Update of the European Association of Cardiovascular Imaging (EACVI) Core Syllabus for the European Cardiovascular Magnetic Resonance Certification Exam

An updated version of the European Association of Cardiovascular Imaging (EACVI) Core Syllabus for the European Cardiovascular Magnetic Resonance (CMR) Certification Exam is now available online. The syllabus lists key elements of knowledge in CMR. It represents a framework for the development of training curricula and provides expected knowledge-based learning outcomes to the CMR trainees, in particular those intending to demonstrate CMR knowledge in the European CMR exam, a core requirement in the CMR certification process

Geodiversity assessment of Paraná state (Brazil): an innovative approach

Geodiversity is considered as the natural range of geological, geomorphological, and soil features, including their assemblages, relationships, properties, interpretations, and systems. A method developed for the quantitative assessment of geodiversity was applied to Parana ́ , a Brazilian state with an area of about 200,000 km2. The method is based on the overlay of a grid over different maps at scales ranging from 1/500,000 to 1/650,000, with the final Geodiversity Index the sum of five partial indexes calculated on a 25 9 25 km grid. The partial indexes represent the main components of geodi- versity, including geology (stratigraphy and lithology), geomorphology, paleontology, and soils. The fifth partial index covers mineral occurrences of geodiversity, such precious stones and metals, energy and industrial minerals, mineral waters, and springs. The Geodiversity Index takes the form of an isoline map that can be used as a tool in land-use planning, particularly in identifying priority areas for conservation, management, and use of natural resources at the state level.The Portuguese authors express their gratitude for the financial support given by the Fundacao para a Ciencia e a Tecnologia to the Centro de Geologia da Universidade do Porto, which partially supports this research. The Brazilian author expresses his gratitude for the financial support given by the CNPq (Conselho Nacional de Desenvolvimento Cientifico e Tecnologico) (Process Number 200074/2011-3)

ADAM2 Interactions with Mouse Eggs and Cell Lines Expressing α4/α9 (ITGA4/ITGA9) Integrins: Implications for Integrin-Based Adhesion and Fertilization

Integrins are heterodimeric cell adhesion molecules, with 18 α (ITGA) and eight β (ITGB) subunits forming 24 heterodimers classified into five families. Certain integrins, especially the α(4)/α(9) (ITGA4/ITGA9) family, interact with members of the ADAM (a disintegrin and metalloprotease) family. ADAM2 is among the better characterized and also of interest because of its role in sperm function. Having shown that ITGA9 on mouse eggs participates in mouse sperm-egg interactions, we sought to characterize ITGA4/ITGA9-ADAM2 interactions.An anti-β(1)/ITGB1 function-blocking antibody that reduces sperm-egg binding significantly inhibited ADAM2 binding to mouse eggs. Analysis of integrin subunit expression indicates that mouse eggs could express at least ten different integrins, five in the RGD-binding family, two in the laminin-binding family, two in the collagen-binding family, and ITGA9-ITGB1. Adhesion assays to characterize ADAM2 interactions with ITGA4/ITGA9 family members produced the surprising result that RPMI 8866 cell adhesion to ADAM2 was inhibited by an anti-ITGA9 antibody, noteworthy because ITGA9 has only been reported to dimerize with ITGB1, and RPMI 8866 cells lack detectable ITGB1. Antibody and siRNA studies demonstrate that ITGB7 is the β subunit contributing to RPMI 8866 adhesion to ADAM2.These data indicate that a novel integrin α-β combination, ITGA9-ITGB7 (α(9)β(7)), in RPMI 8866 cells functions as a binding partner for ADAM2. ITGA9 had previously only been reported to dimerize with ITGB1. Although ITGA9-ITGB7 is unlikely to be a widely expressed integrin and appears to be the result of "compensatory dimerization" occurring in the context of little/no ITGB1 expression, the data indicate that ITGA9-ITGB7 functions as an ADAM binding partner in certain cellular contexts, with implications for mammalian fertilization and integrin function

ICAR: endoscopic skull‐base surgery

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Dissertações produzidas no Programa de Pós-Graduação e Mestrado em Enfermagem da Universidade Federal do Paraná

Trata-se de estudo descritivo, retrospectivo e documental com objetivo de analisar as dissertações produzidas pelo Curso de Mestrado em Enfermagem do Programa de Pós-Graduação em Enfermagem da Universidade Federal do Paraná, considerando o ajustamento de suas linhas de pesquisa. Para tanto foi realizada leitura crítica dos resumos e análise da temática das dissertações e da inserção na linha de pesquisa, bem como de métodos, abordagens, sujeitos, local, instrumentos e técnicas de pesquisa. Foram analisados 64 resumos de dissertações disponíveis on-line. Das produções analisadas há predominância do enfoque qualitativo e da utilização de entrevista. Verificou-se que as dissertações têm anuência com as linhas de pesquisa do Programa do Curso de Mestrado e sua análise pode contribuir para o redimensionamento de caminhos, linhas e pesquisas que o programa tem desenvolvido

Integralidade e cuidado a grávidas adolescentes na Atenção Básica Comprehensive care of pregnant adolescents in Primary Care

O pré-natal em adolescentes tem se caracterizado por ações técnicas buscando-se na atualidade qualificar o cuidado na perspectiva da integralidade. O Programa de Agentes Comunitários de Saúde/Programa Saúde da Família (PACS/PSF) constitui estratégia para avançar nas mudanças requeridas, o que motivou esta investigação científica, que teve como objetivos conhecer o processo de cuidado pré-natal a adolescentes grávidas por profissionais de saúde do PACS/PSF e analisá-lo na perspectiva da integralidade. É um estudo qualitativo, tendo a integralidade como enfoque teórico. Foi desenvolvido em unidades de PACS/PSF em um município da Bahia, sendo sujeitos do estudo profissionais que cuidam de gestantes adolescentes. O material empírico foi produzido por meio de entrevista semiestruturada e observação não participante, em consultas e visitas domiciliárias e analisado pela técnica de análise de discurso. A análise revelou que o cuidado pré-natal à adolescente se concretiza sob o modelo biomédico, e o cumprimento de rotinas e protocolos institucionais sobrepõe-se à singularidade da adolescente. Assim, distancia-se da integralidade, na medida em que as práticas são orientadas por sujeições ideológicas a um modelo que nega às adolescentes grávidas a oportunidade de serem sujeitos.<br>Prenatal adolescent care is characterized by technical actions seeking to provide assistance from the perspective of comprehensive care. The Community Health Agent Program/Family Health Program (PACS/PSF) is a strategy for implementing the changes envisaged, which motivated this scientific investigation. The scope of the research was to assess prenatal care to pregnant adolescents by health professionals of PACS/PSF and analyze it from the standpoint of comprehensive care. It is a qualitative study, with comprehensive care as its theoretical focus. It was conducted in PACS/PSF units in a city in the State of Bahia, and the subjects of study were the practitioners who treat pregnant adolescents. The empirical material was produced by means of semi-structured interviews and non-participative observation in consultations and homecare visits and was analyzed using the speech analysis technique. This revealed that prenatal care for adolescents is provided using the biomedical model, where compliance with institutional protocols and routines takes precedence over considering the specific aspects of the adolescent. Thus it is far removed from comprehensive care, in that the practices are guided by ideological adherence to a model that fails to grant pregnant adolescents the opportunity to be treated as individuals