cultural and social produced by Fascist political confinement in Eboli and Aliano. The historical record, made by seventy political deported, helped the renewed Italian political class to face a problem known as the "Southern question".

PHARMACOGENETICS OF FLUOROPYRIMIDINES: FROM THE IMPLEMENTATION OF GUIDELINES TO IDENTIFICATION OF NOVEL GERMLINE VARIANTS RELATED TO TOXICITY

La medicina di precisione trova un valido alleato nella farmacogenomica che mira a identificare varianti genetiche coinvolte nella risposta terapeutica. Nei trattamenti su misura, \ue8 necessaria un'attenzione particolare per quei farmaci che mostrano un basso indice terapeutico, come le fluoropirimidine (FL) che rappresentano la spina dorsale nella gestione di molti tipi di tumori solidi. FL portano a una grave grave tossicit\ue0 (G 653) in una percentuale considerevole di pazienti, causando occasionalmente la morte dei pazienti. Le FL sono metabolizzate principalmente dalla diidropirimidina deidrogenasi (DPD; DPYD) in metaboliti inattivi. Attualmente sono note solo quattro varianti genetiche della DPYD (DPYD * 2A, DPYD * 13, DPYD c.2846A> T e DPYD-HapB3) che riducono l'attivit\ue0 della DPD e di conseguenza sono associate alla tossicit\ue0 correlata alla FL. I quattro SNP utilizzati nel test di genotipizzazione sono raccomandati prima dell\u2019inizio di un trattamento basato su FL. Nonostante l'elevata specificit\ue0, questo test ha dimostrato una bassa sensibilit\ue0, lasciando inspiegabile la maggior parte degli eventi tossici. Recentemente, \ue8 emerso il ruolo precedentemente trascurato di nuove e rare varianti genetiche nella variabilit\ue0 intra-individuale nella risposta ai farmaci. In questa tesi di dottorato, abbiamo mirato a migliorare le conoscenze sulla validit\ue0 clinica e l'utilit\ue0 clinica del test diagnostico clinico DPYD proposto dalle attuali linee guida farmacogenomiche, studiando l'impatto delle quattro varianti della DPYD sulla tossicit\ue0 correlata alle fluoropirimidine e ai costi per la gestione della tossicit\ue0 in grandi coorti di pazienti. Inoltre, abbiamo analizzato il contributo di varianti genetiche nuove e rare in una serie di farmaco-geni nello sviluppo della tossicit\ue0 correlata alle fluoropirimidine. Qui, mostriamo come il test dei quattro SNP per DPYD consente di identificare un gran numero di pazienti che svilupperanno gravi reazioni avverse al trattamento a base di FL in un gruppo di 763 pazienti oncologici. Ci\uf2 \ue8 particolarmente vero se i quattro SNP DPYD sono disposti nel noto punteggio di attivit\ue0 genica (GAS) che pesa ciascun SNP in base al suo impatto specifico sul fenotipo della proteina DPD. Abbiamo anche dimostrato, in un sottogruppo di 550 pazienti con carcinoma del colon-retto, come il genotipo DPYD per il set di quattro SNP o il GAS siano correlati al costo di gestione per gravi tossicit\ue0 correlate alla FL. Questa scoperta ha notevoli implicazioni nell'utilit\ue0 del test che ne garantisce l'applicazione nella pratica clinica di routine. Successivamente abbiamo analizzato, con un approccio di sequenziamento di nuova generazione, il ruolo potenziale di varianti nuove o rare nei geni nella via di disintossicazione in 108 pazienti che non presentano le ben note 4 varianti di rischio DPYD e sviluppato grave tossicit\ue0 correlata al FL. Abbiamo identificato 9 rare varianti di DPYD, 3 erano missense molto rare e 6 erano missense uniche. In confronto, una popolazione di 106 pazienti trattati con un regime basato su FL, senza alcuna reazione avversa, ha mostrato una riduzione di nuove varianti (valore p = 0,001, secondo il test esatto di Fisher). Inoltre, come previsto, abbiamo trovato un arricchimento statisticamente significativo di varianti esoniche rare, molto rare e nuove sulla DPYD nella coorte di pazienti con grave tossicit\ue0 rispetto a quelle senza. Nonostante la necessit\ue0 clinica di personalizzare il trattamento su ciascun paziente, ad oggi tradurre le informazioni genetiche di ciascun paziente in un'indicazione terapeutica rimane un compito impegnativo. Lo studio della