Socioeconomic Challenges – A Global Perspective Evaluating Invisible Connections-Resolutioning Necessary Global Collaborative

The author proports to you that currently held views of nations and governments as possessive in singular economics, as well as resulting socioeconomic behaviors and challenges, is in fact mistaken from the onset. Herein she endeavors the task, through the course of this research and it’s presentation to bring to light an awareness and understanding the interconnections of a singular and reactionary system. Separate only in the minds of nations this system is wholly interdependent and reactionary, as such it is merely a singular spoke of a global collective. Further as socioeconomic challenges among nations are equally diverse and interconnected, reactionary and affecting of the whole: internal communal and societal degradation, weakening financial systems, repressive and proportional representation systems and the rise of radical extremism. Reactionary of the whole, the causation and resolutioning then too must come of the whole. A single unified global action effective of a singular unified system

Modeling beams with elements in phase space

Conventional particle codes represent beams as a collection of macroparticles. An alternative is to represent the beam as a collection of current carrying elements in phase space. While such a representation has limitations, it may be less noisy than a macroparticle model, and it may provide insights about the transport of space charge dominated beams which would otherwise be difficult to gain from macroparticle simulations. The phase space element model of a beam is described, and progress toward an implementation and difficulties with this implementation are discussed. A simulation of an axisymmetric beam using 1d elements in phase space is demonstrated

Theory of Double-Sided Flux Decorations

A novel two-sided Bitter decoration technique was recently employed by Yao et al. to study the structure of the magnetic vortex array in high-temperature superconductors. Here we discuss the analysis of such experiments. We show that two-sided decorations can be used to infer {\it quantitative} information about the bulk properties of flux arrays, and discuss how a least squares analysis of the local density differences can be used to bring the two sides into registry. Information about the tilt, compressional and shear moduli of bulk vortex configurations can be extracted from these measurements.Comment: 17 pages, 3 figures not included (to request send email to [email protected]

Interstitials, Vacancies and Dislocations in Flux-Line Lattices: A Theory of Vortex Crystals, Supersolids and Liquids

We study a three dimensional Abrikosov vortex lattice in the presence of an equilibrium concentration of vacancy, interstitial and dislocation loops. Vacancies and interstitials renormalize the long-wavelength bulk and tilt elastic moduli. Dislocation loops lead to the vanishing of the long-wavelength shear modulus. The coupling to vacancies and interstitials - which are always present in the liquid state - allows dislocations to relax stresses by climbing out of their glide plane. Surprisingly, this mechanism does not yield any further independent renormalization of the tilt and compressional moduli at long wavelengths. The long wavelength properties of the resulting state are formally identical to that of the ``flux-line hexatic'' that is a candidate ``normal'' hexatically ordered vortex liquid state.Comment: 21 RevTeX pgs, 7 eps figures uuencoded; corrected typos, published versio

Experimental pulse technique for the study of microbial kinetics in continuous culture

A novel technique was developed for studying the growth kinetics of microorganisms in continuous culture. The method is based on following small perturbations of a chemostat culture by on-line measurement of the dynamic response in oxygen consumption rates. A mathematical model, incorporating microbial kinetics and mass transfer between gas and liquid phases, was applied to interpret the data. Facilitating the use of very small disturbances, the technique is non-disruptive as well as fast and accurate. The technique was used to study the growth kinetics of two cultures, Methylosinus trichosporium OB3b growing on methane, both in the presence and in the absence of copper, and Burkholderia (Pseudomonas) cepacia G4 growing on phenol. Using headspace flushes, gas blocks and liquid substrate pulse experiments, estimates for limiting substrate concentrations, maximum conversion rates Vmax and half saturation constants Ks could rapidly be obtained. For M. trichosporium OB3b it was found that it had a far higher affinity for methane when particulate methane monooxygenase (pMMO) was expressed than when the soluble form (sMMO) was expressed under copper limitation. While for B. cepacia G4 the oxygen consumption pattern during a phenol pulse in the chemostat indicated that phenol was transiently converted to an intermediate (4-hydroxy-2-oxovalerate), so that initially less oxygen was used per mole of phenol.

