35 research outputs found

    ИННОВАЦИОННЫЕ МЕТОДЫ ЛЕЧЕНИЯ СИСТЕМНЫХ АУТОИММУННЫХ ЗАБОЛЕВАНИЙ

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    In the present paper we consider the problem of innovative treatment of systemic autoimmune diseases for example, rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). The use of biological therapy is suitable for severe rheumatoid arthritis and promotes remission in 25–30% of cases. Application biological therapy (as anti-B cell therapy) in cases of systemic lupus erythematosus severe forms can reduce the immuno activity level, and also leads to the regression of secondary vasculitis in lung tissue and renal parenchyma. The analysis of drugs and principles of treatment of rheumatoid arthritis and systemic lupus erythematosus was done. Particular attention is paid to the safety and efficacy of biological agents and synthetic base anti-inflammatory drugs. Рассматриваются проблемы инновационного лечения системных аутоиммунных заболеваний на примере ревматоидного артрита и системной красной волчанки. Проведен анализ лекарственных средств и принципов лечения ревматоидного артрита и системной красной волчанки. Применение генно-инженерных биологических препаратов целесообразно при тяжелом и быстропрогрессирующем течении ревматоидного артрита и способствует достижению ремиссии в 25–30% случаев. Использование генно-инженерных биологических препаратов (в виде анти-В-клеточной терапии) при тяжелых формах системной красной волчанки позволяет снизить уровень иммуновоспалительной активности, а также приводит к регрессу вторичного васкулита легочной ткани и почечной паренхимы. Особое внимание уделено вопросам безопасности и эффективности генно-инженерных биологических препаратов и синтетических базисных противовоспалительных средств.

    Measurement of prompt D0^{0} and D\overline{D}0^{0} meson azimuthal anisotropy and search for strong electric fields in PbPb collisions at root SNN\sqrt{S_{NN}} = 5.02 TeV

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    The strong Coulomb field created in ultrarelativistic heavy ion collisions is expected to produce a rapiditydependent difference (Av2) in the second Fourier coefficient of the azimuthal distribution (elliptic flow, v2) between D0 (uc) and D0 (uc) mesons. Motivated by the search for evidence of this field, the CMS detector at the LHC is used to perform the first measurement of Av2. The rapidity-averaged value is found to be (Av2) = 0.001 ? 0.001 (stat)? 0.003 (syst) in PbPb collisions at ?sNN = 5.02 TeV. In addition, the influence of the collision geometry is explored by measuring the D0 and D0mesons v2 and triangular flow coefficient (v3) as functions of rapidity, transverse momentum (pT), and event centrality (a measure of the overlap of the two Pb nuclei). A clear centrality dependence of prompt D0 meson v2 values is observed, while the v3 is largely independent of centrality. These trends are consistent with expectations of flow driven by the initial-state geometry. ? 2021 The Author. Published by Elsevier B.V. This is an open access article under the CC BY licens

    Measurement of nuclear modification factors of Υ(1S), Υ(2S), and Υ(3S) mesons in PbPb collisions at √sNN = 5.02 TeV

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    Measurement of prompt ψ(2S) production cross sections in proton–lead and proton–proton collisions at √SNN = 5.02 TeV

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    Measurement of quarkonium production cross sections in pp collisions at √s =13 TeV

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    RuSim1000

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    The dataset for evaluating Russian-language distributional models that focus on revealing similarity (possibly accompanied by association) as opposed to pure association

    MULTIFUNCTIONAL RASTER MOTION SENSOR

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    Background. Modern sensors as sources of information determine the level of quality of informationmeasuring and control systems of complex industrial-technological objects, especially in such science-intensive fields as power engineering, aviation, rocket-space technology, weapons and military equipment, etc. One of the tasks in the development of rocket-space systems is the measurement and control of movements of mechanical systems. The existing displacement sensors are not capable of simultaneous measurement of angular and linear movements. To solve this problem a displacement sensor was developed, which has extended functionality and is able to measure linear and angular movements simultaneously. Materials and methods. The amplitude-logic method of processing modulated signals from a raster displacement sensor was used in this work. In the course of the work, a design diagram of a multifunctional displacement sensor and a schematic diagram of the secondary converter were developed. Results. As a result of the conducted research, the possibility of creating a multifunctional displacement sensor capable of working in a wide temperature range of 20 ÷ 600 ℃, capable of simultaneously measuring linear and angular movements was confirmed

    MATHEMATICAL MODEL OF A TRANSFORMER LINEAR DISPLACEMENT SENSOR

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    Background. At present, the efficiency of development and operation of modern automated systems of control and management of various technological processes is largely determined by the technical and economic characteristics of the primary transducers of information (sensors) among which the important place belongs to displacement sensors. The mathematical model of mutual inductive linear displacement sensors underlying the calculation algorithm developed on the basis of the solution of the boundary electrodynamic problem of interaction of a homogeneous alternating field with an electromagnetic rod is considered. Materials and methods. The systems of Poisson's and Laplace's equations with respect to the vector potential were used in this work. Results. As a result of this research, a mathematical model was proposed, which was used in the development of the TDS designed to measure the movements of the solar panels of a satellite vehicle in open space conditions
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