51 research outputs found
Anomalous scaling behavior in Takens-Bogdanov bifurcations
A general algorithm is presented for estimating the nonlinear instability
threshold, , for subcritical transitions in systems where the
linearized dynamics is significantly non-normal (i.e. subcritical bifurcations
of {\em Takens-Bogdanov} type). The -dimensional degenerate node is
presented as an example. The predictions are then compared to numerical studies
with excellent agreement.Comment: 6 page
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Recirculation in multiple wave conversions
A one-dimensional multiple wave-conversion model is constructed that allows energy recirculation in ray phase space. Using a modular eikonal approach, the connection coefficients for this model are calculated by ray phase-space methods. Analytical results (confirmed numerically) show that all connection coefficients exhibit interference effects that depend on an interference phase, calculated from the coupling constants and the area enclosed by the intersecting rays. This conceptual model, which focuses on the topology of intersecting rays in phase space, is used to investigate how mode conversion between primary and secondary waves is modified by the presence of a tertiary wave
Nomadic devices in the vehicle environment: planning of field operation tests in Europe
The market for the Nomadic Devices, such as on-board navigation devices and smart phones,
integrated to road vehicles is increasing rapidly today. While providing uselful services for
travellers, at the same time, these devices may introduce significant usability and distraction
problems, jeopardizing their safety as the devices are not usually specially designed for the
vehicle context. Consequently, there is a need to study the impacts of such devices by Field
Operational Tests (FOT). TeleFOT (Field Operational Tests of Aftermarket and Nomadic
Devices in Vehicles), is a European Commission co-funded integrated project aiming to
assess the impacts of aftermarket and nomadic devices used in vehicles for driver support and
to raise wide awareness of the functions and potential these devices offer, by implementing
Field Operational Tests. To do so it will build, mobilise and integrate European test
communities for long term testing and assessment of driver support functions through
aftermarket and nomadic devices. It will also work on the related methodological framework
Resonant Absorption as Mode Conversion?
Resonant absorption and mode conversion are both extensively studied
mechanisms for wave "absorption" in solar magnetohydrodynamics (MHD). But are
they really distinct? We re-examine a well-known simple resonant absorption
model in a cold MHD plasma that places the resonance inside an evanescent
region. The normal mode solutions display the standard singular resonant
features. However, these same normal modes may be used to construct a ray
bundle which very clearly undergoes mode conversion to an Alfv\'en wave with no
singularities. We therefore conclude that resonant absorption and mode
conversion are in fact the same thing, at least for this model problem. The
prime distinguishing characteristic that determines which of the two
descriptions is most natural in a given circumstance is whether the converted
wave can provide a net escape of energy from the conversion/absorption region
of physical space. If it cannot, it is forced to run away in wavenumber space
instead, thereby generating the arbitrarily small scales in situ that we
recognize as fundamental to resonant absorption and phase mixing. On the other
hand, if the converted wave takes net energy way, singularities do not develop,
though phase mixing may still develop with distance as the wave recedes.Comment: 23 pages, 8 figures, 2 tables; accepted by Solar Phys (July 9 2010
Three Dimensional MHD Wave Propagation and Conversion to Alfven Waves near the Solar Surface. I. Direct Numerical Solution
The efficacy of fast/slow MHD mode conversion in the surface layers of
sunspots has been demonstrated over recent years using a number of modelling
techniques, including ray theory, perturbation theory, differential eigensystem
analysis, and direct numerical simulation. These show that significant energy
may be transferred between the fast and slow modes in the neighbourhood of the
equipartition layer where the Alfven and sound speeds coincide. However, most
of the models so far have been two dimensional. In three dimensions the Alfven
wave may couple to the magneto-acoustic waves with important implications for
energy loss from helioseismic modes and for oscillations in the atmosphere
above the spot. In this paper, we carry out a numerical ``scattering
experiment'', placing an acoustic driver 4 Mm below the solar surface and
monitoring the acoustic and Alfvenic wave energy flux high in an isothermal
