Hiv/Aids prevalence at the accident & emergency centre of a tertiary and referral health institution in Ghana

Background: Ghana has an estimated HIV prevalence of 1.4%, but the HIV prevalence of patients presenting at emergency departments in Ghana is not well documented in published literature. This study evaluated the prevalence of HIV infection at the Accident & Emergency Department, Komfo Anokye Teaching Hospital (KATH A&E), Kumasi, Ghana.Methods: A descriptive cross-sectional survey was carried out on patients aged 18 and above presenting to KATH A&E. An opt-in testing approach was used; consenting patients were screened for HIV using rapid HIV finger-stick testing with HIV 1-2 STAT-PAK. Sero-positivity was confirmed by OraQuick HIV 1-2 test. Data was analysed using multivariate logistic regression.Results: 1125 patients presenting at the KATH A&E during the study period were offered the Rapid HIV test. 667 of these patients consented to have the test. HIV prevalence was 13.5% (90/667). 53 females (58.9%) were HIV positive compared to 37 males (41.1%). The age group 30-50 years had the highest risk of being HIV-positive. Other socio-demographic variables such as educational level and occupation were significantly associated with HIV-infection (Pvalue = 0.001 at 95% CI).Conclusion: This study shows that emergency department HIV testing in Ghana is feasible. The prevalence of HIV sero-positive patients presenting at KATH A&E was tenfold higher than national estimates. We conclude that this study showed a high prevalence among patients seeking emergency care in our setting. Testing in the emergency department could lead to early detection of HIV-infected patients for linkage to care.Keywords: HIV Infections; HIV Screening; Prevalence, Diagnosis, Emergency Departmen

Strategies to Target Tumor Immunosuppression

The tumor microenvironment is currently in the spotlight of cancer immunology research as a key factor impacting tumor development and progression. While antigen-specific immune responses play a crucial role in tumor rejection, the tumor hampers these immune responses by creating an immunosuppressive microenvironment. Recently, major progress has been achieved in the field of cancer immunotherapy, and several groundbreaking clinical trials demonstrated the potency of such therapeutic interventions in patients. Yet, the responses greatly vary among individuals. This calls for the rational design of more efficacious cancer immunotherapeutic interventions that take into consideration the “immune signature” of the tumor. Multimodality treatment regimens that aim to enhance intratumoral homing and activation of antigen-specific immune effector cells, while simultaneously targeting tumor immunosuppression, are pivotal for potent antitumor immunity

The relative importance of mortgage pricing determinants in mortgage affordability in Ghana: An ex post attribution

Purpose: The purpose of this study is to explore the mortgage affordability problem in Ghana, an issue that has been associated inter alia with high mortgage rates, which results from the high cost of capital, an unstable macroeconomy and unfavourable borrowers’ characteristics. Concurrent improvements in both the macroeconomy and borrowers’ characteristics have rendered the identification of the most problematic mortgage pricing determinant difficult, consequently making the targeting of policy interventions problematic. Design/methodology/approach: This research sought to resolve this aforementioned difficulty by providing empirical evidence on the relative importance of mortgage pricing determinants. A data set of mortgage rates of selected Ghanaian banking financial institutions from 2003 to 2013 was examined and analysed by applying Fisher’s model of interest rates and an ex post analysis of the standard regression coefficients. Findings: The risk premium factor emerged as the most important determinant in Ghana compared with the inflation premium and the real risk-free rate, although all are statistically significant and strongly correlated with mortgage rates. Originality/value: This study provides an insight on the relative importance of mortgage pricing determinates and subsequent macro-economic guidance to support policy interventions which could reduce mortgage rates/enhance mortgage affordability. The paper specifically aims to engender wider debate and provide guidance to the Ghanaian Government and/or private enterprises that seek to provide affordable mortgages. Further research is proposed which could explore ways of reducing mortgage rates as a means of engendering social equality and adopt innovative international best practice that has already been tried and tested in countries such as South Africa and the USA

Fertility Problems and Fertility Care in Sub-Saharan Africa: The Case of Kenya

Having children is important to most people. Nevertheless, fertility care for involuntarily childless couples is not a high priority for governments in developing countries. Governments and Non-governmental Organizations (NGOs) in these countries give more urgency and money to programs which support contraception and safe abortions, because of concerns, for example, about population growth and life-threatening diseases such as HIV/AIDS. In highly pronatalist countries, however, the consequences of having fertility problems can have an enormous negative impact on the life and well-being of involuntarily childless couples. The focus of this chapter will be on infertility, fertility problems and involuntary childlessness in Kenya. In this chapter we describe the findings of a mixed method study among men and women with fertility problems that was carried out in Kenya in 2016. The following themes are addressed: knowledge of fertility problems, the need to have children, rejections from society because of not having a child, fertility-related quality of life, loneliness versus support and sharing, and fertility treatment (considerations and experiences)

Long-term impacts of season of grazing on soil carbon sequestration and selected soil properties in the arid Eastern Cape, South Africa

BACKGROUND AND AIMS : The karoo biomes of South Africa are major feed resources, yet soil nutrient depletion and degradation is a major problem. The objective of this study was to assess impacts of long-term (>75 years) grazing during spring (SPG), summer (SUG), winter (WG) and exclosure (non-grazed control) treatments on soil nutrients, penetration resistance and infiltration tests. METHODS : A soil sampling campaign was carried out to collect soil to a depth of 60 cm to analyse bulk density, soil physical and chemical parameters as well as soil compaction and infiltration. RESULTS : Generally, grazing treatments reduced soil organic C (SOC) stocks and C:N ratios, and modified soil properties. There was higher SOC stock (0.128 Mg ha-1 yr-1) in the exclosure than in the SPG (0.096 Mg ha-1 yr- 1), SUG (0.099 Mg ha-1 yr-1) and WG (0.105 Mg ha-1 yr-1). The C:N ratios exhibited similar pattern to that of C. From the grazing treatments, the WG demonstrated 7 to 10% additional SOC stock over the SPG and SUG, respectively. CONCLUSIONS : Short period animal exclusion could be an option to be considered to improve plant nutrients in sandy soils of South Africa. However, this may require a policy environment which supports stock exclusion from such areas vulnerable to land degradation, nutrient and C losses by grazing-induced vegetation and landscape changes.Department of Science and Technology University of Pretoria) and the European Communities, 7th framework program under the grant agreement No. 266018, ANIMALCHANGE project.http://link.springer.com/journal/111042016-12-31hb201