Determinants of Creutzfeldt-Jakob disease : a genetic epidemiologic study

Creutzfeldt-Jakob disease (CJD) is the most common form of the human transmissible spongiform encephalopathies.1 The disease is characterised by rapid neurodegeneration leading to death within weeks to months. CJD is a rare disorder with an intriguing etiology, involving genetic and iatrogenic transmission. Ten to fifteen percent of patients with CJD are determined by mutations in the prion protein gene.2 The clinical expression of these familial forms is highly variable and may range from a ‘typical’ CJD phenotype with rapid deterioration to a slowly progressive dementia mimicking Alzheimer’s disease. Apart from the causative mutations, a common polymorphism within the prion protein gene determines susceptibility to CJD.3 Subjects who are homozygous for either allele of this polymorphism are at increased risk of CJD. There is growing evidence that this polymorphism further may influence clinical expression of CJD. Finally, the effect of the prion protein may extend to other forms of neurodegenerative disorders. Besides a role in rare diseases such as Gerstmann-Sträussler-Scheinker disease and fatal familial insomnia, the gene may also have an effect on cognitive decline and dementia in the general populatio

Standaarden bieden houvast aan alle zorgverleners

Contains fulltext : 174053.pdf (publisher's version ) (Open Access)Ondersteuning bij diagnostiek en behandeling bij stoornissen in het middelengebruik. Richtlijnen en zorgstandaarden geven handvatten om effectief het gesprek aan te gaan met (weinig gemotiveerde) verslaafden, om samen te werken met naasten, en om effectieve interventies aan te bieden. Een overzicht van het aanbod. Verslavingszorginstellingen, beroepsgroepen en verzekeraars werken samen met patiëntvertegenwoordigers aan goede verslavingszorg en preventie. Zij hebben daarvoor zorgstandaarden en richtlijnen ontwikkeld of herzien.3 p

Isolation and Characterization of Mutants of Thiophene Synthesis in Tagetes Erecta

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Are smokers protected against SARS-CoV-2 infection (COVID-19)? The origins of the myth

A number of recent studies have found low percentages of smokers among COVID-19 patients, causing scientists to conclude that smokers may be protected against SARS-CoV-2 infection. National and international media were interested in this story and we soon began receiving questions about this topic in general practice. In this article, we shed light on the process that resulted in the misinterpretation of observational research by scientists and the media. We also point out the methodological flaws of various studies on which hasty conclusions were based. Finally, we address the role of primary healthcare providers in mitigating the consequences of erroneous claims about a protective effect of smoking.Prevention, Population and Disease management (PrePoD)Public Health and primary car