farmacogenomica nel trattamento a base di FL ha gi\ue0 fornito marcatori utili e validi per la pratica clinica, lo studio di varianti genetiche rare e nuove potrebbe in futuro migliorare ulteriormente gli strumenti disponibili per una medicina di precisione nel trattamento del cancro.Precision medicine finds a valuable ally in pharmacogenomics which is aimed at identifying genetic variants involved in therapeutic response. In tailored treatments, a specific attention is required for those drugs showing a low therapeutic index, such as fluoropyrimidines (FL) which represent the backbone in the management of many types of solid tumours. FL lead to severe toxicity (G 653) in a considerable percentage of patients, occasionally resulting in patients death. FL are mainly metabolized by dihydropyrimidine dehydrogenase (DPD; DPYD) into inactive metabolite. At present only four DPYD genetic variants (DPYD *2A, DPYD *13, DPYD c.2846A>T and DPYD-HapB3) are known to decrease DPD activity and consequently to be associated to FL-related toxicity. The four SNP genotyping test is recommended before an FL-based treatment by international shared pharmacogenetic guidelines, Despite the high specificity, this test demonstrated a low sensitivity, leaving the majority of the toxic events unexplained. Recently, the previously neglected role of novel and rare genetic variants in the intra-individual variability in the response to drugs has emerged. In this PhD thesis, we aimed at improving the knowledge on the clinical validity and clinical utility of the DPYD clinical diagnostic test proposed by the current pharmacogenomic guidelines, by investigating the impact of the four DPYD variants on fluoropyrimidines-related toxicity and costs for toxicity management in large cohorts of patients. In addition, we analysed the contribution of novel and rare genetic variants in a set of pharmaco-genes in the development of fluoropyrimidines-related toxicity. Here, we show how the four-SNPs test for DPYD allow to identify a large number of patients who will develop severe adverse reactions to FL-based treatment in a group of 763 oncological patients. This is especially true if the four DPYD SNPs are arranged in the so-called gene activity score (GAS) weighing each SNP according to its specific impact on the DPD protein phenotype. We also demonstrated, in a subset of 550 colorectal cancer patients, how the DPYD genotype for the four-SNPs set or the GAS are related to the management cost for severe toxicities related to FL. This finding has notable implication in the utility of the test warranting its application in the routine clinical practice. We subsequently analyzed, by a next generation sequencing approach, the potential role of novel or rare variants in genes in the detoxification pathway in 108 patients that are wild type for the well-know 4 DPYD risk variants and developed severe FL-related toxicity. We identified 9 rare DPYD variants, 3 were very rare missense (c.G345C, p.M115I; c.A2060C p.D687A and c.A2137G, p.N713D), and 6 were singleton missense (c.A110G, p.D37G; c.G481A, p.E161K; c.C800T, p.T267I; c.G958A, p.G320R; c.A1110G, p.I370M;c.C1579T, p.P527S). in comparison, a population of 106 patients treated with a FL-based regimen, without any adverse reaction, displayed a depletion of novel variants (p value =0.001, by Fisher\u2019s Exact Test). Also, as expected, we found a statistically significant enrichment of rare, very rare and novel exonic DPYD variants in the cohort of patients with severe toxicity as compared to those without (P =0.0187, P =0.0187, P =0.0291, respectively, , by Fisher\u2019s Exact Test). Despite the clinical need of tailoring treatment on each patient, to date translating the genetic information of each patient into a therapeutic indication remains a challenging task. The study of the pharmacogenomics in FL-based treatment has already provided useful and valid markers for the clinical practice, the study of rare and novel genetic variants could in the future further improve available tools for a precision medicine in cancer treatment

