Oxygen isotope composition of diatoms from sediments of Lake Kotokel (Buryatia).

This is a summary of new oxygen isotope data for diatoms from Lake Kotokel sediments, with implications for responses of the lake system and its environment to global change over the past 46 kyr. Fossil diatoms in all samples are free from visible contamination signatures and contain no more than 2.5% Al2O3, which ensures reliable reconstructions. The δ18O values in diatoms vary between +23.7 and +31.2‰ over the record. The results mainly represent diatom assemblages of summer blooming periods, except for the time span between 36 and 32 kyr, when the isotopic signal rather records a shift from summer to spring blooming conditions. Possible water temperature changes only partly explain the changes in the isotopic record. The observed isotopic patterns are produced mainly by isotope changes in lake water in response to variations in air temperature, hydrology, and atmospheric circulation in the region. During Marine Isotope Stage (MIS) 2 (Last Glacial maximum), high δ18Odiatom resulted from rapid evaporation and low fluvial inputs. The high δ18O values of about +29 to +30‰ during the first half of MIS 1 (Holocene interglacial) suggest an increased share of summer rainfalls associated with southern/southeastern air transport. The δ18O decrease to +24‰ during the second half of MIS 1 is due to the overall hemispheric cooling and increased moisture supply to the area by the Atlantic transport. The record of Lake Kotokel sediments provides an example of complex interplay among several climatic controls of δ18Odiatom in the Late Pleistocene and the Holocene

Methods of internal control in integrated management accounting system of the enterprise

The purpose of internal control procedure of material and information flows is expression of independent opinion about accounting of material and information flows of the organization, development of recommendations about elimination of detected violations and preparing data to implement automated management accounting system, based on integrated system. Internal control procedure of material and information flows in the enterprise can solve complex of problems about identifying deficiencies in accounting, searching for reserves using information resources, identifying opportunities for implementation of automated management accounting system at the enterprise. Internal control was planned and conducted thus to argue that management statements are free of misstatement, and information flows provide required operability of the entire system. Internal control was carried out on a sample basis and included examining, on a test basis evidence supporting the amounts and disclosures in management reports. The disclosure of information about innovative activities, assessment of compliance with the principles and rules of accounting used in the preparation of management reporting, the review of key performance indicators, as well as evaluating the presentation of management reports are presented

Methods of internal control in integrated management accounting system of the enterprise

The purpose of internal control procedure of material and information flows is expression of independent opinion about accounting of material and information flows of the organization, development of recommendations about elimination of detected violations and preparing data to implement automated management accounting system, based on integrated system. Internal control procedure of material and information flows in the enterprise can solve complex of problems about identifying deficiencies in accounting, searching for reserves using information resources, identifying opportunities for implementation of automated management accounting system at the enterprise. Internal control was planned and conducted thus to argue that management statements are free of misstatement, and information flows provide required operability of the entire system. Internal control was carried out on a sample basis and included examining, on a test basis evidence supporting the amounts and disclosures in management reports. The disclosure of information about innovative activities, assessment of compliance with the principles and rules of accounting used in the preparation of management reporting, the review of key performance indicators, as well as evaluating the presentation of management reports are presented

COMPARISON OF CLINICAL ACTIVITY OF PIMECROLIMUS IN PEDIATRIC PATIENTS WITH MILD AND MODERATE ATOPIC DERMATITIS

Atopic dermatitis (ad) is prevalent disease in younger children. Calcium inhibitor pimecrolimus (elidel, cream 1%) is the latest anti-inflammatory drug offered for management of ad. The activity of pimecrolimus was evaluated in open, prospective, randomized, comparison trial, on 60 children (age from 3 months to 7 years) with mild and moderate ad. Pimecrolimus was more effective in management of mild ad on the assumption of regular use of drug (TIS < 17), and topical corticosteroids were effective in patients with moderate ad.Key words: children, atopic dermatitis, pimecrolimus, topical corticosteroids, management

COMPARISON OF CLINICAL ACTIVITY OF PIMECROLIMUS IN PEDIATRIC PATIENTS WITH MILD AND MODERATE ATOPIC DERMATITIS

Atopic dermatitis (ad) is prevalent disease in younger children. Calcium inhibitor pimecrolimus (elidel, cream 1%) is the latest anti-inflammatory drug offered for management of ad. The activity of pimecrolimus was evaluated in open, prospective, randomized, comparison trial, on 60 children (age from 3 months to 7 years) with mild and moderate ad. Pimecrolimus was more effective in management of mild ad on the assumption of regular use of drug (TIS &lt; 17), and topical corticosteroids were effective in patients with moderate ad.Key words: children, atopic dermatitis, pimecrolimus, topical corticosteroids, management.</strong

Современные проблемы менеджмента, маркетинга и предпринимательства

В монографии, подготовленной по итогам дискуссии на Первых Герчиковских чтениях «Современные проблемы менеджмента, маркетинга и предпринимательства», дается комплексный анализ широкого спектра проблем развития и функционирования субъектов предпринимательской деятельности в условиях современной динамичной внешней среды. Подробно рассматриваются различные теоретические и прикладные вопросы эволюции деятельности фирм и трансформации их бизнес-моделей с учетом сложных процессов в мировой экономике в начале XXI века. Детально проанализированы тенденции развития международного менеджмента, концепции глобализации и глокализации как основные сценарии развития международного маркетинга, рассмотрены вопросы стратегического менеджмента и корпоративного управления в международном бизнесе, освещены современные тренды в инновационном предпринимательстве, вопросы брендинга и стратегических коммуникаций, исследованы проблемы конкурентоспособности фирм и вопросы внешнеэкономической деятельности российских компаний. Для руководителей всех уровней управления, специалистов по маркетингу, брендингу и внешнеэкономической деятельности, предпринимателей, научных сотрудников, аспирантов