atmosphere placed above it. These calculations indeed show that energy
conversion to upward travelling Alfven waves can be substantial, in many cases
exceeding loss to slow (acoustic) waves. Typically, at penumbral magnetic field
strengths, the strongest Alfven fluxes are produced when the field is inclined
30-40 degrees from the vertical, with the vertical plane of wave propagation
offset from the vertical plane containing field lines by some 60-80 degrees.Comment: Accepted for the HELAS II/ SOHO 19/ GONG 2007 Topical Issue of Solar
Physic
Determinant representation for some transition probabilities in the TASEP with second class particles
We study the transition probabilities for the totally asymmetric simple
exclusion process (TASEP) on the infinite integer lattice with a finite, but
arbitrary number of first and second class particles. Using the Bethe ansatz we
present an explicit expression of these quantities in terms of the Bethe wave
function. In a next step it is proved rigorously that this expression can be
written in a compact determinantal form for the case where the order of the
first and second class particles does not change in time. An independent
geometrical approach provides insight into these results and enables us to
generalize the determinantal solution to the multi-class TASEP.Comment: Minor revision; journal reference adde
Epigenome-wide association study of kidney function identifies trans-ethnic and ethnic-specific loci
BACKGROUND: DNA methylation (DNAm) is associated with gene regulation and estimated glomerular filtration rate (eGFR), a measure of kidney function. Decreased eGFR is more common among US Hispanics and African Americans. The causes for this are poorly understood. We aimed to identify trans-ethnic and ethnic-specific differentially methylated positions (DMPs) associated with eGFR using an agnostic, genome-wide approach. METHODS: The study included up to 5428 participants from multi-ethnic studies for discovery and 8109 participants for replication. We tested the associations between whole blood DNAm and eGFR using beta values from Illumina 450K or EPIC arrays. Ethnicity-stratified analyses were performed using linear mixed models adjusting for age, sex, smoking, and study-specific and technical variables. Summary results were meta-analyzed within and across ethnicities. Findings were assessed using integrative epigenomics methods and pathway analyses. RESULTS: We identified 93 DMPs associated with eGFR at an FDR of 0.05 and replicated 13 and 1 DMPs across independent samples in trans-ethnic and African American meta-analyses, respectively. The study also validated 6 previously published DMPs. Identified DMPs showed significant overlap enrichment with DNase I hypersensitive sites in kidney tissue, sites associated with the expression of proximal genes, and transcription factor motifs and pathways associated with kidney tissue and kidney development. CONCLUSIONS: We uncovered trans-ethnic and ethnic-specific DMPs associated with eGFR, including DMPs enriched in regulatory elements in kidney tissue and pathways related to kidney development. These findings shed light on epigenetic mechanisms associated with kidney function, bridging the gap between population-specific eGFR-associated DNAm and tissue-specific regulatory context
Rare coding variants in RCN3 are associated with blood pressure
Background: While large genome-wide association studies have identified nearly one thousand loci associated with variation in blood pressure, rare variant identification is still a challenge. In family-based cohorts, genome-wide linkage scans have been successful in identifying rare genetic variants for blood pressure. This study aims to identify low frequency and rare genetic variants within previously reported linkage regions on chromosomes 1 and 19 in African American families from the Trans-Omics for Precision Medicine (TOPMed) program. Genetic association analyses weighted by linkage evidence were completed with whole genome sequencing data within and across TOPMed ancestral groups consisting of 60,388 individuals of European, African, East Asian, Hispanic, and Samoan ancestries. Results: Associations of low frequency and rare variants in RCN3 and multiple other genes were observed for blood pressure traits in TOPMed samples. The association of low frequency and rare coding variants in RCN3 was further replicated in UK Biobank samples (N = 403,522), and reached genome-wide significance for diastolic blood pressure (p = 2.01 × 10− 7). Conclusions: Low frequency and rare variants in RCN3 contributes blood pressure variation. This study demonstrates that focusing association analyses in linkage regions greatly reduces multiple-testing burden and improves power to identify novel rare variants associated with blood pressure traits
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