Jenis Dan Faktor Penyebab Alih Kode Dalam Transaksi Jual Beli Di Pasar

Penelitian ini merupakan penelitian deskriptif kualitatif. Fokus penelitian ini yaitu jenis alih kode berdasarkan sifatnya dan faktor penyebab terjadinya alih kode. Data diperoleh dengan menggunakan teknik observasi, wawancara, rekam, simak, dan introspeksi. Data dianalisis dengan metode deskriptif kualitatif. Hasil penelitian ini menunjukkan bahwa jenis alih kode yang terjadi dalam transaksi jual beli terdiri dari alih kode sementara dan alih kode permanen. Alih kode sementara meliputi alih kode dari bahasa Indonesia ke bahasa Bugis kembali ke bahasa Indonesia dan sebaliknya, sedangkan alih kode permanen juga terjadi meliputi alih kode dari bahasa Indonesia ke bahasa Bugis dan sebaliknya juga. Selanjutnya, faktor penyebab terjadinya alih kode disebabkan oleh empat faktor: (1) faktor penutur, (2) faktor lawan tutur, (3) faktor hadirnya pihak ketiga, dan (4) faktor perubahan topik pembicaraa

Elaboración de una escala de actitudes hacia la violencia de género en adolescentes de instituciones educativas públicas, 26 de octubrePiura

La presente investigación tuvo como objetivo la elaboración de una escala denominada Actitudes hacia la violencia de género. Fue de tipo tecnológica, con un diseño instrumental, la muestra de 830 alumnos entre 12 y 17 años de edad de las instituciones educativas públicas del distrito 26 de octubre, el muestreo fue no probabilístico por conveniencia. Se determinó la validez de contenido, con un acuerdo al 100% en claridad y relevancia, además en el aspecto de coherencia se obtuvo como índice de acuerdo (IA) 1.00. Asimismo, en la validez de constructo, en la dimensión sexual se obtuvo un total de 793** en contraste a la dimensión de Violencia Psicológica que obtuvo un valor de ,922** y la dimensión Violencia Sexual, con un total de ,930**. En el análisis factorial exploratorio, se obtuvo un valor de 0,730, varianza total explicada de 35,922 %, además de obtenerse dos agrupaciones factoriales, el primer factor con un total de 13 reactivos, mientras que en el segundo factor 9 reactivos, descartándose un total de 14 ítems y 1 dimensión. Con respecto a la confiabilidad compuesta a través del método de omega, se obtuvo puntuaciones de 0.836 en la primera dimensión y en la segunda dimensión 0.826

Factores maternos, fetales y placentarios asociados a restricción del crecimiento intrauterino en gestantes atendidas en un Hospital de Piura

Introducción: La restricción del crecimiento intrauterino tiene una incidencia en el Perú del 10%, la cual varía según el territorio, ésta trae consigo múltiples consecuencias por lo que nace la necesidad de identificar los factores asociados; contribuye directamente al tercer objetivo de desarrollo sostenible al abordar los desafíos de salud materno-infantil y promover una vida sana y bienestar especialmente para las gestantes. Objetivo: Determinar la asociación entre los factores maternos, fetales y placentarios y la RCIU en gestantes evaluadas en un Hospital de Piura. Metodología: se ejecutó un estudio observacional, retrospectivo de casos y controles, con una muestra constituida por 86 casos y 86 controles obtenidos por un muestreo no probabilístico apareados por edad, se analizó con la prueba chi cuadrado, con un nivel de confianza de 95% y significancia menor 5%. Se calculó el Odds Ratio para determinar la asociación y se hizo una regresión logística de las variables dicotómicas para identificar cuales aportan mayor relación causal. Resultados: La preeclampsia demostró tener un mayor riesgo de asociación con la RCIU con un P: 0.00, OR: 6.3 y un IC: 1.85-2.60. Conclusiones: Existe asociación entre los factores maternos y la RCIU