Formation of Small-Scale Condensations in the Molecular Clouds via Thermal Instability

A systematic study of the linear thermal instability of a self-gravitating magnetic molecular cloud is carried out for the case when the unperturbed background is subject to local expansion or contraction. We consider the ambipolar diffusion, or ion-neutral friction on the perturbed states. In this way, we obtain a non-dimensional characteristic equation that reduces to the prior characteristic equation in the non-gravitating stationary background. By parametric manipulation of this characteristic equation, we conclude that there are, not only oblate condensation forming solutions, but also prolate solutions according to local expansion or contraction of the background. We obtain the conditions for existence of the Field lengths that thermal instability in the molecular clouds can occur. If these conditions establish, small-scale condensations in the form of spherical, oblate, or prolate may be produced via thermal instability.Comment: 16 page, accepted by Ap&S

Imprints of the Quantum World in Classical Mechanics

The imprints left by quantum mechanics in classical (Hamiltonian) mechanics are much more numerous than is usually believed. We show Using no physical hypotheses) that the Schroedinger equation for a nonrelativistic system of spinless particles is a classical equation which is equivalent to Hamilton's equations.Comment: Paper submitted to Foundations of Physic

Symptom burden and lived experiences of patients, caregivers and healthcare professionals on the management of malignant bowel obstruction: A qualitative systematic review

Background: Malignant bowel obstruction occurs in up to 50% of people with advanced ovarian and 15% of people with gastrointestinal cancers. Evaluation and comparison of interventions to manage symptoms are hampered by inconsistent evaluations of efficacy and lack of agreed core outcomes. The patient perspective is rarely incorporated. Aim: To synthesise the qualitative data regarding patient, caregiver and healthcare professionals’ views and experience of malignant bowel obstruction to inform the development of a core outcome set for the evaluation of malignant bowel obstruction. Design: A qualitative systematic review was conducted, with narrative synthesis. The review protocol was registered prospectively (https://www.crd.york.ac.uk/prospero, CRD42020176393). Data sources: MEDLINE, EMBASE, CINAHL, PsycINFO and Scopus databases were searched for studies published between 2010 and 2021. Reference lists were screened for further relevant publications, and citation tracking was performed. Results: Nine papers were included, reporting on seven studies which described the views and experiences of malignant bowel obstruction through the perspectives of 75 patients, 13 caregivers and 62 healthcare professionals. Themes across the papers included symptom burden, diverse experiences of interventions, impact on patient quality of life, implications and trajectory of malignant bowel obstruction, mixed experience of communication and the importance of realistic goals of care. Conclusion: Some of the most devastating sequelae of malignant bowel obstruction, such as pain and psychological distress, are not included routinely in its clinical or research evaluation. These data will contribute to a wider body of work to ensure the patient and caregiver perspective is recognised in the development of a core outcome set

The range and suitability of outcome measures used in the assessment of palliative treatment for inoperable malignant bowel obstruction: A systematic review

Background: Malignant bowel obstruction, a complication of certain advanced cancers, causes severe symptoms which profoundly affect quality of life. Clinical management remains complex, and outcome assessment is inconsistent.Aim: To identify outcomes evaluating palliative treatment for inoperable malignant bowel obstruction, as part of a four-phase study developing a core outcome set. Design: The review is reported in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA); PROSPERO (ID: CRD42019150648). Eligible studies included at least one subgroup with obstruction below the ligament of Treitz undergoing palliative treatment for inoperable malignant bowel obstruction. Study quality was not assessed because the review does not evaluate efficacy. Data sources: Medline, Embase, the Cochrane Database, CINAHL, PSYCinfo Caresearch, Open Grey and BASE were searched for trials and observational studies in October 2021. Results: A total of 4769 studies were screened, 290 full texts retrieved and 80 (13,898 participants) included in a narrative synthesis; 343 outcomes were extracted verbatim and pooled into 90 unique terms across six domains: physiological, nutrition, life impact, resource use, mortality and survival. Prevalent outcomes included adverse events (78% of studies), survival (54%), symptom control (39%) and mortality (31%). Key individual symptoms assessed were vomiting (41% of studies), nausea (34%) and pain (33%); 19% of studies assessed quality of life. Conclusions: Assessment focuses on survival, complications and overall symptom control. There is a need for definitions of treatment ‘success’ that are meaningful to patients, a more consistent approach to symptom assessment, and greater consideration of how to measure wellbeing in this population